Distribution Of Blood Groups Research Articles

Exploring the Link: A Cross-Sectional Study on the Correlation Between Periodontal Health and ABO & Rh Blood Group Phenotype in Intellectually Disabled Individuals of Dakshina Kannada District

Background and Aim Across the globe individuals with intellectual disabilities ID are frequently noted to exhibit inferior oral hygiene and periodontal health. Previous research has demonstrated a link between periodontal health and blood grouping among apparently healthy individuals with periodontitis patients. This study attempted to assess a relationship between periodontal health and blood grouping phenotypes among individuals with intellectual disabilities in Dakshina Kannada District.Methods In Dakshina Kannada district a cross-sectional survey was conducted among 548 intellectually disabled individuals enrolled in special needs institutions. Among them 115 individuals were identified as having Down syndrome while the remaining 433 individuals had other intellectual disabilities. During the survey oral hygiene indices such as Oral Hygiene Index Simplified OHI-S Gingival index GI and Periodontal Screening and Recording PSR index were measured and ABO blood group patterns were established through self-reports verified by medical records.Results Among 548 intellectually disabled individuals distribution of blood group was as follows 32.11 had blood group A 26.64 had blood group B 23.90 had blood group O and 17.33 had blood group AB. Results of our research indicated that Down syndrome individuals with blood group lsquoOrsquo 41.7 and Rh lsquopositiversquo 58.26 were more susceptible to periodontitis.Conclusion Among intellectually disabled individuals there exists a robust correlation between periodontal health and ABO blood group phenotypes.

Distribution of ABO and Blood Groups among various Caste and Ethnic Groups – A cross-sectional Hospital Based Study in a Teaching Hospital of Western Nepal

Introduction: Red blood cells contain antigens on its membrane which are inherited according to Mendelian Law. Despite the identification of more than 400 red blood cell antigens, ABO and Rhesus blood group systems are clinically most significant. The current study aimed at determining the distribution of blood groups among different caste and ethnic groups of Western Nepal. Methods: A descriptive cross-sectional study conducted among individuals in the Blood Bank of Department of Pathology of a Teaching Hospital from January 2018 to July 2019. Ethical approval was taken from the Institutional Review Committee (Ref. 384). Convenient sampling was done. Data were entered in Microsoft Excel and analysed using Statistical Package for the Social Sciences version 21.0. Point estimate at 95% Confidence Interval was calculated along with frequency and proportion for binary data. Results: In ABO system, the frequency of O, A, B and AB blood groups were found to be 960(33.9%) (95% Confidence Interval= 32.15-35.64), 930(32.8%) (95% Confidence Interval= 31.11-34.57), 716(25.3%) (95% Confidence Interval= 23.68-26.88) and 226(8.0%) (95% Confidence Interval=6.98-8.98) respectively. Rh positive was the dominant Rhesus blood group, 2758(97.4%) (95% Confidence Interval=96.73-97.94). Blood group O was dominant in Brahmin, Bishwakarma, Gurung, Pariyar, Tamang, Terai Brahmin and Limbu. Conclusions: The frequency distribution pattern of ABO blood group was observed as blood group O>A>B>AB. Variation in the blood group distribution was observed in different ethnic groups.

Blood Transfusion Service Challenges and Patterns at Kampala International University Teaching Hospital, Ishaka-Bushenyi, Western Uganda: Insights from a Comprehensive Prospective Study

Uganda, a developing East African nation with nearly 20% of its populace living below the poverty line, faces significant constraints in its national blood transfusion service. Despite serving over 3 million individuals in Regional Referral Hospitals, a chronic scarcity of blood persists, impacting critical healthcare provisions, notably at Mulago, Uganda’s National Referral Hospital. This study conducted a meticulous assessment of the indications and influential factors shaping blood transfusion services at Kampala International University Teaching Hospital, Ishaka-Bushenyi, adopting a prospective descriptive cross-sectional design encompassing a 100% review of the target patient population receiving blood transfusions. Employing a pretested questionnaire as the data collection instrument, the gathered information underwent meticulous coding, sorting, entry, and analysis utilizing statistical software. Results were systematically presented through tables and charts. The findings revealed that a considerable proportion (42.3%) of transfused individuals fell within the age range of 20-39 years, with infants and young children (<5 years) comprising 22.4% of the recipients. Males accounted for 58.7% of the transfused population. Predominant indications for blood transfusions included anemia (30.4%), obstetric and gynecological conditions (23.4%), surgical operations (19.0%), infections (14.2%), and incidents involving road traffic accidents or assault (13.0%). The study identified the availability of a blood storage facility as a significant factor motivating the utilization of blood transfusion services, with an 87.4% availability rate reported. Notably, the demand for transfusions was notably high among females (56.1%) compared to males (43.9%), with anemia (53.3%) and blood group O (48.6%) constituting the majority of cases. Blood group distributions varied across different indications, with group O being predominant in most categories. Additionally, the Rh factor played a role, with Rh+ constituting 90.5% of cases and Rh- comprising 9.5%. Blood Group O had the highest occurrence of Rh+, while Blood Group A had the highest occurrence of Rh-. In summary, the study outlined several prominent factors influencing blood transfusion indications at KIUTH, notably anemia, obstetric and gynecological conditions such as postpartum hemorrhage and cesarean sections, surgical procedures (e.g., abdominal obstructions), infections (e.g., malaria), and incidents involving road traffic accidents or assault. These indicators are influenced by factors such as blood availability, age, gender, medical conditions, and blood type, with Blood Group O Rh+ being the most prevalent. Keywords: Blood transfusion, Gynaecology, Anaemia, Blood Group O.

Duffy Red Cell Antigen Phenotype among Indigenous Pregnant Women attending Antenatal Clinic at Federal Teaching Hospital Gombe, Nigeria.

Background and Objectives: Duffy (FY) blood group system is implicated in transfusion incompatibilities and haemolytic disease of the foetus and newborn. The primary objective was to determine the Duffy phenotype among the indigenous pregnant women in Gombe, Gombe State, Nigeria. Materials and Methods: This was a cross sectional study where simple random sampling was employed on consented participants. Two hundred and fifty nine pregnant women attending antenatal clinic at Federal Teaching Hospital Gombe were randomly recruited into the study. Three milliliters (3mls) of blood was taken, and Duffy antigens typed by standard tube technique (LORNE LABORATORY UK). Results: Among the Indigenous tribe, the percentage of Fy(a+b+) was seen in 2.2% of Fulani and 3.4% of Tangale, Fy(a+b-) phenotype was seen in 4.3% of Tangale, 6.8% of Fulani,9.5% of Tera, 10.3% of Hausa and 10.5% of Waja. Fy(a-b+) phenotype was seen in 5.3% of Waja, 7.6% of Fulani,8.7% of Tangale, 9.5% of Tera and 12.5% of Bolawa. Fy(a-b-) phenotype was seen in 2.4% of Tula,6.4% of Bolawa,7.3% of Waja, 7.8% of Tera, 17.8% of Tangale, 11.8% of Hausa and 46.5% of Fulani. 84.6% of the study population had the null Duffy phenotype. Conclusion: The research showed the phenotypic distribution of Duffy blood group among the study participants with relatively high percentage of null Duffy phenotype hence possible risk of alloimmunisation.

Distribution of ABO and Rh Blood Groups in Patients With Endometriosis at King Abdulaziz University Hospital: A Case-Control Study.

Background There is no sound evidence for the association of blood groups with the risk of endometriosis, and no studies from Saudi Arabia have examined this association. Therefore, the primary aim was to determine whether there is an association between the distribution of ABO and Rh blood groups and the incidence of endometriosis in a cohort from Saudi Arabia and also to evaluate the potential risk factors related to endometriosis among the population. Methods This case-control study included women diagnosed with endometriosis (n = 44) who presented to King Abdulaziz University Hospital Obstetrics and Gynecology Clinic, Jeddah, Saudi Arabia, between 2010 and 2021. Women from the blood donors database of King Abdulaziz University Hospital were included as a control group (n = 184). The total sample size was 228. Demographic data, diagnosis method, ABO blood type, and Rh blood type were obtained from hospital records. In addition, data were collected from self-reported questionnaires, which included family history, dysmenorrhea, age of menarche, age of childbearing, number of children, history of abortion, parity, number of children, use of oral contraceptives for alleviating dysmenorrhea, iron deficiency, duration of menstrual flow, and volume of bleeding during menses. Odds ratio, Pearson chi-squared test (χ2), and independent t-test were used to analyze the associations between variables. Results Most of the participants had blood type O (n = 117, 51.3%), which was followed by blood type A (n = 59, 26.0%), and the majority were Rh+ (n = 215, 94.3%). There was no significant difference in the risk of endometriosis according to ABO (P = 0.237) and Rh (P = 0.283) blood types. However, endometriosis was found to have a significant relationship with dysmenorrhea, heavy bleeding during menses, history of abortion, long duration of menstrual flow, lower number of children, late pregnancy, and use of oral contraceptive pills to relieve dysmenorrhea (p ≤ 0.05). Conclusions The present results indicate that ABO and Rh blood types are not associated with the risk of endometriosis. However, there was a strong, significant association between endometriosis and other factors.

The Relationship of ABO and Rh Blood Group Types With Severe COVID-19 Disease Mortality in ICU Patients: Insights From a Single-Center Experience in Southern Saudi Arabia.

Introduction The global COVID-19 pandemic has triggered an unprecedented public health crisis, emphasizing the need to understand factors influencing disease outcomes. This study explores the role of genetic variations in blood group antigens, particularly ABO and RhD, in shaping mortality rates among critically ill COVID-19 patients in the southern region of Saudi Arabia. Methods Utilizing a retrospective, noninterventional approach, we analyzed medical records of 594 COVID-19 patients admitted to the intensive care unit (ICU) at Aseer Central Hospital from August 2020 to April 2021. The cohort, with a mean age of 60.5 years, consisted of a predominantly male population. Results The study encompassed a diverse age range of 18 to 103 years, with a mean age of 60.5 ± 17.3 years. Of the 594 patients, 398 (67%) were male, and only 5 (0.8%) had a history of smoking. Blood group distribution revealed 275 (48.4%) with O-, 189 (33.3%) with A+, and 51 (9%) with AB- types. Predominant chronic conditions included diabetes mellitus (35.5%). Tragically, 320 patients (54.6%) experienced mortality, with a 100% mortality rate for the B+ blood group and 92.9% for O- blood group. Conclusion This analysis establishes significant statistical links, underscoring the pivotal role of blood type, particularly the Rh factor, in influencing mortality risk among critically ill COVID-19 patients. These findings contribute valuable insights into risk stratification and personalized care for severe cases, emphasizing the importance of genetic considerations in understanding disease outcomes.

ABO gene may be salient to the out of Africa migrations to the Americas

The source populations of Native Americans lived in Asia and Eurasia some 35,000 to 40,000 years ago. Consensus is that they migrated to Beringia some 25,000 to 30,000 years ago, when the low sea levels from the Last Glacial Maximum period allowed a land bridge to form to Beringia. Subsequently, the Native American ancestors migrated south to North and South America, whereas the remaining Beringia population, Eskimos, migrated into Canada and Greenland. Genetic evidence along with anthropological research adds much to the understanding of the course of their migrations and population growth. Because present-day Native Americans are essentially all of ABO O blood type, and the other Beringia populations, the Eskimos, were polymorphic for the ABO blood groups given the extensive research revealing pleiotropy of ABO blood group alleles, this unusual population frequency distribution of ABO blood groups offers an opportunity to understand how a population with no diversity of ABO blood groups differs from one that is similar in other genes but polymorphic in ABO blood groups. ABO blood groups in migrating populations provide supporting evidence for the timelines, destinations, and cultures of those populations leaving Africa. Other genes add to the power of ABO blood groups to provide this evidence. One of those genes, in the case of Native American and Eskimo migrations, is the gene for a dental trait called shovel shaped incisors, ectodysplasin A receptor (EDAR), which is prevalent in northeast Asian populations and is fixed in Native American populations. Because of the known climatic conditions in Africa at the time of the major out-of-Africa migration periods and malaria-related climatic aspects of the selection of the ABO A2 vs ABO A1 gene, it appears that the population ratio of ABO A2 to ABO A1 and EDAR associated shovel shaped incisor frequencies is associated with the timelines of the population leaving Africa as well as their further migrations. Because Native Americans have a very high shovel shaped incisor frequency and no ABO A2, their timeline of migrating from northeast Asia and Eurasia, observed using this approach and agreeing with other lines of evidence, is supported to be 25,000–30,000 years ago. Furthermore, separation of the Beringia population into a monomorphic ABO O group, the Native Americans, and an ABO polymorphic group, the Eskimos, in light of research supporting pleiotropy of ABO alleles enhances our understanding of their respective divergent migration paths, cultures, and population growth.

Magnitude of Red Blood Cell Alloimmunization Among Pregnant Women Attending Antenatal Care at Wolaita Sodo University Comprehensive Specialized Hospital, Southwest Ethiopia.

Maternal red cell alloimmunization occurs when a woman's immune system becomes sensitive to unfamiliar red blood cell antigens. This leads to the production of alloantibodies, which can have serious implications for the fetus and newborn. However, there is a lack of comprehensive information about the extent of red cell alloimmunization in underdeveloped countries like Ethiopia. Therefore, this study aimed to determine the magnitude of red cell alloimmunization among pregnant women attending antenatal care at Wolaita Sodo University Comprehensive Specialized Hospital from September 01 to November 30, 2022. In this institutional-based cross-sectional study, 422 pregnant women were participated and recruited using a systematic random sampling technique. Data on sociodemographic characteristics, obstetric history, and other clinical information were collected using structured questionnaires through face-to-face interview. Blood grouping and indirect antihuman globulin tests were performed. The relationship between red cell alloimmunization and the independent variables was determined using the chi-square test. P-value <0.05 was considered statistical significance. In this study, the blood group distributions among the participants were as follows: O, 177 (41.9%); A, 124 (29.4%); B, 76 (18%); and AB, 45 (3.86%). Among the pregnant women included in the study, a total of 51 (12.08%) were identified as RhD-negative. Out of these RhD-negative women, 5 (9.8%) were found to have developed alloimmunization with red blood cell antigens. Miscarriage and post-partum hemorrhage were found to be important factors associated with the occurrence of red cell alloimmunization in these women. This study showed that one out of ten pregnant women was alloimmunized. Therefore, antenatal blood grouping and indirect antihuman globulin screening should be performed routinely to manage and minimize the undesirable outcomes of alloimmunization during pregnancy.

Investigation of Antigen and Gene Frequency of Kell(K) and Rh(D) Blood Groups in Xinjiang

To investigate the phenotypes and gene frequencies of Kell blood group system K antigen and Rh blood group system D antigen in Xinjiang, and summarize and understand the distribution of Kell(K) blood type and Rh(D) blood type in this area. A total of 12 840 patients who met the inclusion criteria during physical examination and treatment in our hospital and 18 medical institutions in our district from January 1, 2019 to December 31, 2019 were collected for identification of Kell blood group system K antigen and Rh blood group System D antigen, and the distribution of K and D blood groups in different regions, genders and nationalities were investigated and statistically analyzed. The proportion of K positive in the samples was 1.39%, the highest was 1.91% in southern Xinjiang, and the lowest was 1.03% in northern Xinjiang(P<0.01). The proportion of Rh(D) negative samples was 2.75% and the gene frequency was 16.64%. The proportion of Rh(D) negative samples was 4.03% and the gene frequency was 20.10% in southern Xinjiang, followed by eastern Xinjiang and the lowest in northern Xinjiang (P<0.01). The frequency of K antigen in Uygur nationality was the highest, reaching 2.16%, Kirgiz 1.54%, and the distribution trend of D/d antigen was similar to that of K antigen. Among women, the K positive frequency of Kazak nationality was slightly higher than that of Mongolian nationality. The highest proportion of K positive in Uygur women was 2.38%, which was higher than that in Uygur men (1.86%). The frequency of d phenotype in Kazak women was 3.15%, which was higher than that in Kirgiz （2.89%） (P<0.01). The distributions of Kell(K) and Rh(D) blood groups in northern and southern Xinjiang and eastern Xinjiang had its own unique characteristics and differences. There are significant differences in blood group distribution among different ethnic groups and gender groups. In the future, k antigen detection can be included to further improve the investigation on the distribution of Kell blood group system in this region.

Non-O Blood Group and Pretreatment Risk of Venous Thromboembolism in Patients with Diffuse Large B-Cell Lymphoma

Introduction: Diffuse large B-cell lymphoma (DLBCL) is the most frequent aggressive non-Hodgkin lymphoma (NHL). It has been extensively documented that the risk of venous thromboembolism (VTE) is augmented in patients with aggressive lymphomas. The timing of VTE occurrence in this group of patients is highly variable and depends on diverse risk factors. Lately, it has been observed that ABO blood group type can have a prognostic impact on both thrombosis development and survival outcomes in patients with cancer. Therefore, the study aimed to examine the ABO blood group as a risk factor for VTE development in patients with DLBCL, to examine the relation between ABO blood groups and the timing of VTE development, and to investigate the association between ABO group type and treatment and survival outcomes. Methods: A total of 340 patients with DLBCL (newly diagnosed and relapsed) have been included in the study and all of them have been treated at the Lymphoma Center, Clinic for Hematology, University Clinical Center of Serbia. Data regarding VTE events were collected for all the patients included in the study, from the time of diagnosis to 3 months after the last cycle of therapy. ABO blood group has been determined before the treatment initialization. VTE was diagnosed objectively based on clinical examination, laboratory evaluation, and radiographic studies. Results: The median patients' age was 60 years (range, 19-89 years) and 52.9% were males. Newly diagnosed patients were dominant in the study population (94.4%). The majority of patients had advanced stage (stage III Ann Arbor 22.3% and stage IV 30.7%, respectively) of the disease. The median international prognostic index (IPI) was 2 (range, 0-5). Complete remission (CR) and partial remission (PR) were most commonly recorded (51.7% and 28.8%, respectively). The rate of VTE was 12.6% (43 patients), with the highest frequency of lower and upper extremity deep vein thrombosis (12 patients each). VTE was diagnosed before the initiation of specific hematological treatment in 54.5% of DLBCL patients, whilst 45.5% of DLBCL patients have been diagnosed with VTE following the hematological treatment initiation. The following distribution of ABO blood groups among DLBCL patients was detected: A blood group 39.4%, B blood group 17.6%, AB blood group 9.1%, and O blood group 33.8%. No significant association between VTE development and ABO group type was found (p=0.706) nor between VTE development and time of VTE development (p=0.895). The rate of VTE in DLBCL patients with A blood type was 4.7%, in B 2.1%, in AB 1.8%, and in O 4.1%, respectively (p=0.706). DLBCL patients with the non-O blood group developed VTE significantly more frequently prior to the hematological treatment commencement than after the treatment initiation (6.2% vs. 2.6%, p=0.003). Univariate logistic regression analysis showed that non-O blood type in DLBCL patients is a prognostic factor for VTE development prior to hematological treatment initiation (odds ratio (OR)=8.56, 95% confidence interval (CI): 1.92-38.21, p=0.005). Multivariate logistic regression model demonstrated that non-O blood type is an independent predictor of pretreatment VTE development in DLBCL patients (OR=18.33, 95% CI: 1.51-222.87, p=0.022). Therapy response of DLBCL patients was significantly associated with the ABO blood group (p=0.012) in the way that A and AB blood types were associated with unsatisfactory treatment response (no statistically significant association was found between ABO blood type and DLBCL patients' Ann Arbor stage, mediastinal involvement, bulky disease, extranodal disease, IPI, central nervous system involvement). Univariate regression analysis showed that A blood type is a predictor of unsatisfactory therapy response in patients with DLBCL (OR=1.85, 95% CI: 1.04-3.29, p=0.035). However, in multivariate regression model, this finding lost statistical significance. No significant association was observed regarding ABO blood type, progression-free survival, and overall survival in patients with DLBCL (p=0.398 and p=0.593, respectively). Conclusion: In DLBCL patients, non-O blood group is an independent predictor of VTE occurrence prior to initiation of a specific hematologic treatment. DLBCL patients with A blood group could be at risk of insufficient treatment response.

The frequency of ABO and Rhesus(D) blood group antigens among blood transfused patients in Northern Ethiopia, 2023: Retrospective study

BackgroundData about the distribution of ABO and RhD blood groups is important for effective blood utilization, which is maintained by identifying the most clinically required blood type. However, there is a scarcity of data in Ethiopia about the distribution of ABO and RhD blood groups among blood-transfused patients, particularly in the study area. ObjectiveTo determine the frequency of ABO and RhD blood groups among blood transfused patients at Dessie Comprehensive Specialized Hospital, Northern Ethiopia, 2023. MethodA hospital-based retrospective study was conducted from September 1 to September 30, 2022, to determine the frequency of ABO and RhD blood groups among blood-transfused patients at Dessie Comprehensive Specialized Hospital. The study was conducted on data from blood-transfused patients from October 2019 to June 2022. A total of 3762 blood transfused patients’ data was collected from the blood transfusion log book records. The data were coded, entered, and cleaned using Epi-data version 4.6 and analyzed for descriptive statistics using Stata version 14.0. ResultA total of 3762 blood-transfused patients were included in the study. Of those, females made up 57.3 % (2156/3762). Of 3762 blood transfused patients, the majority (33.9 %, 1277/3762) had ABO blood group B, and 81.3 % (3060/3762) of the blood transfused patients were RhD-positive. Eight thousand three hundred fifteen units of whole blood were transfused to 3762 patients, with a mean of 2.2 units of blood transfused per patient. Furthermore, the majority of the study participants 42.82 %, (1611/3762) were given two units of blood, and 8.77 % (330/3762) were given four units of blood. ConclusionMost of the study participants had B and RhD-positive blood groups. The majority of the blood transfused patients were females. Most of the blood was transfused in the medical ward, and whole blood was transfused for all patients.

A Study of Association of ABO and Rh Blood Group with Colorectal Cancer in Khuzestan Province, Iran

Background: Colorectal cancer, a solid tumor with a high prevalence, contributes significantly to annual mortality rates. Various factors, including blood groups, may influence cancer risk. Multiple studies have suggested a potential connection between ABO and Rh blood groups and colorectal cancer risk. This study aims to investigate the role of ABO and Rh blood groups as risk factors in colorectal cancer patients.&#x0D; Materials and Methods: We conducted a retrospective study involving 71 colorectal cancer patients diagnosed between 2018 and 2020 in Khuzestan province, Iran, with known ABO blood types. Large-scale data from 29,922 blood donors in Khuzestan served as the healthy population control. The study analyzed the distribution of ABO blood groups among the blood donors.&#x0D; Results: Our findings revealed that the distribution of blood groups among colorectal cancer patients was as follows: O (31.0%), A (29.6%), B (29.6%), and AB (9.8%). However, our analysis did not establish a significant association between colorectal cancer risk and ABO antigens (P-value = 0.636) or Rh blood group (P = 0.198). Additionally, no significant differences in ABO blood types were observed concerning gender (P = 0.802), cancer type (P = 0.338), or tumor type (P = 0.207) among colorectal cancer patients.&#x0D; Conclusion: This study does not support a significant correlation between ABO and Rh blood groups and the risk of colorectal cancer, nor does it find associations with cancer type or tumor type.

Relation of Immune Thrombocytopenia and Blood Group: A Retrospective Single Center Study

Aim: Although blood group antigens were initially identified as erythrocyte surface antigens and their significance was mainly ascribed to serology, it soon became evident that these antigens are widely distributed in human tissues such as platelets. Immunthrombocytopenia (ITP) is a common autoimmune disorder characterized by a low platelet count. In our study, we investigated the relationship between ABO and Rhesus (Rh) blood groups and primary ITP.&#x0D; Material and Methods: A retrospective study was conducted at our center with 304 patients diagnosed with primary ITP and 491 blood donors.&#x0D; Results: ABO phenotype in patients group A, B, O, AB were 42.8%, 14.1%, 34.9%, 8.2%, respectively and 51.6%, 8.1%, 27.9%, 12.4% in the control group, respectively. Rh phenotype in patients group positive or negative 87.5%, 12.5 % respectively and 88.8%, 11.2% in the control group, respectively. A total of 304 patients with primary ITP, consisting of 203 (66.8%) females, and 101(33,2%) males were included in this study. The mean age was 49,5 ±18 years. There was no significant difference in the distribution of ABO blood types and Rh factor by gender (respectively p=0.176, p= 0.195).&#x0D; Conclusion: In our study, no significant difference was found between the blood group distribution in the population and the blood group distribution of patients diagnosed with primary ITP.

The effectiveness of eucalyptus globulus and thymus vulgaris in reducing COVID-19 symptoms among COVID-19 patients at Al- Nasiriya City

Objective: To determine how Thymus vulgaris and Ecalyptus globulus affected the symptoms of coronavirus disease-2019 patients.Method: The experimental case-control study was conducted in Al-Nasiriya city, Iraq, from December 15, 2020, toFebruary 20, 2021, and comprised patients of either gender aged 20-50 years diagnosed with coronavirus disease-2019 infection. The patients’ symptoms ranged from mild to severe. Half of the sample was exposed to the study’streatment protocol, while the other half acted as control. Thyme, orange and lemon were employed as sources ofvitamin C, as well as eucalyptus leaves and oil. The cases were exposed to eucalyptus vapours for 5-10 minutes afterthoroughly washing the plant leaves (7-10 leaves or 5 drops of oil) and boiling them in drinking water at 100°C for 10-15 minutes. Data was analysed using SPSS 23.Results: Of the 48 patients, 24(50%) were in each of the two groups. Age and gender were not significantly different(p&gt;0.05), while body mass index and blood group distribution was significantly different between the groups (p&lt;0.05).Overall, 22(45.8%) subjects had mild symptoms, 20(41.7%) had moderate symptoms and 6(12.5%) had severesymptoms. The improvement in the symptoms among the cases was significantly more than the controls (p&lt;0.05)except nasal congestion (p&gt;0.05).Conclusion: Using eucalyptus vapours in the form of dried leaves or oil could significantly lessen coronavirus disease-2019 symptoms.Keywords: Eucalyptus, Thymus, Plant, Citrus, Cough, Smell, COVID-19, Leaves, Vaccines, Vitamins.

Multi-factors assessment in COVID-19 patients: Fungal infection, ABO blood group, and age factors

Abstract Background: The coronavirus disease 2019 (COVID-19) pandemic is a serious and global public health concern. Severity of infection, fatality rates, and treatment responses across different countries, age groups, and demographic groups suggest that the nature of infection is diverse. Objectives: Evaluation of several factors: presence of fungal infection, analysis of ABO blood group distribution pattern, age distribution, percentage of death, and well-being outcome for each blood group patient. Materials and Methods: Data collection included the presence of fungal infection and measurement of its percentage. Classification of patients according to ABO blood group and measuring their mean age distribution and death-wellbeing outcome. Results: This study showed the presence of 5% of fungal infection among the patients. This study showed that the distribution of ABO blood group in 90 patients with COVID-19 was as follows: 38.9% (35), 28.9% (26), 26.7% (24), and 5.6% (5) for O, A, B, and AB blood group patients respectively. The analysis of variance study revealed no significant difference in age distribution between different ABO blood group patients. The outcome for these patients was that 35.6% died and 64.4% recovered. A higher percentage of deaths occurred in patients with B blood group (approximately 45.8%, 11 out of 24 patients) and a lower percentage of deaths noted in patients with A blood group (about 34.6%, 9 out of 26 patients). The higher percentage of recovery was among O blood group patients with 71.4% (25 out of 35 patients). The lower percentage of recovery was among B blood group patients with 54.2% (13 out of 24 patients). Conclusion: This study concluded that despite the higher percentage of COVID-19 infections in patients with O blood group, its high good outcome is promising. On the other hand, this point must be taken into consideration while planning vaccinations, since patients with B blood group have a high percentage of deaths and lower percentage of recovery.

ABO, Rh, and Kell Blood Group Antigen Frequencies among Pregnant Women in Sokoto, Nigeria.

Background: Blood group antigens have been used to evaluate ethnic diversity of human populations and they also play most important roles in pregnancy and blood transfusion. Knowledge of antigen frequencies is important to assess the risk of alloimmunization and to guide the probability of finding antigen-negative donor blood. This study was aimed at determining the frequencies of ABO, Rh and Kell blood group antigens phenotype among pregnant women. Materials and Methods: The study was cross sectional in nature conducted among 1,250 consecutively recruited pregnant women in the department of Obstetrics and Gynaecology, antenatal clinic in Sokoto from January 2020 to September 2020. The blood grouping were determined using standard tube techniques for ABO while column agglutination card was used for Rh C, E, c, e and Kell blood groups. The data were collected, and calculations were done to determine the frequencies of ABO, Rh, and Kell blood group antigens and chi square was used to determine statistical significance . Results: The distribution of the ABO blood group revealed that 48.5% were group O, 27.3% were group B, 19.4% were group A and 4.8% were group AB. Out the subjects investigated, 93.1%, 30.2%, 24.6% , 90.2% and 97.6%were RhD, RhC, RhE, Rhc and Rhe positive respectively while 2.4% were Kell positive while 97.6% were Kell negative. ABO antigens has statistically significant correlation with Kell antigens. Conclusion: There is phenotypic variability of ABO and Rh blood group antigens with low prevalence of Kell antigen that has statistical relationship with ABO antigen. Incorporation of blood group phenotyping as premarital screening may reduce the prevalence of alloantibody formation.

Evaluation of ABO/Rh Blood Group Distributions and Clinical Characteristics in Patients with Adrenal Incidentaloma: A Case-Control Study

Evaluation of ABO/Rh Blood Group Distributions and Clinical Characteristics in Patients with Adrenal Incidentaloma: A Case-Control Study

KAN GRUPLARI İNFERTİLİTEDE ETKİN Mİ? BİR TERSİYER MERKEZİN 8 YILLIK VERİLERİNİN DEĞERLENDİRİLMESİ

Objective&#x0D; The aim is to compare blood groups between spontaneously&#x0D; pregnant fertile patients and infertile female&#x0D; patients undergoing treatment for infertility diagnosis&#x0D; is defined as the failure to achieve pregnancy despite&#x0D; regular unprotected sexual intercourse for one year&#x0D; during the reproductive period without using any contraceptive&#x0D; method.&#x0D; Material and Method&#x0D; Our study includes statistically evaluating the blood&#x0D; groups and demographic data of a total of 608 patients,&#x0D; including 304 fertile patients who presented for&#x0D; routine pregnancy follow-up at the Department of Obstetrics&#x0D; and Gynecology, Süleyman Demirel University,&#x0D; between January 2015 and January 2023, and 304&#x0D; infertile patients receiving treatment at the Süleyman&#x0D; Demirel University Assisted Reproductive Techniques&#x0D; (ART) Center.&#x0D; Results&#x0D; The mean age of the volunteers in the fertile group&#x0D; was calculated as 30.68±4.70, while the mean age of&#x0D; the volunteers in the infertile group was 32.50±5.35.&#x0D; Blood group A was found to be dominant in both the&#x0D; fertile and infertile groups, followed by blood groups&#x0D; O, B, and AB. When compared based on education,&#x0D; it was determined that the majority of patients in the&#x0D; infertile group had received undergraduate or postgraduate&#x0D; education. Income levels were categorized as&#x0D; low, medium, and high income based on occupational&#x0D; distributions in both groups, revealing that the majority&#x0D; of participants in both groups had a low-income level.&#x0D; Conclusion&#x0D; Infertility is a multifactorial condition resulting from a&#x0D; combination of various factors such as genetics, environment,&#x0D; lifestyle, and health. The prevalence of infertility&#x0D; increases with age, and blood group distribution&#x0D; does not have a direct impact on infertility.

ABO-adjusted cPRA metric for kidney allocation in an Asian-predominant population.

Recent studies showed that ABO-adjusted calculated panel reactive antibody (ABO-cPRA) may better reflect the histocompatibility level in a multi-ethnic population, but such data in Asians is not available. We developed an ABO-adjusted cPRA metric on a cohort of waitlist kidney transplant patients (n = 647, 99% Chinese) in Hong Kong, based on HLA alleles and ABO frequencies of local donors. The concordance between the web-based ABO-cPRA calculator and the impact on kidney allocation were evaluated. The blood group distribution for A, B, O and AB among waitlist kidney candidates were 26.2%, 27.5%, 40.1%, and 6.1%, and their chances of encountering incompatible blood group donors were 32.6%, 32.4%, 57.6%, and 0%, respectively. There is poor agreement between web-based ABO-cPRA calculator and our locally developed metrics. Over 90% of patients showed an increase in cPRA after ABO adjustment, most notably in those with cPRA between 70% and 79%. Blood group O patients had a much greater increase in cPRA scores after adjustment while patients of blood group A and B had similar increment. 10.6% of non-AB blood group waitlist patients had ABO-cPRA elevated to ≥80%. A local ABO-adjusted cPRA metric is required for Asian populations and may improve equity in kidney distribution for patients with disadvantageous blood groups. The result from the current study potentially helps other countries/localities in establishing their own unified ABO-cPRA metrics and predict the impact on kidney allocation.

Are ABO/Rh blood groups A risk factor for polycystic ovary syndrome?

This study goaled to evaluate the ABO/Rh blood group distribution and its relationship with clinical and biochemical factors in polycystic ovary syndrome (PCOS) patients. ABO/Rh blood group distribution of the patients and the healthy individuals were compared. In addition, the features of clinical and biochemical factors were compared according to the ABO/Rh blood groups. Two hundred and sixty-five patients were involved in the study. At the time of diagnosis, hirsutism (86%) and oligomenorrhea (80.9%) were the most prevalent symptoms. There were 166 (62.6%) patients with baseline ultrasonography results consistent with PCOS. In 111 (41.9%) patients, insulin resistance was found. ABO blood group distributions in the patient (42.6% A, 17% B, 9.4% AB, 30.9% O) and control (42% A, 16% B, 8% AB, 34% O) groups were found to be similar (P = .9). There was no difference between oligomenorrhea, hirsutism, hair loss, acne, obesity, high androgen level, insulin resistance, and ultrasound characteristics according to ABO/Rh blood groups. In this study, ABO/Rh blood group distribution in individuals with PCOS was found to be similar to healthy individuals, and it was determined that ABO/Rh blood group was not a risk factor for PCOS. In addition, no correlation was found between the clinical and biochemical characteristics of the patients at the time of diagnosis and the ABO/Rh blood group.