Disruption Of Communication Research Articles

Bacillus spp. Inhibit Edwardsiella tarda Quorum-Sensing and Fish Infection.

The disruption of pathogen communication or quorum-sensing (QS) via quorum-quenching (QQ) molecules has been proposed as a promising strategy to fight bacterial infections. Bacillus spp. have recognizable biotechnology applications, namely as probiotic health-promoting agents or as a source of natural antimicrobial molecules, including QQ molecules. This study characterized the QQ potential of 200 Bacillus spp., isolated from the gut of different aquaculture fish species, to suppress fish pathogens QS. Approximately 12% of the tested Bacillus spp. fish isolates (FI). were able to interfere with synthetic QS molecules. Ten isolates were further selected as producers of extracellular QQ-molecules and their QQ capacity was evaluated against the QS of important aquaculture bacterial pathogens, namely Aeromonas spp., Vibrio spp., Photobacterium damselae, Edwardsiela tarda, and Shigella sonnei. The results revealed that A. veronii and E. tarda produce QS molecules that are detectable by the Chr. violaceum biosensor, and which were degraded when exposed to the extracellular extracts of three FI isolates. Moreover, the same isolates, identified as B. subtilis, B. vezelensis, and B. pumilus, significantly reduced the pathogenicity of E. tarda in zebrafish larvae, increasing its survival by 50%. Taken together, these results identified three Bacillus spp. capable of extracellularly quenching aquaculture pathogen communication, and thus become a promising source of bioactive molecules for use in the biocontrol of aquaculture bacterial diseases.

COVID-19 and Aphasia.

Purpose of Review Aphasia is an acquired neurological language disorder after brain damages. Persons with aphasia (PWA) are more susceptible to behavioral and emotional implications due to inherent communication and/or cognitive difficulties. Currently, little is known regarding the impact of COVID-19 on PWA.Recent FindingsThere are now growing reports with evidence of neurological and dysexecutive syndromes subsequent to interference of brain functions in acute patients with COVID-19, leading to variable aphasia-like symptoms. COVID-19 affected chronic PWA more in terms of disrupted communication and daily routines, worsened psychosocial well-being, and difficulties getting aphasia services that adequately addressed their needs.SummaryAcute versus chronic PWA were disproportionately affected by COVID-19. Recognizing, examining, and managing COVID-19-related neurological and behavioral problems in PWA is not straightforward. As we passed the 1-year mark and approaching the 2-year mark of the onset of COVID-19, more research is necessary to prioritize strategies for improving current evidence-based care and rehabilitation of aphasia.

Oxyphyllanene B overcomes temozolomide resistance in glioblastoma: Structure–activity relationship and mitochondria-associated ER membrane dysfunction

The identification of novel therapeutic candidates from natural products for the development of chemoresistant glioblastoma multiforme (GBM) treatment has been a highly significant and effective strategy. Sesquiterpenes are a class of naturally occurring 15-carbon isoprenoid compounds, and several types of sesquiterpenes have the ability to induce growth inhibition and apoptosis in a variety of cancer cell lines. In the present study, 56 sesquiterpenes of five types, namely, eudesmane-type (I) (1-24), eremophilane-type (II) (25-32), cadinane-type (III) (33-41), guaiane-type (IV) (42-49), and oplopanone-type (V) (50-56), were screened for their antiglioma activity, structure-activity relationship analysis (SAR), and underlying mechanism based on patient-derived recurrent GBM strains, patient-derived GBM cell sphere, GBM organoid (GBO) models, and temozolomide (TMZ)-resistant GBM cell lines. We found that compound 12 (oxyphyllanene B, OLB) showed the most potent antiglioma activity, and we confirmed that OLB could induce apoptosis in a time- and dose-dependent manner in TMZ-resistant GBM cells and GBOs. SAR announced that the presence of an α, β-unsaturated carbonyl moiety was likely to enhance cytotoxic activities. Mechanistic studies demonstrated that OLB induced abnormal changes in ER and mitochondria-associated membrane (MAM) networks, which triggered ER stress, mitochondrial dysfunction, and apoptosis. Furthermore, our findings suggested that OLB-triggered PACS2 activation might form a committed step to disrupt ER-mitochondria communication and showed for the first time that the expression levels of PACS2 might positively correlate with the progression and chemotherapy resistance of glioma. Our results indicated that OLB might be a promising candidate for treating TMZ-resistant GBM cells by activating PACS2, which triggered a crucial event to promote the disruption of ER-mitochondria communication and overcome chemotherapy resistance of GBM.

Pheromone-Mediated Mating Disruption as Management Option for Cydia spp. in Chestnut Orchard.

Simple SummaryInvestigations were conducted to evaluate the effectiveness of mating disruption (MD) to control chestnut tortrix moths. Surveys were performed at four sites in northern Italy in 2019–2020. MD was carried out using the pheromone dispenser Ecodian® CT. The total number of trapped males was significantly lower in MD plots than in control ones for all sites and years. Trap catch suppression in MD plots averaged 89.5% and 93.8% for Cydia fagiglandana and 57.4% and 81% for Cydia splendana in 2019 and 2020, respectively. A reduction of about 71% of larval infestation of chestnut fruits was only recorded in the MD plot at one site in 2019. Although the reduction in male catches in MD plots was observed, this research highlighted the need to perform further studies to investigate the effect of MD in reducing larval damage of chestnut fruits.(1) Background: Pheromone-based devices are successfully used to control insect pests in agriculture. (2) Methods: Investigations were conducted to evaluate the effectiveness of mating disruption (MD) to control the chestnut tortrix moths, Cydia fagiglandana and Cydia splendana. Surveys were performed in northern Italy in 2019–2020. MD was carried out using the pheromone dispenser Ecodian® CT. The effectiveness of MD was assessed by recording male adult catches in pheromone-baited sticky traps and larvae in chestnut fruits, comparing MD and control plots. (3) Results: The total number of trapped males was significantly lower in MD plots than in control ones, for all sites and years. Trap catch suppression in MD plots averaged 89.5% and 93.8% for C. fagiglandana and 57.4% and 81% for C. splendana in 2019 and 2020, respectively. The larval infestation rate in fruits did not vary between plots except for one site where a reduction of about 71% in the MD plot was recorded in 2019. (4) Conclusions: Low catches in MD plots turned out to be a good measure of the effectiveness of communication disruption, but no satisfactory data have been obtained regarding fruit infestation, highlighting how the reduction of male catches cannot always be considered as a reliable indicator of successful control. Specific investigations about background population density, dispersal and mating/oviposition behavior are thus essential for a viable management strategy.

Connexin Expression Is Altered in Liver Development of Yotari (dab1 -/-) Mice.

Disabled-1 (Dab1) protein is an intracellular adaptor of reelin signaling required for prenatal neuronal migration, as well as postnatal neurotransmission, memory formation and synaptic plasticity. Yotari, an autosomal recessive mutant of the mouse Dab1 gene is recognizable by its premature death, unstable gait and tremor. Previous findings are mostly based on neuronal abnormalities caused by Dab1 deficiency, but the role of the reelin signaling pathway in nonneuronal tissues and organs has not been studied until recently. Hepatocytes, the most abundant cells in the liver, communicate via gap junctions (GJ) are composed of connexins. Cell communication disruption in yotari mice was examined by analyzing the expression of connexins (Cxs): Cx26, Cx32, Cx37, Cx40, Cx43 and Cx45 during liver development at 13.5 and 15.5 gestation days (E13.5 and E15.5). Analyses were performed using immunohistochemistry and fluorescent microscopy, followed by quantification of area percentage covered by positive signal. Data are expressed as a mean ± SD and analyzed by one-way ANOVA. All Cxs examined displayed a significant decrease in yotari compared to wild type (wt) individuals at E13.5. Looking at E15.5 we have similar results with exception of Cx37 showing negligible expression in wt. Channels formation triggered by pathological stimuli, as well as propensity to apoptosis, was studied by measuring the expression of Pannexin1 (Panx1) and Apoptosis-inducing factor (AIF) through developmental stages mentioned above. An increase in Panx1 expression of E15.5 yotari mice, as well as a strong jump of AIF in both phases suggesting that yotari mice are more prone to apoptosis. Our results emphasize the importance of gap junction intercellular communication (GJIC) during liver development and their possible involvement in liver pathology and diagnostics where they can serve as potential biomarkers and drug targets.

Disrupted affective communication characterizes mothers of infants with disorganized but also ambivalent attachments: An Israeli study.

This study examined whether maternal disrupted communication, which is associated with disorganized infant attachment, also characterizes mothers of ambivalent infants. The study, conducted in Israel, included a Jewish sample (N=163; 68 Girls) from diverse socioeconomic status, collected between 1991 and 1993 in an earlier study. The sample over-represented ambivalent and disorganized attachments. Attachment was assessed in the Strange Situation Procedure (SSP) at 12months and disrupted communication was coded from the SSP using the Atypical Maternal Behavior Instrument for Assessment and Classification (AMBIANCE; Lyons-Ruth et al., 1999). Mothers of ambivalent infants showed higher disrupted communication than mothers of secure, avoidant, and disorganized infants. The findings shed further light on the correlates of ambivalent attachment and call for research regarding maternal and infant characteristics that differentiate ambivalent versus disorganized attachment.

Numerical Considerations in the Simulation of Equatorial Spread F

AbstractThe ionospheric irregularities known as equatorial spread F (ESF) have drawn great attention in decades due to their disruption of communications and navigation systems. ESF is generally attributed to Rayleigh–Taylor instability, but there are still many remaining issues about its formation and evolution. Numerical simulations have been widely used to study such a phenomenon due to the complex nonlinear evolution of ESF. A two‐dimensional ESF model was developed in this work and a series of experiments were conducted to study the effects of grid resolution and numerical diffusion on idealized ESF simulation. It was found that advection schemes with the total variation diminishing property are preferred for preventing spurious oscillations which occur near the steep density gradients in the ESF. On the other hand, schemes with low diffusion are also desirable in order to model complicated dynamic structures of the ESF. Moreover, numerical experiments suggest that some of the secondary instabilities in idealized ESF simulations, although with morphological similarities, are possibly initiated by numerical seeding, which may differ from the observed evolution of secondary ESF.

Content Moderation of Speech in Political Discussions

AbstractSocial media platforms have been hailed as “politically disruptive communication technologies” (Hong & Nadler, 2012). Individuals express opinions and engage with politicians, the press, and each other on social media, sometimes using offensive language (Rossini et al., 2020). Content moderation has been adopted by many social media platforms to screen and evaluate offensive speech. In the present study we trained offensive speech classifiers to analyze offensive speech examples by integrating three archival datasets. We then used the trained classifier to examine a large body of comments about YouTube videos posted during the 2018 midterm election cycle. This provided information on the prevalence of various kinds of offensive comments and the pattern of content moderation used by YouTube. We also examined comment negativity using offensive speech lexicons. Our results showed systematic variance in the prevalence of offensive speech topics depending upon the political orientation of the content. Language use was significantly different between left and right‐leaning videos for comments related to sexism.

Study of the possibility of using pheromones to control the number of polyphagous soybean (Glycine max) pests

The soybean is an economically important crop for Krasnodar krai. The biological control of polyphagous soybean pests is necessary for organic farming. The aim of our study was to study the possibility of using a synthetic analogs of sex pheromones to control the number of polyphagous soybean pests (Glycine max). The present investigation consisted in the fact that as a primary means of regulation of the number of click beetles (Coleoptera: Elateridae), such as Agriotes gurgistanus Heyden, A. tauricus (Faldermann) and A. sputator (L.) and the cotton bollworm Helicoverpa armigera (Hubner) (Lepidoptera: Noctuidae), methods of mass capture of males (elimination) and disruption of chemical communication (disorientation) were used on soybeans.. The studies were carried out in the soybean plot with an area of 8 hectares (GPS: 45.03° N 38.52° E; FSBSI FRCBZR, Krasnodar), and in the experimental plot “Zolotaya Niva” with an area of 10 hectares (GPS: 45.13°N 39.35°E Voronezhskaya village, Krasnodar Krai). Preparative forms of pheromones were made on specially designed technological equipment at FSCBPP. Glue traps for monitoring and mass catching of cotton bollworms (type “Attracon”) were also manufactured using FSCBPP technological equipment. Estrontype pheromone traps were purchased from the manufacturer. To determine the dynamics of flight and the number of pests, pheromone traps were placed on experimental plots at the rate of one trap per 1–3 hectares. In experiments on mass trapping of insects (elimination), traps were placed in the amount of 5–10 traps per hectare. The effectiveness of the method was determined by the fertilization of females in control and experiment. Females click beetles were captured using the lure method and LED traps.It was found that the effectiveness of the method of elimination of male click beetles (Agriotes gurgistanus, A. tauricus and A. sputator) was 89–95%, and the level of impaired chemical communication (disorientation) reached 91–99%. The disorientation effect for the cotton moth H. armigera was 92%, with the damage to plants and soybeans not exceeding 2.0%. The effectiveness of this method was 88.6–94.5%, during disorientation of three representatives of Elateridae family and cotton moth H. armigera (Lepidoptera: Noctuidae) it was found that the effectiveness of this method was 91.0–99.6% for Elateridae, and 92.0% for H. armigera. This work has presented a novel approach to the possibility of using pheromones as not only the main means of monitoring phytophages, but also a method for controlling polyphagous pests of soybeans, which is important in the development of protection for organic farming systems.

Human factors affecting intraoperative patient safety.

This review addresses the importance of some of the human factors for intraoperative patient safety with particular focus on the active failures. These are the mishaps or sentinel events related to decisons taken and actions performed by the individual at the delivery end of a system. Such sentinel events may greatly affect intraoperative patient safety. Intimidating, aggressive and disruptive communication is a cause of adverse staff interaction, which may then represent an important patient safety threat. Also, anaesthesiologist's physical and mental state and limitations may interfere with patient safety. The concept of physician well being is multidimensional and includes factors related to each physician as an individual as well as to the working environment. Creating optimal safe conditions for patients, therefore, requires actions at both the personal level and the working conditions. Also, initiatives to ban rude and dismissive communication should be implemented in order to further improve intraoperative patient safety.

Methamphetamine Dysregulation of the Central Nervous System and Peripheral Immunity.

Methamphetamine (METH) is a potent psychostimulant that increases extracellular monoamines, such as dopamine and norepinephrine, and affects multiple tissue and cell types in the central nervous system (CNS) and peripheral immune cells. The reinforcing properties of METH underlie its significant abuse potential and dysregulation of peripheral immunity and central nervous system functions. Together, the constellation of METH's effects on cellular targets and regulatory processes has led to immune suppression and neurodegeneration in METH addicts and animal models of METH exposure. Here we extensively review many of the cell types and mechanisms of METH-induced dysregulation of the central nervous and peripheral immune systems. SIGNIFICANCE STATEMENT: Emerging research has begun to show that methamphetamine regulates dopaminergic neuronal activity. In addition, METH affects non-neuronal brain cells, such as microglia and astrocytes, and immunological cells of the periphery. Concurrent disruption of bidirectional communication between dopaminergic neurons and glia in the CNS and peripheral immune cell dysregulation gives rise to a constellation of dysfunctional neuronal, cell, and tissue types. Therefore, understanding the pathophysiology of METH requires consideration of the multiple targets at the interface between basic and clinical neuroscience.

Disruptive Communication as a Means to Engage Children in Solving Environmental Challenges: A Case Study on Plastic Pollution.

Environmental degradation and how we care for our planet are some of the greatest challenges the world is up against at this moment. These challenges has received increased focus in both, research and the public sphere. So far, most of this attention revolved around adult’s attitudes and behavior. However, environmental engagement amongst the younger generation gains in popularity. Using plastic pollution as a case, this qualitative study aims to acquire insights into the mental models of children. We collected qualitative data during an innovative, structured workshop according to the “Nature In Your Face” (NIYF) framework. The approach challenges the assumption that the societal change can be achieved gradually, with non-invasive techniques. Instead, we explore the potential of disruption to push citizens out of their comfort zone, thereby making room for co-creation. The disruption was performed by confronting 36 fifth graders from a Norwegian primary school, with disturbing images of plastic contaminating their local shorelines. The data was obtained by using the workshop framework, combined with semi-structured group interviews. The interview data was analyzed by means of thematic analysis. We found that the disruptions triggered emotional reactions like anger and fear. With these emotions as a driving force, the first workshop step was introduced, the Framing of the problem. The next step, Twisting the problem, was reflected in the children developing their own, creative solutions and creatively engaged with them in groups. The last step, Using, was only touched upon in the workshop and is therefore beyond the scope of this paper. Our results indicate that there are three prominent themes reflecting how children discuss plastic pollution. The children talked about their (1) Emotions related to plastic pollution, (2) Attitudes related to plastic, and (3) Perceptions of plastic pollution. These themes were further subdivided into different types of emotions, characteristics of plastic as a material as well as perceptions on different locations of unnecessary plastic. Psychologically, the mechanisms underlying the identified themes were linked to eco-anxiety, denial, self-efficacy, and cognitive dissonance. We conclude that disruptive eco-visualization can create an emotional response amongst children, which can be transformed into co-creation of ideas.

The Hazard Consequence Prediction System: A Participatory Action Research Approach to Enhance Emergency Management.

Emergency managers (EMs) need nuanced data that contextualize the local-scale risks and impacts posed by major storm events (e.g. hurricanes and nor'easters). Traditional tools available to EMs, such as weather forecasts or storm surge predictions, do not provide actionable data regarding specific local concerns, such as access by emergency vehicles and potential communication disruptions. However, new storm models now have sufficient resolution to make informed emergency management at the local scale. This paper presents a Participatory Action Research (PAR) approach to capture critical infrastructure managers concerns about hurricanes and nor'easters in Providence, Rhode Island (USA). Using these data collection approach, concerns can be integrated into numerical storm models and used in emergency management to flag potential consequences in real time during the advance of a storm. This paper presents the methodology and results from a pilot project conducted for emergency managers and highlights implications for practice and future academic research.

Mitigating Broadcasting Storm Using Multihead Nomination Clustering in Vehicular Content Centric Networks

Vehicles are highly mobile nodes; therefore, they frequently change their topology. To maintain a stable connection with the server in high-speed vehicular networks, the handover process is restarted again to satisfy the content requests. To satisfy the requested content, a vehicular-content-centric network (VCCN) is proposed. The proposed scheme adopts in-network caching instead of destination-based routing to satisfy the requests. In this regard, various routing protocols have been proposed to increase the communication efficiency of VCCN. Despite disruptive communication links due to head vehicle mobility, the vehicles create a broadcasting storm that increases communication delay and packet drop fraction. To address the issues mentioned above in the VCCN, we proposed a multihead nomination clustering scheme. It extends the hello packet header to get the vehicle information from the cluster vehicles. The novel cluster information table (CIT) has been proposed to maintain several nominated head vehicles of a cluster on roadside units (RSUs). In disruptive communication links due to the head vehicle’s mobility, the RSU nominates the new head vehicle using CIT entries, resulting in the elimination of the broadcasting storm effect on disruptive communication links. Finally, the proposed scheme increases the successful communication rate, decreases the communication delay, and ensures a high cache success ratio on an increasing number of vehicles.

Changes in Brain Functional and Effective Connectivity After Treatment for Breast Cancer and Implications for Intervention Targets.

Background: Patients with breast cancer frequently report cognitive impairment both during and after completion of therapy. Evidence suggests that cancer-related cognitive impairments are related to widespread neural network dysfunction. The default mode network (DMN) is a large conserved network that plays a critical role in integrating the functions of various neural systems. Disruption of the network may play a key role in the development of cognitive impairment. Methods: We compared neuroimaging and neurocognitive data from 43 newly diagnosed primary breast cancer patients (mean age = 48, standard deviation [SD] = 8.9 years) and 50 frequency-matched healthy female controls (mean age = 50, SD = 10 years) before treatment and 1 year after treatment completion. Functional and effective connectivity measures of the DMN were obtained using graph theory and Bayesian network analysis methods, respectively. Results: Compared with healthy females, the breast cancer group displayed higher global efficiency and path length post-treatment (p < 0.03, corrected). Breast cancer survivors showed significantly lower performance on measures of verbal memory, attention, and verbal fluency (p < 0.05) at both time points. Within the DMN, local brain network organization, as measured by edge-betweenness centralities, was significantly altered in the breast cancer group compared with controls at both time points (p < 0.0001, corrected), with several connections showing a significant group-by-time effect (p < 0.003, corrected). Effective connectivity demonstrated significantly altered patterns of neuronal coupling in patients with breast cancer (p < 0.05). Significant correlations were seen between hormone blockade therapy, radiation therapy, chemotherapy cycles, memory, and verbal fluency test and edge-betweenness centralities. Discussion: This pattern of altered network organization in the default mode is believed to result in reduced network efficiency and disrupted communication. Subregions of the DMN, the orbital prefrontal cortex and posterior memory network, appear to be at the center of this disruption and this could inform future interventions. Impact statement This prospective study is the first to investigate how post-treatment changes in functional and effective connectivity in the regions of default mode network are related to cancer therapy and measures of memory and verbal learning in breast cancer patients. We demonstrate that the interactions between treatment, brain connectivity, and neurocognitive outcomes coalesce around a subgroup of brain structures in the orbital frontal and parietal lobe. This would suggest that interventions that target these regions may improve neurocognitive outcomes in breast cancer survivors.

Plant-insect communication in urban forests: Similarities of plant volatile compositions among tree species (host vs. non-host trees) for alder leaf beetle Agelastica coerulea

Behavior of insects, such as pollination and grazing, is usually determined by biogenic volatile organic compounds (BVOCs). However, particularly in O3-polluted urban forests, the BVOCs-based plant-insect communication can be disrupted by the reaction of O3 with leaf-emitted BVOCs, such as between Japanese white birch (Betula platyphylla var. japonica) and a leaf beetle (Agelastica coerulea). To understand plant-insect communication in O3-polluted environments, it is necessary to identify chemical species of BVOCs that contribute to attractiveness toward insects but are diminished by elevated O3. In this study, we conducted olfactory response tests and gas chromatography mass spectrometry (GC-MS) analyses to clarify whether there is a similarity of BVOC components among Betulaceae host trees that can explain the attraction of the stenophagous insect A. coerulea. The olfactory response tests indicated that Betulaceae host trees attract A. coerulea via leaf-emitted BVOCs, while there was no preference of the leaf beetles to non-host trees (Sorbus commixta and Morus bombycis). However, GC-MS analyses indicated that the composition of BVOC blends considerably differed among Betulaceae host trees, although alders (Alnus hirsuta and A. japonica) had a similar composition of BVOC blend in each season (June and September) during which the adult leaf beetle is active. A distinct characteristic of the emission from B. platyphylla was that 2-carene and limonene, which are O3-reactive species, were emitted with a high monoterpene ratio irrespective of the season. Thus, these volatiles and the blend could be expected to lead the disrupted communication found between B. platyphylla and A. coerulea under elevated O3 in previous field studies. In addition, our results indicated that A. coerulea is attracted to more than one blend within Betulaceae host trees, suggesting that grazing damages can be affected by different host preferences and O3 reactivity with specific BVOCs in the field. BVOCs-based plant-insect interactions should be further studied in multi-species communities to better understand plant-insect communication in O3-polluted environments.

ФЕНОМЕН НАРУШЕННОЙ КОММУНИКАЦИИ В РОМАНЕ ТЕОДОРА ФОНТАНЕ «ЭФФИ БРИСТ» И В ЕГО ЭКРАНИЗАЦИИ РАЙНЕРОМ ВЕРНЕРОМ ФАСБИНДЕРОМ: РЕЧЬ И ЖЕСТ

The subject of this article’s comparative intermedial analysis is the phenomenon of disrupted communication in the novel by the German writer Theodor Fontane “Effi Briest” (1895) and in the film adaptation of this work by Rainer Werner Fassbinder “Fontane Effi Briest” (1974). The article consists of five parts: 1) introduction; 2) analysis of dialogues in Fontane’s novel; 3) description of the means of creating the effect of disrupted communication in Fassbinder’s film; 4) comparative analysis of some fragments of two works by the method of close reading; 5) conclusions. Methodologically, the research is based on the achievements of the theory of communication, carpalistics, comparative and intermedial approaches to the study of film adaptations. The main point of the article is that the effect of disrupted communication, which is observed in numerous dialogues of Fontane’s novel, is also created by visual means in Fassbinder’s film, among which a significant place is occupied by a gesture. The gesture of turning away deserves special attention: the characters of the film turn away from each other, turn their backs to the interlocutor and the viewer, turn to their reflection. The unconventionality and intensity of such gestures accentuate the problematic nature of communication between the characters. This structure, peripheral in Fontane’s work, becomes central in the film of Fassbinder, grasping the viewers’ attention. In this regard, the article adds to a traditional discussion about the hierarchical relationship between a literary text and its film adaptation.

The Evolution of the Hallmarks of Aging.

The evolutionary theory of aging has set the foundations for a comprehensive understanding of aging. The biology of aging has listed and described the “hallmarks of aging,” i.e., cellular and molecular mechanisms involved in human aging. The present paper is the first to infer the order of appearance of the hallmarks of bilaterian and thereby human aging throughout evolution from their presence in progressively narrower clades. Its first result is that all organisms, even non-senescent, have to deal with at least one mechanism of aging – the progressive accumulation of misfolded or unstable proteins. Due to their cumulation, these mechanisms are called “layers of aging.” A difference should be made between the first four layers of unicellular aging, present in some unicellular organisms and in all multicellular opisthokonts, that stem and strike “from the inside” of individual cells and span from increasingly abnormal protein folding to deregulated nutrient sensing, and the last four layers of metacellular aging, progressively appearing in metazoans, that strike the cells of a multicellular organism “from the outside,” i.e., because of other cells, and span from transcriptional alterations to the disruption of intercellular communication. The evolution of metazoans and eumetazoans probably solved the problem of aging along with the problem of unicellular aging. However, metacellular aging originates in the mechanisms by which the effects of unicellular aging are kept under control – e.g., the exhaustion of stem cells that contribute to replace damaged somatic cells. In bilaterians, additional functions have taken a toll on generally useless potentially limited lifespan to increase the fitness of organisms at the price of a progressively less efficient containment of the damage of unicellular aging. In the end, this picture suggests that geroscience should be more efficient in targeting conditions of metacellular aging rather than unicellular aging itself.

Impact of climate change on human health: evidence from riverine island dwellers of Bangladesh

ABSTRACT This study aims to explore the impact of climate change on health, including local adaptation strategies. A mixed-method approach has been used in this study. The results reveal that increasing the frequency of flooding, severity of riverbank erosion and drought, and rising disease outbreak are the highest indicators of climate change perceived by riverine island (char) dwellers, which is similar to the observed data. It also uncovers, approximately all respondents encounter several health-related issues during different seasons where prevailing cold and cough with fever, skin diseases, and diarrhoea are the leading ailments. Several adaptation strategies are accommodated by char inhabitants in order to enhance resilience against the climate change health impacts, but the paucity of money, disrupted communication, lack of formal health-care centre are the most obstacles to the sustainability of adaptation. This research recommends that healthcare-associated project should be performed through proper monitoring for exterminating char dwellers’ health issues.

Book Review: The Era of Disinformation: Disruptive Politics, Technology, and Communication in the United States

Book Review: The Era of Disinformation: Disruptive Politics, Technology, and Communication in the United States