At present the waterflood efficiency is lower in most low permeable heterogeneous reservoirs, and the effect is poor using common polymer as profile control and displacement agent. As a new agent for profile control and displacement, the flow behavior of the nanomicron microsphere is evaluated in laboratory in this paper. The experimental result shows that it has well injectivity and flowability when flowing through the low permeability core. Because the nano-micron microsphere has a behavior of gradual expansion, it can be able to decrease permeability of porous medium very well. Especially in the process of subsequent water injection, the injection pressure increases firstly and then appears a small fluctuation declining, which shows that nano-micron microsphere solution has better antiscour performance and ability of gradual controlling and sealing.