Introduction. Currently, a shortage of studies demonstrating the relationship between body composition disorders in men with excess adipose tissue and metabolic syndrome (MS), depending on the level of testosterone, estradiol, sex hormone binding globulin (SHBG), anthropometric parameters, or blood pressure (BP) has been noted.Aim: to examine a relationship between disturbed anthropometric parameters, level of sex hormones and BP in men with MS.Materials and Methods. There were enrolled 64 overweight men to the study. The patients were divided into 3 groups based on the body mass index (BMI): group 1 – with overweight (n = 24), group 2 – with the first degree of obesity (n = 21), group 3 – with the second and third degree of obesity (n = 19). A correlation analysis was carried out between the data of bioimpedance analysis (BIA) and laboratory data, as well as additionally assessing the level of inter-group difference.Results. Our study allowed to find the relationship between the parameters of body composition in men with overdeveloped adipose tissue and MS that was coupled to the level of testosterone, estradiol, SHBG, anthropometric parameters as well as blood pressure indicators. A moderate negative correlation was observed across entire patient sample between the testosterone level and several anthropometric parameters: waist circumference (WC), WC/hip circumference and BMI (p < 0.05). A weak negative correlation was found between the level of testosterone, fat mass (FM) and the proportion of FM in the general sample. A weak negative correlation between systolic BP and testosterone level throughout the patient sample was found, but a moderate negative correlation was observed solely in group 3. A positive weak correlation was found between testosterone and estradiol level in the general sample as well as in group 2, whereas in group 1 it was moderate. In contrast, in group 3 such a correlation was negative and weak. A positive correlation can be also traced between testosterone and SHBG level particularly being moderate in the entire sample as well as in groups 1 and 2, and noticeable in group 3.Conclusion. The relationship was revealed between the parameters of body composition in men with excessive adipose tissue and MS related to testosterone, estradiol, SHBG level as well as anthropometric parameters and ВР corroborating systematic and multi-layered nature underlying obesity.