Disorders In Men Research Articles

Thyroid cancer in children: A multicenter international study highlighting clinical features and surgical outcomes of primary and secondary tumors.

Background:Thyroid gland malignancies are rare in pediatric patients (0.7% of tumors); only 1.8% are observed in patients aged <20 years, with a higher prevalence recorded in women and adolescents. Risk factors include genetic syndromes, MEN disorders, autoimmune diseases, and exposure to ionizing radiation. Radiotherapy is also associated with an increased risk of secondary thyroid cancer. This study describes the clinical features and surgical outcomes of primary and secondary thyroid tumors in pediatric patients.MethodsInstitutional data were collected from eight international surgical oncology centers for pediatric patients with thyroid cancer between 2000 and 2020. Statistical analyses were performed using the GraphPad Prism software.ResultsAmong 255 total cases of thyroid cancer, only 13 (5.1%) were secondary tumors. Primary thyroid malignancies were more likely to be multifocal in origin (odds ratio [OR] 1.993, 95% confidence interval [CI].7466–5.132, p = 0.2323), have bilateral glandular location (OR 2.847, 95% CI.6835–12.68, p = 0.2648), and be metastatic at first diagnosis (OR 1.259, 95% CI.3267–5.696, p > 0.999). Secondary tumors showed a higher incidence of disease relapse (OR 1.556, 95% CI.4579-5.57, p = 0.4525) and surgical complications (OR 2.042, 95% CI 0.7917–5.221, p = 0.1614), including hypoparathyroidism and recurrent laryngeal nerve injury. The overall survival (OS) was 99% at 1 year and 97% after 10 years. No EFS differences were evident between the primary and secondary tumors (chi-square 0.7307, p = 0.39026).ConclusionsThis multicenter study demonstrated excellent survival in pediatric thyroid malignancies. Secondary tumors exhibited greater disease relapse (15.8 vs. 10.5%) and a higher incidence of surgical complications (36.8 vs. 22.2%).

PS09: Fordyce spots as a genital manifestation of body dysmorphic disorder in men: cases from a psychodermatology clinic

PS09: Fordyce spots as a genital manifestation of body dysmorphic disorder in men: cases from a psychodermatology clinic

Association between domains of quality of life and patients with Klinefelter syndrome: a systematic review.

ObjectiveKlinefelter syndrome (KS) is the second-most prevalent chromosomal disorder in men, though late diagnosis is very common and 50–75% of men remain undiagnosed. Evidence suggests that men with KS have impaired quality of life (QoL) but research on how the diagnosis of KS is associated with different QoL domains and what factors influence patients’ QoL is limited. This study aimed to provide a systematic review of the published evidence on factors that influence QoL in men with KS.DesignSystematic review and meta-analysis with narrative synthesis.MethodsMedline, Cochrane, Embase, Psychinfo, CINAHL, BASE and relevant publication reference lists were searched in January 2021. Eligible studies included randomised control trials, cohort studies, cross-sectional studies and epidemiology studies on KS and its effect on QoL and all domains of World Health Organisation (WHO) Quality of Life 100 (WHOQOL-100). Clinical studies with no date restriction published in English were included.ResultsThematic analysis was completed on 13 studies, with a meta-analysis of intelligence quotient completed on 7 studies. Twelve out of the 13 studies suggested that KS negatively affected the QoL outcomes and KS was associated with impairments in physical, psychological, level independence and social relationship domains of WHOQOL-100. Meta-analysis suggested that men with KS have significantly lower full-scale Intelligence Quotient vs controls (P < 0.00001).ConclusionsThis is the first evidence synthesis of QoL in men with KS. Current evidence suggests that combined physical and psychological impairments affect men with KS who also experience impairments in relationships and independence in society. Further research is needed to identify factors that influence the QoL in men with KS.

The Influence of Pressure Level on the Behavioral Risk Level of Correctional Inmates

The results of mental health disorders research by the University of South Wales showed that 36% experienced mental health disorders in the form of anxiety and women, the incidence rate was higher than men, 61%: 39%. The study was conducted 62 surveys in 12 countries covering 22,790 correctional prison residents found that every 6 months there was a prevalence of psychosis in men 3.7% and women 4% major depression in men 10% and women 12% and personality disorders in men 65% men and 42% women. From these data, many Penitentiary Citizens experience mental health disorders such as stress and sexual deviations. Deviations committed by Penitentiary Members include such as hallucinating / fantasizing, masturbating, and biological violation activities carried out by men and women in Correctional Institutions. This study uses the General Strain Theory theory by Robert Agnew using a quantitative approach. The data collected uses primary data in the form of distributing questionnaires to a predetermined sample of Penitentiary Guards. From the results of the study above the level of risk of deviant behavior of Correctional Guidance Citizens continues to increase along with the increasing level of pressure experienced by Correctional Guidance Citizens&#x0D;

Relationships Between Psychopathy and DSM Personality Disorders in Men and Women.

The current investigation asseses the relationship between DSM personality disorders (PDs) and PCL psychopathy in a community study: the Cambridge Study in Delinquent Development (CSDD). The children (Generation 3) of the original CSDD males (Generation 2) were assessed for PDs and psychopathy in early adulthood. Generation 3 consisted of both males (n = 291) and females (n = 260) and allowed for analyses separately for each gender. Cluster B PDs showed the strongest relationships with psychopathy, especially Borderline and Antisocial PD. Histrionic PD did not appear to have strong relationships with psychopathy, and there were no indications that histrionic PD overlaps with psychopathy in females as past research has hypothesized. There were however some other gender-specific relationships in the analyses, most notably between psychopathy and schizoid and schizotypal PDs for females, and between psychopathy and paranoid PD in males. Implications for the understanding of psychopathy in males and females are discussed.

Investigating the multi-target therapeutic mechanism of Guihuang formula on Chronic Prostatitis

Ethnopharmacological relevanceChronic prostatitis (CP) is a complex, intractable and prevalent urological disorder in men with no effective treatment. Guihuang formula (GHF) is a traditional Chinese medicine compound that is advantageous as a CP treatment, but its aetiology is poorly understood. Research and exploration of the mechanism of GHF will help the development of a potentially valuable drug for CP and provide deeper insight into CP. Aim of the studyTo examine and further clarify the multi-target therapeutic mechanism of GHF on CP. Materials and methodsThe chemical components in GHF were identified using UPLC-Q/TOF-MS. The active components and potential targets of GHF for the treatment of CP were screened and analyzed using network pharmacology and molecular docking. We constructed a CP rat model to investigate the therapeutic effect of GHF on CP and verify the influence of key targets and core pathways based on the results of network pharmacology. ResultsA total of 143 ingredients were identified in GHF using UPLC-Q/TOF-MS, and 111 potential targets for GHF of CP were predicted. The “drug-ingredient-target-pathway” network was constructed and in compliance with the “Jun-Chen-Zuo-Shi” principle. GHF significantly reduced the prostate index, alleviated histological damage in the prostate, decreased CD3+ T cells and CD45+ leukocyte infiltration in the prostate, downregulated the expression of the proinflammatory cytokines IL-1β, IL-6, IL-18, COX-2, MCP-1 and TNF-α, decreased ROS levels and alleviated the production of MDA accompanied by an increase of SOD and GSH-PX levels. Meanwhile, GHF suppressed apoptosis in macrophages, downregulated the mRNA levels of PI3K, AKT and P65 NF-κB and inhibited the phosphorylation of the PI3K, AKT and P65 NF-κB. ConclusionA network pharmacology and experimental validation-based strategy was used to elucidate the underlying “multicomponent, multitarget, and multipathway” mode of action of GHF against CP. We verified that GHF inhibited oxidative stress and inflammatory response, suppressed apoptosis in macrophages, inhibited the activation of the inflammation-related PI3K/AKT/NF-κB pathway in CP rat. These findings extend the conventional views of “one drug hits one target”, and offer novel insights and indication paradigm for the future discovery on the multi-target therapeutic mechanism of traditional Chinese medicine compound.

Trichogenic effect of low level laser therapy combined with platelet-rich plasma for the management of androgenetic alopecia

Background: (AGA) is a very common hair disorder in men, Topical minoxidil and more recently low-level light therapy and Platelet-rich plasma therapy have been used in the management of (AGA). Objectives: To assess the Trichogenic effect of LLLT combined with PRP in the management of AGA. Patients and methods: Forty seven patients with AGAwere subjected to PRP therapy plus LLLT, affected area of all patients were treated for three months and then follow up for another three months. Efficacy was evaluated using global photography, folliscopic pictures analysis, answers for standardized hair growth questions and score of patient Gratification. Results: There was statistically significant improvement in diameter, vellus hair, terminal hair and density after treatment for three months although these improvements were decreased at three month after stoppage of treatment but still better than the baseline. Conclusion combination of LLLT with PRP could be a good treatment modality of AGA.

Interaction between COMT Val158 Met polymorphism and childhood trauma predicts risk for depression in men.

Depression is a disabling illness with complex etiology. While the catechol-O-methyltransferase (COMT) gene, in particular the functional Val158 Met polymorphism, has been related to depression, the mechanisms underlying this gene-disease association are not completely understood. Therefore, we explore the association of COMT Val158 Met polymorphism with depression as well as its interaction with childhood trauma in 1136 young adults from a population-based study carried out in the city of Pelotas, Brazil. The diagnosis was performed through the Mini International Neuropsychiatric Interview 5.0 (MINI 5.0), and trauma was assessed with the Childhood Trauma Questionnaire (CTQ). Total DNA was extracted and genotyped by real-time PCR, and the QTLbase dataset was queried to perform large-scale quantitative trait locus (QTL) analysis. Our research showed no direct association between the Val158 Met polymorphism and the diagnosis of depression (women: χ2 =0.10, d= 1, p= 0.751; men: χ2 =0.003, df =1, p= 0.956). However, the Met-allele of the Val158 Met polymorphism modified the effect of childhood trauma in men (OR =2.58 [95% CI: 1.05-6.29]; p= 0.038) conferring risk for depression only on those who suffer from trauma. The conditional effect from moderation analysis showed that trauma impacts the risk of depression only in men carrying the Met-allele (effect: 0.9490, standard error [SE]: 0.2570; p= 0.0002). QTLbase and dataset for Val158 Met polymorphism were consistent for markers that influence chromatin accessibility transcription capacity including histone methylation and acetylation. The changes caused in gene regulation by childhood trauma exposure and polymorphism may serve as evidence of the mechanism whereby the interaction increases susceptibility to this disorder in men.

How to manage puberty and prevent fertility disorders in men with CAH?

Gonadal dysfunction is an adverse outcome in patients with congenital adrenal hyperplasia (CAH), which may become apparent already during puberty. In males, gonadal dysfunction can be caused by primary gonadal failure due to testicular adrenal rest tumours (TART), and by secondary gonadal failure due to poor hormonal control. Yearly evaluation for TART using ultrasonography is recommended from the start of puberty or even earlier when poor hormonal control is present. We recommend yearly evaluation of gonadal function by measuring LH, FSH, testosterone, and inhibin B. When TART is present, cryopreservation of semen should be considered as soon as possible.

Barriers to help-seeking for eating disorders in men: A mixed-methods systematic review.

Barriers to help-seeking for eating disorders in men: A mixed-methods systematic review.

The effectiveness of solution-focused therapy on emotional, cognitive, motivational and biological symptoms of major depressive disorder in men and women

The effectiveness of solution-focused therapy on emotional, cognitive, motivational and biological symptoms of major depressive disorder in men and women

Diagnostic cytokine marker of male infertility - interleukin 4.

Analysis of the study is to assess the diagnostic significance of cytokines in the sperm plasma of men of reproductive age (20 - 45 years) of two groups: of patients with chronic bacterial prostatitis, not complicated by infertility and with loss of fertility. The study of sperm plasma - the WHO standard. Determination of the level of cytokines in seminal plasma - by enzyme immunoassay («Cytokine», Russia). Two methods of mathematical statistics were used: discriminant analysis and classification trees (decision trees).The similarity of interpretations of discriminant analysis and decision tree was noted, where the main role in both cases belongs to the cytokine IL-4. The level of sperm IL-4 in combination with therapeutic monitoring can be used for the medical management of patients with chronic prostatitis in order to prevent the development of infertility and to develop methods for screening diagnostics of fertility disorders in men.

Clinical and pathogenetic aspects of formation, early diagnosis, and medicated correction of cardiorenal disorders in men with hypertension against the background of purine metabolism disturbance

Aim: to review literary sources and analyse the modern view of the mechanisms of development of kidney and heart damage in patients with combination of hypertension (HP) and hyperuricemia and methods of their medicated correction. Materials and methods. A review of the scientific literature for the last 10 years was done. It demonstrates that today high levels of uric acid (UA) are considered not only as a consequence of deteriorating renal function, but also as one of the factors of renal damage. The role of the kidneys in the pathogenesis and development of hypertension is the subject of a lively debate, whose significance is determined by the presence of a long period of latent renal dysfunction. According to the literature, in patients with essential hypertension, a direct correlation was found between the uric acids level and the left ventricular diastolic dysfunction (LVDD). Early diagnosis of heart lesions is possible using speckle-tracking echocardiography, which is an innovative technology for studying myocardial deformation, allowing subclinical diagnosis of heart muscle lesions. This technique is informative in hypertension even in the absence of hypertrophy and LVDD. The article also elucidates modern methods for diagnosing kidney damage against the background of hypertension, in particular, lipocalin associated with neutrophil gelatinase (NGAL). However, the significance of this biomarker in impaired renal function under conditions of hyperuricemia has not been studied. According to the literature, cystatin C is a marker of early diagnosis of cardiovascular events and a marker of renal glomerular function in the absence of an increase in serum creatinine levels. The role of this marker has been proven for many diseases of the kidneys and the cardiovascular system; however, there are no data on their definition as markers of damage to the heart and kidneys in hypertension in conditions of hyperuricemia. Conclusions. The identification of causal relationships and mechanisms of complications in hypertensive patients with purine metabolism disturbance needs further study. Therefore, early diagnosis of structural and functional changes in the main target organs (in particular, the heart and kidneys) and the determination of biochemical markers (NGAL, cystatin C) to identify their functional disturbances at the preclinical stage are important.

Delayed ejaculation in men with depressive disorders.

Delayed ejaculation belongs to the group of sexual disorders in men. The causes of delayed ejaculation or anejaculation are not exactly known. It is assumed that it can be caused by psychogenic or organic influences or their combinations. One of the causes of delayed ejaculation may be elevated prolactin levels, which may be increased by psychosocial stress, pituitary disorders or also treatment with selective serotonin reuptake inhibitors in the treatment of depression. We tested a selected group of 50 men who were diagnosed with a depressive disorder and whose antidepressant treatment lasted for at least 24weeks. These patients reported long-term delayed ejaculation or, in some cases, anejaculation as comorbidity. The results showed significant Spearman's correlation between elevated prolactin levels and intravaginal ejaculation latency values (R=0.45), as well as between Beck's Depression-II inventory and intravaginal ejaculation latency and latency values (R=0.48).

An ethnopharmacological survey of medicinal plants used in the traditional treatment of human infertility in eastern Algeria

Objective: To summarize medicinal plants used in the treatment of couple fertility disorders. Methods: An ethnopharmacological survey was conducted with 30 traditional healers from some localities of Skikda region in eastern Algeria. A standard questionnaire was used in the interview which focused mainly: the treated fertility disorders, the used medicinal plants species, parts used, and preparation methods. The relative frequency of citation and percentages of infertility troubles were calculated and analyzed. Results: The most important treated disorders in men were dysfunction of libido (44.22%), low sperm concentration and motility (25.33%), low semen volume (17.67%) and prostate disorders (5.66%). Women were treated mainly for menstruation disorders (35.32%), breast problems (29.53%) and sexual asthenia (25.82%). The survey identified 28 plant species belonging to 15 families, used by different ethnic groups, particularly women (58.00%), to address different fertility disorders. Three plant families were largely used viz Lamiaceae, Asteraceae, and Apiaceae. In term of relative frequency citation, ten dominated plant species were: Zingiber officinalis L. (0.96), Nigella sativa L. (0.83), Lepidium sativum L. (0.80), Capsicum annuum L. (0.60), Cuminum cyminum L. (0.56), Origanum vulgare L. (0.55), Allium sativum L. (0.50), Petroselinum sativum L. (0.43), Salvia officinalis L. (0.42), and Foeniculum vulgare L. (0.40). A number of investigated plants were scientifically confirmed by phytochemical and pharmacological studies to have one or more significant effects on couple fertility. However, much controversy was found in literature concerning the efficacy of some cited plants. Conclusions: The study highlights the important use of medicinal plants in management of couple infertility in eastern Algeria. More experimental studies are recommended to confirm or to refute these traditional uses and to ascertain the safety of these medicinal plants to consumers.

Eating disorders in men: limited models of diagnosis and treatment are failing patients.

Eating disorders in men: limited models of diagnosis and treatment are failing patients.

The Reproductive Impact of Eating Disorders in Adolescents

Eating disorders are common, chronic illnesses that frequently arise during adolescence. Because of the impact on nutrition, individuals with eating disorders have significant health consequences, including effects on reproductive health. Adolescent women with eating disorders frequently have menstrual irregularities, though the causes of these abnormalities are complex and vary depending on the type of eating disorder. Teens with eating disorders may have changes in current and future fertility, and eating disorders during pregnancy can have medical and psychologic impacts for both mother and child. Though not well researched, eating disorders in men can affect reproductive health and potentially impact fertility. Lastly, eating disorders in adolescents can have significantly deleterious, irreversible effects on bone health.

The effectiveness of solution-focused therapy on emotional, cognitive, motivational and biological symptoms of major depressive disorder in men and women

Background and purpose: Depression as the most common psychiatric and mood disorder affects many people in all parts of the world. Depression is associated with long periods, variety of symptoms, high rate of recurrence and many physical and mental disorders. The purpose of the present study was to compare the effectiveness of treatment focused on emotion and strategic treatment focused on emotional, cognitive, motivational and biological symptoms of major depressive disorder. Methods: The current research was applied in terms of the purpose of the research. The design of the semi-experimental research was pre-test-post-test with a control group and a three-month follow-up. The statistical population of the research included all women and men who referred to the counseling and psychological center of the beautiful mind of Bojnord city in 2019-20, who referred to psychiatrists, psychologists and mental health specialists, and the specialists of the center gave them a diagnosis of major depressive disorder. The sample of this research includes 45 people from the mentioned society who, using simple randomization method, were divided into three groups of emotion-focused couple therapy (n=15), solution-oriented couple therapy (n=15) and control group (n=15) were assigned. The data was obtained using a depression questionnaire (made by the researcher). Mean and standard deviation were used in the descriptive statistics section, and variance analysis method with repeated measures was used in the inferential statistics section. Results: The results showed that emotion-focused therapy has a greater effect on the emotional, motivational and biological (vegetative) symptoms of major depressive disorder than solution-oriented strategy therapy (P &lt; 0.01) and solution-oriented strategy therapy has more impact than focused therapy. Emotion has a greater effect on the cognitive symptoms of major depressive disorder (P&lt;0.01). The results of this research were also permanent in the follow-up phase. Conclusion: It can be concluded that emotion-focused therapy and solution-oriented strategic therapy focused on emotional, cognitive, motivational symptoms and biological symptoms of major depressive disorder were effective, and these treatments can be used to reduce the problems of people with major depression. profit

Feasibility of a deep learning-based diagnostic platform to evaluate lower urinary tract disorders in men using simple uroflowmetry.

PurposeTo diagnose lower urinary tract symptoms (LUTS) in a noninvasive manner, we created a prediction model for bladder outlet obstruction (BOO) and detrusor underactivity (DUA) using simple uroflowmetry. In this study, we used deep learning to analyze simple uroflowmetry.Materials and MethodsWe performed a retrospective review of 4,835 male patients aged ≥40 years who underwent a urodynamic study at a single center. We excluded patients with a disease or a history of surgery that could affect LUTS. A total of 1,792 patients were included in the study. We extracted a simple uroflowmetry graph automatically using the ABBYY Flexicapture® image capture program (ABBYY, Moscow, Russia). We applied a convolutional neural network (CNN), a deep learning method to predict DUA and BOO. A 5-fold cross-validation average value of the area under the receiver operating characteristic (AUROC) curve was chosen as an evaluation metric. When it comes to binary classification, this metric provides a richer measure of classification performance. Additionally, we provided the corresponding average precision-recall (PR) curves.ResultsAmong the 1,792 patients, 482 (26.90%) had BOO, and 893 (49.83%) had DUA. The average AUROC scores of DUA and BOO, which were measured using 5-fold cross-validation, were 73.30% (mean average precision [mAP]=0.70) and 72.23% (mAP=0.45), respectively.ConclusionsOur study suggests that it is possible to differentiate DUA from non-DUA and BOO from non-BOO using a simple uroflowmetry graph with a fine-tuned VGG16, which is a well-known CNN model.

The effectiveness of solution-focused therapy on emotional, cognitive, motivational and biological symptoms of major depressive disorder in men and women

Aim: The aim of this study was to determine the effectiveness of strategic solution-oriented therapy on emotional, cognitive, motivational and biological symptoms of major depressive disorder. Methods: The present study was applied in terms of research purpose. The quasi-experimental research design was pretest-posttest with control group and quarterly follow-up. The statistical population of the study included all men and women who referred to Bojnourd Beautiful Mental Counseling and Psychology Center in 2019-20, who referred to psychiatrists, psychologists and mental health specialists and the center specialists diagnosed them with major depressive disorder. The sample of this study includes 30 people from the mentioned community who were selected using purposive sampling method and using simple randomization method in two groups of solution-focused therapy (n= 15) based on Quick (2008) protocol and control group (n=15) were assigned. Data were obtained using a Depression Inventory (researcher-made). In the descriptive statistics section, mean and standard deviation and in the inferential statistics section, the analysis of variance with repeated measures was used. Results: The results showed that strategic solution-oriented therapy reduces the symptoms of emotional (F=41.16, P&lt;0.001), cognitive (F=12.87, P&lt;0.001), motivational (F=4.93, P=0.035) and biological (F=29.85, P&lt;0.001) disorders. Major depression was effective. Conclusion: It can be concluded that strategic solution-oriented therapy is effective on emotional, cognitive, motivational and biological symptoms of major depressive disorder and can be used to improve the problems of people with major depression.