Diseases Of Digestive Organs Research Articles

Diseases of digestive organs as a cause of disability in Rostov region

The analysis presented in the article of the primary disability of the adult population due to diseases of digestive organs in the Rostov region for 20122018 was characterized by an increase in the number of persons recognized as disabled for the first time as in the Southern Federal District and the Russian Federation. In the structure of the first recognized disabled persons, their share was higher than in the Southern Federal District, but lower than in the Russian Federation. The level of primary disability for 20122018 was lower than in the Southern Federal District and the Russian Federation. The age structure was dominated by persons with disabilities of working age (women aged 4554; men 4559 years old) as well as in the Southern Federal and Russian Federation. The severity of disability was dominated by group II persons with disabilities, with a tendency to increase their specific weight, as in the Southern Federal District and the Russian Federation; Group III persons with disabilities ranked second, with a tendency to reduce their share and level. There has been an increase in the proportion of group I disabled persons.

Анализ изотопического состава выдыхаемого воздуха методами диодной лазерной спектроскопии в районе 2 μm для диагностики Helicobacter pylori-ассоциированных заболеваний-=SUP=-*-=/SUP=-

Spectral analysis of 13СО2/12СО2 isotope ratio in exhaled air based on tunable diode laser spec-troscopy was applied for diagnostics of digestive organ diseases associated with Helicobacter pylori infection. Special spectrophotometer based on tunable diode laser was developed for the analysis of breath isotope content. Spectral range near 2.05 microns where the rotational-vibration R-branch of the 20013-00001 band of 12CO2 interferes with the P-branch of the 20012-00001 band of 13CO2 was used. The 13C-Urea Breath Test (13C-UDT) was used for the H. pylori infection diagnostic in gastrointestinal tract of 309 tested persons. The results of the isotope breath test were compared with the data of morphological analysis of gastric and duodenal mu-cosa obtained by fibrogastroduodenoscopia. For the first time the total value of the histology analysis results for biopsy material taken in the stomach body, in the distal part of stomach and in the duodenum was proposed to be used for the comparative analysis with 13C-UBT data. A relationship of 13C-UBT data with age, nosology, activity and severity of inflammation process, atrophy degree, and type of eradication therapy was analyzed. Distribution of 13C-UBT data ob-tained before and after therapy was demonstrated to reflect epidemiology of gastroduodenal dis-eases, H.pylori infection incidence, specifics of gastrointestinal tract colonization by H.pylori, parameters of inflammation process, as well as therapy effectiveness and peculiarity of the in-fection restoration at failed eradication therapy.

THE DYNAMICS OF PREVALENCE OF DISEASES OF DIGESTIVE ORGANS IN POPULATION OF THE REPUBLIC OF ARMENIA

The article presents the results of analysis of morbidity of diseases of digestive organs шт the Republic of Armenia. It is established that in the Republic of Armenia during 1990-2015 primary morbidity of diseases of digestive organs in children population reliably increased up to 2.4 times and in adult population - up to 1.9 times. The leading diseases in the structure of primary morbidity among children population is gastroduodenitis (39.7%) and among adult population - gastritis (54.6%). In the Republic, the indices of total morbidity of diseases of digestive organs during the same period of time increased reliably from 57,5‰ to 100,3‰ in children population and from 50,9‰ to 60,2‰ adult population. At the same time, during last 15 years at stabilization of level of morbidity with temporary disability average duration of one case of disease with temporary disability up to 11.6% and primary disability up to 2.9%.

Analysis of Somatic Health State of Students at Lesya Ukrainka Eastern European National University

The research urgency is caused by necessity of studying the students somatic health level due to a sharp deterioration of health state during the last decade. The aim of the investigation is studying the dynamics and nosological forms of students diseases of higher educational institutions. The results of the work. It is established that the incidence of students in the dynamics of 2010–2016 is growing rapidly. The diseases of cardiovascular system, stomach and digestive organs, musculoskeletal system are the most common. In the analysis of nosologic forms of diseases for a gender characteristics, the percentage of women with pathology, from the first to the fourth year study within the specified research period is significantly more than men. Conclusions. The state of students health is unsatisfactory. This requires the search for new approaches for setting issue of youth health.

Мониторинг факторов риска развития болезней органов пищеварения (По материалам исследования в г. Ереване, Армения)

Мониторинг факторов риска развития болезней органов пищеварения (По материалам исследования в г. Ереване, Армения)

The Nationwide Study of Erdheim-Chester Disease in Japan

Background: Erdheim-Chester disease (ECD) is a subtype of non-Langerhans histiocytic disorder that is shown to be driven by hyperactivation of MAPK pathway (most frequently caused by BRAFV600E mutation) and characterized by generalized organ dysfunction with infiltration of CD68-positive, CD1a-negative histiocytes. However, ECD is a rare entity and therefore very little is known about epidemiology of this disorder.Methods: We underwent a postal questionnaire-based, multi-center retrospective study to clarify the clinical features of ECD patients. We first sent 3850 questionnaires to various departments including orthopedics, respiratory medicine, dermatology, hematology, and pathology to cover as many ECD patients as possible, and identified 71 ECD patients in Japan. We further collected detailed clinical information and patients' samples if available. All cases were pathologically proven and the diagnoses of ECD were self-reported by each institute. DNA was extracted from each clinical sample and Sanger sequencing or allele-specific polymerase chain reaction (PCR) for BRAFV600E mutation were underwent with specific primers.Results: Among 71 patients with ECD, detailed clinical information about 38 patients were collected. The median age was 51 years old (range: 25-76 years old) and there was a male predominance (1.9:1). Major affected lesions were the bone (84 %), central nervous system (CNS; 50 %), cardiovascular lesion (37 %), skin (37 %), retroperitoneum (37 %), endocrines (37 %), lung (24 %), and digestive organ (12 %). C-reactive protein at onset was higher than upper normal limit in 24 of 29 patients (median 23.8 mg/L). The median time from the onset to diagnosis was 17 months and median survival from initial onset was 10.9 years. In the univariate analyses, age older than 60 years old at initial onset (hazard ratio [HR], 30.2; 95% CI, 5.7-159; p < 0.001), weight loss (HR, 5.4; 95% CI, 1.4-20.8; p = 0.014), CNS involvement (HR, 25.2; 95% CI, 3.1-203; p = 0.0024), cardiovascular lesion (HR, 3.6; 95% CI, 1.2-10.8; p = 0.021) and digestive organ disease (HR, 5.6; 95% CI, 1.6-20.2; p = 0.0085) were associated with poor prognosis. Interestingly, the bone involvement was associated with better outcome (HR, 0.20; 95% CI, 0.065-0.63; p = 0.0052). Multivariate analysis revealed that older age was an independent poor prognostic factor (HR, 18.9; 95% CI, 2.12-169; p = 0.0085). In addition, patients with CNS involvement were significantly older than patients without CNS disease (median, 63.7 vs 44.0 years old; p < 0.001). We also analyzed the BRAF V600E mutation status in seven cases. Allele-specific PCR identified that three of seven patients had BRAFV600E mutation.Conclusion: Our nationwide survey revealed that older age was associated with CNS involvement and poor prognosis in ECD patients. In addition, the bone, cardiovascular, CNS and digestive organ involvement might also affect clinical outcome. It is of note that the bone lesion was associated with better survival in the univariate analysis. However, larger and prospective studies are warranted. Regional disparity such as percentage of bone lesions should be also investigated. DisclosuresOgura:Payment for lectures including service on speakers bureaus: Speakers Bureau.

ПРЕДИКТОРИ ФОРМУВАННЯ ПОРУШЕННЯ МИКРОБІОЦЕНОЗУ КИШЕЧНИКА У ДІТЕЙ ПЕРШОГО РОКУ ЖИТТЯ І ЙОГО ПРОФІЛАКТИКА

Метою дослідження було виявлення чинників порушення мікрофлори кишечнику та надання профілактичних заходів. Обстежено 30 дітей. Визначені фактори ризику: у половини дітей вік батьків 30 і більше років; обтяжена спадковість, здебільшого з боку матері, хронічні захворювання органів травлення (70%), ЛОР-органів (23,3%), алергічні реакції і захворювання (40%); патологічна вагітність у всіх жінок (токсикоз, гострі та загострення хронічних захворювань, дефіцитна анемія); патологічні пологи (кесарів розтин у 16,6% вагітни). У 30% пацієнтів виявлено подовження фази транзиторного дисбіозу новонародженої дитини до другого півріччя життя. Клінічні прояви дисбактеріозу в дітей відповідали легкій компенсованій формі (I ступень тяжкості) але дані бактеріологічного дослідження -II–III мікробіологічним ступеням дисбіозу. Профілактику дисбактеріоза потрібно починати з дитячого віку майбутньої мами; під час вагітності жінкам "групи ризику" слід проводити дослідження стану біоценозу кишечнику і коригувати його порушення. Діти, народжені від матерів цієї групи ризику, потребують первинної профілактики порушення мікробіоценоза кишечника.

DENTAL STATUS OF CHILDREN WITH THE TEETH FORMATION DISORDERS

Aim of research: to analyze the dental status of children with the teeth formation disorders on the background of the digestive diseases (DD). Object of research – the change of the teeth hard tissues and periodontal tissues, subject of research – clinical characteristics of the status of teeth hard tissues and periodontal ones. Results of research: in children with chronological enamel hypoplasia (CEH) and molar-incisor hypomineralization (MIH) on the background of digestive diseases (Class ICD-10, К00-К93: “Gastritis and duodenitis” (К29), “Cholecystitis” (К81), “Other bile-excreting diseases” (К83)) was fixed the high and very high intensity of the dental caries, respectively. Caries as CEH and MIH complication was diagnosed in 55,81 % and 42,85 % of examined, respectively. In children with CEH and MIH on the background of digestive organ diseases was diagnosed the middle severity of gingivitis РМА, Papillary, Marginal, Alveolar Indices): 29,13±8,87 % and 25,24±8,97 %, respectively. The rate of persons with the healthy periodontal tissues according to CPI (Community Periodontal Index) was 21,42±21,91 % in children with CEH and 7,14±13,11 % in examined with MIH. In examined with CEH and MIH was fixed the satisfactory hygiene of the oral cavity according to Green-Vermillion index (OHI – Oral Hygiene Index). Conclusion: children with teeth hard tissues formation disorders on the background of digestive diseases need the dispensary observation and course of the therapeutic and prophylactic arrangements for preventing the possible complications (caries, gingivitis, periodontitis).

Long-term Risk of Hospitalization for Somatic Diseases in Survivors of Adolescent or Young Adult Cancer.

Survivors of adolescent and young adult cancers are at risk for treatment-induced late adverse effects; however, to our knowledge, the long-term risk of hospitalization in this specific group of cancer survivors has not been thoroughly evaluated. To examine relative and absolute excess risk for hospitalizations up to 34 years after diagnosis of adolescent and young adult cancer compared with population comparisons. This was a cohort study, conducted in Denmark, of 33,555 five-year survivors of adolescent or young adult cancer, diagnosed from 1943 through 2004, when they were 15 to 39 years of age, and 228,447 population comparisons, matched to the survivors by sex and year of birth. Cancer survivors and comparisons were followed up for hospitalizations in the Danish Patient Register through December 2010. Standardized hospitalization rate ratios (RRs) and absolute excess risks (AERs) were calculated. After a median follow-up of 14 years, we identified 53,032 hospitalizations in cancer survivors, whereas 38,423 were expected, resulting in an overall RR of 1.38 (95% CI, 1.37-1.39). The data analysis was started in January 2015 and ended in June 2015. Additional data analyses requested by the reviewers were conducted in August 2015. The highest risks were found for the main diagnostic groups of diseases of blood and blood-forming organs (RR, 2.00; 95% CI, 1.87-2.14), infectious and parasitic diseases (RR, 1.69; 95% CI, 1.61-1.77), and malignant neoplasms (RR, 1.63; 95% CI, 1.59-1.68). The overall AER was 2803 (95% CI, 2712-2893) per 100,000 person-years; the highest AERs were found for malignant neoplasms, diseases of digestive organs, and diseases of the circulatory system (18%, 15%, and 14% of total AER, respectively). Survivors of the 10 most common cancers in adolescents and young adults were at significantly increased risk for diseases in the 12 main diagnostic groups. The highest risks were those of survivors of leukemia (RR, 2.21; 95% CI, 2.02-2.42), brain cancer (RR, 1.93; 95% CI, 1.86-2.00), and Hodgkin lymphoma (RR, 1.87; 95% CI, 1.80-1.94). The large number of survivors and the use of hospital discharge diagnoses made it possible to draw a comprehensive picture of the complex inpatient disease burden experienced by survivors of adolescent and young adult cancer. The findings underscore a great diversity of cancer-related health problems that physicians and patients should be knowledgeable about.

Evaluation of Misdiagnosed Cases of Subarachnoid Hemorrhage and Causal Factors for Misdiagnosis

Diagnosis has a major impact on the outcome of subarachnoid hemorrhage (SAH). We studied patients with SAH who were admitted to our hospital in an effort to identify ways to prevent misdiagnosis. A total of 494 patients with SAH were admitted to the Department of Neurosurgery from 2003 through 2010. Misdiagnosis occurred in 30 patients (6.1%). We studied the symptoms and the types of misdiagnoses in these 30 patients. Misdiagnosis occurred 37 times in the 30 patients (6 patients were given more than 1 misdiagnosis). There were 3 types of misdiagnoses. Type 1 cases were misdiagnosed as a common cold, type 2 cases were misdiagnosed as circulatory organ disease, and type 3 cases were misdiagnosed as digestive organ disease. Type 1 cases were mild, and diagnosis required detailed medical history analyses. Type 2 cases were severe and were diagnosed based on electrocardiographic and echocardiographic changes characteristic of SAH. Symptoms of type 3 cases included vomiting, and diagnosis required recognition of meningeal irritation syndrome and detailed medical history analyses.

The organization of comprehensive rehabilitation of the children presenting with inflammatory intestinal diseases and celiacia under the conditions of a health resort

In this study we report the experience with the provision of rehabilitative services for the children presenting with long-standing chronic diseases of the digestive organs (ulcerative colitis, Crohn's disease, celiac disease) based at a regional health resort. The possibility of comprehensive rehabilitation was substantiated with the contribution by non-medical specialists including a psychologist, social worker, and educator. A number of organizational problems related to rehabilitation logistics and scientific support have been successfully solved. Standard programs comprising the mechanisms of comprehensive rehabilitation and methods for the evaluation of its effectiveness are proposed.

The health of the Moscow region population at the end of the 19th-beginning of the 21st centuries

The paper presents the results of a multiyear study of the health of the population from the end of the 19th to the beginning of the 21st centuries, as well as an estimate of the modern medical-geographic situation in the Moscow region. It is shown that the demographic indices and the level of morbidity over all pathologies have changed. In the historical past, infant mortality was especially significant, but at present, it is now the mortality of the adult population. In the structure of mortality and morbidity, the role has passed from infectious diseases and digestive organ diseases to morbidity of respiratory organs, the circulatory system, and ocular organs. The territorial structure of morbidity has been analyzed. Its earlier revealed distinct attribution to industrial districts with determined sources of pollution at the beginning of the 21st century is less pronounced, which is obviously a result of the total multifactor action of the environment on the health of the population. As well, territorial peculiarities of morbidity from socially significant diseases have proved more stable.

Trends in Cause-Specific Mortality in Oxygen-dependent Chronic Obstructive Pulmonary Disease

Since the introduction of long-term oxygen treatment (LTOT) in chronic obstructive pulmonary disease (COPD) with chronic hypoxia, the proportion of women and the age of patients starting LTOT have increased markedly. We hypothesize that this might have led to shifts in the causes of death over time. To test for time trends in cause-specific mortality in COPD with LTOT. Patients starting LTOT for COPD in Sweden between January 1, 1987 and December 31, 2004 were included in a national prospective study and monitored until withdrawal of LTOT, death, or December 31, 2004. The primary end point was cause of death obtained from the Swedish Causes of Death Register. A total of 7,628 patients (53% women) were monitored for a median of 1.7 years (range, 0-18.0 yr). No patient was lost to follow-up and 5,457 patients died during the study. The crude overall mortality increased by 1.6%/year (95% confidence interval [CI], 0.9-2.2%/yr; P < 0.001). The absolute risk of death increased for circulatory disease by 2.8%/year (95% CI, 1.3-4.3%/yr; P < 0.001) and for digestive organ disease by 7.8%/year (95% CI, 1.9-14.0%/yr; P = 0.009). The absolute risk of death decreased for respiratory disease by 2.7%/year (95% CI, 2.0- 3.3%/yr; P < 0.001) and for lung cancer by 3.4%/year (95% CI, 1.1-5.7%/yr; P = 0.004). In oxygen-dependent COPD, mortality has increased over time both overall and of nonrespiratory causes, including cardiovascular disease. This highlights the importance of optimized diagnostics and treatment of comorbidities to decrease morbidity and mortality.

Association of digestive organ disease with metabolic syndrome: role of adipocytokine and its molecular mechanisms.

Recently, lifestyle-related disease due to excess nutrition and insufficient physical exercise has been increasing in developed countries, including Japan. Metabolic syndrome is related to visceral fat accumulation in individuals with upper body obesity. Adipose tissue is an endocrine organ that secretes adipocytokines such as adiponectin, leptin, and TNF-α. Obesity alters the secretion of adipocytokines, leading to insulin resistance and various other metabolic disorders. Little is known about how altered regulation of adipocytokines is related to the development and progression of digestive organ disease. Clarification of the mechanisms whereby such altered adipocytokine secretion participates in pathophysiology of digestive organ disease could lead to the development of preventive and therapeutic measures.

Digestive organ diseases and metabolic syndrome

Digestive organ diseases and metabolic syndrome

Suicidal tendencies among the elderly in Mie Prefecture, Japan, between 1996 and 2002

This study aims to show the causative factors of suicide among the elderly (over 65) in Mie Prefecture, and to discuss the prevention of the factors contributing to suicide in the elderly group. We obtained an agreement from the Mie Prefectural Police Headquarters and investigated all inquest records collected between 1996 and 2002 in Mie Prefecture and focused on suicide in the elderly group. During the test period, the number of suicides in the elderly group was 842. In causative factors, the two major causative factors of suicide were “suffering from physical illness” and “psychiatric disorders”. In particular, the three most frequent physical illnesses were “cardiovascular disease”, “orthopedic disorder”, and “digestive organ disease”, and these physical illnesses are mentally stressful, and thus have a psychiatric component, the same as psychiatric illnesses do. Consequently, it is concluded that improvements in the home nursing and mental health care should include the prevention of suicide in the elderly who “suffer from physical illness” and “psychiatric disorders” to prevent suicide. In addition, medical staff and the general public should be educated on the factors that can influence elderly persons’ mental condition, and should be cautioned to observe elderly persons for suicidal signs and symptoms.

FECAL CALPROTECTIN IN SCREENING DIAGNOSTICS OF GASTRODUODENAL ULCERS

Gastroduodenal ulcers is one of the most common diseases of digestive organs. The absence of stable tendency towards the lower morbidity with this pathology, frequent recurrent course, complication severity and high rate of disability of patients make researchers to clarify etiological and pathogenetic aspects of ulcer, to develop and improve the known methods of diagnostics and treatment of patients. We have investigated the efficiency of fecal calprotectin use in the screening diagnostics of gastroduodenal ulcers in 36 patients with gastroduodenal ulcers, 43 patients with gastric cancer, and 27 patients aged 17-80 with gastric dyspepsia (average age 45±6,82 years old). It was revealed that the level of fecal calprotectin is significantly higher at gastroduodenal ulcers than at gastric dyspepsia, and does not differ from the same analysis at gastric cancer. The analysis is highly specific and exceeds ESR by its sensitivity.

Natural Killer-Like T Cell Lymphoma of the Small Intestine: Report of a Case

We report the case of a 77-year-old Japanese man with natural killer (NK)-like T cell lymphoma of the small intestine diagnosed after an emergency laparotomy for perforated peritonitis. Immunohistochemical staining of the tumor showed that the patient had CD3+ CD8+ CD30- CD56+ CD68- CD79a- UCHL-1+ EMA- LMP-1 NK-like T cell lymphoma. The patient had a history of hepatocellular carcinoma (HCC) and was also diagnosed with T cell non-Hodgkin's lymphoma associated with T cell receptor (TCR) reconstruction in the Jgamma chain. Intestinal T cell lymphoma is uncommon and very few cases of CD56+ T cell lymphoma, otherwise known as NK-like T cell lymphoma, have been reported. The patient did not have a history of gluten-sensitive enteropathy (celiac disease). Multiple lesions appeared within months after the initial operation and his condition deteriorated rapidly. We think that this patient probably had NK-type granular lymphocyte-proliferative disorder (NK-GLPD) because the percentage of CD16+ CD56+ cells among peripheral blood mononuclear cells was elevated, at 21%. We report this case to help elucidate the relationship between underlying digestive organ disease and the development of intestinal NK-like T cell lymphoma. An accumulation of other such cases is needed to determine the etiology of this disease.

Incompleteness of the Structure of Liver Veins and Tissue Components in Neonatal Animals

Introduction: The formation of the liver structure at mammal embryogenesis is interconnected by drawing up of venous mains. In parallel to the transformation of the main veins, there is a reduction of the blood formation function and the liver transformation from the primary organ of embryogenesis into the secondary one, but the exception is immaturity and underdeveloped maturity mammals (Smirnova, 1967; Mechtiev, 1968; Bresler, 1993). The purpose of research is to establish morphofunctional criteria of the incompleteness in the blood vessels and in tissue components of the liver in neonatal animals.Material and Methods: The afferent and efferent liver veins of calves, piglets and puppies at one day of age were investigated. The complex of morphological, roentgenological, ultrasound and statistic methods was used.Results: It was established that the liver veins in newborn animals portoumbilical (afferent) and caval (efferent) collectors. In 1‐day‐old calves, the afferent collector is connected with caval way of the large vein flow of the main type. Relative weight of the liver in the calves is 2.31–2.85%, hepatocytes form balks and they are not always oriented radially to the central venuels. There are no seats of haemopoesis. Sonography of the liver and its veins proves inconstancy of the sizes depending on acts of breath. In 1‐day‐old piglets, many treelike anastomoses follow with the left hepatic vein. Relative weight of the liver in the piglets is 2.27–4.64%. The parenchyma of the organ is spongy with the seats of haemopoesis (0.04 3.61%). In 1‐day‐old puppies afferent and efferent collectors combine through the venous duct. Additionally, in the abdominal cavity of puppies, there are the vitelline artery (starts from a. mesenterica) and vein (runs to v. porta near the afferent collector), following to the umbilical ring. Relative weight of the liver in the puppies is about 5.18–6.04%. Hepatocytes form the chaotic congestion with haemopoetic points (2.04–7.14%).Conclusion: Thus, incompleteness of morphology of the liver is shown in preservation of provisional vein structures and tissue components of the embryonic type, which is one of the factors complicating diseases of digestive organs in neonatal animals.

Molecular mechanisms in digestive organ diseases based on accumulation of visceral fat--role of adiponectin

Molecular mechanisms in digestive organ diseases based on accumulation of visceral fat--role of adiponectin