Detection of disease in rice plants is important to avoid damage and reduce yields. In this study, the influence of data augmentation techniques on the application of a combination model of Convolutional Neural Network (CNN) and Multilayer Perceptron (MLP) was carried out to detect diseases in rice plants. This study uses a dataset of rice images for disease detection which contains 6034 images of rice with five categories, namely Bacterial Leaf Bligh, Blast, Brown Spot, normal, and tungro. This dataset is divided into three parts, namely training data, validation data and test data. The data augmentation techniques used are rotation, brightness and zoom on rice images. The combination model of CNN and MLP is built using the Python programming language and the TensorFlow deep learning framework. In measuring the success rate of the built model, it can be measured using the accuracy, precision and recall values obtained in the model test. Several scenarios were carried out to produce the best model, namely the use of data augmentation techniques, the number of layers and the number of iterations (epochs). From the experiments that have been carried out which have been tested with data as many as 25 digital images, the best model is obtained with an testing accuracy of 92%, 94% precision and 92% recall. This model applies a random zoom augmentation technique with a value of 0.5 – 1.0, CNN+MLP with 3 layers and a dataset ratio of 80:20 and an epoch early stop, This result has increased by more than 10%.