Direct Translation Research Articles

Spanish version of the short European Health Literacy Survey Questionnaire HLS-Q12: Transcultural adaptation and psychometric properties.

Health literacy has a direct impact on the health of populations. It is related to education, capacity for self-care, and management of health resources. The Health Literacy Survey Questionnaire HLS-Q12 is one of the reference instruments but has not yet been adapted to Spanish. The aims of the study were to cross-culturally adapt and evaluate the psychometric properties of the Spanish version of the HLS-Q12. Data was collected from June 2020 to March 2022. The sample consisted of 60 patients who initiated cancer treatment for the first time within a clinical trial. Double direct translation, back-translation, cognitive debriefing with a 10-patient sample, and an expert committee were used for cross-cultural adaptation. For validation of the HLS-Q12, a psychometric analysis was performed to assess feasibility, reliability, sensitivity to change and construct validity with other measures such as health-related quality of life, empowerment, and health needs. The HLS-Q12 is equivalent at the semantic, conceptual, and content level to the original version and its psychometric properties demonstrated good internal consistency with a Cronbach's alpha of 0.88 and a McDonald´s omega of 0.91, a high degree of fit for the confirmatory factor analysis, and a statistically significant sensitivity to change (p = 0.025). Based on robust psychometric values, the Spanish version of HLS-Q12 was found to be a good cross-culturally adapted tool for collecting correct information on health literacy in cancer patients regardless of tumour type or stage. Although more studies are needed, this version of HLS-Q12 could be used in research for collecting data on the health literacy needs of Spanish-speaking patients.

Validation of the Russian version of the Social Media Disorder Scale (SMDS) questionnaire in adolescents

Introduction. An urgent medical and social problem at present is the need to develop nationally adapted versions of the questionnaire for assessing dependence on social networks, which is due to the avalanche-like increase in the prevalence of this phenomenon, especially among adolescents and youth, and often associated with disorders of the neuropsychic and somatic spectrum.Aim. Validation of the English-language Social Media Disorder scale (SMDS) questionnaire based on 9 criteria, including psychopathological aspects of engagement with social networking sites.Materials and methods. After the procedures of direct and reverse translation of the questionnaire, the psychometric validation of the test was carried out on a Russian-speaking sample of 3074 adolescents aged 11–19 years (46.1% of boys and 53.9% of girls, median age 14 (13–16) years) – students of 10 educational institutions in Krasnoyarsk. The external validity of the SMDS- RU questionnaire was assessed using the following methods: Chen Internet Addiction Scale (CIAS) – to assess the presence of Internet addicted behavior; the Strengths and Challenges Questionnaire (SDQ) – to analyze the mental health of the subjects.Results. Expiratory and confirmatory factor analyzes demonstrated good agreement between the test components. The results of confirmatory factor analysis confirmed its single-factor structure (CFI = 0.9, TLI = 0.9, RMSEA = 0.06), an acceptable Cronbach’s Alpha value (Cronbach’s Alpha = 0.7) indicates its sufficient internal consistency and reliability. The external validity of the SMDS-RU questionnaire was confirmed by established associations with the results of the Chen Internet Addiction Test (CIAS) and the Strengths and Challenges Questionnaire (SDQ) by R. Goodman. Test-retest reliability when measured at 6-month intervals also demonstrated acceptable results: the Spearman correlation coefficient between the sums of scores of two measurements was 0.66, p < 0.001.Conclusion. The Russian-language version of the Social Network Addiction Questionnaire (SMDS-RU) developed for teenagers has sufficient information content, reliability, internal and external validity and can be actively used in the Russian adolescent population.

The Mismatch Between World Bank Actions and the Decentralization of Educational Systems in LMICs

The World Bank’s (WB) growing emphasis on decentralizing educational systems has sparked widespread discussion in the literature. This study examines whether WB reforms are indeed associated with decentralizing educational systems in low- and middle-income countries (LMICs), as commonly assumed. Using unique, untapped country-level panel data on 30 LMICs from 1990 to 2019, I do not find a significant association between the WB’s actions and changes observed in educational systems. Employing the institutional logics perspective, I argue that the WB’s diffusion of “homogeneous” educational reforms may clash with “heterogeneous” socioeconomic, political, and cultural contexts, thus hindering the direct translation of reforms into tangible outcomes on the ground.

Multiple Dimensions of Machismo: Linguistic Considerations for Latino Sexual Minority Men in the United States.

The literature differentiates between two domains of machismo: traditional machismo and caballerismo. Research has largely focused on measuring machismo among English speakers. We evaluated whether Estrada's (2011) 2-factor model of machismo was invariant across languages (English versus a direct Spanish translation). A series of multigroup confirmatory factor analyses were conducted between respondents who completed the survey in English (n = 428) and Spanish (n = 102). Analyses suggested the hypothesized 2-factor model did not fit across language groups. While the traditional 2-factor structure emerged in the English language data, exploratory factor analysis indicated a 3-factor structure of machismo among Spanish-speaking respondents. One of the new factors (inherent machismo), among Spanish-speaking respondents, was associated with Internalized Heterosexism, suggesting that the new factor structure may capture the belief that masculine men are superior. These findings suggest there is a need for the development of culturally appropriate Spanish language assessment.

Machine translation: Turkish–English bilingual speakers’ accuracy detection of evidentiality and preference of MT

Machine translation (MT) is the automated process of translating text between different languages, encompassing a wide range of language pairs. This study focuses on non-professional bilingual speakers of Turkish and English, aiming to assess their ability to discern accuracy in machine translations and their preferences regarding MT. A particular emphasis is placed on the linguistically subtle yet semantically meaningful concept of evidentiality. In this experimental investigation, 36 Turkish–English bilinguals, comprising both early and late bilinguals, were presented with simple declarative sentences. These sentences varied in their evidential meaning, distinguishing between firsthand and non-firsthand evidence. The participants were then provided with MT of these sentences in both translation directions (Turkish to English and English to Turkish) and asked to identify the accuracy of these translations. Additionally, participants were queried about their preference for MT in four crucial domains: medical, legal, academic, and daily contexts. The findings of this study indicated that late bilinguals exhibited a superior ability to detect translation accuracy, particularly in the case of firsthand evidence translations, compared to their early bilingual counterparts. Concerning the preference for MT, age of acquisition and the accuracy detection of non-firsthand sentence translations emerged as significant predictors.

Physiologically Based Pharmacokinetic (PBPK) Modeling to Predict CYP3A-Mediated Drug Interaction between Saxagliptin and Nicardipine: Bridging Rat-to-Human Extrapolation.

The aim of this study was to predict the cytochrome P450 3A (CYP3A)-mediated drug-drug interactions (DDIs) between saxagliptin and nicardipine using a physiologically based pharmacokinetic (PBPK) model. Initially, in silico and in vitro parameters were gathered from experiments or the literature to construct PBPK models for each drug in rats. These models were integrated to predict the DDIs between saxagliptin, metabolized via CYP3A2, and nicardipine, exhibiting CYP3A inhibitory activity. The rat DDI PBPK model was completed by optimizing parameters using experimental rat plasma concentrations after co-administration of both drugs. Following co-administration in Sprague-Dawley rats, saxagliptin plasma concentration significantly increased, resulting in a 2.60-fold rise in AUC, accurately predicted by the rat PBPK model. Subsequently, the workflow of the rat PBPK model was applied to humans, creating a model capable of predicting DDIs between the two drugs in humans. Simulation from the human PBPK model indicated that nicardipine co-administration in humans resulted in a nearly unchanged AUC of saxagliptin, with an approximate 1.05-fold change, indicating no clinically significant changes and revealing a lack of direct translation of animal interaction results to humans. The animal-to-human PBPK model extrapolation used in this study could enhance the reliability of predicting drug interactions in clinical settings where DDI studies are challenging.

Cultural Translation and Validation of the Bariatric Quality of Life Index to European Portuguese.

Obesity is a chronic noncommunicable disease, defined by a body mass index over 30 kg/m2. Its impact is not restricted to its association with higher risks of mortality and morbidity from other noncommunicable diseases, but also with a decrease in quality of life (QoL). There are several tools to assess QoL, from generic health-related tools to obesity-related specific ones. However, to assess QoL in patients undergoing bariatric surgery, only the Bariatric Analysis and Reporting Outcome System was available, which presented some significant problems. Therefore, the Bariatric Quality of Life (BQL) Index was developed. The aim of this study was the validation and cultural adaptation of the BQL Index for European Portuguese. A cross-sectional study was conducted, with the presentation of two questionnaires to the participants: BQL Index and EQ-5D-3L (European Quality of Life 5 Dimensions and 3 Level) Index. Direct translation followed reviewing, back-translation, comparison, and pilot testing were performed. Retest was done six months after the baseline. The following psychometric properties were assessed: convergent validity using the Spearman r correlation coefficient between BQL Index and EQ-5D-3L Index; internal consistency based on Cronbach alpha coefficient; and reproducibility between test and retest through Spearman r correlation coefficient and intraclass correlation coefficient (ICC). A total of 260 participants were included, the mean age was 45 ± 10 years old, the mean body mass index was 44 ± 6.5 kg/m2 and 78% were females. The most frequent obesity-related comorbidities were osteoarticular disease (69%), anxiety/depression (60%), and hypertension (54%). The most common eating patterns were volume eater (67%) and sweet eater (62%). Quality of Life scores were 41.3 ± 9.3 for the BQL Index, 0.35 ± 0.19 for the EQ-5D-3L Index and 55.7 ± 19.8 for the EQ-5D-3L VAS. The translation yielded good convergent validity (r = 0.62), good internal consistency (alpha = 0.94), and good reproducibility (r = 0.62 and ICC = 0.79). Our translation exhibited good parametric properties, with validity within the original BQL values, higher internal consistency, and good reproducibility.

The effects of a training package to teach note taking on the formation of equivalence classes.

Effective note taking may enhance learning outcomes for students and serve as a directly observable form of mediation within a test context. Frampton et al. (2023) used stimulus fading to teach note taking in the form of a graphic organizer (GO) during matching-to-sample baseline relations training (MTS-BRT). Moderately high yields were observed with young adults despite the use of linear series training, abstract stimuli, and five-member classes. The present study taught the same note taking strategy using an intervention package including video illustration, voice-over instructions, and feedback to eight college students. Participants were taught to construct the GO during MTS-BRT with three three-member classes of familiar stimuli. Then the effects of MTS-BRT alone with three five-member classes of abstract stimuli was evaluated. Participants efficiently completed training with familiar stimuli and passed the posttest on the first attempt. With the abstract stimuli, participants engaged in GO construction during MTS-BRT and the six participants that demonstrated high levels of fidelity to the trained note taking strategy passed the posttest on the first attempt. These results replicate findings from Frampton et al. while using a more efficient intervention package. Benefits of teaching overt mediation responses are discussed as well as future directions for translation to applied contexts.

Translation and psychometric assessment of the mastectomy module of the BREAST-Q questionnaire for use in Nigeria

BackgroundThe majority of non-metastatic breast cancer patients in sub-Saharan Africa are recommended to have mastectomy. The impact of mastectomy on a predominantly young African patient population requires evaluation. The BREAST-Q is a validated patient-reported outcome measure of quality-of-life following breast surgery that has been translated into 30 languages-none in Africa. This study aimed to translate and assess the psychometric properties of the mastectomy module of the BREAST-Q for use in Nigeria.MethodsThe BREAST-Q mastectomy module was translated from English to Yoruba and its psychometric properties assessed using best practice guidelines. Translation was performed in 4 steps: forward translation (x2), back translation, back translation review, and cognitive interviews with post-mastectomy patients. The translated BREAST-Q instrument was administered to post-mastectomy patients (n = 21) alongside the EORTC-QLQ BR23 to evaluate construct validity. Test-retest reliability was evaluated using intraclass correlation coefficients (ICC); surveys were re-administered 4 weeks apart.ResultsThe translation process identified English phrases not amenable to direct translation, including “emotionally healthy” and descriptions of pain (“nagging,” “throbbing,” “sharp”). Translations were amended to reflect local context and question intent. During cognitive interviews, patients provided suggestions to simplify complex phrases, e.g. “discomfort in your breast area.”. Internal consistency within scales was over 0.70 for psychosocial wellbeing (α = 0.84–0.87), sexual wellbeing (α = 0.98–0.99), physical wellbeing in chest (α = 0.84–0.86), and satisfaction with care (α = 0.89–0.93). ICC for test-retest reliability was moderate (0.46–0.63).ConclusionsThe Yoruba version of the BREAST-Q mastectomy module presents a unique opportunity to adequately capture the experiences of Nigerian women post mastectomy. This instrument is being used in a pilot study of Nigerian patients to identify targets for intervention to improve the patient experience and compliance with breast cancer surgery.

The 2024 revision of the Norwegian standard for the safe practice of anaesthesia.

The Norwegian standard for the safe practice of anaesthesia was first published in 1991, and revised in 1994, 1998, 2005, 2010 and 2016 respectively. The 1998 version was published in English for the first time in Acta Anaesthesiologica Scandinavica in 2002. It must be noted that this is a national standard, reflecting the specific opportunities and challenges in a Norwegian setting, which may be different from other countries in some respects. A feature of the Norwegian healthcare system is the availability, on a national basis, of specifically highly trained and qualified nurse anaesthetists. Another feature is the geography, with parts of the population living in remote areas. These may be served by small, local emergency hospitals. Emergency transport of patients to larger hospitals is not always achievable when weather conditions are rough. These features and challenges were considered important when designing a balanced and consensus-based national standard for the safe practice of anaesthesia, across Norwegian clinical settings. In this article, we present the 2024 revision of the document. This article presents a direct translation of the complete document from the Norwegian original.

First characterization of the nuclear receptor superfamily in the Mediterranean mussel Mytilus galloprovincialis: developmental expression dynamics and potential susceptibility to environmental chemicals.

Endocrine-disrupting chemicals (EDCs) represent a global threat to human health and the environment. In vertebrates, lipophilic EDCs primarily act by mimicking endogenous hormones, thus interfering with the transcriptional activity of nuclear receptors (NRs). The demonstration of the direct translation of these mechanisms into perturbation of NR-mediated physiological functions in invertebrates, however, has rarely proven successful, as the modes of action of EDCs in vertebrates and invertebrates seem to be distinct. In the present work, we investigated the members of the NR superfamily in a bivalve mollusk, the Mediterranean mussel Mytilus galloprovincialis. In addition to annotating the M. galloprovincialis NR complement, we assessed the potential developmental functions and susceptibility to EDC challenge during early development by gene expression analyses. Our results indicate that a majority of mussel NRs are dynamically expressed during early development, including receptors characterized by a potential susceptibility to EDCs. This study thus indicates that NRs are major regulators of early mussel development and that NR-mediated endocrine disruption in the mussel could be occurring at a larger scale and at earlier stages of the life cycle than previously anticipated. Altogether, these findings will have significant repercussions for our understanding of the stability of natural mussel populations. This article is part of the theme issue 'Endocrine responses to environmental variation: conceptual approaches and recent developments'.

Translation strategies in the process of conveying neologisms, abbreviations and acronyms in English language computer texts

The rapid advancement of technology gave rise to the emergence of numerous neologisms that have permeated various languages, with a particular emphasis on personal computers. This research still remains relevant as ongoing technological advancements continue to shape language usage. Translation of computer messages and the terms that make them up – abbreviations, acronyms, etc. – remains a crucial area of study. Thus, this article aims to examine the usage of acronyms and abbreviations in English language computer texts, identify patterns in their frequency, and characterize the diverse categories in which they appear. Special attention is given to translating computer abbreviations. The present paper employs a comparative analysis of the structural, semantic and functional characteristics of English acronyms and abbreviations, facilitating a contrast of these lexical units and the identification of defining characteristics. The descriptiveanalytical approach and continuous sampling method were also used to illustrate the research findings. Themost effective approaches identified for conveying English language computer abbreviations and acronyms include direct translation of the full form of the abbreviation, finding equivalent shortenings in the target language, transcoding, transliteration, descriptive translation and loan translation. The author highlights the significance of context awareness and appropriate interpretation in light of the fact that some acronyms and abbreviations have multiple meanings, and some of which may be lexically opposed to the required one. Given the distinctive features of computer texts characterized by a specific structure and abundance of computer neologisms, particularly acronyms and abbreviations, stemming from the rapid evolution of information and communication technologies, this study contributes to a deeper understanding of the production and translation of computer acronyms and abbreviations.

Targeting chemokine-receptor mediated molecular signaling by ethnopharmacological approaches

Ethnopharmacological relevanceInfection and inflammation are critical to global human health status and the goal of current pharmacological interventions intends formulating medications/preventives as a measure to deal with this situation. Chemokines and their cognate receptors are major regulatory molecules in many of these ailments. Natural products have been a keen source to the drug development industry, every year contributing significantly to the growing list of FDA approved drugs. A multiverse of natural resource is employed as a part of curative regimen in folk/traditional/ethnomedicine which can be employed to discover, repurpose, and design potent medications for the diseases of clinical concern. Aim of the studyThis review aims to systematically document the ethnopharmacologically active agents targeting the infectious-inflammatory diseases through the chemokine-receptor nexus. Materials and methodsArticles related to chemokine/receptor modulating ethnopharmacological anti-inflammatory, anti-infectious natural sources, bioactive compounds, and formulations have been examined with special emphasis on women related diseases. The available literature has been thoroughly scrutinized for the application of traditional medicines in chemokine associated experimental methods, their regulatory outcomes, and pertinence to women's health wherever applicable. Moreover, the potential traditional regimens under clinical trials have been critically assessed. ResultsA systematic and comprehensive review on the chemokine-receptor targeting ethnopharmaceutics from the available literature has been provided. The article discusses the implication of traditional medicine in the chemokine system dynamics in diverse infectious-inflammatory disorders such as cardiovascular diseases, allergic diseases, inflammatory diseases, neuroinflammation, and cancer. On this note, critical evaluation of the available data surfaced multiple diseases prevalent in women such as osteoporosis, rheumatoid arthritis, breast cancer, cervical cancer and urinary tract infection. Currently there is no available literature highlighting chemokine-receptor targeting using traditional medicinal approach from women's health perspective. Moreover, despite being potent in vitro and in vivo setups there remains a gap in clinical translation of these formulations, which needs to be strategically and scientifically addressed to pave the way for their successful industrial translation. ConclusionsThe review provides an optimistic global perspective towards the applicability of ethnopharmacology in chemokine-receptor regulated infectious and inflammatory diseases with special emphasis on ailments prevalent in women, consecutively addressing their current status of clinical translation and future directions.

Navigation and robotics-current status and future implications

Both navigation systems and robotics enable greater precision in the implantation of an artificial knee joint. However, they do not improve clinical outcomes. We hypothesized that although implantation of atotal knee arthroplasty results in reconstruction of the alignment in the coronal plane, the variable rotational tibial and variable translational femoral and tibial component positioning lead to achange in the remaining alignment parameters of the lower extremity. However, these parameters could be determined using anavigation system or robot and could represent future implications for these systems. The kinematics and the position between femur and tibia before and after implantation of atotal knee arthroplasty were determined using anavigation system in nine healthy knee joints of Thiel-fixed whole-body cadavers. After arthroplasty, there was no change in the natural coronal alignment. In extension and the early degrees of flexion, the rotational position of the femur relative to the tibia was altered. This also led to achange in the positioning of the medial and lateral epicondyle in relation to the tibia; while both epicondyles were positioned more laterally in relation to the tibia after arthroplasty, the lateral epicondyle was significantly more lateral in relation to the tibia up to 20° of flexion. Following arthroplasty of aknee joint using the established technique, agood reconstruction of the coronal alignment was achieved with simultaneous changes in the alignment in both the rotational and translational directions between the femur and tibia. Using navigation as well as robotics, we would be able to quantify all alignment parameters and could achieve an alignment of the components or areconstruction of the overall alignment in all six degrees of freedom. We might also be able to achieve aclinical advantage or increase the service life even further.

Regularizing cross-attention learning for end-to-end speech translation with ASR and MT attention matrices

The cross-attention mechanism enables Transformer to capture correspondences between the input and output. However, in the domain of end-to-end (E2E) speech-to-text translation (ST), the learned cross-attention weights often struggle to accurately correspond with actual alignments, given the need to align speech and text across different modalities and languages. In this paper, we present a simple yet effective method called regularized cross-attention learning, for end-to-end speech translation in a multitask learning (MTL) framework. RCAL leverages the knowledge from auxiliary automatic speech recognition (ASR) and machine translation (MT) tasks to generate a teacher cross-attention matrix, serving as prior alignment knowledge to enhance cross-attention learning within the ST task. An additional loss function is introduced as part of the MTL framework to facilitate this process. We conducted experiments on the MuST-C benchmark dataset to evaluate the effectiveness of RCAL. The results demonstrate that the proposed approach yields significant improvements over the baseline, with an average enhancement of +0.8 BLEU across four translation directions in two experimental settings, outperforming state-of-the-art E2E and cascaded speech translation models. Further analysis and visualization reveal that the model with RCAL effectively learns high-quality alignment information from auxiliary ASR and ST tasks, thereby improving the ST alignment quality. Moreover, the experiments with different sizes of MT and ST data provide strong evidence supporting our model’s robustness in various scenarios.

Development of a method and an assessment construct for person-centered translation of dementia public stigma scales.

With the number of people with dementia dramatically increasing over time and dementia becoming a major health concern worldwide, scales have been developed to assess the stigma socially attached to this neurodegenerative disorder. There are, however, almost no available methods and assessment constructs for person-centered translation of dementia public stigma scales. To develop such a method and such an assessment construct by translating the Dementia Public Stigma Scale (DPSS) into standard written Chinese. We translated the DPSS following three major steps: (1) literal translation and mistranslation identification; (2) panel discussions of items with problematic translations; and (3) the final checking of the translated scale. Informed by the translation and adaptation process, we then developed a method for person-centered translation of dementia public stigma scales. Based on this method and our panel discussions, we finally proposed a tripartite assessment construct for quality evaluation of the translation of dementia public stigma scales. Forward and backward translation did not work sufficiently in dementia public stigma scale translation. Mistranslations were induced by three major causes, including confusion caused by multiple Chinese meanings of the immediate Chinese direct translation, the lack of immediate Chinese direct translation because of varying positive/negative emotions attached to multiple translations, and the lack of culture-specific idioms in Chinese. Based on these factors, we proposed a tripartite dementia translation assessment construct. Following this assessment tool, we determined the best Chinese version that could further be tested for its psychometric properties among the public. A method and an assessment construct for person-centered translation of dementia public stigma scales were developed. Such a method and such an assessment construct could be followed in the translation of dementia public stigma scales and the translation evaluation of such scales.

The development of Japanese-English and English-Japanese parallel corpus, including search system and its utilisation

Parallel corpora play a central role in translation studies, contrastive linguistics, bilingual lexicography and language teaching/learning, facilitating the comparison of linguistic features across languages. But it is challenging to construct a parallel corpus and there are few of them. Also, they can quickly become outdated and unusable. Professor Yasunori Nishina, Faculty of Global Communication, Kobe Gakuin University, Japan, is an expert in applied translation, corpus linguistics and applied linguistics working to develop a website for searching Japanese-English and English-Japanese parallel corpora. He is revitalising an existing unusable, unsearchable corpus with assistance from Lago NLP. He has a keen focus on design as he wants to ensure diversity of genres and translation directions and, in a world first, is incorporating the ability to analyse parallel corpora. The tool that Nishina and Lago NLP are developing with support from the JSPS KAKENHI grant number 20K00692 (and 23K00599 from 2023) is called Parallel Link. Nishina will also collaborate with a researcher at the University of Oxford, UK, where experts who developed the Japanese corpus online search tool are based. The University has established a collaborative relationship with the National Institute for Japanese Language and Linguistics (NINJAL), which is the centre for Japanese language research, and has carried out joint projects of the Oxford NINJAL Corpus of Old Japanese (ONCOJ). Nishina has completed the development of version 1.20 of Parallel Link and intends to develop it to version 2.0 in the coming years.

Vibration nonstationary representation of the railway vehicle's gear system considering spalling failure under variable speed conditions: Numerical modeling and field testing

The nonstationary representation of spalling faults in the helical gear transmission system of railway vehicles remains unclear under variable speed conditions, and the selection of sensitive features in faults recognition has been confirmed as a problem to be addressed in this field. Thus, a vehicle-track coupled model with a helical gear transmission system was built in this study, which considered the spalling faults and employed field testing data to verify the model. The model was adopted to analyze the non-stationary representation of a helical gear system with spalling faults in the translational directions under variable speed conditions. Subsequently, the data originating from the simulation and field testing were adopted in this study, such that the ReliefF-MSVM (Multi-class SVM) algorithm was driven to sift the sensitive features in the translational directions and obtain the optimal sensitive features and diagnostic direction. The result achieved with the sensitive features selected suggested that the vertical statistical characterization of the helical gear transmission system of railway vehicles exhibited low dimensionality and high robustness, and the diagnostic results were optimal. This study can provide a theoretical reference for dynamics analysis, health monitoring, and fault diagnosis in the helical gear system of railway vehicles.

Mapping the everyday concept of disgust in five cultures

Past research has shown that disgust is a heterogeneous category and lacks unity in its defining features. In the two studies reported in this paper, we examined the internal structure of disgust in English, and its translation equivalents of asco in Spanish, Ekel in German, garaf in Arabic, and yanwu in Chinese. In Study 1, 517 participants listed the most accessible constitutive features (definition, elicitors, and physical responses) of the concept of disgust in their culture. In Study 2, 653 participants were asked to judge the extent to which each of the 63 features extracted from Study 1 was typical of the concept of disgust in their respective culture. Results revealed differences in content, as well as internal structures across the five cultural groups: the disgust concepts differed in the degree of typicality of their constitutive features, the relevance of single features, the extent to which they shared features and the structural properties of the features. Taken together, our results question the assumed conceptual equivalence of the disgust concept across five cultures and raise questions about the suitability of deploying direct translations of disgust terms in cross-cultural research.

Progress and Challenges in Tumor Ferroptosis Treatment Strategies: A Comprehensive Review of Metal Complexes and Nanomedicine.

Ferroptosis is a new form of regulated cell death featuring iron-dependent lipid peroxides accumulation to kill tumor cells. A growing body of evidence has shown the potential of ferroptosis-based cancer therapy in eradicating refractory malignancies that are resistant to apoptosis-based conventional therapies. In recent years, studies have reported a number of ferroptosis inducers that can increase the vulnerability of tumor cells to ferroptosis by regulating ferroptosis-related signaling pathways. Encouraged by the rapid development of ferroptosis-driven cancer therapies, interdisciplinary fields that combine ferroptosis, pharmaceutical chemistry, and nanotechnology are focused. First, the prerequisites and metabolic pathways for ferroptosis are briefly introduced. Then, in detail emerging ferroptosis inducers designed to boost ferroptosis-induced tumor therapy, including metal complexes, metal-based nanoparticles, and metal-free nanoparticles are summarized. Subsequently, the application of synergistic strategies that combine ferroptosis with apoptosis and other regulated cell death for cancer therapy, with emphasis on the use of both cuproptosis and ferroptosis to induce redox dysregulation in tumor and intracellular bimetallic copper/iron metabolism disorders during tumor treatment is discussed. Finally, challenges associated with clinical translation and potential future directions for potentiating cancer ferroptosis therapies are highlighted.