Opposite Direction Research Articles

Anticoagulation reversal (vitamin K, prothrombin complex concentrates, idarucizumab, andexanet-α, protamine).

Bleeding events are common in patients prescribed anticoagulants and can have devastating consequences. Several specific and nonspecific agents have been developed to reverse the effects of anticoagulant drugs or toxins. Vitamin K, as the oldest of these antidotes, specifically counteracts the effects of pharmaceuticals and rodenticides designed to deplete stores of vitamin K-dependent factors. In cases of life-threatening bleeding, the addition of prothrombin complex concentrates (PCCs) allows for the immediate replacement of coagulation factors. While the use of PCCs has been extended to the non-specific reversal of the effects of newer direct oral anticoagulants, the specific agents idarucizumab, targeting dabigatran and andexanet-α, binding factor Xa inhibitors, have recently been developed and are being preferentially recommended by most guidelines. However, despite having rapid effects on correcting coagulopathy, there is to date a lack of robust evidence establishing the clear superiority of direct oral anticoagulant-specific reversal agents over PCCs in terms of haemostatic efficacy, safety or mortality. For andexanet-α, a potential signal of increased thromboembolic risks, comparatively high costs and low availability might also limit its use, even though emerging evidence appears to bolster its role in intracranial haemorrhage. Protamine is the specific agent for the reversal of unfractionated heparin anticoagulation used mainly in cardiovascular surgery. It is much less effective for low molecular weight heparin fragments and is usually reserved for cases with life-threatening bleeding.

Lack of mismatch repair enhances resistance to methylating agents for cells deficient in oxidative demethylation

The human alkylation B (AlkB) homologs, ALKBH2 and ALKBH3, respond to methylation damage to maintain genomic integrity and cellular viability. Both ALKBH2 and ALKBH3 are direct reversal repair enzymes that remove 1-methyladenine (1meA) and 3-methylcytosine (3meC) lesions commonly generated by alkylating chemotherapeutic agents. Thus, the existence of deficiencies in ALKBH proteins can be exploited in synergy with chemotherapy. In this study, we investigated possible interactions between ALKBH2 and ALKBH3 with other proteins that could alter damage response and discovered an interaction with the mismatch repair (MMR) system. To test whether the lack of active MMR impacts ALKBH2 and/or ALKBH3 response to methylating agents, we generated cells deficient in ALKBH2, ALKBH3, or both in addition to Mlh homolog 1 (MLH1), another MMR protein. We found that MLH1koALKBH3ko cells showed enhanced resistance toward SN1- and SN2-type methylating agents, whereas MLH1koALKBH2ko cells were only resistant to SN1-type methylating agents. Concomitant loss of ALKBH2 and ALKBH3 (ALKBH2ko3ko) rendered cells sensitive to SN1- and SN2-agents, but the additional loss of MLH1 enhanced resistance to both types of damage. We also showed that ALKBH2ko3ko cells have an ATR-dependent arrest at the G2/M checkpoint, increased apoptotic signaling, and replication fork stress in response to methylation. However, these responses were not observed with the loss of functional MLH1 in MLH1koALKBH2ko3ko cells. Finally, in MLH1koALKBH2ko3ko cells, we observed elevated mutant frequency in untreated and temozolomide treated cells. These results suggest that obtaining a more accurate prognosis of chemotherapeutic outcome requires information on the functionality of ALKBH2, ALKBH3, and MLH1.

Solvent Exchange Dynamics in M2(dobdc): An Interplay among Binding Strength, Exchange Kinetics, and Cooperativity.

Solvent exchange is a crucial step in ensuring the complete activation of metal-organic frameworks (MOFs); however, the conditions for solvent exchange vary among MOFs, even within the isostructural variants. This study examines the factors contributing to solvent exchange by investigating the isostructural M2(dobdc) (M═Mg, Co, Zn) series. Common solvents N,N-dimethylformamide (DMF), ethanol (EtOH), and methanol (MeOH) are employed to assess the solvent exchange at coordinatively unsaturated sites (CUS) of M2(dobdc). By monitoring both solvents released from the MOF during solvent exchange and the coordination environment of metals within the MOF, a picture is constructed of exchange rates during early stages of solvent exchange as well as expulsion of the last traces of bound solvents. This differentiation is achieved by a combination of bulk monitoring of solvent phase composition and microscopic application of Raman spectroscopy on the single-crystal level. The kinetics of solvent replacement is revealed to have a substantial contribution from cooperativity; this phenomenon is observed in both the forward and reverse directions. Thermogravimetric analysis coupled with IR spectroscopy and density functional theory (DFT) calculations are employed to elucidate the relationship between solvent exchange rates and solvent binding energy. The solvent exchange rates are determined by the kinetic barriers of solvent exchange that do not follow the order of the solvent binding affinity. This work contributes to understanding the solvent exchange of MOFs by examining the interplay among the binding strength, exchange kinetics, and cooperativity. It further provides valuable insights for scrutinizing MOF activation protocols.

Mussel-inspired fabrication of nonwovens using fluoride-free profiled fibers for directional water transport

Fabrics with directional water transport performance have attracted considerable attention in daily life. They are in high demand, owing to their ability to transport sweat away from the skin to improve personal comfort. However, the fabrication of such materials has still remained a critical task. This article reports a nonwoven with the directional water transport function, achieved using a synergistic combination of a microstructure and a wettability gradient. The three-step fabrication strategy involves needling bonding of Y cross-section polyamide fiber webs with two needling densities (30 and 190 needle/cm2), followed by single-sided spraying of polydopamine–silicon carbide powder–polyethyleneimine dispersion and a fluoride-free hydrophobic agent. Using fiber webs with different needling densities endows the nonwoven fabric with a differential capillary effect, enhancing the directional water transport property. The unique microstructure achieves the directional water transport property by improving permeability at lower needling densities and hindering transport through a denser needling density in the reverse direction. At the same time, the wetting gradient effect promotes water transfer from the hydrophobic surface to the hydrophilic surface. The successful preparation of these interesting directional water transport materials offers new insights into the role of fibrous materials, the needling density of nonwovens, and the development of highly comfortable moisture-wicking textiles.

Dynamic behavior of electro-osmosis in variable charge soils: Insights on termination and direction reversal

Electro-osmosis offers an effective method for dewatering and remediating low permeability soil. Long-term observations on nonlinear behavior of electro-osmosis and the influencing factors are not commonly reported. Connection between cessation and direction reversal of electro-osmotic flow (EOF), and the evolution of electro-chemical parameters inside of the soil mass thus remains unclear. The dynamic response of EOF in variable charge soil could be significant, whereas the investigations on which are currently lacking. A series of electro-osmotic experiments were performed with two natural variable charge soils. The results indicated that initial electro-osmotic rate was positively proportional to electric current and initial electrical conductivity of the pore fluid, which could be explained by the ion migration model. The dynamic evolution of electro-osmotic rate and electro-chemical parameters corresponding to the solute and pH conditionings at the electrode compartments demonstrated that: 1) coupling effects of non-uniform distribution of voltage gradient and pH determined the magnitude and direction of EOF rate; 2) compared to the final pHIEP value, the bigger, close and smaller values of the novel index “voltage gradient weighed mean of spatial pH″ represented the forward, terminated and reversed EOF respectively; 3) the classical Helmholtz-Smoluchowski model are proved to be more applicable interpreting the coupled nonlinearity of electro-osmosis during the later steady phase. This work would facilitate future research for a comprehensive electro-osmotic model, and provide guidance to condition the initial and boundary conditions in application of electro-osmotic dewatering and electrokinetic remediation.

Reconfigurable metasurface array for diverse retrodirective reflections and radar cross section reduction

Abstract Retroreflectors can scatter the arbitrarily incident wave back to incoming direction, demonstrating great potential in wireless communication. However, there are limitations in adaptive retroreflection and polarization modulation with the existing retroreflectors. In this paper, a novel metasurface array with a reconfigurable transmission line (TL) network has been proposed to flexibly achieve multiple manipulation functions of electromagnetic wave including upper half-space cross-polarized retroreflection and circularly polarized retroreflection in the diagonal planes and radar cross section (RCS) reduction. To accomplish these capabilities, a novel transmission mode for ferrite circulators has been developed, enabling precise phase control of the TL. By adjusting the operation states of the circulators, multiple phase differences between forward and reverse transmission directions including ±90° and ±180° are generated. With the obtained phase differences, the metasurface array can flexibly achieve the adaptive retroreflection fields with multiple polarization characteristics based on the spatial field superposition and the RCS reduction based on the phase cancellation. To validate the concept and feasibility of the proposed reconfigurable retrodirective metasurface, an X-band prototype has been fabricated and measured. Good agreement between the simulation and the experiment is observed to verify the effectiveness of our retrodirective design in upper half-space wave manipulation.

Causal Effect of Atrial Fibrillation on Heart Failure Risk in East Asian Ancestry: ABidirectional Mendelian Randomization Study Using Genome-wide Association Data.

Atrial fibrillation (AF) and heart failure (HF) are prevalent cardiovascular conditions in East Asia, with a complex interrelationship. The directionality of the causal impact of AF on HF risk remains uncertain. This study employs Mendelian randomization (MR) to investigate the potential causal effect of AF on HF. Utilizing summary data from genome-wide association studies (GWAS) within the Medical Research Council Integrative Epidemiology Unit open GWAS database, we analyzed 8180 AF cases and 28 612 controls, alongside 9413 HF cases and 203 040 controls, all of East Asian descent. We conducted MR analysis using the inverse variance weighted (IVW) method, complemented by various sensitivity analyses, including bidirectional MR to assess causality in the reverse direction. Genetically predicted AF was found to be causally associated with an increased risk of HF in East Asian populations (odds ratio = 1.14, 95% CI: 1.10-1.19, P <.001) as per the IVW method. These findings were consistent across multiple MR methods. Sensitivity analyses revealed no significant heterogeneity or pleiotropy. Notably, bidirectional MR analysis showed no causal effect of HF on the risk of developing AF. The MR analysis supports a unidirectional causal relationship between AF and increased HF risk in East Asian individuals. The absence of a reverse causal effect reinforces the importance of maintaining sinus rhythm to mitigate HF risk. Further research is warranted to corroborate these findings and to explore their clinical implications in depth.

A Novel Continuously Variable Transmission with Circumferentially Arranged Disks (CAD CVT)

This paper presents a novel Continuous Variable Transmission (CVT) design. CVT is highly beneficial for actuators with rotary output as it can improve the energy efficiency of the actuators by providing an optimum transmission ratio. This property of CVT is highly beneficial for fossil-fuel-based vehicles, electric vehicles, wind turbines, industrial robots, etc. With the exception of Spherical CVT and DH CVT, all known CVTs like push belt CVTs, toroidal CVTs, Milner CVTs, etc., require additional gear sets and clutches for direction reversal and neutral gear ratio. However, Spherical CVT and DH CVT have low torque capacity due to a single traction point constraint. Foregoing in view, a new CVT named CAD CVT has been developed. The paper presents the design conception, the operating principle, the transmission ratio, the torque capacity, frictional losses, and experimental verification of the basic functionality by manufacturing a Proof of Concept (PoC). The proposed CVT is the only CVT capable of independent direction reversal and high torque capacity as it can transmit torque through multiple traction points. The new CVT will significantly impact high-torque applications in different engineering applications, especially land transport consisting of heavy vehicles like trucks, buses, and trailers.

Neuronal functional connectivity is impaired in a layer dependent manner near chronically implanted intracortical microelectrodes in C57BL6 wildtype mice

Objective. This study aims to reveal longitudinal changes in functional network connectivity within and across different brain structures near chronically implanted microelectrodes. While it is well established that the foreign-body response (FBR) contributes to the gradual decline of the signals recorded from brain implants over time, how the FBR affects the functional stability of neural circuits near implanted brain–computer interfaces (BCIs) remains unknown. This research aims to illuminate how the chronic FBR can alter local neural circuit function and the implications for BCI decoders. Approach. This study utilized single-shank, 16-channel,100 µm site-spacing Michigan-style microelectrodes (3 mm length, 703 µm2 site area) that span all cortical layers and the hippocampal CA1 region. Sex balanced C57BL6 wildtype mice (11–13 weeks old) received perpendicularly implanted microelectrode in left primary visual cortex. Electrophysiological recordings were performed during both spontaneous activity and visual sensory stimulation. Alterations in neuronal activity near the microelectrode were tested assessing cross-frequency synchronization of local field potential (LFP) and spike entrainment to LFP oscillatory activity throughout 16 weeks after microelectrode implantation. Main results. The study found that cortical layer 4, the input-receiving layer, maintained activity over the implantation time. However, layers 2/3 rapidly experienced severe impairment, leading to a loss of proper intralaminar connectivity in the downstream output layers 5/6. Furthermore, the impairment of interlaminar connectivity near the microelectrode was unidirectional, showing decreased connectivity from Layers 2/3 to Layers 5/6 but not the reverse direction. In the hippocampus, CA1 neurons gradually became unable to properly entrain to the surrounding LFP oscillations. Significance. This study provides a detailed characterization of network connectivity dysfunction over long-term microelectrode implantation periods. This new knowledge could contribute to the development of targeted therapeutic strategies aimed at improving the health of the tissue surrounding brain implants and potentially inform engineering of adaptive decoders as the FBR progresses. Our study’s understanding of the dynamic changes in the functional network over time opens the door to developing interventions for improving the long-term stability and performance of intracortical microelectrodes.

Principle and experimental study of a combined teardrop and heart-shaped channel bluffbody valveless piezoelectric pump.

In this study, we have developed a piezoelectric pump with a combined teardrop- and heart-shaped channel based on the Coanda effect and bionics principle. The bluffbody consists of teardrop- and heart-shaped channels. The vibration and the pump flow rate are evaluated theoretically, and the flow conditions under different bluffbody heights and different main channel widths are simulated. The theoretical and simulation results show that the pump has uneven resistance to flow in forward and reverse directions, and the height of the teardrop bluffbody and the width main channel affect the flow in the channel. Test data show that under the same pressure, when the main channel is 5mm and the bluffbody height is 8mm, the pump flow rate is 460.8 ml/min. The pump alleviates the serious backflow problem through the fluid blocking structure and is expected to become an active driver of microfluidic devices.

Evolution of the hydrographic network in the middle Wieprz River Basin (E Poland)

The Wieprz River Valley (Polesie Plain, east Poland) has evolved with regard to its dimensions, position and course since the end of the Neogene, its geological record showing how the Wieprz channel migrated and modified its character. Changes have also been observed in the water balance of the entire middle river basin, related to climate changes in the Pleistocene and Holocene. We provide new maps of the sub-Quaternary surface and trace topographical changes during the Pleistocene. Two separate rivers, the Pre-Bystrzyca and Pre-Wieprz, existed in Preglacial time. During the Narevian Glaciation, a network of subglacial troughs evolved in the area, largely disturbing and overprinting the earlier hydrographic system. Some of the troughs developed in older river valleys. The trough in which the present-day Wieprz gorge near Łęczna is located was most probably formed at that time. During subsequent glaciations and cold periods, sedimentary changes took place in the troughs and valleys – from erosion and removal of the accumulated material to their complete burial by sediments. During the Mazovian Interglacial (MIS 11c), several lakes formed in the study area, recorded by their infills of organic and mineral-organic deposits. During subsequent advances of the Scandinavian ice-sheet, water flow was dammed in towards the north, resulting in the formation of backwaters. Ice-sheet retreat resulted in the flow of proglacial waters towards the south-east, fluvioglacial sediment transport, and then unblocking of flow and subsequent reversal of flow directions to the north and west. During the Odranian Glaciation (MIS 6), catastrophic flow unblocked and shaped the present-day Wieprz gorge.

Celiac disease and attention-deficit/hyperactivity disorder: a bidirectional Mendelian randomization analysis.

Recent observational research suggests a potential link between celiac disease (CeD) and an increased incidence of attention-deficit/hyperactivity disorder (ADHD). However, the genetic relationship between CeD and ADHD remains unclear. In order to assess the potential genetic causality between these two conditions, we conducted a Mendelian randomization (MR) analysis. We performed a bidirectional MR analysis to investigate the relationship between CeD and ADHD. We carefully selected single nucleotide polymorphisms (SNPs) from publicly available large-scale genome-wide association studies (GWAS) databases, employing rigorous quality screening criteria. MR estimates were obtained using four different methods: fixed-effect inverse variance weighted (fe-IVW), random-effect inverse variance weighting (re-IVW), weighted median (WM), and MR-Egger. The robustness and reliability of our findings were confirmed through sensitivity analyses, assessment of instrumental variable (IV) strength (F-statistic), and statistical power calculations. Our MR analyses did not reveal any significant genetic associations between CeD and ADHD (fe-IVW: OR = 1.003, 95% CI = 0.932-1.079, P = 0.934). Similarly, in the reverse direction analysis, we found no evidence supporting a genetic relationship between ADHD and CeD (fe-IVW: OR = 0.850, 95% CI = 0.591-1.221, P = 0.378). Various MR approaches consistently yielded similar results. Sensitivity analysis indicated the absence of significant horizontal pleiotropy or heterogeneity. However, it's important to note that the limited statistical power of our study may have constrained the causal analysis of the exposure's influence on the outcome. Our findings do not provide compelling evidence for a genetic association between CeD and ADHD within the European population. While the statistical power of our study was limited, future MR research could benefit from larger-scale datasets or datasets involving similar traits. To validate our results in real-world scenarios, further mechanistic studies, large-sample investigations, multicenter collaborations, and longitudinal studies are warranted.

Design, Fabrication and Testing of A Novel Thermally-Actuated Tesla Valve (TATV): A Hybrid Microvalve

Abstract A novel thermally-actuated hybrid microvalve (similar to a Tesla Valve configuration) was designed, fabricated, assembled, and tested using soft lithography-based approaches. The modified design integrates the "normally open and closed" hybrid configurations of Tesla Valves with a thermo-pneumatic (or thermal-hydraulic) actuator microfabricated in-situ that modulates the diodicity of the microvalve apparatus in the microfluidic chip. Diodicity (Di) is defined as the ratio of flow rate in the forward direction to that of the reverse direction (for a constant value of pressure drop that is imposed on a microvalve device). The results from the study successfully demonstrated the operation of an array of Tesla Valves that are normally open in forward direction and marginally closed in reverse direction at room temperature (i.e., with Di &amp;gt; 1, the flow resistance values were different when the inlet and outlet ports were swapped). When the microfluidic chip was heated (at steady-state conditions with a nominal temperature of ~30°C), the diodicity virtually vanished (i.e., Di ≈ 1) resulting in both reverse and forward directions being normally open (or having the same flow resistance - irrespective of the flow direction).

The association between telomere length and blood lipids: a bidirectional two-sample Mendelian randomization study.

Observational studies suggest an association between telomere length (TL) and blood lipid (BL) levels. Nevertheless, the causal connections between these two traits remain unclear. We aimed to elucidate whether genetically predicted TL is associated with BL levels via Mendelian randomization (MR) and vice versa. We obtained genetic instruments associated with TL, triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), apolipoprotein A-1 (ApoA-1) and apolipoprotein B (ApoB) from large-scale genome-wide association studies (GWASs). The causal relationships between TL and BL were investigated via bidirectional MR, multivariable MR and mediation analysis methods. The inverse variance weighted (IVW) method was employed as the principal methodology, complemented by several other estimators to enhance the robustness of the analysis. In the forward MR analyses, we identified significant positive correlation between genetically predicted TL and the levels of TG (β=0.04, 95% confidence interval [CI]: 0.01 to 0.06, p = 0.003). In the reverse MR analysis, TG (β=0.02, 95% CI: 0.01 to 0.03, p = 0.004), LDL-C (β=0.03, 95% CI: 0.01 to 0.04, p = 0.001) and ApoB (β=0.03, 95% CI: 0.01 to 0.04, p = 9.71×10-5) were significantly positively associated with TL, although this relationship was not observed in the multivariate MR analysis. The mediation analysis via two-step MR showed no significant mediation effects acting through obesity-related phenotypes in analysis of TL with TG, while the effect of LDL-C on TL was partially mediated by body mass index (BMI) in the reverse direction, with mediated proportion of 12.83% (95% CI: 0.62% to 25.04%). Our study indicated that longer TL were associated with higher TG levels, while conversely, higher TG, LDL-C, and ApoB levels predicted longer TL, with BMI partially mediating these effects. Our findings present valuable insights into the development of preventive strategies and interventions that specifically target TL-related aging and age-related diseases.

Research on the Coupling Mechanism between Digital Economy Development and Household Energy Transition in China

In order to explore the relationship between the digital economy and China's household green energy structure and utilization efficiency, an empirical test is conducted based on the data of 31 Chinese provinces from 2015 to 2022 using a two-way panel fixed-effects model as well as a coupling model. The results show that the digital economy has a significant positive effect on household green energy structure and utilization efficiency; secondly, this paper focuses on the bi-directional relationship between the two, and finds that the overall coupling situation is good, and the digitalization level and household green energy utilization efficiency in the regions under the "inverted triangle" pattern are highly coupled. The study finds that the overall coupling is good, and the digitalization level and household green energy utilization efficiency in the "inverted triangle" pattern are highly coupled. This study provides a reference for accelerating the national energy transition, boosting China's digital economy in the reverse direction, and providing green and digital kinetic energy for realizing the overall high-quality development of the economy.

Thermodynamic Stability Theories of Irreversible Processes and the Fourth Law of Thermodynamics.

Three approaches for determining the thermodynamic stability of irreversible processes are described in generalized formulations. The simplest is the Gibbs-Duhem theory, specialized to irreversible trajectories, which uses the concept of virtual displacement in the reverse direction. Its only drawback is that even a trajectory leading to an explosion is identified as a thermodynamically stable motion. In the second approach, we use a thermodynamic Lyapunov function and its time rate from the Lyapunov thermodynamic stability theory (LTS, previously known as CTTSIP). In doing so, we demonstrate that the second differential of entropy, a frequently used Lyapunov function, is useful only for investigating the stability of equilibrium states. Nonequilibrium steady states do not qualify. Without using explicit perturbation coordinates, we further identify asymptotic thermodynamic stability and thermodynamic stability under constantly acting disturbances of unperturbed trajectories as well as of nonequilibrium steady states. The third approach is also based on the Lyapunov function from LTS, but here we additionally use the rates of perturbation coordinates, based on the Gibbs relations and without using their explicit expressions, to identify not only asymptotic thermodynamic stability but also thermodynamic stability under constantly acting disturbances. Only those trajectories leading to an infinite rate of entropy production (unstable states) are excluded from this conclusion. Finally, we use these findings to formulate the Fourth Law of thermodynamics based on the thermodynamic stability. It is a comprehensive statement covering all nonequilibrium trajectories, close to as well as far from equilibrium. Unlike previous suggested "fourth laws", this one meets the same level of generality that is associated with the original zeroth to third laws. The above is illustrated using the Schlögl reaction with its multiple steady states in certain regions of operation.

Josephson diode effect in junctions of superconductors with band asymmetric metals

At interfaces connecting two superconductors (SCs) separated by a metallic layer, an electric current is induced when there is a disparity in the phases of the two superconductors. We elucidate this phenomenon based on the weights of the Andreev bound states associated with the states carrying currents in forward and reverse directions. Typically, current phase relation (CPR) in Josephson junctions is an odd function. When time reversal and inversion symmetries are broken at the junction, CPR ceases to be an odd function and the system may exhibit Josephson diode effect. This phenomenon has been studied in spin orbit coupled systems under an external Zeeman field wherein the magnetochiral anisotropy is responsible for the Josephson diode effect. Recently introduced the band asymmetric metal (BAM) model presents a novel avenue, featuring an asymmetric band structure. We investigate DC Josephson effect in SC-BAM-SC junctions and find that band asymmetry can lead to Josephson diode effect and anomalous Josephson effect. We explain the mechanism behind these effects based on interference of plane wave modes within the Bogoliubov de-Genne formalism. We calculate diode effect coefficient for different values of the parameters.

3D Point Cloud Shape Generation with Collaborative Learning of Generative Adversarial Network and Auto-Encoder

A point cloud is a simple and concise 3D representation, but point cloud generation is a long-term challenging task in 3D vision. However, most existing methods only focus on their effectiveness of generation and auto-encoding separately. Furthermore, both generative adversarial networks (GANs) and auto-encoders (AEs) are the most popular generative models. But there is a lack of related research that investigates the implicit connections between them in the field of point cloud generation. Thus, we propose a new bidirectional network (BI-Net) trained with collaborative learning, introducing more priors through the alternate parameter optimizations of a GAN and AE combination, which is different from the way of combining them at the network structure and loss function level. Specifically, BI-Net acts as a GAN and AE in different data processing directions, where their network structures can be reused. If optimizing only the GAN without the AE, there is no direct constraint of ground truth on the generator’s parameter optimization. This unique approach enables better network optimization and leads to superior generation results. Moreover, we propose a nearest neighbor mutual exclusion (NNME) loss to further homogenize the spatial distribution of generated points during the reverse direction. Extensive experiments were conducted, and the results show that the BI-Net produces competitive and high-quality results on reasonable structure and uniform distributions compared to existing state-of-the-art methods. We believe that our network structure (BI-Net) with collaborative learning could provide a new promising method for future point cloud generation tasks.

[formula omitted]-Functions for fields of series- and parallel-connected boreholes with variable fluid mass flow rate and reversible flow direction

A new methodology is developed for the calculation of g-functions for the simulation of geothermal bore fields in non-stationary conditions. The g-functions are able to represent the variations of fluid mass flow rate and reversible flow direction, and model the effect of these variations on the long-term ground temperature response. The thermal model is constructed by coupling an axially-discretized finite line source solution for the ground heat transfer, a thermal resistance circuit model for the interior of the boreholes, as well as connectivity relations between parallel- and series-connected boreholes. Simulation experiments show that the new g-functions are required for the accurate prediction of fluid temperatures in series-connected boreholes with variable mass flow rate and reversible flow direction. A simulation of a borehole thermal energy storage system of 144 boreholes over a period of 20 years shows a maximum absolute error of 0.65 °C. The new g-functions thus extend the simulation capabilities of g-functions to borehole thermal energy storage systems.

Demonstration of heat switch function of loop heat pipe controlled by electrohydrodynamic conduction pump

Loop heat pipes (LHPs) are attractive devices to cool electronic devices in spacecraft. The LHP operation must be shut down in some cases to avoid considerable reductions in the temperature of such electric devices. A new active technology capable of heat switching is developed for LHPs using an electrohydrodynamic (EHD) conduction pump that operates to facilitate liquid flow in the reverse direction against the normal LHP flow. To demonstrate our proposed approach, an EHD conduction pump with rod–ring electrodes was developed and evaluated to obtain generated pressure with varying applied voltages. The LHP with R134a as a working fluid was shut down successfully when a sufficiently high voltage was applied. The LHP shutdown continued until the EHD conduction pump was turned off. A comparison with a test in which a manually controlled mechanical valve caused the capillary limit showed that the EHD pump worked differently from the valve: the shutdown by the EHD pump involved a reverse flow. The consumed electric power for the EHD pump was 10–30 mW for 6–8 kV of applied voltage during the LHP shutdown. Furthermore, pressure loss through the EHD pump during normal LHP operation was approximately 0.5 % of the capillary pressure.