Opposite Direction Research Articles

Impact of Socio-Demographic Attributes and Mutual Gaze of Virtual Humans on Users' Visual Attention and Collision Avoidance in VR.

This study investigated the extent that the non-verbal behaviors of virtual humans (VHs) and their socio-demographic attributes altered users' collision avoidance behaviors in Virtual Reality (VR). Users interacted with VHs representing different levels of ethnicities and gender, exhibiting different conditions of physical movement, and gaze behaviors. The VHs were depicted in three major ethnic conditions namely Asian, Caucasian, and Black. The physical movement states of the VHs were either static in the path of the user or walking toward the user in the opposite direction. The non-verbal gaze behavior of the VHs was either direct gaze or averted gaze. We used an HTC Vive tracking system to track users' performing real walking while we collected objective measures (i,e., continuous gaze, fixation gaze, clearance distance, and travel length), and subjective variables (i.e., game experiences and social presence). The results showed that the ethnicity of the VHs significantly impacted the gaze behavior of the users, and the gender of the VHs affected the user avoidance movement and their reciprocal gaze behavior. Our results revealed that users' physical movement, gaze behaviors, and collision avoidance were moderated by the VHs' perceived ethnicity, gender, and gaze behaviors. Understanding the impact of the socio-demographics attributes of VHs and their gaze behavior on users' collision avoidance is critical for applications in which users are navigating through virtual traffic, crowd, and other inter-personal simulations.

Directionality Reversal and Shift of Rotational Axis in a Hemithioindigo Macrocyclic Molecular Motor.

Molecular motors are central driving units for nanomachinery, and control of their directional motions is of fundamental importance for their functions. Light-driven variants use easy to provide, easy to dose, and waste-free fuel with high energy content, making them particularly interesting for applications. Typically, light-driven molecular motors work via rotations around dedicated chemical bonds where the directionality of the rotation is dictated by the steric effects of asymmetry in close vicinity to the rotation axis. In this work, we show how unidirectional rotation around a virtual axis can be realized by reprogramming a molecular motor. To this end, a classical light-driven motor is restricted by macrocyclization, and its intrinsic directional rotation is transformed into a directional rotation of the macrocyclic chain in the opposite direction. Further, solvent polarity changes allow to toggle the function of this molecular machine between a directional motor and a nondirectional photoswitch. In this way, a new concept for the design of molecular motors is delivered together with elaborate control over their motions and functions by simple solvent changes. The possibility of sensing the environmental polarity and correspondingly adjusting the directionality of motions opens up a next level of control and responsiveness to light-driven nanoscopic motors.

OsLdh7, a rice lactate dehydrogenase, confers stress resilience in rice under cadmium stress through NAD+/NADH regulation

Lactate dehydrogenase (Ldh, EC 1.1.1.27), an oxidoreductase enzyme catalyses the interconversion of pyruvate to L-lactate and vice-versa with concomitant oxidation and reduction of NADH and NAD+. The enzyme functions as a ROS sensor and mitigates stress response by maintaining NAD+/NADH homeostasis. In this study, we delineated the role of the Ldh enzyme in imparting cadmium stress tolerance in rice. Previously, we identified a putatively active Ldh in rice (OsLdh7) through in-silico modelling. Biochemical characterization of the OsLdh7 enzyme revealed it to be optimally active at pH 6.6 in the forward direction and pH 9 in the reverse direction. Overexpression of OsLdh7 in rice cv.IR64, increased tolerance of the transgenic lines to cadmium stress compared to the wild type (WT) at both seedling and reproductive stages. The transgenic lines showed increased enzyme activity in the reverse direction under cadmium stress, attributed to elevated cytosolic pH resulting from increased calcium concentration. This increased NADH content is highly essential for functioning of the ROS scavenging enzymes, RbohD and MPK6. qPCR analysis revealed that the overexpression lines had increased transcript abundance of these genes indicating an effective ROS scavenging mechanism. Additionally, the overexpression lines showed an efficient cadmium sequestration mechanism compared to the WT by increasing the transcript levels of the vacuolar transporters of cadmium as well as total phytochelatin content. Thus, our findings indicated OsLdh7 imparts cadmium stress tolerance in rice through a two-pronged approach by mitigating ROS and sequestering cadmium ions, highlighting its potential for crop improvement programs.

Dynamic evolution of amplitude and position of geomagnetic secular acceleration pulses since 2000

Recent studies on the behavior of geomagnetic secular acceleration (SA) pulses have provided a basis for understanding the dynamic processes in the Earth’s core. This analysis statistically evaluates the evolution of the SA pulse amplitude and position since 2000 by computing the three-year difference in SA with the CHAOS-7 geomagnetic field model (CHAOS-7.17 release). Furthermore, the study explores the correlation between the acceleration pulse amplitude and geomagnetic jerks and the dynamic processes of alternating variation and polarity reversal of pulse patches over time. Research findings indicate that the variation in pulse amplitude at the Core Mantle Boundary (CMB) closely resembles that observed at the Earth’s surface, with an average period of 3.2 years. The timing of peak pulse amplitude aligns with that of the geomagnetic jerk, suggesting its potential utility as a novel indicator for detecting geomagnetic jerk events. The acceleration pulses are the strongest near the equator (2°N) and more robust in the high-latitude region (68°S) of the Southern Hemisphere, indicating that the variation is more dramatic in the Southern Hemisphere. The acceleration pulses fluctuate unevenly in the west-east direction, with characteristics of local variation. In the Western Hemisphere, the pulse patches are distributed near the equator, exhibiting an evident westward drifting mode. The positive and negative patches alternate in time, displaying a polarity reversal in the west-east direction, with an average interval of approximately 32°. These characteristics can be attributed to the rapid magnetic field fluctuations disclosed by the model of stratification at the top of the Earth’s core. In the Eastern Hemisphere, the pulses are weaker between 10°E and 60°E, with the most active pulses occurring around 80°E to 105°E and near 150°E. The pulse patches exhibit a broader distribution in the north-south direction, with relatively strong patches still occurring near 40°N and 40°S. These local variation characteristics match the actual cases of zonal flows and geostrophic Alfvén waves in the Earth’s core.

Reverse cannulation method as a strategy for aortic aneurysm surgery: A computational fluid dynamics study on minimizing neurological risks

ObjectivesTo evaluate the blood flow velocity and wall shear stress in total arch replacement with a “shaggy” aorta, using computational fluid dynamics, and determine the optimal cannulation method. MethodsA patient-specific aortic arch aneurysm model was constructed by using computed tomography scans. Three cannulas were assessed, as follows: dispersive with a steep angle, dispersive with a gentle angle, and the endo-hole type. The cannula tips were oriented toward the aortic arch (standard direction) and aortic root (reversed direction), with an ideal angle (base orientation: 0°), tip orientations rotated 20° clockwise and counterclockwise from the base orientation. The variables of interest included the blood flow velocity, streamlines, wall shear stress, and flow distribution. ResultsThe standard direction resulted in variable accelerated flow and wall shear stress locations based on cannula tip orientation, leading to unstable cerebral branch flow. Minor deviation in the cannula tip angle and cannula type led to significant alterations in flow distribution. Conversely, in the reverse direction for all cannulas, no accelerated blood flow was observed in the proximal aortic arch or cerebral vessel ostia even with angular adjustments, helping maintain a stable cerebral branch flow. Minimal variation in blood flow distribution was observed across all cannula types and angles. ConclusionOur simulations indicate that, irrespective of the cannula type or orientation, directing the cannula tip toward the aortic root (reversed direction) prevents accelerated blood flow in critical areas, suggesting its potential as an optimal approach for aortic arch surgery in “shaggy” aorta cases.

Passive and active field theories for disease spreading

The worldwide COVID-19 pandemic has led to a significant growth of interest in the development of mathematical models that allow to describe effects such as social distancing measures, the development of vaccines, and mutations. Several of these models are based on concepts from soft matter theory. Considerably less well investigated is the reverse direction, i.e. how results from epidemiological research can be of interest for the physics of colloids and polymers. In this work, we consider the susceptible-infected-recovered (SIR)-dynamical density functional theory (DDFT) model, a combination of the SIR model from epidemiology with DDFT from nonequilibrium soft matter physics, which allows for an explicit modeling of social distancing. We extend the SIR-DDFT model both from an epidemiological perspective by incorporating vaccines, asymptomaticity, reinfections, and mutations, and from a soft matter perspective by incorporating noise and self-propulsion and by deriving a phase field crystal (PFC) model that allows for a simplified description. On this basis, we investigate via computer simulations how epidemiological models are affected by the presence of non-reciprocal interactions. This is done in a numerical study of a zombie outbreak.

Revealing reaction intermediates in one-carbon elongation by thiamine diphosphate/CoA-dependent enzyme family

2-Hydroxyacyl-CoA lyase/synthase (HACL/S) is a thiamine diphosphate (ThDP)-dependent versatile enzyme originally discovered in the mammalian α-oxidation pathway. HACL/S natively cleaves 2-hydroxyacyl-CoAs and, in its reverse direction, condenses formyl-CoA with aldehydes or ketones. The one-carbon elongation biochemistry based on HACL/S has enabled the use of molecules derived from greenhouse gases as biomanufacturing feedstocks. We investigated several HACL/S family members with high activity in the condensation of formyl-CoA and aldehydes, and distinct chain-length specificities and kinetic parameters. Our analysis revealed the structures of enzymes in complex with acyl-CoA substrates and products, several covalent intermediates, bound ThDP and ADP, as well as the C-terminal active site region. One of these observed states corresponds to the intermediary α–carbanion with hydroxymethyl-CoA covalently attached to ThDP. This research distinguishes HACL/S from related sub-families and identifies key residues involved in substrate binding and catalysis. These findings expand our knowledge of acyloin-condensation biochemistry and offer attractive prospects for biocatalysis using carbon elongation.

Bidirectional causal associations between aging and major mental disorders: A population-based study using the two-sample mendelian randomization method from the UK biobank (AM-SRNMA 002)

AimsWhile observational studies have suggested associations linking aging and mental disorders, the question of causality has remained unclear. This study aimed to explore the causal relationship between aging level and major mental disorders. MethodsWe utilized Two-Sample Mendelian randomization (2SMR) with mental disorders data and aging indicators information from an extensive genome-wide association study (GWAS) database. The GWAS database is a comprehensive resource that compiles genetic association data, encompassing a sample size of over 450,000 individuals. We employed five methods for 2SMR and single nucleotide polymorphisms were chosen as instrumental variables. ResultsOur analyses consistently supported a bidirectional causal association between the Frailty Index (FI) and Major Depressive Disorder (MDD). Furthermore, our findings indicated potential influences, such as Attention-Deficit/Hyperactivity Disorder (ADHD) and Bipolar Disorder (BD) affecting GrimAge, and Anxiety Disorder (AD) impacting Left Hand Grip Strength (LHGS). In contrast, we observed no significant correlations for other mental disorders on FI, Telomere Length (TL), GrimAge, Appendicular Lean Mass (ALM), and LHGS. In the reverse direction, FI showed a significant impact on the risk of MDD, AD, and ADHD, while LHGS affected the risk of MDD. Importantly, no significant associations were found between other factors and the risk of MDD, BD, AD, Schizophrenia (SZ), and ADHD. ConclusionsThis 2SMR analysis has presented evidence for a bidirectional causal relationship between FI and MDD, while the relationship between ADHD, BD, and GrimAge should be more considered. Our study provides genetic evidence supporting a causal link between aging indicators and several mental illnesses.

Thg1 family 3'-5' RNA polymerases as tools for targeted RNA synthesis.

Members of the 3'-5' RNA polymerase family, comprised of tRNAHis guanylyltransferase (Thg1) and Thg1-like proteins (TLPs), catalyze templated synthesis of RNA in the reverse direction to all other known 5'-3' RNA and DNA polymerases. Discovery of enzymes capable of this reaction raised the possibility of exploiting 3'-5' polymerases for post-transcriptional incorporation of nucleotides to the 5'-end of nucleic acids without ligation, and instead by templated polymerase addition. To date, studies of these enzymes have focused on nucleotide addition to highly structured RNAs, such as tRNA and other non-coding RNA. Consequently, general principles of RNA substrate recognition and nucleotide preferences that might enable broader application of 3'-5' polymerases have not been elucidated. Here, we investigated the feasibility of using Thg1 or TLPs for multiple nucleotide incorporation to the 5'-end of a short duplex RNA substrate, using a templating RNA oligonucleotide provided in trans to guide 5'-end addition of specific sequences. Using optimized assay conditions, we demonstrated a remarkable capacity of certain TLPs to accommodate short RNA substrate-template duplexes of varying lengths with significantly high affinity, resulting in the ability to incorporate a desired nucleotide sequence of up to 8 bases to 5'-ends of the model RNA substrates in a template-dependent manner. This work has further advanced our goals to develop this atypical enzyme family as a versatile nucleic acid 5'-end labeling tool.

Impact of acupuncture on ischemia/reperfusion injury: Unraveling the role of miR-34c-5p and autophagy activation

We have previously reported that the expression of miR-34c-5p was up-regulated during acupuncture treatment in the setting of a cerebral ischemia/reperfusion injury (CIRI), indicating that miR-34c-5p plays an important role in healing from a CIRI-induced brain injury. This study sought to evaluate the effects of acupuncture on miR-34c-5p expression and autophagy in the forward and reverse directions using a rat focal cerebral ischemia/reperfusion model. After 120 minutes of middle cerebral artery occlusion and reperfusion, rats were treated with acupuncture at the "Dazhui" (DU20), "Baihui" (DU26) and "Renzhong" (DU14) points. Neurologic function deficit score, cerebral infarct area ratio, neuronal apoptosis and miR-34c-5p expression were evaluated 72 hr after treatment. The autophagy agonist RAPA and the antagonist 3MA were used to evaluate the neuro protective effects of autophagy-mediated acupuncture. We found that acupuncture treatment improved autophagy in the brain tissue of CIRI rats. Acupuncture reversed the negative effects of 3MA on CIRI, and acupuncture combined with RAPA further enhanced autophagy. We also found that acupuncture could increase miR-34c-5p expression in hippocampal neurons after ischemia/reperfusion. Acupuncture and a miR-34c agomir were able to enhance autophagy, improve neurologic deficits, and reduce the cerebral infarct area ratio and apoptosis rate by promoting the expression of miR-34c-5p. Silencing miR-34c resulted in a significantly reduced activating effect of acupuncture on autophagy and increased apoptosis, neurologic deficit symptoms, and cerebral infarct area ratio. This confirms that acupuncture can upregulate miR-34c-5p expression, which is beneficial in the treatment of CIRI.

Causal effects of autoimmune diseases on temporomandibular disorders and the mediating pathways: a Mendelian randomization study.

The role of autoimmune diseases (ADs) in temporomandibular disorders (TMDs) has been emphasized in observational studies. However, whether the causation exists is unclear, and controversy remains about which specific disorder is destructive in TMDs. This Mendelian randomization (MR) study aims to estimate the causal effect of common ADs on TMDs. Genetic data from published genome-wide association studies for fourteen common ADs, specifically multiple sclerosis (MS, N = 15,283), ankylosing spondylitis (AS, N = 22,647), asthma (N = 408,422), celiac disease (N = 15,283), Graves' disease (N = 458,620), Hashimoto thyroiditis (N = 395,640), primary biliary cirrhosis (PBC, N = 11,375), primary sclerosing cholangitis (PSC, N = 14,890), psoriasis vulgaris (N = 483,174), rheumatoid arthritis (RA, N = 417,256), systemic lupus erythematosus (SLE, N = 23,210), Type 1 diabetes (T1D, N = 520,580), inflammatory bowel disease (IBD, N = 34,652), and Sjogren's syndrome (SS, N = 407,746) were collected. Additionally, the latest summary-level data for TMDs (N = 228,812) were extracted from the FinnGen database. The overall effects of each immune traits were assessed via inverse-variance weighted (IVW), weighted median, and MR-Egger methods, and performed extensive sensitivity analyses. Finally, 731 immune cell phenotypes (N = 3,757) were analyzed for their mediating role in the significant causality. Univariable MR analyses revealed that genetically predicted RA (IVW OR: 1.12, 95% CI: 1.05-1.19, p < 0.001) and MS (IVW OR: 1.06, 95% CI: 1.03-1.10, p = 0.001) were associated with increased risk of TMDs. Two out of 731 immune cell phenotypes were identified as causal mediators in the associations of RA with TMDs, including "CD25++ CD8+ T cell % CD8+ T cell" (mediation proportion: 6.2%) and "CD3 on activated CD4 regulatory T cell" (5.4%). Additionally, "CD127 on granulocyte" mediated 10.6% of the total effect of MS on TMDs. No reverse directions, heterogeneity, and pleiotropy were detected in the analyses (p > 0.05). This MR study provides new evidence regarding the causal impact of genetic predisposition to RA or MS on the increased risk of TMDs, potentially mediated by the modulation of immune cells. These findings highlight the importance for clinicians to pay more attention to patients with RA or MS when consulting for temporomandibular discomfort. The mediating role of specific immune cells is proposed but needs further investigation.

Aerodynamic Performance of a Hovering Cycloidal Rotor: A CFD Study with Experimental Validation

A three‐dimensional (3D) unsteady Reynolds averaged Navier‐Stokes (URANS) computational fluid dynamics (CFD) toolkit for cycloidal rotors was developed and used to perform a parametric study. It included blade aspect ratio, side disks, pitch mechanism, blade camber, and shaft size. The influence of the pitch rod length showed the importance of the lift distribution between the upstream and downstream parts of the rotor cylinder. The application of blade camber significantly affected thrust and power, while having a limited effect on efficiency. A similar effect was obtained by varying the pitch rod lengths. The presence of a central axis in the rotor had a negligible effect on efficiency. The most significant impact on efficiency came from the side disks, which behaved similarly to winglets on fixed‐wing aircraft. However, changing the aspect ratio of the blades showed a similar response to that of aircraft wings, but with a smaller effect, making it conceivable to fly a square-bladed cyclorotor without side disks. To verify the CFD model, a cycloidal rotor was also built using 3D printed parts and carbon fiber tubing. It was then operated on a test rig where thrust and power were measured for speeds ranging from 408 to 2528 RPM. On the test bench, the blades were pitched with a uniform asymmetric mechanism. The maximum nose‐up pitch angle in upstream of the rotor axis was 34.8°. Due to its rotation around the rotor and its pitching in the opposite direction, the maximum nose‐up pitch angle of the downstream blade was 38.6°. The obtained rotor thrust and power curves and the flow visualization around the rotor confirmed the validity of the CFD toolkit.

Back-and-Forth (BaF): a new greedy algorithm for geometric path planning of unmanned aerial vehicles

The autonomous task success of an unmanned aerial vehiclel (UAV) or its military specialization called the unmanned combat aerial vehicle (UCAV) has a direct relationship with the planned path. However, planning a path for a UAV or UCAV system requires solving a challenging problem optimally by considering the different objectives about the enemy threats protecting the battlefield, fuel consumption or battery usage and kinematic constraints on the turning maneuvers. Because of the increasing demands to the UAV systems and game-changing roles played by them, developing new and versatile path planning algorithms become more critical and urgent. In this study, a greedy algorithm named as the Back-and-Forth (BaF) was designed and introduced for solving the path planning problem. The BaF algorithm gets its name from the main strategy where a heuristic approach is responsible to generate two predecessor paths, one of which is calculated from the start point to the target point, while the other is calculated in the reverse direction, and combines the generated paths for utilizing their advantageous line segments when obtaining more safe, short and maneuverable path candidates. The performance of the BaF was investigated over three battlefield scenarios and twelve test cases belonging to them. Moreover, the BaF was integrated into the workflow of a well-known meta-heuristic, artificial bee colony (ABC) algorithm, and detailed experiments were also carried out for evaluating the possible contribution of the BaF on the path planning capabilities of another technique. The results of the experiments showed that the BaF algorithm is able to plan at least promising or generally better paths with the exact consistency than other tested meta-heuristic techniques and runs nine or more times faster as validated through the comparison between the BaF and ABC algorithms. The results of the experiments further proved that the integration of the BaF boosts the performance of the ABC and helps it to outperform all of fifteen competitors for nine of twelve test cases.

The relationship between psoriasis and vitiligo: From a comprehensive study.

Both psoriasis and vitiligo are autoimmune skin diseases. Previous observational studies have indicated a relationship between the two conditions, and simultaneous onset of both diseases poses increased health risks to patients. However, limited research has explored the causal relationship between psoriasis and vitiligo. To investigate whether a causal association exists between psoriasis and vitiligo. A case of Chinese patients diagnosed with psoriasis and vitiligo has been reported. Transcriptome sequencing was performed on normal, psoriasis, vitiligo, and co-morbid skin tissues of the patients, and single-cell transcriptome sequencing was conducted on the co-morbid skin tissues. A comprehensive Mendelian randomization analysis of Genome-wide association studies (GWAS) was performed on a cohort of 261 018 European individuals with psoriasis from the IEU Open GWAS Project and vitiligo from the National Institutes of Health (NIH) Database of Genotypes and Phenotypes. Case report and transcriptome results showed that skin tissue with vitiligo combined with psoriasis exhibited both vitiligo and psoriasis. Single-cell transcriptome sequencing results showed that in comparison to normal skin and psoriatic skin, the proportions of CD8+ T cells, natural killer cells, naive T cells, T helper cells 17, regulatory T cells, conventional type 1 dendritic cells, Conventional type 2 dendritic cells, and plasmacytoid dendritic cells were all increased in skin tissue with vitiligo combined with psoriasis. Mendelian randomization analysis included 4510 patients with psoriasis and 4680 patients with vitiligo. The results showed no causal relationship between vitiligo and psoriasis in the forward direction (p=0.192; odds ratio [OR], 1.059; 95% confidence interval [CI], 0.971-1.155) or in the reverse direction (p=0.459; OR, 0.927; 95% CI, 0.757-1.134). This study suggests that the association between psoriasis and vitiligo may be closely related to immunity, however, Mendelian randomization studies do not support a causal relationship. These findings hold significant implications for clinicians aiming to enhance their understanding and treatment approaches for psoriasis and vitiligo.

Bi-directional two-sample Mendelian randomization identifies causal association of depression with temporomandibular disorders.

Depression and anxiety have been suggested to be associated with temporomandibular disorders (TMD) in observational studies. However, the causal association and the direction in the relationship between depression/anxiety and TMD remain unknown. This study investigated the potential causal relationship between depression/anxiety and TMD with two-sample bi-directional Mendelian randomization (MR). Summary statistics of depression (N = 500 199), anxiety disorder (N = 17 310) and TMD (N = 195 930) were sourced from large-scale genome-wide association studies (GWAS). The primary Mendelian randomization (MR) estimation employed the inverse-variance weighted meta-analysis (IVW). Additional MR sensitivity methods and multivariate MR (MVMR) were applied to address pleiotropy. IVW results indicated a causal effect of genetically predicted depression on TMD (OR = 1.887, 95% CI = 1.504-2.367, p < .001), which was supported by other sensitivity MR approaches. MVMR results suggested that the negative effect of depression on TMD persisted after conditioning on other potential confounders. The association of anxiety disorder with TMD was not supported by our findings. In the reverse direction, we did not find compelling evidence suggesting the causal effect of TMD on depression and anxiety disorder. The present study suggests a potential causal association between genetic liability for depression and the risk of TMD. Our MR findings align with prior epidemiological research, underscoring the significance of early detection and prevention of depression in the treatment of TMD.

Persistent and anti-persistent motion in bounded and unbounded space: resolution of the first-passage problem

The presence of temporal correlations in random movement trajectories is a widespread phenomenon across biological, chemical and physical systems. The ubiquity of persistent and anti-persistent motion in many natural and synthetic systems has led to a large literature on the modelling of temporally correlated movement paths. Despite the substantial body of work, little progress has been made to determine the dynamical properties of various transport related quantities, including the first-passage or first-hitting probability to one or multiple absorbing targets when space is bounded. To bridge this knowledge gap we generalise the renewal theory of first-passage and splitting probabilities to correlated discrete variables. We do so in arbitrary dimensions on a lattice for the so-called correlated or persistent random walk, the one step non-Markovian extension of the simple lattice random walk in bounded and unbounded space. We focus on bounded domains and consider both persistent and anti-persistent motion in hypercubic lattices as well as the hexagonal lattice. The discrete formalism allows us to extend the notion of the first-passage to that of the directional first-passage, whereby the walker must reach the target from a prescribed direction for a hitting event to occur. As an application to spatio-temporal observations of correlated moving cells that may be either repelled or attracted to hard surfaces, we compare the first-passage statistics to a target within a reflecting domain depending on whether an interaction with the reflective interface invokes a reversal of the movement direction or not. With strong persistence we observe multi-modality in the first-passage distribution in the former case, which instead is greatly suppressed in the latter.

Spin-polarization and Coulomb interaction dependent thermal rectification in a quantum dot system

Based on the master equation approach, we investigate the thermal transport through a diode composed of a quantum dot under Coulomb interaction and tunnel-coupled to two ferromagnetic leads with antiparallel spin polarizations. We analyze the effects of spin polarizations, Coulomb interaction, mean temperature and Zeeman splitting on the thermal rectification. Firstly, we find that the thermal rectification effect is enhanced with the increase of spin polarization, because the mirror-symmetry of the system is broken by the anti-parallel spin polarization. Especially, when both leads are fully spin polarized, the asymmetry of the heat transferred by Coulomb interaction under the opposite temperature bias leads to the appearance of perfect thermal rectification and negative differential thermal conductance. Secondly, we find whether the system is in a Coulomb blockade state greatly affects the thermal rectification coefficient. As the average temperature increases or the intradot Coulomb interaction decreases, the system gradually escapes from the Coulomb blockade state, resulting in a reversal of the thermal rectification direction and ultimately leading to an increase in the rectification coefficient. Thirdly, we also find that the Zeeman splitting can be utilized to modulate the behavior of thermal rectification. Thermal rectification occurs only when Zeeman splitting and spin polarization coexist, and under different spin polarizations, the rectification coefficient exhibits different trends with the change of Zeeman splitting. These observations indicate that this structure holds potential application at a thermal rectifier as well as a thermal detector of magnetic fields.

Stała Współpraca Strukturalna (PESCO) jako przykład dyferencjalizmu eksperymentalnego w Unii Europejskiej

POLAND IN THE EUROPEAN UNION TOWARDS EUROSCEPTIC SELF-ISOLATION By joining the European Union on 1 May 2004, Poland symbolically finalized the transformation process from the position of a nation state (NS) towards a member state (MS). The European Union Member States, in addition to being the main actors of the integration process, are also affected by various natural centrifugal forces in this atypical international organization. It results from selfishness and particularism of the states as well as from natural national selfinterests, on which stable national preferences are clearly defined and exposed by member states. From the perspective of the transformation process of Poland as the largest and most important EU member state located in Central and Eastern Europe, we can distinguish two periods: 1. 2004-2015. At that time, Poland strongly supported the European Commission (EC) and the Community method, which gives the EC a central role in the decision-making process. This period can be defined by the process of transition from a nation state to a Member State. 2. From 2015, when Poland was ruled by anti-liberal and more Eurosceptic government. This period, in turn, can be defined by the hybrid accumulation of features of a national state and a Member State, which makes us deal with a national member state (NMS). However, the tendency that can be observed runs in the direction of a backward transformation from a Member State to a nation-state. The subject of this study is only the second period in the European policy of Poland expressed by the accumulation of the features of NS and MS with a tendency in the reverse direction of transformation from a Member State to a nation- state. The main research thesis focuses on the statement that after 2015 Poland in the European Union drifts towards Eurosceptic self-isolation.

Transitions for zero carbon futures: From just to generous

The ‘just transition’ concept has gained popularity in recent years and is being widely applied as a guiding concept within policy frameworks promoting low carbon transitions. Justice is at the heart of much of the policy rhetoric surrounding these transitions, favoured for the emphasis it places on fairness, equity and inclusivity. The use of justice as the guiding virtue for the transition has remained largely unquestioned. This paper examines the concept of just transition and experiments with positioning generosity as a guiding principle. It is argued that this may enable a more transformative, inclusive zero carbon future that prioritises wellbeing over mere survival. This does not seek to position a just transition and a generous transition in direct opposition to one another, instead intending to highlight how the concept of generosity might act as a catalyst for or complement to justice.

Anticoagulation reversal (vitamin K, prothrombin complex concentrates, idarucizumab, andexanet-α, protamine).

Bleeding events are common in patients prescribed anticoagulants and can have devastating consequences. Several specific and nonspecific agents have been developed to reverse the effects of anticoagulant drugs or toxins. Vitamin K, as the oldest of these antidotes, specifically counteracts the effects of pharmaceuticals and rodenticides designed to deplete stores of vitamin K-dependent factors. In cases of life-threatening bleeding, the addition of prothrombin complex concentrates (PCCs) allows for the immediate replacement of coagulation factors. While the use of PCCs has been extended to the non-specific reversal of the effects of newer direct oral anticoagulants, the specific agents idarucizumab, targeting dabigatran and andexanet-α, binding factor Xa inhibitors, have recently been developed and are being preferentially recommended by most guidelines. However, despite having rapid effects on correcting coagulopathy, there is to date a lack of robust evidence establishing the clear superiority of direct oral anticoagulant-specific reversal agents over PCCs in terms of haemostatic efficacy, safety or mortality. For andexanet-α, a potential signal of increased thromboembolic risks, comparatively high costs and low availability might also limit its use, even though emerging evidence appears to bolster its role in intracranial haemorrhage. Protamine is the specific agent for the reversal of unfractionated heparin anticoagulation used mainly in cardiovascular surgery. It is much less effective for low molecular weight heparin fragments and is usually reserved for cases with life-threatening bleeding.