The gently inclined medium-thick orebody is generally viewed as difficult to extract. This paper presents a sublevel open stoping using long-hole with back filling method, particularly for inclined medium-thick orebodies. This method not only changes the temporal sequence of ore stoping and realizes transportation using gravity and trackless devices, but also improves production capacity and efficiency. Nonetheless, this method also has some disadvantages; for example, the orebody has more contact with country rock, and the method has a more complex loss and dilution process. This paper starts with the analysis of the results of physical simulation experiments that examine the interactive relationship among the lower stope footwall dip angle, the footwall surface roughness, draw point interval and production blast ring and concludes their influence on the ore-recovery ratio in each production cycle. Secondly, based on physical simulation results, the multivariate linear fit was carried out on the SPSS using the dimensional analysis method. Thus a statistical model was developed for investigating the influence of gently inclined medium thick orebody, the footwall dip angle, the footwall roughness and interval of draw points on the recovery ratio, which can accurately forecast the ore-recovery ratio under different parameters in the physical simulation process. The optimal structural parameters obtained from physical simulation and statistical analysis was then applied to industrial experiments. Based on the 3D laser scanning during in-suit experiments, it was found that the lower stope had an 82% recovery ratio and an 18% dilution ratio, while the upper stope had a recovery ratio of 85% and a dilution ratio of 12%. Moreover, the production capacity could be up to 600t/d. The physical simulation and industrial experiments both demonstrate that the new mining method can be adopted for the safe and efficient mining of gently inclined medium-thick orebodies.