This paper proposes a fractional-N digital phase-locked loop (DPLL) architecture with feedforward multi-tone spur cancellation scheme. The proposed cancellation loop is capable of suppressing both internal spur, i.e., fractional-N spur, and externally coupled spur from input paths. It can be further extended for multi-stage operation for mitigating multiple spur sources. Both theoretical analysis and simulation results are provided in this paper to explore the design tradeoffs of the proposed technique. A proof-of-concept prototype is implemented in 65 nm CMOS. It measures external spur reduction of 15 to 35 dB and the worst-case fractional spur of 73.66 to 117 dBc with 20–50 dB improvement after enabling the cancellation loop. The measured reference spur ranges from 110.1 to 116.1 dBc across the entire DPLL operation range (3.2–4.8 GHz) thanks to design techniques. The measured in-band phase noise achieves 103 dBc at 100 kHz frequency offset and out-of-band phase noise of 122 dBc at 3 MHz frequency offset with integrated phase noise of 38.1 dBc from 10 kHz to 40 MHz.