Digital Dissertations Research Articles

Content analysis of dissertations for examination of priority areas of nursing science

BackgroundBased on current and future research priorities to inform Ph.D. education, emerging and priority areas were developed through the Idea Festival Advisory Committee of the Council for the Advancement of Nursing Science. PurposeThe purpose of this study was to examine the bibliographic, methodologic, study topic characteristics, and emerging and priority areas of two randomly selected samples of nursing doctoral dissertations from the Proquest Digital Dissertations and Theses database between January 2017 and September 2018. MethodsUsing human- (N = 101) and computer-coding (N = 242), we analyzed text data using descriptive statistics and data visualization. FindingsHealth behavior (32.7%) and quantitative sciences (17.8%) were the most common emerging and priority areas, and translation science and –omics/microbiome were absent. Health, practice, education, and leadership were four study topic themes. DiscussionThis approach may serve as a metric for the state of Ph.D. nursing education. A replication study is recommended in three to five years.

The relationship between teacher academic optimism and student academic achievement: A meta-analysis

This meta-analysis of 13 studies examines the relationship between teacher academic optimism and student academic achievement. The studies have been reached from Web of Science, ERIC, Proquest Digital Dissertations, Turkish Academic Network and Information TR Directory, Google Academic and Council of Higher Education Thesis Center databases. The correlation scores of the studies included in the meta-analysis were computed by the Fisher z method and Comprehensive Meta-Analysis V3 (CMA) Program was used. As a result, the relationship between teacher academic optimism and student academic achievement has a strong effect size with a value of 0.513 according to the random effects model. Additionally, the moderator analysis was performed for verbal and non-verbal courses. There was no statistically significant difference observed and no publication bias in the meta-analysis study. Education policy makers and school administrators can put on their agenda the strengthening of teacher academic optimism for student academic achievement.

Efficacy and safety of primary needle-knife fistulotomy in biliary cannulation: a systematic review and meta-analysis.

We aimed to conduct a systematic review and meta-analysis on the efficacy and safety of primary needle-knife fistulotomy (NFK) in biliary cannulation. An electronic bibliographic search of digital dissertation databases was performed from inception till March 2020. All prospective studies, including randomized trials evaluating the use of NFK as a primary cannulation technique in biliary cannulation, were analyzed. The primary outcome was a successful cannulation rate and the secondary outcomes were post-ERCP pancreatitis rate and overall post-ERCP complication rate. A total of four prospective studies, including three randomized trials, were included for the analysis. The pooled cannulation success rate for primary NFK was 95.7% (95% CI. 83.1-99.0, P < 0.001). When compared with standard wire-guided cannulation, the analysis did not show any difference between the two techniques in terms of cannulation success (OR, 3.59, 95% CI, 0.34-37.39; P = 0.28; low certainty of evidence). The overall rate of post-ERCP pancreatitis with primary NFK was 1.5 % (95% CI, 0.6-3.9, P < 0.001). When compared with conventional wire-guided technique, the odds of developing post-ERCP pancreatitis with NFK were 0.22 (95% CI, 0.04-1.04, P = 0.06; moderate certainty of evidence). To conclude, NKF seems to be an effective means of biliary cannulation in expert hands. Although it may be associated with a lower rate of post-ERCP pancreatitis, the current strength and quality of evidence to support its use as a primary cannulation strategy is low. It may be considered in ERCPs at higher risk of pancreatitis by experienced endoscopists.

Comparative Effectiveness of Fecal Immunochemical Tests versus Flexible Sigmoidoscopy for Colorectal Cancer Screening: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.

Fecal immunochemical tests (FITs) and flexible sigmoidoscopies are commonly used modalities for colorectal cancer (CRC) screening. We performed a systematic review and meta-analysis to compare the effectiveness of FIT and sigmoidoscopy in CRC screening. PRISMA statement and Cochrane guidelines were followed for this review. Digital dissertation databases were searched from inception till December 1st 2020 and randomized clinical trials comparing the detection rates of CRC for FIT and sigmoidoscopy were included. Outcomes for analysis included participation rates and detection rates of CRC, advanced adenomas and advanced colorectal neoplasia for both screening modalities. Five randomized clinical trials with a total of 261,755 patients were included for the analysis. The participation rate for FIT was significantly higher compared to flexible sigmoidoscopy (OR 2.11, 95% CI 1.29-3.44, p=0.003). In intention-to-screen analysis, the detection rate for advanced colorectal neoplasia was significantly lower with FIT (OR 0.62, 95% CI 0.45-0.84, p=0.002) as compared to flexible sigmoidoscopy but not statistically different for CRC (OR 1.15, 95% CI 0.65-2.02, p=0.63). Despite lower participation amongst patients, CRC screening with flexible sigmoidoscopy leads to higher detection of advanced colorectal neoplasia, when compared to a single round of fecal immunochemical testing.

Prophylactic Antibiotics Do Not Prevent Infectious Complications of Endoscopic Ultrasound Fine-Needle Aspiration of Pancreatic Cysts: A Systematic Review and Meta-Analysis.

Despite limited evidence, endoscopic societies recommend routine use of antibiotic prophylaxis for endoscopic ultrasound fine-needle aspiration of pancreatic cystic lesions. Recent studies suggest lack of benefit in this setting. Our objective is to conduct a systematic review and meta-analysis to assess the efficacy of antibiotics in prevention of infectious complications after ultrasound fine-needle aspiration of pancreatic cystic lesions. A bibliographic search of digital dissertation databases was performed from inception until March 2020. Randomized controlled trials, cohort, and case-control studies that compared prophylactic antibiotics with placebo or no therapy were included in the analysis. The primary outcome was the development of cyst infections. Secondary outcomes were incidence of fever; procedural complications such as bile leak, pancreatitis, or bleeding; and medication-related adverse events. Six studies with a total of 1683 patients were included. The overall incidence of cyst infections was 0.53%. For the primary outcome, there was no significant difference between the 2 groups (odds ratio, 0.54; 95% confidence interval, 0.16-1.82; P = 0.32). No significant difference was noted regarding other complications like fever, pancreatitis, or bile leak. In conclusion, the rate of infectious complications is very low, and antibiotic prophylaxis does not seem to confer any additional benefit in their prevention.

Mechanistic Rationale and Clinical Efficacy of Hyperbaric Oxygen Therapy in Chronic Neuropathic Pain: An Evidence-Based Narrative Review.

Background Chronic neuropathic pain is a condition affecting an increasing proportion of the general population and its management requires a comprehensive, multidisciplinary program. A growing body of evidence supports the use of hyperbaric oxygen therapy (HBOT) in several chronic neuropathic pain conditions; however, its role and efficacy remain unclear. Purpose To summarize current evidence for the mechanistic rationale of HBOT in chronic neuropathic pain conditions and to evaluate its clinical efficacy. Methods This narrative review was conducted after searching the following databases (Medline, Embase, Cochrane, PsycINFO, the Web of Science, Scopus, ClinicalTrials. gov, WHO ICTRP, and ProQuest Digital Dissertation) from January 1946 to March 2020. Articles published in English that involved either animal or human studies with acute or chronic neuropathic pain evaluating any HBOT-related intervention were included. Results A total of 2971 citations were identified. A total of 29 studies were included in this review. The mechanisms of action for HBOT use in neuropathic conditions included the primary effects of hyperoxia and edema resolution, as well as the secondary effects pertinent to the production of oxygen and nitrogen reactive species (serving as pain signaling molecules), nitric oxide-dependent release of opioid peptides, and reduction of inflammatory mediators. A robust evidence for HBOT use in the clinical setting was associated with chronic regional pain syndrome and chronic primary bladder pain syndrome. Some evidence supported its use for chronic secondary (peripheral) neuropathic pain including radiation-induced plexus neuropathies, postherpetic neuralgia, and trigeminal neuralgia. Conclusions HBOT has been shown to have antinociceptive and analgesic effects in animal models of inflammatory, neuropathic, and chronic pain. Human studies demonstrated beneficial effects of HBOT in improving clinical outcomes such as pain scores, pain-related symptoms, and quality of life. A systematic methodology of HBOT application is necessary to confirm its safety and efficacy.

A delay in colonoscopy after positive fecal tests leads to higher incidence of colorectal cancer: A systematic review and meta-analysis.

A delay in performing colonoscopies after positive fecal tests in a screening program may risk neoplastic progression. Our objective is to conduct a systematic review and meta-analysis to evaluate the effects of timing of a colonoscopy after a positive fecal test on the detection of colorectal cancer. Cochrane guidelines and PRISMA statement were followed for this review. Digital dissertation databases were searched from inception to June 1, 2020, and all studies reporting the detection rates of colorectal cancer on the basis of different time intervals between a positive fecal test and the post-test colonoscopy were included. We compared the detection rates of colorectal cancer (overall and advanced-stage) and advanced adenoma based on different time intervals. A total of 361637 patients from six observational studies were included for the analysis. The odds of detecting any colorectal cancer (odds ratio [OR] 1.58, 95% confidence interval [CI] 1.23-2.03, P<0.001), advanced-stage colorectal cancer (OR 2.16, 95% CI 1.47-3.16, P<0.001), or advanced adenomas (OR 1.17, 95% CI 1.06-1.28, P=0.001) are significantly higher if the colonoscopies are performed after 6months from a positive fecal test, compared with within 6months. There was no significant difference in the detection rates based on a 1-month, a 2-month, or a 3-month cut-off. A delay of colonoscopies beyond 6months after positive fecal tests is associated with a higher odds of detecting colorectal cancer. A timely follow up of patients with positive fecal tests is warranted.

Tissue Engineering in the Craniomandibular Region: Where Do We Stand?

The science of tissue engineering is a promising one to a craniofacial biologist with a plethora of research studies being conducted over the years. Stem cells (SCs) along with scaffolds and biological stimulants have been at the epicenter of such studies. The field has also gained importance due to prevalent drawbacks with organ transplantation, such as shortage in the number of donors coupled with other complications associated with the procedure. Moreover, it finds its applications in congenital defects as well. Several electronic databases were thoroughly researched including the Directory of Open Access Journals (DOAJ), Google scholar, Digital Dissertations and meta Register of Controlled Trials for relevant data. References and citations of articles and existing reviews were also researched. The search was confined to articles in English, published till March 2021. Casecontrol, cross-sectional, retrospective and prospective studies, systematic reviews and meta-analysis were included in this article. A hand search of the reference lists of the included articles was also carried out to include missed out articles. Here, the aim was to provide a comprehensive review of tissue engineering in general and its application in the craniomandibular region in particular to some of the potential futuristic novel methods which are being developed.

Risk prediction models for emergence delirium in paediatric general anaesthesia: a systematic review

ObjectivesEmergence delirium (ED) occurs in approximately 25% of paediatric general anaesthetics and has significant adverse effects. The goal of the current systematic review was to identify the existing literature investigating...

Promotion of Project «Antiplagiat.RSL» for Raising the Level of Russian Education and Science

Nowadays the plagiarism problem has become a real nuisance for thespheres of science and education, thus the specialists of the RussianState Library resolved to study the issue in depth. The results ofthose studies were planned to be organized in a series of articles tobe published.Purpose:The article is devoted to the key aspects connected withusage of digital collection of dissertation theses and author’s abstractstogether with the “Antiplagiat.RSL” software for plagiarism tests.There are given grounds for broadening the scope of verification byway of involving more educational and research organizations withtheir works to be studied.Materials and Methods:Using the materials of the results of theplagiarism tests carried out at the Russian State Library and havinganalyzed the foreign publications on the theme, the authors offersystematization of the common types of the borrowings revealed. Thearticle points out their routes and brings forth the prognosis of thedevelopment of Russian education and science in view of plagiarismresentment with drawing the attention of the scientific community tothe existing problem and supporting the atmosphere of intolerancetowards the very phenomenon as such.Results:The authors bring the information concerning the developmentof the digital dissertation base of the RSL. There is given characteristicsof the service offering the scientific and educational establishments ofthe nation to carry out an independent and objective examination ofthe texts to be published. The article would also prove the uniquenessof that kind of offer due to the opportunity to verification of the textsagainst the original database and to the presence of the scientificallysound methodology on which the verifications are based.Conclusions:The necessity of independent and objective evaluation ofincorrect borrowings in thesis and other research papers has long agobeen stated. Still there evidently lacks a somewhat common idea of whoand how could realize the evaluation procedure, and on which groundstoo. The Russian State Library deserves a leading position in this respectfor its possessing a rich collection of research works in Russian and inforeign languages as well. Its expertise could become a part of a certainregulation mechanism for supervising norms of academic integrity.

The Impacts of Mathematics Instructional Strategy on Students with Autism: A Systematic Literature Review

&lt;p style="text-align:justify"&gt;Mathematics is one of the most challenging subjects for many students. A similar problem is faced by special needs students, such as students with Autism Spectrum Disorder (ASD). Various instructional strategies are implemented by specialists to help ASD students understand mathematics in schools. To explore the impacts of an instructional strategy of mathematics on ASD students, the authors conducted a review of literature from 2011 to 2017 using various databases including ProQuest Digital Dissertations and Theses Full Text, Google Scholar, and Science Direct. A total of 39 articles were found. Most of the instructional strategy aimed to assist ASD students in solving mathematics problems. The implications of the study are also discussed in this literature review, which indicates that teachers need to use the appropriate instructional strategy to meet the needs of students with ASD and maximize their mathematics learning outcomes in schools.&lt;/p&gt;

Effects of Internet-based psycho-educational interventions on mental health and quality of life among cancer patients: a systematic review and meta-analysis.

To systematically review evidence regarding the benefits of Internet-based psycho-educational interventions among cancer patients. We performed a systematic review with meta-analysis and qualitative evidence synthesis. Systematic searches for published studies in English or Chinese identified eligible randomized and clinical controlled trials. The following databases were searched: Medline, Embase, CINAHL, PsycINFO, Web of Science, Cochrane Central Register of Controlled Trials (CENTRAL), Proquest Digital Dissertations, Foreign Medical Retrieval System, China National Knowledge Infrastructure, China Science and Technology Journal Database, China Wanfang Database, and Taiwanese Airiti Library. We also searched the gray literature and reviewed reference lists from relevant articles. Studies were scored for quality using the Cochrane Risk of Bias Tool. Seven eligible studies (1220 participants) were identified that used three intervention tools: website programs (n = 5), e-mail counseling (n = 1), and a single-session psycho-educational intervention (n = 1). The quality of all studies was moderate. The meta-analysis showed that Internet-based psycho-educational interventions had a significant effect on decreasing depression (standardized mean difference (SMD) - 0.58, 95% confidence interval (CI) (- 1.12, - 0.03), p = 0.04) and fatigue (mean difference (MD) - 9.83, 95% CI (- 14.63, - 5.03), p < 0.01). However, there was no evidence for effects on distress (SMD - 1.03, 95% CI (- 2.63, 0.57), p = 0.21) or quality of life (MD 1.10, 95% CI (- 4.42, 6.63), p = 0.70). Internet-based psycho-educational interventions reduce fatigue and depression in cancer patients. More rigorous studies with larger samples and long-term follow-up are warranted to investigate the effects of these interventions on cancer patient quality of life and other psychosocial outcomes.

Efficacy of Hemospray in Upper Gastrointestinal Bleeding: A Systematic Review and Meta-Analysis.

Hemospray is a non-contact modality of endoscopic hemostasis that has been used in the management of upper gastrointestinal bleeding (UGIB) with varying success. Our aim was to evaluate the efficacy of Hemospray in the management of UGIB. An electronic bibliographic search of digital dissertation databases was performed from inception till October 2019. All prospective studies, including randomized controlled trials evaluating the efficacy of Hemospray in the management of UGIB were analysed. The primary outcome was immediate haemostasis and the secondary outcome was rebleeding rate. Subgroup analyses based on etiology of UGIB (tumour-related, variceal, etc) were also performed. A total of 11 prospective studies, including 4 randomized trials were included for the analysis. The pooled immediate haemostasis rate with Hemospray was 93% (95% CI 90.3-95%, p<0.001). Rebleeding occurred in 14.4% (95% CI 8.8-22.8%, p<0.001) of patients. For the subgroup of tumour-related bleeding, the immediate haemostasis rate was 95.3% (95% CI 89.6-97.3%; p <0.001) and rebleeding rate was 21.9% (95% CI 13.9-32.7%, p <0.001). In patients with variceal bleeding, immediate haemostasis was achieved in 92.7% (95% CI 83.6-96.9%; p<0.001) of patients, with a rebleeding rate of 3.1% (95% CI 0.9-10.2%, p <0.001). Hemospray shows high immediate haemostasis and low bleeding percentages. The odds were in its favour compared to conventional endoscopic modalities, but not statistically significant. The results are undermined by the risk of bias in the studies. Nevertheless, it is an easy technique that should be further investigated with better studies.

Documenting Digital Projects: Instituting Guidelines for Digital Dissertations and Theses in the Humanities

Dissertations and theses with interactive digital components seldom fit neatly into the institutional format requirements designed for traditional humanities texts. This creates challenges for students, administrators, and librarians who are charged with preparing these works for library deposit. While disciplinary acceptance of digital dissertations in the humanities may be increasing across institutions, little attention is given to the mechanics of documenting and submitting such projects. Readers, also, are challenged to find and interpret digital projects that may not be entirely described in the accompanying paper. To address this, the authors examined a set of digital theses and dissertations at their institution to determine how these digital components might fit into traditional manuscript formatting guidelines. This article introduces the resulting set of local documentation guidelines for digital dissertations and theses aimed at improving access, preservation, and reproducibility.

Effectiveness of the Manchester Triage System on time to treatment in the emergency department: a systematic review.

The objective of this review was to synthesize the best available evidence on the effectiveness of the Manchester Triage System (MTS) on time to treatment (TtT) for patients who visit the emergency department (ED). The objectives of the MTS are to define a safe wait time for medical attention. Triage systems, such as the MTS, use criteria to ensure patient safety by determining appropriate wait times for each individual who visits the ED. The TtT is the time interval between arrival at the ED to initiation of therapeutic interventions. A short TtT is important in different clinical situations and may reduce infections and mortality. The MTS may have an impact on the TtT. This review considered studies that included any patients visiting the ED with any complaints or medical diagnoses who were triaged using the MTS by nurses or doctors, and the TtT was measured. This review considered randomized controlled trials, as well as quasi-experimental, before-and-after, case-control and analytical cross-sectional studies. Studies published after 1994 in English, Spanish, Portuguese, French and German were considered for inclusion. This systematic review was conducted in accordance with JBI methodology. The search strategy aimed to find both published and unpublished studies in MEDLINE, CINAHL, Lilacs, Web of Science, Embase, Scopus, Cochrane Central Register of Controlled Trials, Google Scholar, Banco de Teses - CAPES, and Digital Dissertations. The results of this search were assessed by one reviewer who excluded duplicate results. Titles and abstracts were screened by two independent reviewers for assessment against the inclusion criteria. The full texts of potentially eligible papers were retrieved and independently assessed by two reviewers using a standardized critical appraisal instrument from JBI. Data were extracted from studies included in the review and were presented using a narrative form. Tables were used to summarize the characteristics and findings of the studies. The review included two before-and-after studies, with a total of 2265 participants. One study was of moderate quality, and the other was of high quality. One study included only patients with acute ischemic stroke, while the other included patients with any complaint. Both studies were performed with consecutive samples. The median TtT was 10 minutes before implementing the MTS and 12 minutes after implementing the MTS in the study that included patients with any complaints. In the study including patients with acute ischemic stroke, the median TtT decreased by 15 minutes after implementing the MTS (from 75 to 60 minutes). Because of the heterogeneity in the characteristics of the populations of the two studies, the results could not be pooled. The MTS reduced the median TtT for patients triaged at the highest priority levels (orange and yellow), but it did not decrease the median TtT in all patients. The existing evidence base regarding the effectiveness of the MTS comes from two studies with methodological limitations that could not be pooled. The evidence indicates the MTS may confer benefit to some patients who visit the ED by reducing TtT, but not for all patients. Further research is needed before firm conclusions can be made.

La Calidad Percibida por el Cliente del Servicio Hotelero. Una Revisión Bibliográfica

Este artículo analiza las principales concepciones teóricas sobre los aspectos conceptuales de la calidad percibida del servicio en hoteles. La revisión bibliográfica alcanza desde el año 1985 hasta el año 2018. Se han incluido publicaciones físicas y digitales, provenientes de libros, tesis y artículos científicos, relativos al servicio hotelero. Entre los conceptos estudiados se trata la conceptualización de calidad de servicio hotelero y las variables relacionadas con calidad percibida del servicio. Se propuso como objetivo general conceptualizar la calidad percibida por el cliente del servicio hotelero y como objetivos específicos: 1. Conceptualizar la calidad del servicio hotelero y 2. Analizar las variables relacionadas con la calidad percibida del servicio. Se arribó a las siguientes conclusiones: los postulados básicos considerados en la calidad percibida del servicio en hoteles deben tomar en cuenta las expectativas y las percepciones de los clientes, incluir los comportamientos poscompra del cliente, medirse en función de las características de los clientes y adaptarlos al servicio hotelero y al entorno actual; los fundamentos teóricos y prácticos en relación a la calidad percibida del servicio en hoteles aún son muy limitados; calidad percibida del servicio en hoteles, a diferencia del concepto clásico, es “la diferencia que encuentran los clientes de un hotel al comparar lo que recibió frente a lo que esperó; una actitud, diferente a la satisfacción específica y equivalente a la satisfacción global, que es considerada una variable multidimensional que debe tomar en cuenta las expectativas deseadas y/o las esperadas y las percepciones de los clientes, medirse en función de las características de los clientes, adecuadas al entorno y de manera continua.”

Beyond forest plots: clinical gestalt and its influence on COPD telemonitoring studies and outcomes review

BackgroundChronic obstructive pulmonary disease (COPD) is a progressive chronic condition. Improvements in therapies have resulted in better patient outcomes. The use of technology such as telemonitoring as an additional intervention...

Perancangan Aplikasi Skripsi Online Menggunakan Algoritma String Matching Knuth Morris-Pratt Pada Fakultas Teknik Universitas Islam Sumatera Utara

&lt;p&gt;&lt;em&gt;This Online Thesis application aims to save a collection of theses at the Islamic University of North Sumatra in the form of electronic files and distributed so that they can be accessed and read online by visitors but cannot be copied files. This system has a facility to record user activities to find out visitor statistics, theses that are read frequently, browser statistics used by users and pages accessed by users, and has a fast search facility and detailed search for users. The article discusses how to design and implement Knuth Morris-Pratt String Matching Algorithm in the Online Thesis Application that is able to handle the storage of thesis files on the server in the form of Portable Document format (PDF) which is converted into Flipbook form using Turn Js as a tool in making flipbook display. This system was developed using PHP, MySql, and HTML5. The results obtained are a Web-based Online Thesis Application that features a flipbook that can help library management in managing digital theses, knowing which pages visitors are visiting, theses that are often read, and knowing visitor statistics. And can provide information about existing digital thesis and help library visitors in finding and reading digital thesis online.&lt;/em&gt;&lt;/p&gt;&lt;p&gt;&lt;em&gt; &lt;/em&gt;&lt;/p&gt;&lt;p&gt;&lt;em&gt;Keywords: thesis, flipbook, String Matching Knuth Morris-Pratt&lt;/em&gt;&lt;/p&gt;

The effect of linguistic comprehension instruction on generalized language and reading comprehension skills: A systematic review.

The effect of linguistic comprehension instruction on generalized language and reading comprehension skills: A systematic review.

Health outcomes of iron supplementation and/or food fortification in iron-replete children aged 4\u201324\xa0months: protocol for a systematic review and meta-analysis

BackgroundDirect supplementation or food fortification with iron are two public health initiatives intended to reduce the prevalence of iron deficiency (ID) and iron deficiency anaemia (IDA) in 4–24-month-old infants. In most high-income countries where IDA prevalence is < 15%, the recommended daily intake levels of iron from supplements and/or consumption of fortified food products are at odds with World Health Organisation (WHO) guidelines that recommend shorter-term (3 months/year) supplementation only in populations with IDA prevalence > 40%. Emerging concerns about delayed neurological effects of early-life iron overexposure have raised questions as to whether recommended guidelines in high-income countries are unnecessarily excessive. This systematic review will gather evidence from supplementation/fortification trials, comparing health outcomes in studies where iron-replete children did or did not receive additional dietary iron; and determine if replete children at study outset were not receiving additional iron show changes in haematological indices of ID/IDA over the trial duration.MethodsWe will perform a systematic review of the literature, including all studies of iron supplementation and/or fortification, including study arms with confirmed iron-replete infants at the commencement of the trial. This includes both dietary iron intervention or placebo/average dietary intakes. One reviewer will conduct searches in electronic databases of published and ongoing trials (Medline, Web of Science, Scopus, CENTRAL, EBSCO [e.g. CINAHL Complete, Food Science and Technology s], Embase, ClinicalTrials.gov, ClinicalTrialsRegister.eu and who.it/trialsearch), digital theses and dissertations (WorldCat, Networked Digital Library of Theses and Dissertations, DART-Europe E-theses Portal, Australasian Digital Theses Program, Theses Canada Portal and ProQuest). For eligible studies, one reviewer will use a data extraction form, and a second reviewing entered data for accuracy. Both reviewers will independently perform quality assessments before qualitative and, if appropriate, quantitative synthesis as a meta-analysis. We will resolve any discrepancies through discussion or consult a third author to resolve discrepancies. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement will be used as the basis for reporting.DiscussionRecommended iron supplementation and food fortification practices in high-income countries have been criticised for being both excessive and based on outdated or underpowered studies. This systematic review will build a case for revisiting iron intake guidelines for infants through the design of new trials where health effects of additional iron intake in iron-replete infants are the primary outcome.Systematic review registrationPROSPERO CRD42018093744.