Structural changes in the components of the global socio-economic development, conditions of instability limiting Russia’s access to international financial resources, technology, low activity of industrial enterprises in the development of knowledge-intensive areas of production determine the need for improvements in technology creation and innovation diffusion in the framework of the national innovation system through the use of competency centers potential in various areas of expertise for the development and introduction of advanced science and technology in the practice of economic activity of industrial enterprises. As part of our proposed development of an innovative concept the central place is occupied by the phenomenon of innovation diffusion, which is associated with the spread of product and process innovation through the system of information, economic, organization and management links between all elements and subsystems of the national innovation system. When speaking on innovation diffusion the E. Rogers point of view, who defined the innovation diffusion as a process by which an innovation goes in time and space through communication channels among the participants of the socio-economic system has become classic. The author’s model of innovation diffusion, taking into account the specifics of the Russian Federation, is a relationship of six members: 1) RD 2) large, small and medium businesses; 3) the State; 4) technological centers of excellence; 5) offshore design and programming centers; 6) regional engineering centers. According to the authors, the current world market requires a model of diffusion of innovations, which is the combination of technology transfer and knowledge spillover, based on the type of multilateral networking. The novelty of the proposed model of innovation diffusion lies in the fact that the theoretical models of innovation diffusion of other authors did not take into account the peculiarities of innovations diffusion in each country, and in particular, the authors of the model take into account the innovation diffusion only for the Russian Federation in modern conditions. The proposed measures for the innovation diffusion in the Russian Federation are based on the analysis of statistical indicators to measure technology transfer for the 2010–2014, collected by the Federal Service of State Statistics from the «balance of payments for technology» form.