This study extensively elaborates the approach towards making ease in 3D milling of Titanium Alloy Grade 5; by adapting the controlled parameters and specific strategies in cutting tool encroachment in milling. Every manufacturer is anxious about the machinability index (20%) of Ti6Al4V, which affects the machining efficiency proportionally. During machining, Phase alteration above the 8820C produces a Beta lamellar equiaxed microstructure, which is hard; also, limited thermal conductivity allows the generated heat towards the cutting tool to lead the Thermo-assisted wear. Higher temperatures also initiated chemically eagerness of Ti6Al4V and reacted with cutting tool edge and escorts towards catastrophic failure. The difficult Machinability demonstrates the detrimental notable effect on the cutting tool's health and follows the Ti6Al4V surface quality. The Cooling methods can flush out chips and frictional heat with ample lubrication, desirably controlling the worse effect of Machinability to some extent blissfully. The cutting tool material and coating, has chemically inert and excellent thermal conductivity with an aggressive rake angle with higher relief angle, improves the shearing tendency of Ti6Al4V by avoiding smearing, ultimately speculated surface quality with desired Tool life through higher Machining efficiency in milling.