Differential Mean Research Articles

MethylDMV: SIMULTANEOUS DETECTION OF DIFFERENTIAL DNA METHYLATION AND VARIABILITY WITH CONFOUNDER ADJUSTMENT.

DNA methylation has emerged as promising epigenetic markers for disease diagnosis. Both the differential mean (DM) and differential variability (DV) in methylation have been shown to contribute to transcriptional aberration and disease pathogenesis. The presence of confounding factors in large scale EWAS may affect the methylation values and hamper accurate marker discovery. In this paper, we propose a exible framework called methylDMV which allows for confounding factors adjustment and enables simultaneous characterization and identification of CpGs exhibiting DM only, DV only and both DM and DV. The proposed framework also allows for prioritization and selection of candidate features to be included in the prediction algorithm. We illustrate the utility of methylDMV in several TCGA datasets. An R package methylDMV implementing our proposed method is available at http://www.ams.sunysb.edu/~pfkuan/softwares.html#methylDMV.

Preparation of Future Teachers for the Organization of Profile Training in 12-Year School

The leading ideas of profile educat ion at the junct ion of high and general school pedagogy and peculiarit ies of t raining pedagogical shot in Kazakhst an for it s implem ent at ion in t he t ransit ion t o 12 - year educat ion are considered in t he art icle. Profile educat ion is a means of different iat ion and individualizat ion of learning, allowing t aking int o account changes in t h e st ruct ure, cont ent and organizat ion of the educat ional process, more fully consider t he int erest s, apt it udes and abilit ies of st udent s, t o creat e condit ions for the pupils according t o their professional int erest s and int ent ions to cont inue educat ion. T he purpose of profile educat ion in the schools of Kazakhst an is to creat e condit ions for t he development and implement at ion of individual educat ional programs for senior school pupils. T he purpose of t he present st udy is t o present t heoret ical just ificat ion and pract ical check of struct ure and the cont ent of preparat ion of fut ure t eachers t o the organizat ion of profile t raining in 12-year school in Kazakhst an.