Abstract Background: Early Childhood Caries (ECC) is a prevalent dental condition among children under six years, characterized by tooth decay linked to microbial interaction with sugary substances. ECC poses significant health risks, including pain, infections, and tooth loss, impacting oral health and overall well-being. Objective: This systematic review and meta-analysis aims to comprehensively evaluate the epidemiology of Early Childhood Caries (ECC) in Nigeria. The study seeks to consolidate existing literature, assess study quality, and analyze data on ECC prevalence, distribution, and severity across different regions of Nigeria. Methods: Following Meta-Analysis of Observational Studies in Epidemiology (MOOSE) guidelines, databases including PubMed/MEDLINE, Cochrane, Scopus, and African Journals Online were systematically searched. Inclusion criteria encompass cross-sectional and cohort studies reporting ECC prevalence in healthy Nigerian children under six. Data extraction will utilize standardized protocols, focusing on WHO criteria such as dmft scores and caries severity. Quality assessment will be conducted using the Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Prevalence Studies. Results: Initial searches identified a scarcity of comprehensive studies, predominantly from southern Nigeria, highlighting the absence of national-level data on ECC in Nigeria. Data synthesis will explore geographic and demographic factors influencing ECC prevalence and severity, aiming to provide a holistic understanding of the disease burden. Conclusion: This review addresses the critical gap in ECC epidemiology within Nigeria, aiming to inform targeted interventions and policy decisions. By synthesizing available data, the study aims to contribute towards improving oral health outcomes among Nigerian children.
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