Abstract

BackgroundThe private sector plays a large role in malaria treatment provision in Nigeria. To improve access to, and affordability of, quality-assured artemisinin-based combination therapy (QA-ACT) within this sector, the Affordable Medicines Facility-Malaria began operations in 2010 and transitioned to a private sector co-payment mechanism (PSCM) until 2017. To assess the impact of the scheme on the ACT market, cross-sectional household and outlet surveys were conducted in 2018 to coincide with the final stockages of ACT medicines procured under the PSCM.MethodsAn outlet survey was conducted targeting private pharmacies and Proprietary and Patent Medicine Vendors (PPMVs) across different regions of Nigeria to assess supply-side market factors related to availability and cost of anti-malarials, including artemisinin-based combinations subsidised under the PSCM (called green leaf ACT on account of their green leaf logo) and those not subsidised (non-green leaf ACT). A concurrent household survey was conducted to determine demand-side factors related to treatment-seeking practices, ACT brand preference and purchase decision. Data were compared with previous ACTWatch surveys to consider change over time.ResultsAvailability of artemisinin-based combinations increased significantly over the PSCM period and was almost universal by the time of the 2018 market survey. This increase was seen particularly among PPMVs. While the cost of green leaf ACT remained relatively stable over time, the cost of non-green leaf ACT reduced significantly so that by 2018 they had equivalent affordability. Unsubsidised brands were also available in different formulations and dosages, with double-strength artemisinin-based combination reported as the most frequently purchased dosage type, and child artemisinin-based combinations popular in suspension and dispersible forms (forms not subsidised by the PSCM).ConclusionsThe PSCM had a clear impact on increasing not only the reach of subsidized QA brands, but also of non-subsidised brands. Increased market competition led to innovation from unsubsidised brands and large reductions in costs to make them competitive with subsidised brands. Concerns are drawn from the large market share that non-QA brands have managed to gain as well as the continued market share of oral artemisinin monotherapies. Continued monitoring of the market is recommended, along with improved local capacity for QA-certification and monitoring.

Highlights

  • The private sector plays a large role in malaria treatment provision in Nigeria

  • The actual sample size of outlets achieved in the field differed to the planned sample size because of unavailability of pharmacies in rural areas; from a planned 116 pharmacies in rural areas, only 36 were sampled

  • Only 207 Proprietary and Patent Medicine Vendors (PPMVs) were sampled in rural areas compared to the 270 originally planned

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Summary

Introduction

Affordability of, quality-assured artemisinin-based combination therapy (QA-ACT) within this sector, the Affordable Medicines Facility-Malaria began operations in 2010 and transitioned to a private sector co-payment mechanism (PSCM) until 2017. Many populations most afflicted with malaria are in remote rural areas with limited access to health facilities [5,6,7]. These populations are often served by a variety of healthcare providers including public health facilities, private hospitals, pharmacies, drug stores and roaming traders [8]. While public health care provision can be controlled and monitored by national malaria control programmes, private channels are often unregulated and case management practices unsupervised. There is increasing recognition that in order to reach many population groups, engagement with the private sector is needed in order to harmonize diagnostic and treatment methods, reduce the prevalence of substandard and counterfeit drugs, and ensure the removal of mono-artemisinin drugs and other antimalarials no longer recommended as first-line treatment [9, 10]

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