Differences In Status Research Articles

Diversity of ESI-MS Based Phosphatidylcholine Profiles in Basidiomycetes.

Phosphatidylcholines (PC) are the main membrane lipid constituents comprising more than 50% of total glycerophospholipids. They coordinate a number of cell functions, particularly cell growth, homeostasis, secretion, recognition and communication. In basidial fungi PC are synthesized via the Kennedy pathway as well as through methylation of phosphatidylethanolamines (PE) and then undergo remodeling in Lands cycle that replaces fatty acids in PC molecules. The molecular profile of PC is determined by the genetic features that are characteristic for every species and depend on the environment. Here we present the results of ESI-MS based analyses of PC profiles of 38 species of basidiomycetes belonging to Agaricales (12), Polyporales (17), Russulales (5), Gleophyllales (2), Cantharellales (1), Auriculariales (1), Phallales (1). Although the variety of PC molecular species of basidiomycetes is rather diverse (20–38 molecular species in every profile), only 1–3 main molecular species represent 70–90% of total PC content. The most abundant of them are C36:4 and C36:3, followed by C34:1, C34:2, C36:5, C36:2. In the majority of basidiomycetes, C36:4 reaches up to 50–70% of total PC molecular species. Based on the results of hierarchical cluster analysis four main types of PC profiles which characterized the studied fungi independently from their taxonomic position, ecology, trophic status, and hyphal differentiation have been revealed. Comparative analyses of studied fungi using PCA method have shown that species of Polyporales differ from those of Agaricales by higher variability of PC profiles.

International View on Preventive Measures to Combat the Metabolic Syndrome Development in Children

This review analyzes the published data on preventive measures to combat the metabolic syndrome (MS) development in children. Recent international studies discuss various risks and territorial differentiation in health status of children with MS. Such databases as PubMed, SCOPUS and Web of Science were used for literature review. It consists of 12 sources, all articles were published between 2020 and 2021. This issue is studied very poorly and requires additional clinical research and identification of new aspects of preventive measures to combat the development of MS in children. The discussion of this topics and further study of the modern aspects of preventive measures of this syndrome are crucial for the timely MS diagnosis and implementation of modern prevention methods due to its wide prevalence, high socio-economic significance, and deteriorating quality of life of children with MS and obesity.

Development and external validation of a prediction model for overall survival after resection of distal cholangiocarcinoma.

Various prognostic factors are associated with overall survival (OS) after resection of distal cholangiocarcinoma (dCCA). The objective of this study was to develop and validate a prediction model for 3-year OS after pancreatoduodenectomy for dCCA. The derivation cohort consisted of all patients who underwent pancreatoduodenectomy for dCCA in the Netherlands (2009-2016). Clinically relevant variables were selected based on the Akaike information criterion using a multivariate Cox proportional hazards regression model, with model performance being assessed by concordance index (C-index) and calibration plots. External validation was performed using patients from the Belgium Cancer Registry (2008-2016), and patients from two university hospitals of Southampton (U.K.) and Verona (Italy). Independent prognostic factors for OS in the derivation cohort of 454 patients after pancreatoduodenectomy for dCCA were age (HR 1.02, 95% CI 1.01-1.03), pT (HR 1.43, 95% CI 1.07-1.90) and pN category (pN1: HR 1.78, 95% CI 1.37-2.32; pN2: HR 2.21, 95% CI 1.63-3.01), resection margin status (HR 1.79, 95% CI 1.39-2.29) and tumour differentiation (HR 2.02, 95% CI 1.62-2.53). The prediction model was based on these prognostic factors. The optimism-adjusted C-indices were similar in the derivation cohort (0.69), and in the Belgian (0.66) and Southampton-Verona (0.68) validation cohorts. Calibration was accurate in the Belgian validation cohort (slope = 0.93, intercept = 0.12), but slightly less optimal in the Southampton-Verona validation cohort (slope = 0.88, intercept = 0.32). Based on this model, three risk groups with different prognoses were identified (3-year OS of 65.4%, 33.2% and 11.8%). The prediction model for 3-year OS after resection of dCCA had reasonable performance in both the derivation and geographically external validation cohort. Calibration slightly differed between validation cohorts. The model is readily available via www. pancreascalculator.com to inform patients from Western European countries on their prognosis, and may be used to stratify patients for clinical trials.

Neurology in the psychiatric patient: how to think about differentials in altered mental status and diagnoses not to miss – CORRIGENDUM

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Social hierarchies and social networks in humans.

Across species, social hierarchies are often governed by dominance relations. In humans, where there are multiple culturally valued axes of distinction, social hierarchies can take a variety of forms and need not rest on dominance relations. Consequently, humans navigate multiple domains of status, i.e. relative standing. Importantly, while these hierarchies may be constructed from dyadic interactions, they are often more fundamentally guided by subjective peer evaluations and group perceptions. Researchers have typically focused on the distinct elements that shape individuals’ relative standing, with some emphasizing individual-level attributes and others outlining emergent macro-level structural outcomes. Here, we synthesize work across the social sciences to suggest that the dynamic interplay between individual-level and meso-level properties of the social networks in which individuals are embedded are crucial for understanding the diverse processes of status differentiation across groups. More specifically, we observe that humans not only navigate multiple social hierarchies at any given time but also simultaneously operate within multiple, overlapping social networks. There are important dynamic feedbacks between social hierarchies and the characteristics of social networks, as the types of social relationships, their structural properties, and the relative position of individuals within them both influence and are influenced by status differentiation.This article is part of the theme issue ‘The centennial of the pecking order: current state and future prospects for the study of dominance hierarchies’.

Transformation of a female gender identity in South Korea

The goal of this article is to determine a female gender identity in South Korea in the period of traditional society and its transformation till the present time. Identification is carried out on the basis of historical analysis of the most important aspects of cultural and social life. A female gender identity formation is closely related to basic Korean social constituencies such as mentality, national character, state gender policy, values and religious ideas that have an impact on differentiation of gender roles, position and status. It is concluded that gender relationship is an indicator of the civility level. The mechanisms of particular gender sequence formation in the context of different historical periods contribute to uncovering gender relationship peculiarities and general patterns of a Korean female identity transformation.

Differentiation And Equalization In Wage Policy In Russia Throughout The XX Century

The article examines the relationship between the principles of equalization and differentiation in the wage policy in Russia throughout the 20th century, and reveals the factors that caused the changes. Particular attention is paid to the analysis of theoretical concepts justifying wage differences. It is shown that the interaction of differentiation and equalization in wages has undergone a gradual evolution from the dominance of differentiation based on professional skills and qualifications at the beginning of the century to a symbiosis of extremely high status differentiation and a predominantly equalizing approach to differences in professional skills and qualifications during the transition to a free market system and its development

ЧИННИКИ ІНФРАГУМАНІЗАЦІЇ РОСІЯН ТА БІЛОРУСІВ У СПРИЙНЯТТІ УКРАЇНЦІВ

This paper delves into the complexities of intergroup dynamics, specifically focusing on how Ukrainians perceive citizens of countries implicated in largescale invasion, namely Russia and Belarus. The research seeks to illuminate the subjective experiences of Ukrainians in terms of primary and secondary emotions, and further quantifies the extent of infrahumanization--a subtler form of dehumanization--towards these out-groups. The theoretical section of the study elaborates on the concept of infrahumanization and its significance in the context of group identification, differential group status, and the legitimacy and stability of these factors. It provides an insightful understanding of how group identities are formed, the importance of status differentials between groups, and the measures of their perceived legitimacy and stability. The empirical investigation estimates the infrahumanization levels towards Russians and Belarusians, examines the perceived legitimacy and stability of status differences between Ukrainians and these out-groups, and assesses the strength of Ukrainian group identification. The results reveal a marked degree of infrahumanization towards Russians and Belarusians. Infrahumanization of Russians correlates predictably with Ukrainian identity, perceptions of Russians' antagonistic attitudes (legitimacy) towards Ukrainians, stability of status, and personal experiences of positive communications with Russians. In contrast, the study found no significant correlations when examining infrahumanization of Belarusians.

Power dynamics in organisations and the role of information systems

Power dynamics in organisations and the role of information systems

Heart rate variability analysis of students with different motor activity levels

Relevance. Assessment of the functional state of the body is one of the leading tasks of physiology. The article deals with the analysis of the initial vegetative status of students with different levels of motor activity. Materials and Methods. Registration and analysis of the heart rate variability was carried out with the help of a modern complex electrophysiological laboratory CONAN - 4.5. The heart activity of students engaged in physical culture within the educational process was evaluated on the basis of heart rate variability analysis. Results and Discussion. It was revealed that among the entire studied array of students (with the differentiation of the initial vegetative status calculated according to muscle tension index), normotonics are characterized by an optimal ratio between the parasympathetic and sympathetic divisions of the autonomic nervous system. At the same time, the value of the coefficient of physical activity in the studied group was determined at the level of 1.730.1. Conclusion. For vagotonics, the value of the triangular index was 2.50.2 conventional units (CU), which confirms the idea of an increase in the influence on the autonomic nervous system. The value for normotonics is 2.20.1 CU. This group was characterized by the balance between the sympathetic and parasympathetic parts of the autonomic nervous system. In sympathicotonics - 1.90.5 CU, which confirms the idea of increasing the influence of the sympathetic division of the autonomic nervous system. In hypersympathicotonics-1.10.4 CU. To ensure adequate functioning of the cardiovascular system and for normal adaptation to physical exertion in students, it is necessary to form a level of motor activity that quantitatively corresponds to a coefficient of physical activity of at least 1.75.

A Tale of Two Hierarchies: Interactive Effects of Power Differentiation and Status Differentiation on Team Performance

Scholars have long wrestled with whether hierarchical differentiation is functional or dysfunctional for teams. Building on emerging research that emphasizes the distinction between power (i.e., control over resources) and status (i.e., respect from others), we aim to help reconcile the functional and dysfunctional accounts of hierarchy by examining the effects of power differentiation on team performance, contingent on status differentiation. We theorize that power differentiation is dysfunctional for teams with high status differentiation by increasing knowledge hiding, which undermines team performance. In contrast, we predict that power differentiation is functional for teams with low status differentiation by decreasing knowledge hiding, which improves team performance. In a field study, we found that power differentiation harmed team performance via knowledge hiding in teams with high status differentiation, but power differentiation had no effect on knowledge hiding or performance in teams with low status differentiation. In an experiment, we again found that power differentiation harmed team performance by increasing knowledge hiding in teams with high status differentiation. However, power differentiation improved team performance by decreasing knowledge hiding in teams with status equality. Finally, in a third study, we confirm the role of status differentiation in making team climates more competitive and examine the effect of power-status alignment within teams, finding that misalignment exacerbates the dysfunctional effects of power differentiation in teams with high status differentiation. By examining how power and status hierarchies operate in tandem, this work underscores the need to take a more nuanced approach to studying hierarchy in teams. Funding: This research is partially supported by the National Natural Science Foundation of China [Grants 71572079 and 71872086]. Supplemental Material: The online appendix is available at https://doi.org/10.1287/orsc.2021.1540 .

Socio-cultural Perspective of Senior Citizens Health Status in Nepal

This study examines the elderly people’s health status differentials according to selected background variables on the basis of Ageing Survey 2014. The general objective of the study is to identify the health status of elderly people in socio-cultural perspective. This study examined the associations of different twelve socio-cultural factors with combination of health outcome (Good or Bad) in older age by applying the cross tables, Chi squire test and binary logistic regression analysis. These variables are selected on the basis of theoretical and empirical studies sighted in the literature reviews. This research is find out only three major socio-cultural factors that make variation determine in the health status of elderly people in Nepal. General literacy status does not impact the elderly health situation in Nepal so high level education need to elderly to improve health status of elderly. Highly appreciating and follow up elderly advices help to increase health status of elderly so it should be utilized in most societies of Nepal. Only Kirat religion elderly are found to be in good health condition than Hindu religion. So other religions of Nepal have not significant impact on health status of elderly compare to Hindu religion.

Neurology in the psychiatric patient: how to think about differentials in altered mental status and diagnoses not to miss

SUMMARYA wide variety of neurological conditions may present first to a psychiatrist and it is important to be aware of these in differential diagnosis. A careful history, examination and a broad differential diagnosis can help set up an appropriate management plan – with room to change if things change in unexpected ways. In this article we explore common ground shared by psychiatry and neurology and show how incorporation of neurological knowledge can improve the practice of psychiatry. Using four fictional case vignettes of altered mental status we explore important neurological differential diagnoses which could present to the Psychiatrist.

Tumor response as defined by iRECIST in gastrointestinal malignancies treated with PD-1 and PD-L1 inhibitors and correlation with survival

BackgroundAtypical tumor response patterns during immune checkpoint inhibitor therapy pose a challenge to clinicians and investigators in immuno-oncology practice. This study evaluated tumor burden dynamics to identify imaging biomarkers for treatment response and overall survival (OS) in advanced gastrointestinal malignancies treated with PD-1/PD-L1 inhibitors.MethodsThis retrospective study enrolled a total of 198 target lesions in 75 patients with advanced gastrointestinal malignancies treated with PD-1/PD-L1 inhibitors between January 2017 and March 2021. Tumor diameter changes as defined by immunotherapy Response Evaluation Criteria in Solid Tumors (iRECIST) were studied to determine treatment response and association with OS.ResultsBased on the best overall response, the tumor diameter ranged from − 100 to + 135.3% (median: − 9.6%). The overall response rate was 32.0% (24/75), and the rate of durable disease control for at least 6 months was 30.7% (23/75, one (iCR, immune complete response) or 20 iPR (immune partial response), or 2iSD (immune stable disease). Using univariate analysis, patients with a tumor diameter maintaining a < 20% increase (48/75, 64.0%) from baseline had longer OS than those with ≥20% increase (27/75, 36.0%) and, a reduced risk of death (median OS: 80 months vs. 48 months, HR = 0.22, P = 0.034). The differences in age (HR = 1.09, P = 0.01), combined surgery (HR = 0.15, P = 0.01) and cancer type (HR = 0.23, P = 0.001) were significant. In multivariable analysis, patients with a tumor diameter with a < 20% increase had notably reduced hazards of death (HR = 0.15, P = 0.01) after adjusting for age, combined surgery, KRAS status, cancer type, mismatch repair (MMR) status, treatment course and cancer differentiation. Two patients (2.7%) showed pseudoprogression.ConclusionsTumor diameter with a < 20% increase from baseline during therapy in gastrointestinal malignancies was associated with therapeutic benefit and longer OS and may serve as a practical imaging marker for treatment response, clinical outcome and treatment decision making.

Regional Differentiation and Influencing Factor Analysis of Residents' Psychological Status during the Early Stage of the COVID-19 Pandemic in South China.

A scientific understanding of the impact of COVID-19 on the psychological status of residents is important for improving medical services and responding to public health emergencies. With the help of some of the most popular network communication tools (including Wechat and Weiboand QQ), online questionnaires were completed by South China citizens during the early stage of the COVID-19 pandemic based on psychological stress theory and using a comprehensive sampling method. Through cooperation with experts from other institutions, the content of the questionnaire was designed to include interviewees’ spatial locations and individual information, identify whether negative emotions were generated, and determine the level of psychological stress and the degree of perception change, etc. According to the data type, mathematical statistics and multiple logistic regression methods were used to examine regional differentiation and influencing factors regarding the psychological stress of residents using 1668 valid questionnaires from 53 municipal administrative units in South China. The results firstly showed that over the whole area there was typical regional differentiation in South China, especially in relation to negative expression and psychological stress, with this feature reflecting the dual urban–rural structure. Secondly, regional differences were obvious. Residents of Hainan showed stronger change of psychological stress than those of the other two provinces. In contrast, Guangdong residents were the least psychological stress, and the concept of a harmonious relationship between human beings and nature was not accepted as well as in the other two provinces. Thirdly, in each province the capital city acted as the regional pole, with greater psychological status. This polarization effect decreased with greater distance, reflecting the theory of growth poles in human geography. Fourthly, gender, education level, occupation, informational correction, and the possibility of infection were notable factors that affected the psychological status of interviewees facing COVID-19. However, the functions were different and were decided by the dependent variable. Lastly, based on conclusions summarized from three perspectives, it was found that regional differentiation, public information, and social structure need to focused upon in order to handle sudden major health issues.

Surgical treatment of chest wall tumors

The term chest wall tumor summarizes aheterogeneous group of malignant and benign tumors, whereby primary and secondary chest wall tumors are differentiated. The incidence of secondary chest wall tumors is higher than that of primary tumors. Primary chest wall tumors can arise from any anatomic structure of the chest wall. Surgical resection is usually the treatment of choice. Resection status and tumor differentiation are relevant prognostic factors. Treatment of secondary chest wall tumors is performed depending on the patient's symptoms and prognosis of the underlying disease. Lung carcinomas infiltrating the chest wall can be resected primarily or secondarily as part of multimodal therapeutic strategies. Anatomic lung resections combined with chest wall resection have ahigher mortality than standard resections. Chest wall reconstruction after resection has the goal of reducing paradoxical respiratory motion, although not every chest wall defect requires reconstruction.

Правовое положение субъекта правоотношений в сфере добычи (производства), переработки, хранения, транспортировки, распределения, оборота и использования энергетических ресурсов: действующее законодательство и проблемные вопросы

Present article is devoted to the legal status of subjects of legal relations in the field of fuel and energy in the current legislation. It is an attempt to identify common legal features of business entities (other economic activities) that carry out such fundamentally different, but at the same time interrelated activities as extraction (production), processing, storage, transportation, distribution, turnover and use of energy resources. The author offers a distinction between the concepts of a subscriber and a consumer of energy resources, in connection with which they are offered a definition of a subscriber. The author also points out such a unique feature of the subjects of the fuel and energy complex as the differentiation of the legal status of the consumer of energy resources into the legal status of the consumer-a citizen and the legal status of the consumer-a legal entity, and touches on the problems of arbitrability of disputes in the fuel and energy sector.

Hyperglycemia Altered DNA Methylation Status and Impaired Pancreatic Differentiation from Embryonic Stem Cells.

The prevalence of type 2 diabetes (T2D) is rapidly increasing across the globe. Fetal exposure to maternal diabetes was correlated with higher prevalence of impaired glucose tolerance and T2D later in life. Previous studies showed aberrant DNA methylation patterns in pancreas of T2D patients. However, the underlying mechanisms remained largely unknown. We utilized human embryonic stem cells (hESC) as the in vitro model for studying the effects of hyperglycemia on DNA methylome and early pancreatic differentiation. Culture in hyperglycemic conditions disturbed the pancreatic lineage potential of hESC, leading to the downregulation of expression of pancreatic markers PDX1, NKX6−1 and NKX6−2 after in vitro differentiation. Genome-wide DNA methylome profiling revealed over 2000 differentially methylated CpG sites in hESC cultured in hyperglycemic condition when compared with those in control glucose condition. Gene ontology analysis also revealed that the hypermethylated genes were enriched in cell fate commitment. Among them, NKX6−2 was validated and its hypermethylation status was maintained upon differentiation into pancreatic progenitor cells. We also established mouse ESC lines at both physiological glucose level (PG-mESC) and conventional hyperglycemia glucose level (HG-mESC). Concordantly, DNA methylome analysis revealed the enrichment of hypermethylated genes related to cell differentiation in HG-mESC, including Nkx6−1. Our results suggested that hyperglycemia dysregulated the epigenome at early fetal development, possibly leading to impaired pancreatic development.

The Changing Spousal Differentials in Socio-demographic Characteristics in Malaysia

This paper uses matched couple data from the 1991, 2000, and 2010 population censuses to examine the changes in spousal differentials in age, education, and work status, as well as inter-ethnic and international marriages. The general trend is one of decreasing spousal age and educational gaps between 1991 and 2010. Although older-man younger-woman marriages still predominated, the spousal age gap decreased from 4.6 years to 3.9 years, and the proportion of marriages in which the husband was more than 6 years older than the wife declined from 30% to 24%. Educational homogamy (couples having the same educational level) rose from 53% to 64%, while the proportion of women marrying someone of higher education declined from 33% to 21%. Inter-ethnic marriage hovered around 4.2% throughout the study period, after rising from less than 1% in the 1980s. International marriages made up about 1.2% of all marriages in 2010, up from 0.8% in 1991. The labour force participation rate of married women had increased significantly, resulting in the rise of dual-income households. The changing spousal differentials in socio-demographic characteristics are bound to alter gender roles and relations that will impact Malaysia’s family institution and demographic outcomes.

Transdisciplinary Approach for Bioinformatics Education in Southern Brazil

The development and application of bioinformatics has been growing steadily, but its learning and training has been lagging. We have approached this problem through a bi-annual event, called EGB (Escola Gaúcha de Bioinformática), dedicated to undergraduate and graduate students (mainly from biology, biomedicine, chemistry, physics, and computer sciences), as well as professionals, to mingle and be presented to bioinformatics from sequence, structure, and computational standpoints simultaneously. The interactive environment provided by EGB allows for participants mingling, independently from their training background, fostering collaborative learning and experience exchange. Both lecturers and students are encouraged to collaborate and communicate, with no formal acknowledgement of “status differentiation”.