Dietary Niacin Intake Research Articles

Altered Gut Microbiota and Shift in Bacteroidetes between Young Obese and Normal-Weight Korean Children: A Cross-Sectional Observational Study.

Emerging data suggest that the gut microbiome is related to the pathophysiology of obesity. This study is aimed at characterizing the gut microbiota composition between obese and normal-weight Korean children aged 5-13. We collected fecal samples from 22 obese and 24 normal-weight children and performed 16S rRNA gene sequencing using the Illumina MiSeq platform. The relative abundance of the phylum Bacteroidetes was lower in the obese group than in the normal-weight group and showed a significant negative correlation with BMI z-score. Linear discriminative analysis (LDA) coupled with effect size measurement (LEfSe) analysis also revealed that the Bacteroidetes population drove the divergence between the groups. There was no difference in alpha diversity, but beta diversity was significantly different between the normal-weight and obese groups. The gut microbial community was linked to BMI z-score; blood biomarkers associated with inflammation and metabolic syndrome; and dietary intakes of niacin, sodium, vitamin B6, and fat. The gut microbiota of the obese group showed more clustering of genera than that of the normal-weight group. Phylogenetic investigation of communities by reconstruction of unobserved states (PICRUSt) analysis revealed that the functions related to carbohydrate and lipid metabolism in the microbiota were more enriched in the normal-weight group than in the obese group. Our data may contribute to the understanding of the gut microbial structure of young Korean children in relation to obesity. These findings suggest that Bacteroidetes may be a potential therapeutic target in pediatric obesity.

Obesity and Dietary intake of Nutrients among ElderlyPopulation: A Study in an Urban Community

Background Obesity is an important area of health concern in the elderly population due to its association with chronic diseases. There is a scarcity of studies on association of obesity with dietary intake of nutrients which help to detect nutritional needs of the elderly. Objectives To find out the association of obesity with dietary intake of nutrients among elderly population.Methodology The present community-based study was undertaken in the urban field practice area of medical college by involving 247 elderly ge60 years subjects. Anthropometric measurements such as height and weight were recorded to calculate BMI. Diet survey was conducted by involving subsample of 30 elderly subjects from obese and non-obese group. Household of the elderly subject was visited to collect data on 24-hour recall method for three consecutive days using standard guidelines and procedures.Results Total of 62.3 of elderly were having obesity and mean dietary intake of nutrients such as protein P0.0001 fat P0.0001 carbohydrate P0.0001 energy P0.0001 calcium P0.0001 phosphorus P0.0001 riboflavin P0.000 niacin P0.0008 and folic acid P0.0001 per day were significantly higher in obese than non-obese group.Conclusions Dietary intake of protein fat carbohydrate energy calcium phosphorus riboflavin niacin and folic acid was significantly high among obese elderly population.nbsp

Dietary intake of thiamine, riboflavin and niacin among adults aged 65 and above in 15 provinces(autonomous regions and municipalities) in China in 2015

To assess the intake of thiamine, riboflavin and niacin and estimate the association between the adequacy of intake of those three B-vitamins and risk factors among older Chinese adults. A total of 3222 adults aged 65 and above with completed dietary data were derived from the 2015 survey of China Nutritional Transition Cohort Study 2015. The total subjects. Dietary data was recorded by three consecutive days with 24-hour recalls. The intake of those three B-vitamins were assessed by comparing with Chinese dietary thiamine, riboflavin and niacin reference intakes. The food sources of three vitamins were analyzed. Multivariate Logistic regression was used to estimate adjusted odds ratios for factors associated with the inadequacy of intake of those three vitamins. The median daily intake of thiamine, riboflavin and niacin was 0. 8, 0. 7 and 12. 8 mg in males, and 0. 7, 0. 6 and 10. 9 mg in females, respectively. Adults aged 80 and above and living in the southern regions were more likely to have inadequate thiamine intake than adults aged 65-79 and living in northern regions, respectively. Adults had inadequate intake of riboflavin were more likely to be living in a village and adults with lower education levels than adults living in a city and adults with higher education levels. In males, adults had inadequate intake of niacin were more likely to be 80 years and above, with lower education levels, living in the northern regions, living in a village and with the lowest income. In females, adults had inadequate intake of niacin were more likely to be with lower education, living in northern regions and living in a village. About 80% adults were at the risk of the inadequate intake of thiamine and riboflavin in China. Age, education, income, regions and areas of residence were associated with the intake of thiamine, riboflavin and niacin.

Urinary Excretion of N1-Methylnicotinamide, as a Biomarker of Niacin Status, and Mortality in Renal Transplant Recipients.

Renal transplant recipients (RTR) commonly suffer from vitamin B6 deficiency and its functional consequences add to an association with poor long-term outcome. It is unknown whether niacin status is affected in RTR and, if so, whether this affects clinical outcomes, as vitamin B6 is a cofactor in nicotinamide biosynthesis. We compared 24-h urinary excretion of N1-methylnicotinamide (N1-MN) as a biomarker of niacin status in RTR with that in healthy controls, in relation to dietary intake of tryptophan and niacin as well as vitamin B6 status, and investigated whether niacin status is associated with the risk of premature all-cause mortality in RTR. In a prospective cohort of 660 stable RTR with a median follow-up of 5.4 (4.7–6.1) years and 275 healthy kidney donors, 24-h urinary excretion of N1-MN was measured with liquid chromatography-tandem mass spectrometry LC-MS/MS. Dietary intake was assessed by food frequency questionnaires. Prospective associations of N1-MN excretion with mortality were investigated by Cox regression analyses. Median N1-MN excretion was 22.0 (15.8–31.8) μmol/day in RTR, compared to 41.1 (31.6–57.2) μmol/day in healthy kidney donors (p < 0.001). This difference was independent of dietary intake of tryptophan (1059 ± 271 and 1089 ± 308 mg/day; p = 0.19), niacin (17.9 ± 5.2 and 19.2 ± 6.2 mg/day; p < 0.001), plasma vitamin B6 (29.0 (17.5–49.5), and 42.0 (29.8–60.3) nmol/L; p < 0.001), respectively. N1-MN excretion was inversely associated with the risk of all-cause mortality in RTR (HR 0.57; 95% CI 0.45–0.71; p < 0.001), independent of potential confounders. RTR excrete less N1-MN in 24-h urine than healthy controls, and our data suggest that this difference cannot be attributed to lower dietary intake of tryptophan and niacin, nor vitamin B6 status. Importantly, lower 24-h urinary excretion of N1-MN is independently associated with a higher risk of premature all-cause mortality in RTR.

Dietary Inflammatory Index Was Higher in Patients with Schizophrenia (P12-042-19)

ObjectivesThe aim of this study is to compare dietary intakes and dietary inflammatory index (DII) between normal subjects and patients with schizophrenia. MethodsTotal 306 subjects (139 controls and 167 patients with recent-onset schizophrenia spectrum disorder) were participated in this analysis. Dietary intakes of nutrients were analyzed from responses of a 76-items semi-quantitative food frequency questionnaire using CAN-Pro 5.0 software, and DII scores were estimated based on the analyzed results of dietary intakes. The total DII scores were calculated from dietary intakes of nutrients unadjusted or adjusted by energy contents. Then, dietary habit, nutritional intakes, and the DII score were compared between controls and schizophrenia group. Odds ratios (ORs) for schizophrenia and correlation between DII and related clinical data were analyzed by logistic regression analysis and Pearson’s correlation test, respectively. ResultsThere was a significant difference in body mass index between controls (22.49 ± 3.07 kg/m2) and schizophrenia subjects (24.27 ± 5.18 kg/m2) (P = 0.001). Schizophrenia group had remarkably higher energy intake and lower dietary intakes in omega-6 polyunsaturated fatty acids (PUFAs), linoleic acids, niacin, and vitamin E compared with control group (P < 0.05). And, dietary intakes of PUFAs, n-6 PUFAs, linoleic acid, and niacin in male schizophrenia subjects were significantly lower than those in male controls (P < 0.05). Moreover, compared with the female controls, dietary intakes of folate, vitamin A, Fe, and Zn were significantly lower in the female schizophrenia group (P < 0.05). The total DII scores adjusted by energy contents were significantly higher in schizophrenia group compared with control group (P = 0.002). The subjects in high DII category had a significantly higher ORs for schizophrenia compared with those in low DII category in total (OR 1.945, 95% CI: 1.232–3.070, P = 0.004) and in male subjects (OR 2.929, 95% CI: 1.528–5.621, P = 0.001). ConclusionsOur study demonstrated that subjects with schizophrenia had higher DII scores, suggesting the possible link between dietary inflammation and schizophrenia. Funding Sources-

Dietary Niacin Intake Predicts the Decrease of Liver Fat Content During a Lifestyle Intervention

Niacin inhibits fatty acid flux from adipose tissue to liver, reduces hepatic triglyceride synthesis and increases hepatic lipid oxidation. Thus, niacin may have a role in the regulation of liver fat content in humans. We tested if dietary intake of niacin predicts change of liver fat content during a lifestyle intervention. To this end, we estimated the composition of diet from diaries of 202 healthy subjects at risk of type 2 diabetes undergoing lifestyle intervention comprising physical activity and diet counselling. Total-, subcutaneous- and visceral adipose tissue mass were measured by magnetic resonance (MR) tomography and liver fat content by 1H-MR spectroscopy at baseline and after 9 months of follow-up. Among fat compartments, liver fat content showed the largest decrease (−32%, p < 0.0001). High baseline niacin intake predicted a larger decrease of liver fat (p = 0.004). Subjects in the highest quartile of niacin intake at baseline also had the largest decrease of liver fat (1st:−10%; 2nd:−27%; 3rd:−35%; 4th:−37%). Among 58 subjects with nonalcoholic fatty liver disease (NAFLD) at baseline, NAFLD resolved in 23 subjects during the lifestyle intervention. For one standard deviation increase in niacin intake, the odds ratio for resolution of NAFLD was 1.77 (95% CI, 1.00–3.43). High dietary niacin intake may have a favorable effect on the reduction of liver fat during lifestyle intervention.

Dietary Intake and Food Sources of Niacin, Riboflavin, Thiamin and Vitamin B₆ in a Representative Sample of the Spanish Population. The Anthropometry, Intake, and Energy Balance in Spain (ANIBES) Study †.

Thiamin, riboflavin, niacin, and vitamin B6 are essential micronutrients that are mainly involved in energy metabolism; they may prevent the occurrence of developmental abnormalities and chronic degenerative and neoplastic diseases. The aim was to analyze dietary intake and food sources of those four nutrients in subjects (n = 2009) aged 9–75 years old from the Spanish ANIBES (Anthropometric data, macronutrients and micronutrients intake, practice of physical activity, socioeconomic data and lifestyles in Spain) study. Dietary data were collected by means of a validated, photo-based three-day dietary food record. Underreporting was analysed according to the European Food and Safety Authority (EFSA, Parma, Italy) protocol. Mean (max–min) reported intake for the whole population of thiamin was 1.17 ± 0.02 mg/day, (0.30–3.44 mg/day), riboflavin 1.44 ± 0.02 mg/day, (0.37–3.54 mg/day), niacin 29.1 ± 0.2 mg/day (6.7–109 mg/day), and vitamin B6 1.54 ± 0.01 mg/day (0.28–9.30 mg/day). The main sources of intake for thiamin, niacin, and vitamin B6 were meat and meat products, and for riboflavin were milk and dairy products. An elevated percentage of the Spanish ANIBES population meets the EFSA recommended intakes for thiamin (71.2%), riboflavin (72.0%), niacin (99.0%), and vitamin B6 (77.2%).

Targeted Microbiome Intervention by Microencapsulated Delayed-Release Niacin Beneficially Affects Insulin Sensitivity in Humans.

Gut microbiota represent a potential novel target for future prediabetes and type 2 diabetes therapies. In that respect, niacin has been shown to beneficially affect the host-microbiome interaction in rodent models. We characterized more than 500 human subjects with different metabolic phenotypes regarding their niacin (nicotinic acid [NA] and nicotinamide [NAM]) status and their gut microbiome. In addition, NA and NAM delayed-release microcapsules were engineered and examined in vitro and in vivo in two human intervention studies (bioavailability study and proof-of-concept/safety study). We found a reduced α-diversity and Bacteroidetes abundance in the microbiome of obese human subjects associated with a low dietary niacin intake. We therefore developed delayed-release microcapsules targeting the ileocolonic region to deliver increasing amounts of NA and NAM to the microbiome while preventing systemic resorption to avoid negative side effects (e.g., facial flushing). In vitro studies on these delayed-release microcapsules revealed stable conditions at pH 1.4, 4.5, and 6.8, followed by release of the compounds at pH 7.4, simulating the ileocolonic region. In humans in vivo, gut-targeted delayed-release NA but not NAM produced a significant increase in the abundance of Bacteroidetes. In the absence of systemic side effects, these favorable microbiome changes induced by microencapsulated delayed-release NA were associated with an improvement of biomarkers for systemic insulin sensitivity and metabolic inflammation. Targeted microbiome intervention by delayed-release NA might represent a future therapeutic option for prediabetes and type 2 diabetes.

Micronutrient Dietary Intake in Latina Pregnant Adolescents and Its Association with Level of Depression, Stress, and Social Support.

Adolescent pregnant women are at greater risk for nutritional deficits, stress, and depression than their adult counterparts, and these risk factors for adverse pregnancy outcomes are likely interrelated. This study evaluated the prevalence of nutritional deficits in pregnant teenagers and assessed the associations among micronutrient dietary intake, stress, and depression. One hundred and eight pregnant Latina adolescents completed an Automated Self-Administered 24-hour dietary recall (ASA24) in the 2nd trimester. Stress was measured using the Perceived Stress Scale and the Prenatal Distress Questionnaire. Depressive symptoms were evaluated with the Reynolds Adolescent Depression Scale. Social support satisfaction was measured using the Social Support Questionnaire. More than 50% of pregnant teenagers had an inadequate intake (excluding dietary supplement) of folate, vitamin A, vitamin E, iron, zinc, calcium, magnesium, and phosphorous. Additionally, >20% of participants had an inadequate intake of thiamin, riboflavin, niacin, vitamin B6, vitamin B12, vitamin C, copper, and selenium. Prenatal supplement inclusion improved dietary intake for most micronutrients except for calcium, magnesium, and phosphorous, (>50% below the Estimated Average Requirement (EAR)) and for copper and selenium (>20% below the EAR). Higher depressive symptoms were associated with higher energy, carbohydrates, and fats, and lower magnesium intake. Higher social support satisfaction was positively associated with dietary intake of thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, vitamin C, vitamin E, iron, and zinc. The findings suggest that mood and dietary factors are associated and should be considered together for health interventions during adolescent pregnancy for the young woman and her future child.

Low dietary intake of n-3 fatty acids, niacin, folate, and vitamin C in Korean patients with schizophrenia and the development of dietary guidelines for schizophrenia

Inappropriate dietary intake and poor nutritional status are reported to be associated with metabolic syndrome and psychopathology in patients with schizophrenia. We hypothesized that inappropriate dietary habits and insufficient dietary intake of specific nutrients are associated with schizophrenia. To test the hypothesis, we assessed the dietary habits and nutritional intake of patients with schizophrenia and then developed suitable dietary guidelines. In total, 140 subjects (73 controls and 67 patients with schizophrenia from community mental health centers) were included, and dietary intakes were analyzed using a semi-quantitative food frequency questionnaire. As a result, the proportion of overweight or obese patients was significantly higher in schizophrenia subjects (64.2%) compared with control subjects (39.7%) (P=.004). The male schizophrenia patients had significantly lower dietary intakes of protein, polyunsaturated fatty acids (PUFAs), vitamin K, niacin, folate, and vitamin C than the male control subjects. In all multiple logistic regression models, subjects with the “low” dietary intake of protein, n-3 PUFAs, niacin, folate, and vitamin C had a significantly higher odds ratios for schizophrenia compared with those with the “high” dietary intake category of each nutrient. Therefore, maintenance of a healthy body weight and sufficient dietary intake of protein, PUFAs, niacin, folate, and vitamin C are recommended for Korean patients with schizophrenia.

Abstract CT138: Increasing dietary rice bran and navy bean intake for colorectal cancer control and prevention: A randomized-controlled pilot investigation

Abstract Adhering to the American Institute for Cancer Research (AICR) Recommendations for Cancer Prevention, including increasing dietary intake of whole grains and beans, has been shown to reduce colorectal cancer (CRC) burden. Dietary rice bran (RB) and navy beans (NB) are examples of these foods with high dietary fiber content and other important phytochemicals that have inhibited colon carcinogenesis in animal and human epidemiological studies. Alongside widespread affordability and accessibility, we formed a community-academic partnership to advance RB and NB dietary chemoprevention research in a pilot phase II study titled BENEFIT: Beans/Bran Enriching Nutritional Eating For Intestinal health Trial (NCT01929122). We established feasibility of increased consumption in CRC survivors and examined changes in dietary intake and gut microflora. Twenty-nine participants completed the 4-week, randomized-controlled dietary intervention that included consuming RB (30g/day), NB powder (35g/day), or neither (control) via study provided meals and snacks. Fasting blood, urine, and stool were collected at baseline, 2-week, and 4-week time points. The amount of RB or NB consumed (ranging from 4-9% daily caloric intake) led to increased dietary fiber, iron, zinc, thiamin, niacin, vitamin B6, folate, and alpha-tocopherol intake, as measured by NutritionistProTM. Stool microbiome analysis from RB group showed significant genus level increases in Methanobrevibacter, Paraprevotella, Ruminococcus, and Bifidobacterium compared to the control group, as well as increased gut bacterial richness and diversity. The NB group increased gut bacterial richness and revealed increases in three previously unidentified species. Plasma, urine, and stool metabolome changes revealed increases in a number of microbial, host, and diet derived metabolites, such as phytosterols, fatty acids, amino acids, bile acids, and small molecule byproducts of carbohydrate metabolism. In addition, human stool metabolite extracts were assessed before and after RB or NB consumption to observe reduced growth of CRC cells. Dietary biomarkers of RB and NB consumption are under investigation and have revealed specific metabolite profiles including pyridoxine (vitamin B6), beta-hydroxyisovaleroylcarnitine and beta-hydroxyisovalerate (RB), and pipecolate and S-methylcysteine (NB). These results support dietary RB or NB modulation of metabolism from digestion, microbiota, and microbial biotransformation. Our pilot findings warrant further evaluation of these specific foods in a larger cohort and for a longer duration of consumption to assess CRC control and prevention markers in the colon tissue. Next phase studies underway include dietary modulation of human colonic inflammation for CRC chemoprevention. Citation Format: Erica C. Borresen, Renee C. Oppel, Dustin G. Brown, Regina J. Brown, Elizabeth P. Ryan. Increasing dietary rice bran and navy bean intake for colorectal cancer control and prevention: A randomized-controlled pilot investigation [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr CT138. doi:10.1158/1538-7445.AM2017-CT138

Infant Adiposity is Independently Associated with a Maternal High Fat Diet but not Related to Niacin Intake: The Healthy Start Study.

Objectives Over-nutrition during pregnancy resulting from maternal obesity or an unhealthy diet can lead to excess infant adiposity at birth. Specific dietary macro- and micronutrients have been shown to increase fat cell development in both in-vitro and in-vivo models and may therefore link maternal diet to increased infant adiposity. We hypothesized that high maternal dietary niacin intake during pregnancy, especially in combination with a high-fat diet (HFD) would increase infant adiposity. Methods We included 1040 participants from a pre-birth cohort of mother-infant pairs. Maternal diet was assessed using multiple 24-hour dietary recalls. HFD was defined as ≥30% of calories from fat and ≥12% of fat calories from saturated fat. Neonatal body composition (% fat mass [%FM], fat mass [FM], fat-free mass [FFM]) was measured by PEAPOD. We used multivariate regression to assess the joint effect of maternal dietary niacin and maternal HFD on neonatal body composition. Results Dietary niacin was not associated with neonatal body composition, and maternal HFD did not modify this finding. However, maternal HFD was independently associated with %FM (β = 0.8 [0.1, 1.4]%, p < 0.01] and FM (β = 32.4 [6.7, 58.0] g, p < 0.01).Conclusions for Practice Our results suggest that a HFD during pregnancy may increase infant adiposity, therefore supporting the need for improved diet counseling of pregnant women at both the clinical and community levels.

The association of sleep quality and insomnia with dietary intake of tryptophan and niacin

Introduction: Dietary intake of tryptophan and niacin have been related to sleep. However, the sleep-promoting effects of these nutrients are still under investigation. The aim of the current study was to examine the relationship between daily dietary intake of tryptophan and niacin and sleep. Materials and methods: A survey on past week's dietary intake (food frequency questionnaire)was completed by N = 509 Dutch university students (20.8 years old). The SLEEP-50 questionnaire subscale on insomnia was completed, and sleep quality (0-10 score) and total sleep time (TST) were also assessed. Daily intake of tryptophan and niacin was correlated to insomnia rating, sleep quality and TST using nonparametric (Spearman) correlations. Analyses were conducted for the group as a whole, and for men (N = 143) andwomen (N = 366) separately. Results: Mean [SD] scores of insomnia (14.6 [4.3]), sleep quality (7.3 [1.2]), TST (7.7 h [0.9]), and daily dietary intake of tryptophan (0.618 g [0.3]) and niacin (15.88 mg[6.7])were within normal ranges. Insomnia scores correlated significantlywith dietary intake of tryptophan (r = -0.180, p = 0.0001) and niacin (r = -0.157, p = 0.001). When controlling for total caloric intake, the partial correlation between tryptophan intake and insomnia remained significant (r = -0.105, p = 0.029). Niacin intake also correlated significantly with sleep quality (r = .094, p = 0.045). No significant correlation was found with TST. In men, insomnia scores correlated significantly with dietary intake of tryptophan (r = -0.287, p = 0.002) or niacin (r = -0.243, p = 0.008). Sleep quality scores also correlated significantly with dietary intake of tryptophan (r = 0.205, p = 0.026) and niacin (r = -0.240, p = 0.008). In women, none of the correlations were significant. Conclusion: A modest but significant association was found between dietary intake of tryptophan and niacin and insomnia and sleep quality. The nature and causes of the observed gender differences require further investigation.

Dietary vitamin intake correlates with hearing thresholds in the older population: the Korean National Health and Nutrition Examination Survey

Previous animal studies have shown that vitamins may prevent age-related hearing loss. However, no concrete conclusions have been reached about the association between vitamin intake and presbycusis in humans. We investigated the association between dietary vitamin intake and hearing thresholds in adults between 50 and 80 y of age by using data from a large population-based survey. We used data from the 2011 Korea National Health and Nutrition Examination Survey. A pure-tone audiogram and physical examination of the ear were performed, and vitamin intake was calculated by using the 24-h recall method. Data from 1910 participants were analyzed through univariate and multivariate linear regression analyses. After adjustment for age, sex, smoking, and exposure to occupational and explosive noise, intake of vitamin C correlated with better hearing at midfrequency (2000 and 3000 Hz) (coefficient: -0.012; 95% CI: -0.022, -0.002). Dietary supplement use was positively associated with better hearing at all frequencies. The univariate analysis indicated that dietary intakes of retinol, riboflavin, niacin, and vitamin C were positively correlated with better hearing at most frequencies. In contrast, serum concentrations of vitamin D were associated with worse hearing at mid and high (4000 and 6000 Hz) frequencies. Dietary intake of vitamin C was associated with better hearing in the older population. Because less than one-half of elderly participants in this study consumed a sufficient amount of vitamins, and vitamin intake decreased with age, we should consider proper diet counseling to prevent hearing decline.

Vascular endothelial function and oxidative stress are related to dietary niacin intake among healthy middle-aged and older adults

We tested the hypothesis that vascular endothelial function and oxidative stress are related to dietary niacin intake among healthy middle-aged and older adults. In 127 men and women aged 48-77 yr, brachial artery flow-mediated dilation (FMD) was positively related to dietary niacin intake [%change (Δ): r = 0.20, P < 0.05; mmΔ: r = 0.25, P < 0.01]. In subjects with above-average dietary niacin intake (≥ 22 mg/day, NHANES III), FMD was 25% greater than in subjects with below-average intake (P < 0.05). Stepwise linear regression revealed that dietary niacin intake (above vs. below average) was an independent predictor of FMD (%Δ: β = 1.8; mmΔ: β = 0.05, both P < 0.05). Plasma oxidized low-density lipoprotein, a marker of systemic oxidative stress, was inversely related to niacin intake (r = -0.23, P < 0.05) and was lower in subjects with above- vs. below-average niacin intake (48 ± 2 vs. 57 ± 2 mg/dl, P < 0.01). Intravenous infusion of the antioxidant vitamin C improved brachial FMD in subjects with below-average niacin intake (P < 0.001, n = 33), but not above-average (P > 0.05, n = 20). In endothelial cells sampled from the brachial artery of a subgroup, dietary niacin intake was inversely related to nitrotyrosine, a marker of peroxynitrite-mediated oxidative damage (r = -0.30, P < 0.05, n = 55), and expression of the prooxidant enzyme, NADPH oxidase (r = -0.44, P < 0.01, n = 37), and these markers were lower in subjects with above- vs. below-average niacin intake [nitrotyrosine: 0.39 ± 0.05 vs. 0.56 ± 0.07; NADPH oxidase: 0.38 ± 0.05 vs. 0.53 ± 0.05 (ratio to human umbilical vein endothelial cell control), both P < 0.05]. Our findings support the hypothesis that higher dietary niacin intake is associated with greater vascular endothelial function related to lower systemic and vascular oxidative stress among healthy middle-aged and older adults.

Dietary intake and major food sources of niacin in adults living in South Korea

To estimate niacin intakes and major food sources of Korean adults, three consecutive 24‐hour recalls were collected from 167 healthy adults, aged 20–64y, living in Seoul and metropolitan area, Gumi, and Kwangju, Republic of Korea, during November, 2011 – March, 2012. The mean daily niacin intake was 15.57/5.93 mg NE (mean/SD). There was no significant difference in niacin intake by gender. Foods from animal and plant sources provided 47% and 53%, respectively, of the total niacin intake. The top 10 major dietary sources of niacin were pork, rice, beef, Korean Chinese cabbage kimchi, mandarin, mackerel, rice cake, chicken, yellow croaker, and dried anchovy. As for major dietary sources of niacin, the top 10 foods provided 45% of total niacin intake and the top 30 foods contributed 67% of niacin intake. The Korean adults consuming less the Korean Estimated Average Requirements for niacin was 18% of total subjects and 40% had niacin intakes less than Recommended Nutrient Intakes. Therefore, some of Korean adults in this study had inadequate intake of niacin. Korean adults need to be encouraged to consume niacin‐rich foods such as pork, beef, kimchi, mandarin, and mackerel. Supported by 2012 research fund of National Research Foundation of Korea: 2012R1A1A2A04669745

Dietary, Anthropometric, Biochemical and Psychiatric Indices in Shift Work Nurses

Objectives: The aim of this study was to compare nutrients intake, anthropometric, biochemical and psychiatric indices between shift working and day-time nurses. Methods: A cross-sectional comparative study was conducted in which ninety eight female nurses (55 day-time workers and 43 shift workers) from six educational hospitals of Jondi-Shapour University of medical sciences, Ahvaz, Iran were participated. A questionnaire including dietary, anthropometric, disease history and lifestyle pattern questions was completed and 3-day 24-hour recalls, Beck Depression Inventory (BDI) and Hospital Anxiety and Depression Scale (HADS) were collected. Serum hs-CRP and 25(OH)D3 concentrations were measured by immunoturbidimetric and electrochemiluminescent immunoassay method, respectively. Anthropometric indices were measured according to World health organization standard protocol. Independent sample t and chi-square tests were used for statistical analysis. Results: There was a lower dietary intake of thiamin, riboflavin, niacin, folate, magnesium and iron in shift worker compared with day-time nurses (p 3 levels, vitamin D deficiency percentage, hemoglobin and hematocrite concentrations, and also anthropometric and psychiatric variables were found between two groups. Duration of exposure to sunlight was significantly higher in shift workers than in day time nurses. Engagement time in weekly physical exercise was around 11 times greater in day-time nurses compared with the shift work nurses (p = 0.001). Conclusions: This study showed that shift working is associated with some nutritional deficiencies and sedentary lifestyle among female nurses.

Higher Dietary Niacin Intake is Related to Greater Vascular Endothelial Function Associated with Lower Oxidative Stress Among Healthy Middle‐Aged and Older Adults

Endothelium‐dependent dilation (EDD) is impaired with age due in part to decreased activity of the nicotinamide adenine dinucleotide (NAD)‐dependent histone deacetylase sirtuin‐1. We hypothesized that EDD would be related to dietary intake of the NAD precursor niacin among middle‐aged and older (MA/O) adults. In 156 healthy adults aged 45–78, EDD (brachial artery flow‐mediated dilation, FMD) was positively related to self‐reported dietary niacin intake (%Δ: r=0.19, P=0.02). This difference persisted after accounting for clinical characteristics using multiple regression analysis (r=0.16, P=0.04). In a subset of subjects, inhibition of superoxide (infusion of ascorbic acid) improved FMD in niacin insufficient (dietary intake ≤16mg, n=8, 3.7±1.1 vs. 4.7±0.9%, P&lt;0.01), but not sufficient (&gt;16mg, n=19, 5.4±0.5 vs. 5.9±0.6%, P=0.10) adults. Moreover, niacin intake was inversely related to arterial endothelial cell expression of the superoxide‐producing enzyme NADPH oxidase (n=37, r=−0.44, P=0.01). Endothelium‐independent dilation (sublingual nitroglycerin), a measure of vascular smooth muscle sensitivity to nitric oxide, did not differ between groups (P&gt;0.05). These findings suggest that higher dietary niacin intake is associated with greater vascular endothelial function linked to lower oxidative stress among healthy MA/O adults.NIH AG013038, AG006537, AG000279, UL1 RR025780

Serum taurine and risk of coronary heart disease: a prospective, nested case–control study

Taurine (2-aminoethanesulfonic acid), a molecule obtained from diet, is involved in bile acid conjugation, blood pressure regulation, anti-oxidation and anti-inflammation. We performed the first prospective study of taurine and CHD risk. We conducted a case-control study nested in the New York University Women's Health Study to evaluate the association between circulating taurine levels and risk of coronary heart disease (CHD). Taurine was measured in two yearly pre-diagnostic serum samples of 223 CHD cases and 223 matched controls and averaged for a more reliable measurement of long-term taurine levels. Mean serum taurine was positively related to age and dietary intake of poultry, niacin, vitamin B1, fiber and iron, and negatively related to dietary intake of saturated fat (all p values ≤ 0.05). There was no statistically significant association between serum taurine levels and the risk of CHD in the overall study population. The adjusted ORs for CHD in increasing taurine tertiles were 1.0 (reference), 0.85 (95% CI, 0.51-1.40) and 0.66 (0.39-1.13; p for trend = 0.14). There was a significant inverse association between serum taurine and CHD risk among women with high total serum cholesterol (>250 mg/dL) (adjusted OR = 0.39 (0.19-0.83) for the third versus first tertile; p for trend = 0.02) but not among those with low total serum cholesterol (p for interaction = 0.01). The data suggest a possible inverse association of serum taurine with diabetes and hypertension risk. The findings suggest that high levels of taurine may be protective against CHD among individuals with high serum cholesterol levels.

Intakes and adequacy of potentially important nutrients for cognitive development among 5-year-old children in the Seychelles Child Development and Nutrition Study.

To assess the nutritional adequacy of Seychellois children in relation to nutrients reported to be important for cognitive development. Dietary intakes were assessed by 4 d weighed food diaries and analysed using dietary analysis software (WISP version 3·0; Tinuviel Software, UK). Individual nutrient intakes were adjusted to usual intakes and, in order to investigate adequacy, were compared with the UK Estimated Average Requirements for children aged 4-6 years. Children 5 years old were followed up as part of the Seychelles Child Development Nutrition Study (SCDNS), located in the high-fish-consuming population of Mahé, Republic of Seychelles. Analysis was carried out on a sample of 229 children (118 boys, 111 girls). Children consumed a diet of which fortified cereal and milk products contributed the most to nutrient intakes. The majority (≥80 %) of children met requirements for several nutrients important for child development including Fe, folate and Se. Adjusted dietary intakes of Cu, Zn, iodine, niacin and vitamin A were below the Estimated Average Requirement or Recommended Nutrient Intake. Mean adjusted energy intakes (boys 4769 kJ/d (1139·84 kcal/d), girls 4759 kJ/d (1137·43 kcal/d)) were lower than the estimated energy requirement (boys 5104 kJ/d (1220 kcal/d), girls 5042 kJ/d (1205 kcal/d)) for 88 % of boys and 86 % of girls. Nutrition was adequate for most children within the SCDNS cohort. Low intakes of some nutrients (including Zn, niacin and vitamin A) could reflect nutritional database inaccuracies, but may require further investigation. The study provides valuable information on the adequacy of intakes of nutrients which could affect the growth and development of Seychellois children.