The research was carried out to assess the biological and economic effectiveness of the new two-component herbicide Hors D, KS (220 g/l dicamba (sodium salt) and 50 g/l nicosulfuron) of LLC “Agro Expert Group” on corn crops in Krasnodar Krai. The experiments were carried out in the field conditions of All-Russian Research Institute of Biological Plant Protection in 2018-2019 according to the methodological guidelines for registration tests of herbicides in agriculture. The soil is leached chernozem. The area of the plots is 25 m2, the repetition rate is 4 times, the flow rate of the working fluid is 200 l/ha. The experimental scheme included the use of the tested herbicide Hors D, KS in the application rates of 0.6; 0.8 and 1.2 l/ha. Carleone preparation was used as a standard, EC (0.3 and 0.6 l/ha) and control (without herbicides). The treatment was carried out in the phase of 3...5 leaves of the culture. The contamination of corn crops averaged 83 copies/m2. The herbicidal effect of the drugs was assessed by reducing the number and weight of weeds, as well as by the crop yield in comparison with the control. Weeds: common hedgehog, glaucous bristle, ragweed wormwood, tilted backward and Californian cocklebur showed a high sensitivity to drugs. The use of 0.6...1.2 l/ha of Hors D, KS led to an 80 ... 100% herbicidal effect. There was no negative effect of the drug for corn plants, crop yield increases were obtained, which amounted to 62.0...74.7% of the control. The obtained data for two years showed high biological and economic efficiency of the herbicide Hors D, KS against annual dicotyledonous and cereal weeds in corn crops