This paper presents the results of a study of self-sustained processes excited in a Helmholtz resonator after a flow over its orifice. A comparative analysis of various approaches to the numerical modeling of this problem was carried out, taking into account both the requirements for achieving the required accuracy and taking into account the resource greediness of calculations, the results of which were verified by comparison with data obtained during a special experiment. The configuration with a spherical resonator with a natural frequency of 260 Hz and an orifice diameter (about 5 cm) in an air flow with a speed of 6 to 14 m/s was considered. A comparison of the calculation results with data obtained in experiments carried out in the wind tunnel demonstrated that the accuracy of calculations of the characteristics of the self-sustained mode using the simplest URANS class model tends to the accuracy of calculations within the large eddy simulation approach formulated in the WMLES model. At the same time, when using WMLES, it is possible to better reproduce the background level of pulsations. From the point of view of resource greediness, expressed in the number of core hours spent obtaining a solution, both models of the turbulence turned out to be almost equivalent when using the same grid models.