Introduction: Social media has been used at major medical conferences to inform professionals and the public of the latest research presented. Major gastroenterological (GI) conferences have encouraged using Twitter as a primary discussion platform, though disease-specific trends during conference periods has yet to be fully elucidated. Methods: Data relevant to GI and GI-related disease dialogue on Twitter was obtained via Symplur.com for three annual GI conferences: Digestive Disease Week (DDW), the Annual Meeting for the American College of Gastroenterology (ACG), and The Liver Meeting (AASLD) between 2012 and 2016. GI diseases studied were identified using corresponding hashtags (#IBS, #Crohns, #Cirrhosis, #Hepatitis, #Obesity and #GERD). Parameters included Twitter impressions, tweets, tweeting participants and tweets per hour. Trends in disease-specific discussion across years was determined using ANOVA. Two-sample t-tests were used to compare discussion during conference periods to a length-matched, non-conference period selected in January. Results: All GI diseases saw significant increases in discussion from 2012 to 2016 across all parameters as demonstrated on ANOVA. The only two GI conditions to demonstrate a significant difference in mean number of impressions during conference periods as compared to non-conference periods were #Crohns (8989827 vs. 5001764, p= 0.012) and #Hepatitis (20748021 vs. 9425036, p=0.013). During conference periods more tweets were noted for these two conditions (#Crohns: 822.4 vs. 476.3, p=0.006; #Hepatitis: 3606.5 vs. 2233.2, p=0.0008) as well as a greater number of tweeting participants (#Crohns: 1976.2 vs. 1234.2, p=0.019; #Hepatitis: 1636.4 vs. 1011.2, p=0.008). No significant differences were detected between conference and non-conference periods for other GI conditions. Conclusion: GI conditions have seen significant global increases in discussion and reach at major conferences over time. Reach appears to be augmented during conference weeks for Crohn's disease and hepatitis, though may be due to more participants and more tweets suggesting greater professional discussion during the meeting in addition to baseline Twitter discussion by members of the general public. Significant differences were not observed with other GI or GI-related conditions, likely owing to less professionally discrete hashtags, such as #Obesity. Utilization of disease-specific hashtags to isolate professional dialogue during conferences warrants further investigation.Table: Table. Two-sample t-test of Twitter impressions during conference periods vs. non-conference periods
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