Diagnosis System Research Articles

Evaluating the effectiveness of artificial intelligence imaging in the qualitative diagnosis of pulmonary nodules

Our study aimed to evaluate the effectiveness of artificial intelligence (AI) image diagnostic systems in the qualitative diagnosis of pulmonary nodules. We analyzed 291 cases from June 2023 to January 2024 at Chongqing University Three Gorges Hospital. All patients in the study underwent low-dose chest computed tomography scans, which identified lung nodules, followed by thoracic surgery for pathological confirmation. We compared the predictive accuracy of AI-based diagnosis with that of physician-based diagnosis in distinguishing between benign and malignant lung nodules. Among the 291 lung nodules examined, 226 were cancerous, and 65 were benign. Receiver operating characteristic (ROC) curves, plotted based on the malignancy probabilities predicted by both methods, revealed that the AI group achieved an area under the ROC curve (AUC) of 0.727, with a sensitivity of 90.27% and a specificity of 58.46%. In comparison, the physician-reading group had an AUC of 0.737, with a sensitivity of 83.19% and a specificity of 66.15%. Our findings demonstrate that the AI diagnostic system effectively calculates malignancy probabilities for lung nodules, highlighting its significant predictive potential. This system can serve as a valuable adjunct tool for clinicians and imaging physicians in the diagnostic process.

Cellular Membrane-Derived Nanovesicles Expressing hCD64 for Targeting Prostate Cancer.

Extracellular vesicles are ideal therapeutic potentiators for various diseases. However, they commonly lack targeting capability and are rapidly cleared by phagocytes. This requires appropriate administration at high doses, which can lead to toxic and adverse reactions. To overcome these limitations, we developed bleb nanovesicles containing human Fcγ receptor I (hCD64), known for their strong affinity to monomeric IgG. In this study, we focused on prostate cancer, which has a specific membrane antigen. We have utilized the hCD64-expressing bleb nanovesicles attaching anti-prostate-specific membrane antigen (PSMA) antibodies and confirmed their targeting ability in PSMA-related cell lines and prostate cancer xenograft models. Our findings underscore the promising potential of nanovesicle Fcγ receptor-IgG as a platform for cancer diagnosis and therapy systems, inspiring further research.

Multi-Regional Pelvic Floor Muscle Function Diagnosis System Based on Inflatable Stretchable Electrode Array.

Effective prevention and treatment of pelvic floor dysfunction (PFD) necessitates the identification of lesions within the complex pelvic floor muscle (PFM) groups associated with various symptoms. Here, we developed a multi-region pelvic floor muscle functional diagnosis system (MPDS) based on an inflatable stretchable electrode array, which aids in accurately locating areas related to PFD. Clinical diagnostic experiments were conducted on 56 patients with postpartum stress urinary incontinence (PSUI) and 73 postpartum asymptomatic controls. MPDS collects pelvic floor electromyography from all participants. By assessing EMG parameters such as activation time differences (ATD) and using Jensen-Shannon (JS) divergence to verify, with the aim of locating target muscle groups with functional abnormalities. Clinical test results showed that by observing the AT sequence of the PSUI group and the control group, muscle groups with functional abnormalities in the Pubococcygeus muscle (PC) and Puborectalis muscle (PR) regions could be preliminarily diagnosed. In the assessment of regional muscle contribution values based on JS divergence, it was verified that the contribution values of rapid contraction in the PC and PR regions of the PSUI group were relatively lower compared to those of the control group, which correlated with urinary control dysfunction. These experiments demonstrate that the MPDS helps in accurately locating target muscle groups with functional abnormalities, showcasing its potential in precise assessment of complex muscle groups such as PFM, which may improve diagnostic precision and reliability.

Fault stands out in contrast: Zero-shot diagnosis method based on dual-level contrastive fusion network for control moment gyroscopes predictive maintenance

Control moment gyroscopes (CMGs) are the most common control actuators in spacecraft. Their predictive maintenance is crucial for on-orbit operations. However, due to the scarcity of CMG fault data, constructing a diagnosis system for predictive maintenance with CMGs poses significant challenges. Therefore, a zero-shot fault diagnosis method based on a dual-level contrastive learning fusion network was proposed. First, to address the difficulty in training CMG fault diagnosis models without fault data, a contrastive learning method based on CMG clusters was proposed to extract invariant features from healthy CMGs and achieve zero-shot diagnosis for predictive maintenance. Second, considering the limitations of information from a single sensor, a cross-sensor contrastive learning method was proposed to fuse features from different sensors. Third, to tackle the challenges of extracting weak potential fault features, a dual-level joint training method was introduced to enhance the model’s feature extraction capability. Finally, the proposed method was validated using real dataset collected from CMGs serviced on an in-orbit spacecraft. The results demonstrate that the method can achieve zero-shot fault diagnosis for control moment gyroscopes predictive maintenance. The code is available at https://github.com/IceLRiver/DCF.

Automated diagnosis of COVID-19 using chest X-ray image processing by a Convolutional Neural Network

The COVID-19 pandemic has severely impacted global healthcare and financial systems, Highlighting the need for an automatic computer-aided diagnosis system using image recognition for chest X-rays(CXR). This study aims to classify COVID-19, normal, and pneumonia patients from CXR images via a modified ResNet-50 pre-trained CNN model. Our experiments are based on Dataset-1, which contains CXR images of COVID-19 and normal, while Dataset-2 also includes pneumonia. Dataset-1 and Dataset-2 were collected from King Abdul-Aziz Medical City in National Guard, Jeddah, Saudi Arabia. Moreover, a sample from the Kaggle repository was added to Dataset-1 and 2 to make two more Datasets. Our results for diagnosis of raspatory diseases have shown reliability and high accuracy of 95.28% (97.66% Sensitivity and 93.12% Specificity), which will be beneficial in aiding physicians and healthcare centres in the global fight against harmful spreading viruses through employing AI and ML techniques in X-ray medical diagnosis.

Assessment of a Deep-Learning System for Colorectal Cancer Diagnosis Using Histopathology Images

Colorectal Cancer is one of the most common and lethal forms of cancer hence, an early and accurate detection is crucial. Traditional manual diagnosis is a tedious and time-consuming job susceptible to human errors; therefore, it is imperative to use computer-aided detection systems to interpret medical images for a quicker and more accurate diagnosis. In recent years deep-learning approaches have proved to be efficacious in predicting cancer from pathological images. This study assesses several deep-learning techniques for cancer diagnosis on digitized histopathology images, amongst which GoogLeNet and Xception emerged as the most effective, with GoogLeNet exhibiting slightly better precision in identifying cancerous tissues. Building on these findings the study proposes a new model (Xception+) by borrowing the idea from Xception architecture, which outperforms existing architectures with an accuracy of 99.37% for cancer diagnosis and 94.48% for cancer-grade classification. The primary inference of our research is assisting pathologists in detecting colorectal cancer from pathological images faster and more accurately. With notable accuracy and robustness, our proposed model has significant potential to analyze pathological images and detect the patterns associated with other types of cancer. Our study holds promise for driving the advancement of innovative medical diagnostic tools, aiding pathologists and medical practitioners in expediting cancer diagnosis processes.

Evaluating a Natural Language Processing-Driven, AI-Assisted International Classification of Diseases, 10th Revision, Clinical Modification, Coding System for Diagnosis Related Groups in a Real Hospital Environment: Algorithm Development and Validation Study.

International Classification of Diseases codes are widely used to describe diagnosis information, but manual coding relies heavily on human interpretation, which can be expensive, time consuming, and prone to errors. With the transition from the International Classification of Diseases, Ninth Revision, to the International Classification of Diseases, Tenth Revision (ICD-10), the coding process has become more complex, highlighting the need for automated approaches to enhance coding efficiency and accuracy. Inaccurate coding can result in substantial financial losses for hospitals, and a precise assessment of outcomes generated by a natural language processing (NLP)-driven autocoding system thus assumes a critical role in safeguarding the accuracy of the Taiwan diagnosis related groups (Tw-DRGs). This study aims to evaluate the feasibility of applying an International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM), autocoding system that can automatically determine diagnoses and codes based on free-text discharge summaries to facilitate the assessment of Tw-DRGs, specifically principal diagnosis and major diagnostic categories (MDCs). By using the patient discharge summaries from Kaohsiung Medical University Chung-Ho Memorial Hospital (KMUCHH) from April 2019 to December 2020 as a reference data set we developed artificial intelligence (AI)-assisted ICD-10-CM coding systems based on deep learning models. We constructed a web-based user interface for the AI-assisted coding system and deployed the system to the workflow of the certified coding specialists (CCSs) of KMUCHH. The data used for the assessment of Tw-DRGs were manually curated by a CCS with the principal diagnosis and MDC was determined from discharge summaries collected at KMUCHH from February 2023 to April 2023. Both the reference data set and real hospital data were used to assess performance in determining ICD-10-CM coding, principal diagnosis, and MDC for Tw-DRGs. Among all methods, the GPT-2 (OpenAI)-based model achieved the highest F1-score, 0.667 (F1-score 0.851 for the top 50 codes), on the KMUCHH test set and a slightly lower F1-score, 0.621, in real hospital data. Cohen κ evaluation for the agreement of MDC between the models and the CCS revealed that the overall average κ value for GPT-2 (κ=0.714) was approximately 12.2 percentage points higher than that of the hierarchy attention network (κ=0.592). GPT-2 demonstrated superior agreement with the CCS across 6 categories of MDC, with an average κ value of approximately 0.869 (SD 0.033), underscoring the effectiveness of the developed AI-assisted coding system in supporting the work of CCSs. An NLP-driven AI-assisted coding system can assist CCSs in ICD-10-CM coding by offering coding references via a user interface, demonstrating the potential to reduce the manual workload and expedite Tw-DRG assessment. Consistency in performance affirmed the effectiveness of the system in supporting CCSs in ICD-10-CM coding and the judgment of Tw-DRGs.

Classification of Lung Cancer using Pre-Trained Deep Learning Models

Many Computer Assisted Diagnosis (CAD) systems have been designed and used in recent past for diagnosingdifferenttypes of cancer. Identification of carcinoma at an earlier stage is more important, and it is made possible due to the use modern image processing and deep learning methods.The occurrence of Lung cancer is seen to be increased and Computed Tomography (CT) scan images were utilized in investigation to locate and classify lung cancer, also for determining the severity of those cancer. This study is aimed at employing pre-trained deep neural networks for classification of lung cancer images. A gaussian-based approach is used to segment CT scan images. In this research exploits a transfer learning-based classification method for the chest CT images acquired from Cancer Image Archive and available in the Kaggle platform. Pre- trained models VGG and RESNET were trained using segmented chest CT images, and their performance was evaluated using different optimization algorithms were analyzed. Keywords: Computer Aided Diagnosis, lung cancer, deep learning, CT image, gaussian, transfer learning, pre-trained models, optimization algorithms.

A clinical decision support system for diagnosis and severity quantification of lumbosacral radiculopathy using intramuscular electromyography signals

A clinical decision support system for diagnosis and severity quantification of lumbosacral radiculopathy using intramuscular electromyography signals

Deep Learning and MRI Biomarkers for Precise Lung Cancer Cell Detection and Diagnosis

Aim This research work aimed to combine different AI methods to create a modular diagnosis system for lung cancer, including Convolutional Neural Network (CNN), K-Nearest Neighbors (KNN), VGG16, and Recurrent Neural Network (RNN) on MRI biomarkers. Models have then been evaluated and compared in their effectiveness in detecting cancer, using a meticulously selected dataset containing 2045 MRI images, with emphasis being put on documenting the benefits of the multimodal approach for attacking the complexities of the disease. Background Lung cancer remains the most common cause of cancer death in the world, partly because of the challenges in diagnosis and the late stage of presentation. Although Magnetic Resonance Imaging (MRI) has become a critical modality in the identification and staging of lung cancer, too often, its effectiveness is curtailed by the interpretative variance among radiologists. Recent advances in machine learning hold great promise for augmenting the analysis of MRI and perhaps even increasing diagnostic accuracy with the start of timely treatment. In this work, the integration of advanced machine learning models with MRI biomarkers to solve these problems has been investigated. Objective The purpose of the present paper was to assess the effectiveness of integrating various machine-learning models with MRI biomarkers for lung cancer diagnostics, such as CNN, KNN, VGG16, and RNN. The dataset involved 2,045 MRI images, and the performances of the models were investigated by comparing their performance metrics to determine the best configuration of interconnection while underpinning the necessity of this multimodal approach for accurate diagnoses and, consequently, better patient outcomes. Methods For this study, we used 2045 MRI images, with 70% for training and 30% for validation. We used four machine-learning models to work on the photos: CNN, KNN, VGG16, and RNN. Systematic performance measures were included in the study: accuracy, recall, precision, and F1 score. The confusion matrices of this study compared the diagnostic power of every model to comprehend the pragmatic use of the models in a real-world predictive capability. Results The scores for the model were found to be better with the convolutional neural network in terms of recall, accuracy in measures tested, precision, and F1. The rest of the models, KNN, VGG16, and RNN, performed decently but were slightly lower in performance than CNN. The in-depth analysis through confusion matrices thus established the predictive reliability of the models in revealing immense insight into the capability of identifying true positives and minimizing false negatives in enhancing the diagnostic accuracy of lung cancer detection. Conclusion The findings obtained have shown further support and great potential for integrating advanced machine learning models with MRI biomarkers to improve lung cancer diagnosis. The high performance of CNN, high sensitivity and specificity of the KNN model, and robustness of results obtained from VGG16 and RNN models have pointed to the potential feasibility of AI in the accurate detection of cancer. Our work has shown strong support for this multimodal diagnostic approach, which might impact future practice in oncology through the integration of AI to improve treatment strategies and patient outcomes in medical imaging.

Comparative bibliometric analysis of artificial intelligence-assisted polyp diagnosis and AI-assisted digestive endoscopy: trends and growth in AI gastroenterology (2003-2023).

Artificial intelligence is already widely utilized in gastroenterology. This study aims to comprehensively evaluate the research hotspots and development trends within the field of AI in gastroenterology by employing bibliometric techniques to scrutinize geographical distribution, authorship, affiliated institutions, keyword usage, references, and other pertinent data contained within relevant publications. This investigation compiled all pertinent publications related to artificial intelligence in the context of gastrointestinal polyps and digestive endoscopy from 2003 to 2023 within the Web of Science Core Collection database. Furthermore, the study harnessed the tools CiteSpace, VOSviewer, GraphPad Prism and Scimago Graphica for visual data analysis. The study retrieved a total of 2,394 documents in the field of AI in digestive endoscopy and 628 documents specifically related to AI in digestive tract polyps. The United States and China are the primary contributors to research in both fields. Since 2019, studies on AI for digestive tract polyps have constituted approximately 25% of the total AI digestive endoscopy studies annually. Six of the top 10 most-cited studies in AI digestive endoscopy also rank among the top 10 most-cited studies in AI for gastrointestinal polyps. Additionally, the number of studies on AI-assisted polyp segmentation is growing the fastest, with significant increases in AI-assisted polyp diagnosis and real-time systems beginning after 2020. The application of AI in gastroenterology has garnered increasing attention. As theoretical advancements in AI for gastroenterology have progressed, real-time diagnosis and detection of gastrointestinal diseases have become feasible in recent years, highlighting the promising potential of AI in this field.

Parametric optimization and comparative study of machine learning and deep learning algorithms for breast cancer diagnosis.

Breast Cancer is the leading form of cancer found in women and a major cause of increased mortality rates among them. However, manual diagnosis of the disease is time-consuming and often limited by the availability of screening systems. Thus, there is a pressing need for an automatic diagnosis system that can quickly detect cancer in its early stages. Data mining and machine learning techniques have emerged as valuable tools in developing such a system. In this study we investigated the performance of several machine learning models on the Wisconsin Breast Cancer (original) dataset with a particular emphasis on finding which models perform the best for breast cancer diagnosis. The study also explores the contrast between the proposed ANN methodology and conventional machine learning techniques. The comparison between the methods employed in the current study and those utilized in earlier research on the Wisconsin Breast Cancer dataset is also compared. The findings of this study are in line with those of previous studies which also highlighted the efficacy of SVM, Decision Tree, CART, ANN, and ELM ANN for breast cancer detection. Several classifiers achieved high accuracy, precision and F1 scores for benign and malignant tumours, respectively. It is also found that models with hyperparameter adjustment performed better than those without and boosting methods like as XGBoost, Adaboost, and Gradient Boost consistently performed well across benign and malignant tumours. The study emphasizes the significance of hyperparameter tuning and the efficacy of boosting algorithms in addressing the complexity and nonlinearity of data. Using the Wisconsin Breast Cancer (original) dataset, a detailed summary of the current status of research on breast cancer diagnosis is provided.

Leukemia detection and classification using computer-aided diagnosis system with falcon optimization algorithm and deep learning

Leukemia is a type of blood tumour that occurs because of abnormal enhancement in WBCs (white blood cells) in the bone marrow of the human body. Blood-forming tissue cancer influences the lymphatic and bone marrow system. The early diagnosis and detection of leukaemia, i.e., the accurate difference of malignant leukocytes with little expense at the beginning of the disease, is a primary challenge in the disease analysis field. Despite the higher occurrence of leukemia, there is a lack of flow cytometry tools, and the procedures accessible at medical diagnostics centres are time-consuming. Distinct researchers have implemented computer-aided diagnostic (CAD) and machine learning (ML) methods for laboratory image analysis, aiming to manage the restrictions of late leukemia analysis. This study proposes a new Falcon optimization algorithm with deep convolutional neural network for Leukemia detection and classification (FOADCNN-LDC) technique. The main objective of the FOADCNN-LDC technique is to classify and recognize leukemia. The FOADCNN-LDC technique utilizes a median filtering (MF) based noise removal process to eradicate the image noise. Besides, the FOADCNN-LDC technique employs the ShuffleNetv2 model for the feature extraction process. Moreover, the detection and classification of the leukemia process are performed by utilizing the convolutional denoising autoencoder (CDAE) model. The FOA is implemented to select the hyperparameter of the CDAE model. The simulation process of the FOADCNN-LDC approach is performed on a benchmark medical dataset. The investigational analysis of the FOADCNN-LDC approach highlighted a superior accuracy value of 99.62% over existing techniques.

Staining-Independent Malaria Parasite Detection and Life Stage Classification in Blood Smear Images

Malaria is a leading cause of morbidity and mortality in tropical and sub-tropical regions. This research proposed a malaria diagnosis system based on the you only look once algorithm for malaria parasite detection and the convolutional neural network algorithm for malaria parasite life stage classification. Two public datasets are utilized: MBB and MP-IDB. The MBB dataset includes human blood smears infected with Plasmodium vivax (P. vivax). While the MP-IDB dataset comprises 4 species of malaria parasites: P. vivax, P. ovale, P. malariae, and P. falciparum. Four distinct stages of life exist in every species, including ring, trophozoite, schizont, and gametocyte. For the MBB dataset, detection and classification accuracies of 0.92 and 0.93, respectively, were achieved. For the MP-IDB dataset, the proposed algorithms yielded the accuracies for detection and classification as follows: 0.84 and 0.94 for P. vivax; 0.82 and 0.93 for P. ovale; 0.79 and 0.93 for P. malariae; and 0.92 and 0.96 for P. falciparum. The detection results showed the models trained by P. vivax alone provide good detection capabilities also for other species of malaria parasites. The classification performance showed the proposed algorithms yielded good malaria parasite life stage classification performance. The future directions include collecting more data and exploring more sophisticated algorithms.

Implementation of Machine Learning-Based System for Early Diagnosis of Feline Mammary Carcinomas through Blood Metabolite Profiling.

Background: Feline mammary carcinoma (FMC) is a prevalent and fatal carcinoma that predominantly affects unspayed female cats. FMC is the third most common carcinoma in cats but is still underrepresented in research. Current diagnosis methods include physical examinations, imaging tests, and fine-needle aspiration. The diagnosis through these methods is sometimes delayed and unreliable, leading to increased chances of mortality. Objectives: The objective of this study was to identify the biomarkers, including blood metabolites and genes, related to feline mammary carcinoma, study their relationships, and develop a machine learning (ML) model for the early diagnosis of the disease. Methods: We analyzed the blood metabolites of felines with mammary carcinoma using the pathway analysis feature in MetaboAnalyst software, v. 5.0. We utilized machine-learning (ML) methods to recognize FMC using the blood metabolites of sick patients. Results: The metabolic pathways that were elucidated to be associated with this disease include alanine, aspartate and glutamate metabolism, Glutamine and glutamate metabolism, Arginine biosynthesis, and Glycerophospholipid metabolism. Furthermore, we also elucidated several genes that play a significant role in the development of FMC, such as ERBB2, PDGFA, EGFR, FLT4, ERBB3, FIGF, PDGFC, PDGFB through STRINGdb, a database of known and predicted protein-protein interactions, and MetaboAnalyst 5.0. The best-performing ML model was able to predict metabolite class with an accuracy of 85.11%. Conclusion: Our findings demonstrate that the identification of the biomarkers associated with FMC and the affected metabolic pathways can aid in the early diagnosis of feline mammary carcinoma.

Biocompatible WSe2@BSA Dots with Merged Catalyst and Coreactant for Efficient Electrochemiluminescence.

Electrochemiluminescence (ECL) is a powerful tool for clinical diagnosis due to its exceptional sensitivity. However, the standard tripropylamine (TPrA) coreactant for Ru(bpy)3Cl2, the most widely studied and used ECL system, is highly toxic. Despite extensive research on alternative coreactants, they often fall short in poor efficiency. From a reaction kinetics perspective, accelerating electrooxidation rate of Ru(bpy)3Cl2 is an essential way to compensate the efficiency limitation of coreactants, but is rarely reported. Here, a hybrid electrocatalyst@coreactant dots for the ECL of Ru(bpy)3Cl2 is reported. The as-prepared WSe2@bovine serum albumin (WSe2@BSA) dots is biocompatible, and demonstrate dual functions, i.e., the BSA shell works as a coreactant, meanwhile, the WSe2 core effectively catalyzes Ru(bpy)3Cl2 oxidation. As a result, WSe2@BSA dots exhibit an exceptionally high efficiency comparable to TPrA for the ECL of Ru(bpy)3Cl2. In addition, the procedure for synthesizing WSe2@BSA dots is facile (room temperature, atmospheric conditions), rapid (5min), and scalable (for millions of bioassays). A biosensor utilizing WSe2@BSA dots shows promise for highly sensitive detecting glypican-3 in clinical liver cancer serum samples, especially for alpha-fetoprotein-negative patients. This work opens a new avenue for developing a highly efficient ECL system for biosensing and clinical diagnosis.

Lung Cancer Detection Using Convolutional Neural Networks

Lung cancer is among the most prevalent and deadly cancers worldwide. Accurate diagnosis and early detection are critical for improving lung cancer patient outcomes and survival rates. Thanks to developments in medical imaging technology, computer-aided diagnosis (CAD) systems have shown a great deal of promise in helping radiologists identify and diagnose lung cancer from medical images. Here, we present the use of convolutional neural networks (CNNs) to create an early detection system (CAD) for lung cancer. The suggested approach uses lung computed tomography (CT) scans as input and use a CNN architecture to extract high-level features from the pictures. We use transfer learning to enhance a CNN model trained on a large dataset of CT images. The CNN model has been taught to determine if a specific CT image contains lung cancer or not. We evaluate the performance of the proposed CAD system on a dataset of CT scans of the lungs from different institutions. The trial's results show that our CNN-based CAD system can reliably and precisely identify lung cancer from CT scans. We also show the comparative performance of our proposed system against the state-of-the-art machine learning methods for lung cancer prediction. In conclusion, the suggested CNN-based deep learning-based CAD system has produced encouraging results for lung cancer detection from CT scans. The approach might help radiologists identify and classify lung cancer early on, leading to better patient outcomes and survival rates. The viability and usefulness of the suggested approach in clinical practice require more study

Unraveling the drivers of inequality in primary health-care resource distribution: Evidence from Guangzhou, China

BackgroundPrimary health-care (PHC) resource plays a critical role in addressing challenges related to healthcare accessibility and costs, as well as implementing a graded diagnosis and treatment system. This study aims to analyze the extent and components of inequality in PHC resource allocation in Guangzhou. MethodsBy utilizing data from the Annual Report on Healthcare Institutions for community and township health centers in Guangzhou from 2012 to 2020, this paper analyses the distribution of human, material and financial resources. It examines inequities in health resource allocation using the Gini coefficient. Additionally, it investigates the internal structure of overall inequality through the two-stage nested Theil decomposition method and explores the influencing mechanisms of inequality using the concentration index decomposition method. ResultsThe findings indicate that between 2012 and 2020, except for beds in 2018 and 2019, the Gini coefficients for resource allocation relative to population size remained below 0.3. Moreover, the Gini coefficient for geographical area ranged from 0.1228 to 0.3481. The two-stage nested Theil decomposition results reveal that within-district disparity contributes the most to the overall inequality, exceeding 46 %. The Concentration indexes show negative values, and the decomposition analysis highlights the significant contribution of the number of individuals served (over 72 %) to the inequality in health resource allocation. ConclusionAt the administrative district level, the allocation of PHC resources in Guangzhou demonstrates overall equity, with within-district inequality identified as the primary contributor to the overall inequality. The distribution of PHC resources in Guangzhou follows a pro-poor pattern. The key factors influencing equity enhancement in PHC resource allocation in Guangzhou include the number of individuals served, the presence of township health centers among institution types, the number of hospital admissions per capita, and the proportion of children aged 0–3.

Lung cancer classification model using convolutional neural network with feature ranking process

Abstract Lung cancer is the leading cause of cancer-related deaths worldwide, highlighting the importance of early detection to improve patient outcomes. The goal of this study is to create a computer-aided diagnosis (CAD) system that detects and classifies lung cancer based on medical images using a Convolutional Neural Network (CNN) and feature extraction techniques. The study employs the LIDC-IDRI dataset, a comprehensive collection of lung cancer-related medical images, to achieve this goal. Contrast Limited Adaptive Histogram Equalization (CLAHE) is used to improve contrast and detail while reducing noise. The Sobel operator is used to refine the segmentation process by enhancing edges and contours in binary images. Morphological operations such as dilation and filling are used to refine the segmented regions even further. Feature extraction is used to extract statistical data and texture characteristics from segmented regions. Mean and variance calculations reveal information about brightness and variability within regions, whereas co-occurrence matrices and Gray-Level Co-occurrence Matrix (GLCM) properties quantify texture features. The correlation between different regions is also evaluated to assess their relationships. Using the pre-processed and ranked features as inputs, a CNN model with five hidden layers is trained. To classify the segmented regions into cancerous and non-cancerous classes, the model learns patterns and relationships in the data. A confusion matrix is used to assess the accuracy, specificity, and sensitivity of the model's predictions, with an emphasis on correctly identifying lung cancer-affected regions. The results show promising results, with the proposed CAD system identifying lung cancer-affected regions with an accuracy of 99.4375%. The system also outperforms other existing methods with a specificity of 99.12% and a sensitivity of 99.26%. These findings highlight the developed system's potential as a valuable tool for early lung cancer detection, assisting doctors in making accurate diagnoses and improving patient outcomes.

Enhancing the Interpretability of Malaria and Typhoid Diagnosis with Explainable AI and Large Language Models.

Malaria and Typhoid fever are prevalent diseases in tropical regions, and both are exacerbated by unclear protocols, drug resistance, and environmental factors. Prompt and accurate diagnosis is crucial to improve accessibility and reduce mortality rates. Traditional diagnosis methods cannot effectively capture the complexities of these diseases due to the presence of similar symptoms. Although machine learning (ML) models offer accurate predictions, they operate as "black boxes" with non-interpretable decision-making processes, making it challenging for healthcare providers to comprehend how the conclusions are reached. This study employs explainable AI (XAI) models such as Local Interpretable Model-agnostic Explanations (LIME), and Large Language Models (LLMs) like GPT to clarify diagnostic results for healthcare workers, building trust and transparency in medical diagnostics by describing which symptoms had the greatest impact on the model's decisions and providing clear, understandable explanations. The models were implemented on Google Colab and Visual Studio Code because of their rich libraries and extensions. Results showed that the Random Forest model outperformed the other tested models; in addition, important features were identified with the LIME plots while ChatGPT 3.5 had a comparative advantage over other LLMs. The study integrates RF, LIME, and GPT in building a mobile app to enhance the interpretability and transparency in malaria and typhoid diagnosis system. Despite its promising results, the system's performance is constrained by the quality of the dataset. Additionally, while LIME and GPT improve transparency, they may introduce complexities in real-time deployment due to computational demands and the need for internet service to maintain relevance and accuracy. The findings suggest that AI-driven diagnostic systems can significantly enhance healthcare delivery in environments with limited resources, and future works can explore the applicability of this framework to other medical conditions and datasets.