Objective: To explore the value and effect of contrast-enhanced ultrasound in the diagnosis of breast lesions. Methods: Seventy-two patients with breast lesions in Shaanxi Provincial People’s Hospital from June 2020 to December 2021 were selected as the research subjects. All 72 patients met the diagnostic criteria of breast lesions. Two patients with incomplete clinical data were excluded; hence, there were 70 patients remaining. The diagnostic results of the two examination methods and the diagnostic value of the joint examination for breast lesions were analyzed and compared. Results: The results of benign, malignant, missed, and misdiagnosed breast lesions by contrast-enhanced ultrasound were 31, 32, 6, and 1 cases, respectively, accounting for 44.29%, 45.71%, 8.57%, and 1.43%, respectively. The results of benign, malignant, missed, and misdiagnosed breast lesions by ultrasound automatic volume imaging were 21, 24, 17, and 8 cases, respectively, accounting for 30.00%, 34.28%, 24.29%, and 11.43%, respectively. There were statistical differences between the two groups for missed diagnosis and misdiagnosis, but there was no significant difference between the two groups for benign and malignant lesions. The accuracy, sensitivity, and specificity of contrast-enhanced ultrasound were 87.69%, 83.62%, and 83.45%, respectively; the accuracy, sensitivity, and specificity of ultrasound automatic volume imaging were 71.39%, 68.99%, and 74.69%, respectively; the accuracy, sensitivity, and specificity of contrast-enhanced ultrasound combined with ultrasound automatic volume imaging were 96.29%, 92.68%, and 91.78%, respectively. Conclusion: Contrast-enhanced ultrasonography has a high clinical application value and a low inspection error rate in the diagnosis of breast lesions. It merits clinical advancement since it helps doctors diagnose and treat breast lesions more effectively.