Phases Of Development Research Articles

External Validation of a Machine Learning Model for Schizophrenia Classification.

Background and Objective: Excellent generalizability is the precondition for the widespread practical implementation of machine learning models. In our previous study, we developed the schizophrenia classification model (SZ classifier) to identify potential schizophrenia patients in the Japanese population. The SZ classifier has exhibited impressive performance during internal validation. However, ensuring the robustness and generalizability of the SZ classifier requires external validation across independent sample sets. In this study, we aimed to present an external validation of the SZ classifier using outpatient data. Methods: The SZ classifier was trained by using online survey data, which incorporate demographic, health-related, and social comorbidity features. External validation was conducted using an outpatient sample set which is independent from the sample set during the model development phase. The model performance was assessed based on the sensitivity and misclassification rates for schizophrenia, bipolar disorder, and major depression patients. Results: The SZ classifier demonstrated a sensitivity of 0.75 when applied to schizophrenia patients. The misclassification rates were 59% and 55% for bipolar disorder and major depression patients, respectively. Conclusions: The SZ classifier currently encounters challenges in accurately determining the presence or absence of schizophrenia at the individual level. Prior to widespread practical implementation, enhancements are necessary to bolster the accuracy and diminish the misclassification rates. Despite the current limitations of the model, such as poor specificity for certain psychiatric disorders, there is potential for improvement if including multiple types of psychiatric disorders during model development.

"An app is just available at all times"-the process and outcomes of converting the Georgia Tuberculosis Reference Guide into a mobile application.

The physical, paper-based Georgia TB Reference Guide has served as the clinical reference handbook on tuberculosis (TB) diagnostic and treatment guidelines for the state of Georgia in the United States. Supported by the Georgia Department of Public Health, the production of the 112-page palm-sized booklet was previously led by a team of Georgia-based TB experts at Emory University and printed every three-five years with updates to clinical management guidelines and TB consult contact information. However, the costs associated with editorial printing combined with delays in updating a static printed booklet with revised guidance hampered the utility of the tool. Considering the barriers with paper-based production and based on the beneficial use of apps to support the dissemination of clinical management guidance in other settings, the booklet was converted into a mobile application. This paper describes the process of developing a mobile app version of the Georgia TB Reference Guide in an easy-to-update and readily available format. We employed a user-centered design approach to develop the app, including a series of qualitative interviews and quantitative surveys. Participants included a mix of state officials and local TB experts. First, initial foundational interviews were conducted to conceptualize current utilization practices of both the paper and PDF versions of the tool. Second, the findings from the initial interviews were organized thematically and informed the design of the app, which was then beta tested by a round of previously unsampled TB experts as well as a re-sample from the initial interviews. Third, the designs were coded into developmental phases and beta tested among users of the current Georgia TB Reference Guide. Fourth, the app was published and downloaded by a pre-selected group of local users who provided answers to a follow-up survey after using the app for one month. Fifth, user growth, self-reported demographics, and app usage between February and July 2022 were recorded through automatic data metrics built into the app. The paper copy Georgia TB Reference Guide usage themes included commonly referenced content, navigation paths, and desired features and content. The themes were converted into features and designs such as prioritizing commonly reviewed topics and guide customization with bookmarks and notes. Iterations of the designs were driven by feedback from TB experts and included home page featured content, improving content readability, and improving the search feature. The follow-up survey revealed a 90% preference for the app over the paper version of the guide. In the six months following the app's release, the app was downloaded by 281 individuals in the United States. The majority of downloads were in Georgia and the app also expanded organically to 19 other states. The experience of converting the Georgia TB Reference Guide offers specific and effective steps to converting a medical reference guide into a mobile application tool that is readily available, easy to use, and easy to update. The organic dissemination of the app beyond the state of Georgia's borders within the first six months of app launch underscores desire among TB healthcare professionals for high-quality digital reference content outside the state. This experience offers clear outlines for replication in other contexts and demonstrates the utility of similar mobile medical reference tools.

The Evolution Mechanism of Correctness for Cyber-Physical System

Cyber-physical Systems (CPS) are widely used in all areas of life. Ensuring the correctness of CPS remains an enduring challenge during its development and design phases. One approach to ascertain the correctness of CPS is behavior equivalence based on bisimulation. However, whether the implementation development process develops in the right direction has an important impact on obtaining the correct system implementation. Especially, the development process of complex CPS often yields a multitude of implementation versions, the correlation among these versions partly signifies the correctness of the development process. This paper formalizes the relationship between the implementation versions and establishes a formal description of the development process progressing in the correct direction, leveraging the concept of a “limit idea.” Initially, we introduce the concept of “limit bisimulation” for CPS systems to delineate implementations acquired during the CPS development process. Specific limit bisimulations are demonstrated to represent distinct scenarios within the development process. Subsequently, the convergence mechanism of implementations is modeled through bisimulation limits, encapsulating the CPS’s specification as the ultimate goal of obtained implementations during the development process. Finally, the congruence property of the bisimulation limit is proved, which accounts for the relation between specification and implementation versions can be decomposed into a refinement hierarchy. The limit theorem of bisimulation in CPS can help the designer and developer of CPS to comprehend the development course better.

Deriving acceptable limits for non-mutagenic impurities in medicinal products – Durational adjustments

ICH Q3A/B guidelines are not intended for application during the clinical research phase of development and durationally adjusted qualification thresholds are not included. A central tenet of ICH Q3A is that lifetime exposure to 1 mg/day of an unqualified non-mutagenic impurity (NMI) is not a safety concern. An analysis of in vivo toxicology data from 4878 unique chemicals with established NO(A)ELs was conducted to determine whether durationally adjusted qualification limits can be supported. Although not recommended in ICH Q3A/B, a conservative approach was taken by using allometric scaling in the analysis. Following allometric scaling of the 5th percentile of the distribution of NO(A)ELs from available chronic toxicology studies, it was reconfirmed that there is a safety basis for the 1 mg/day qualification threshold in ICH Q3A. Additionally, allometric scaling of the 5th percentile of the distribution of NO(A)ELs from sub-acute and sub-chronic toxicology studies could support acceptable limits of 20 and 5 mg/day for an unqualified NMI for dosing durations of less than or greater than one month, respectively. This analysis supports durationally adjusted NMI qualification thresholds for pharmaceuticals that protect patient safety and contribute to 3Rs efforts for qualifying impurities using new approach methods.

The Rafael gas-condensate discovery – a potential game-changer in the Canning Basin

The Rafael 1 exploration well discovered an abnormally high-pressured gas-condensate pool in the Kimberley region in late 2021. Data supports a minimum gross gas column of 165 m at the well location trapped within a large faulted four-way closure in a dolomite reservoir sequence with strong similarities and age equivalent to the oil-bearing Ungani Dolomite reservoir in the Ungani Field. A successful production test in March 2022 resulted in sustained natural flows of gas and condensate to surface. The presence of thick sandstones of the Anderson Formation and a complete Laurel section beneath the Meda Unconformity were unexpected based on the pre-drill interpretation. Serendipitously, it provided the perfect geological setting for a significant hydrocarbon accumulation and emphasised the need to consider multiple geological scenarios when evaluating prospects to capture the full range of uncertainties and potential pool sizes. Although the range in size of the contingent resources is wide and requires further drilling for refinement, the Rafael 1 discovery could be one of the most significant onshore gas discoveries since Waitsia 1 and provides impetus and incentive for continued exploration in the basin. Several pathways for commercialisation have been identified linked to the resource size. A comprehensive appraisal program is underway including the recently completed acquisition of a 200 km2 3D seismic survey to optimally locate wells, and plans for drilling to reduce uncertainty and support the first phase of development based on a low case contingent resource that could underpin the energy needs of the Kimberley region.

Modelling CO2 storage in oil and gas reservoirs in the Gippsland Basin

The Gippsland Basin has world class geology for carbon capture and storage (CCS) and a long history of oil and gas production. Depleted oil and gas fields within the Gippsland Basin that are candidates for carbon dioxide (CO2) storage are in close proximity to existing infrastructure that could be repurposed as part of a CCS project. Modelling of CO2 storage in the depleted Bream oil and gas reservoir is being progressed. Bream reservoir properties are very well understood due to extensive geological and geophysical data sets available from wells and seismic data. Additionally, the field has been through three key phases of development during its production history; oil production and gas re-injection in 1988, gas cap blowdown started in 2002, and seasonal gas storage and withdrawal started in 2012 through to field shut-in in 2020. This provides a wealth of dynamic data that is used to calibrate the reservoir models to improve our confidence in the CO2 plume prediction. However, there are also challenges in modelling CO2 storage in depleted fields. Unlike saline aquifers, CO2 can be injected into a three-phase depleted reservoir that contains residual oil and gas saturation. The key aspects of our workflow to evaluate the plume behaviour are presented in this paper.

Planning for complex decommissioning projects in Australia – Gippsland Basin case study

Over more than 50 years, safe and successful installation projects have enabled progressive development and expansion of the Gippsland Basin Joint Venture off the coast of Victoria, Australia. This has resulted in a highly integrated network of 19 offshore platforms which are now starting to progressively reach the end of their productive life and detailed planning for the first phase of decommissioning projects has increased in intensity. Decommissioning of these assets is planned to take place in a number of campaigns. The Campaign 1 Decommissioning Project includes the removal of up to 13 platforms and is likely to be the largest single project of its kind in the World. Experience of similar decommissioning projects in Australia is very limited, resulting in unprecedented challenges across many aspects of this project. This requires creative, innovative and adaptable solutions to be developed to enable an efficient execution methodology. This paper will explore the strategies, challenges and successes involved with the early planning and development phase of the Gippsland Basin Joint Venture, Campaign 1 Decommissioning Project. Key insights, from contracting, to execution planning and stakeholder engagement will be discussed, promoting sharing across the industry and improving efficiency for future decommissioning projects in Australia.

Effect of Methyl Violet to Mulberry Silkworm Some Breeds Eggs

To liquidate the larvae, the methyl violet (C24H28N3Cl), used against fungal diseases in fish farming, was used. The goal is to establish physiological responses in different phases of development after treating local and introduced mulberry silkworm breeds of with aqueous solutions of methyl violet. Exogenous exposure to eggs led to the formation of a negative reaction. It has been established that treatment of silkworm eggs with water and a 0.001% solution of methyl violet (from October 20 to November 15, 2018) reduces the weight of the silk layer of cocoons with statistical accuracy by 33.0% (−78.5 mg) and 22.5% (−49 .0 mg) respectively (p<0.001). A negative effect also occurs in other physiological indicators: there is a difference in the weight of caterpillars, cocoons and pupae, and a slight deviation occurs in the weight of caterpillars before cocooning in the aquatic version. The results of this research can be used in developing issues such as identifying more stable and promising mulberry silkworm breeds in the conditions of Azerbaijan, as a prerequisite for predicting the successful introduction of mulberry silkworm.

DEVELOPMENT OF INTERACTIVE MULTIMEDIA LEARNING MATHEMATICS LEARNING MEDIA USING ADOBE FLASH CS6

Ongoing advancements have profoundly reshaped the development of educational media, with validity being a pivotal factor in creating high-quality products, representing a critical phase in their development. In essence, validity holds a key position in the production of superior educational materials. The primary objective of this study is to design and assess the validity of interactive multimedia-based mathematics learning tools using Adobe Flash CS6. This research belongs to the category of Research and Development (R&D) or developmental research. The methodology adopted for this developmental research follows a modified Plomp procedure, involving three of its five stages: the initial investigation phase, the development phase or prototyping, and the assessment phase. To gauge the validity of the media, the research employs a validation sheet as the data collection instrument. The analysis process entails scoring based on assessments made by the validator. The outcomes of the validation testing indicate that the media is deemed highly valid, achieving an impressive validation rate of 90.59%. The media is now deemed ready for use with only minor revisions required. One notable advantage of this learning media is its compact size, ensuring compatibility with all computer types, including those with low specifications.

A maintainable and iterative development approach of critical systems with FoCaLiZe

The life-cycle development of critical systems follows mainly a V-cycle process overlapped with proofs and/or verification techniques. At the first development stage, a critical system must be, precisely, and as completely as possible described. Thus, it is recommended to use a graphical modeling language standard such as the Unified Modeling Language (UML) and the Object Constraint Language (OCL), to which both customers and developers could contribute. Then, the graphical design with its formal specification (requirements) is mapped into a complete formal development environment, using an MDE (Model-driven engineering) approach. The formal environment has to assess the development until the generation of a secure code. In this context, we propose a life-cycle development approach that combines UML/OCL and the FoCaLiZe formal environment for the secure development of critical systems. The proposed approach ensures essential development constraints such as strict boundaries and traceability between development phases. It also ensures a secure maintenance phase using partial transformation techniques from UML/OCL to FoCaLiZe. The latter enhances the transformation from UML/OCL into FoCaLiZe to support incremental development and assist developers in correcting modeling errors. The proposed approach is mostly dedicated to secure and maintainable lifecycle development processes of critical systems. The formal environment assesses the development process until the generation of a secure code. To illustrate the proposed approach, we present the stages of development of a constrained system controlling military objects. The development of this system uses the iterative, incremental, and maintainability stages as described by the development approach, until the generation of secure code.

Evaluation of Vasculogenic Factors in the Developing Embryo at Weeks Five and Seven With a Special Focus on CD133 and TIE2 Markers.

Background Human embryo vasculogenesis (blood vessel development starting from endothelial precursors) includes the ability of mesenchymal cells and pluripotent stem cells to differentiate into endothelial cells. Quantification of endothelial progenitor cells is difficult to assess during the early steps of human embryo development due to several factors, especially due to the paucity of human embryo tissue which is usually discarded after early-stage pregnancy abortive methods. CD133 (Promimin-1) is a general marker of progenitor cells, but combined with other endothelial markers such as CD34, it may identify endothelial progenitor cells during embryonic development. CD34 immunohistochemistry was previously performed by our team to identify human embryo capillaries and comparatively assess microvessel density between different human embryonic tissues.TIE2 is an angiopoietin receptor strongly involved in the newly formed blood vessel maturation due to its expression in some mesenchymal precursors for future pericytes. CD34 assesses the presence of endothelial cells but its single use does not evaluate the endothelial progenitor state as CD133 may do nor vessel maturation as TIE2 may do. Data about the dynamics of CD133/TIE2 expression in the early stages of human embryo development are scarce. Hence, in this study, we aimed tocomparatively assess the dynamic of CD133+ endothelial precursors and TIE2 expression on five and seven-week-old human embryonic tissues with a special emphasis on their expression on embryonic vascular beds. Methodology CD133 and TIE2 immunohistochemistry was performed on five and seven-week-old human embryonic tissues followed by their quantification using the Qu Path digital image analysis (DIA) automated method. Results CD133 and TIE2 showed divergent patterns of expression during the initial phases of human embryonic development, specifically in the vascular endothelium of tiny capillaries. The expression of CD133 in endothelial cells lining the perfused lumen gradually decreased from five to seven-week-old embryos. It remained expressed with greater intensity in cells located at the tip of the vascular bud that emerged into pre-existing capillaries. TIE2 was much more specific than CD133, being restricted to the level of the vascular endothelium; therefore, it was easier to quantify using digital image analysis. The endothelium of the embryonic aorta was an exception to the divergent expression, as CD133 and TIE2 were consistently co-expressed in the seven-week-old embryo. The Qu Path DIA assessment increased the accuracy of CD133 and TIE2 evaluation, being the first time they were quantified by using automated software and not manually. Conclusions High heterogeneity of CD133 and TIE2 was observed between five and seven-week-old embryonic tissues as well as between different embryonic regions from the same gestational age. The unique finding of CD133/TIE2 co-expression persistenceinside aortic endothelium needs further studies to elucidate the role of this co-expression.

4-nitroquinoline 1-oxide-induced oral epithelial lesions exhibit time- and stage-dependent changes in the tumor immune microenvironment.

Oral tongue squamous cell carcinoma (OTSCC) is the most common cancer of the oral cavity and is associated with high morbidity due to local invasion and lymph node metastasis. Tumor infiltrating lymphocytes (TILs) are associated with good prognosis in oral cancer patients and dictate response to treatment. Ectopic sites for immune activation in tumors, known as tertiary lymphoid structures (TLS), and tumor-associated high-endothelial venules (TA-HEVs), which are specialized lymphocyte recruiting vessels, are associated with a favorable prognosis in OSCC. Why only some tumors support the development of TLS and HEVs is poorly understood. In the current study we explored the infiltration of lymphocyte subsets and the development of TLS and HEVs in oral epithelial lesions using the 4-nitroquinoline 1-oxide (4NQO)-induced mouse model of oral carcinogenesis. We found that the immune response to 4NQO-induced oral epithelial lesions was dominated by T cell subsets. The number of T cells (CD4+, FoxP3+, and CD8+), B cells (B220+) and PNAd+ HEVs increased from the earliest to the latest endpoints. All the immune markers increased with the severity of the dysplasia, while the number of HEVs and B cells further increased in SCCs. HEVs were present already in early-stage lesions, while TLS did not develop at any timepoint. This suggests that the 4NQO model is applicable to study the dynamics of the tumor immune microenvironment at early phases of oral cancer development, including the regulation of TA-HEVs in OTSCC.

Gonadotropin-Releasing Hormone (GnRH) and Its Agonists in Bovine Reproduction I: Structure, Biosynthesis, Physiological Effects, and Its Role in Estrous Synchronization.

GnRH is essential for the regulation of mammalian reproductive processes. It regulates the production and release of pituitary gonadotropins, thereby influencing steroidogenesis and gametogenesis. While primarily produced in the hypothalamus, GnRH is also produced in peripheral organs, such as the gonads and placenta. GnRH analogs, including agonists and antagonists, have been synthesized for the reproductive management of animals and humans. This review focuses on the functions of hypothalamic GnRH in the reproductive processes of cattle. In addition to inducing the surge release of LH, the pulsatile secretion of GnRH stimulates the pituitary gland to release FSH and LH, thereby regulating gonadal function. Various GnRH-based products have been synthesized to increase their potency and efficacy in regulating reproductive functions. This review article describes the chemical structures of GnRH and its agonists. This discussion extends to the gene expression of GnRH in the hypothalamus, highlighting its pivotal role in regulating the reproductive process. Furthermore, GnRH is involved in regulating ovarian follicular development and luteal phase support, and estrus synchronization is involved. A comprehensive understanding of the role of GnRH and its analogs in the modulation of reproductive processes is essential for optimizing animal reproduction.

Parenting experiences and outcomes among former adolescent mothers: A mixed methods study.

The purpose of this explanatory sequential mixed methods study was to examine parenting outcomes and experiences over time among marginalized adolescent mothers enrolled in randomized clinical trials (RCT) between 2002 and 2016 testing Minding the Baby® (MTB), an early home visiting program. The quantitative phase examined associations between measures of maternal experiences and parenting outcomes from 71 participants 2-8 years since RCT completion. MTB mothers reported less hostile parenting and fewer child behavior problems. The sequential qualitative phase involved interviews with a subsample (n = 31) and revealed six themes about their personal and parenting maturation. Through integration of quantitative and qualitative data, we generated metainferences, revealing a nuanced understanding of participants' experiences. Integrated findings revealed the complex personal and parenting experiences among former adolescent mothers during their developmental phases of emerging and early adulthood. Findings inform clinical and research approaches to promote personal growth and positive parenting outcomes over time among women who began childbearing in adolescence.

Collaborative servitization in service-oriented company: The case study of telco company.

There is a growing interest in the subject of product-service system (PSS) and collaborative servitization in academia and practice. However, the focus is on exploring the growth of manufacturing companies without specifically analyzing the growth of service companies in applying PSS. There are companies, especially in the telco industry, that expand their service business to complex bundles of products and services. The paper investigates PSS in the service company and the role of collaboration in different PSS development phases: idea generation, development and go to market phase. The study adopted case-based research conducted in international Telco organization. The research demonstrates how a company creates and commercializes integrated packets of products and services, it identifies partners company works with and the benefits and challenges of their cooperation. The study addresses collaboration with customers and identifies five different customer profiles according to their openness to participate in the development of PSS. The study highlights the importance of (1) collaboration models, (2) customer involvement, and (3) strategic focus in successful application of collaborative servitization. The findings complement the literature for collaborative servitization and offer concrete input for companies in terms of how to better organize business, profit from collaboration models and gain market advantage.

Development and validation of clinical implementation methods for patient-reported outcomes in Japanese multi-center palliative care units

BackgroundPatient-Reported Outcomes (PROs) are recommended for use in clinical oncology. However, they are not routinely used in professional palliative care practices in Japan. The reasons include both patient and healthcare provider factors and the implementation of PROs. This study aimed to develop and validate clinical implementation methods for PROs in Japanese palliative care units.MethodsThe Consolidated Framework for Implementation Research (CFIR) was conducted with four palliative care units in Japan. The study was conducted in six steps: unit assessment, development and implementation of a PRO implementation plan, PRO post-implementation survey and analysis of its utilization, a review of the PRO implementation process, creation of a PRO implementation method in a palliative care unit, and use and verification of the implementation method. Steps 1–5 were the development phase, and step 6 was the verification phase.ResultsInterviews were conducted with healthcare providers prior to PRO implementation. Intervention characteristics, patient needs in the palliative care unit, and factors related to the organization were identified as barriers. The implementation plan was developed, and the core members were selected. The implementation procedures were created in the above mentioned steps. PROs were used in the palliative care units. The same was true in the validation phase.ConclusionsThis study guided PROs in specialized palliative care unit in a clinical setting. The method was developed and validated for the implementation of PROs in the palliative care unit. In the PRO implementation process, it was important to assess the unit, address the barriers to implementation, and reduce the burden on healthcare providers. Furthermore, healthcare providers had to be supported by the champion, a person responsible for the implementation of PROs in the palliative care unit.

Testing the validity of feminization U-shape hypothesis for female labor force participation and economic development in Pakistan: a reexamination

Purpose The participation of females in economic activity remains a challenge, and received a lot of attention for a better labor policy discourse. The empirical research focused widely on the relationship between female labor force participation (FLFP) and economic development, called the feminization U-shape hypothesis. However, the linear/nonlinear relationship has been questioned due to empirical and methodological anomalies. Hence, this study aims to extend the previous work by reexamining this relationship in Pakistan. Design/methodology/approach The annual data from 1980 to 2021, the unit root tests augmented Dickey–Fuller and Phillips and Perron, the conventional autoregressive distributed lag bound test approach by including the quadratic-term of GDP per capita and the novel Sasabuchi–Lind–Mehlum (SLM) U test (2010) used for empirical estimation. Findings The findings revealed the prospects of a long-run nonlinear association between FLFP and economic development in Pakistan. However, an inverse U-shape exists between the female labor force participation rate (FLFPR) and GDP per capita, predicting that FLFP may decline in the future. Research limitations/implications The traditional feminization U-shape hypothesis has little empirical support in the case of Pakistan. Therefore, the Government of Pakistan should enhance the enabling environment for females through the provision of better job opportunities, technical skills, on-the-job training and social security benefits during all phases of economic development. Originality/value The conventional approach of testing U-shape is insufficient. To the best of the authors’ knowledge, therefore, this study incorporated a wider data set in a time series that is less evident, an advanced methodology SLM U test (2010), to validate the feminization U-shape hypothesis in Pakistan for the first time.

HTLV-1-Associated Myelopathy (HAM) Incidence in Asymptomatic Carriers and Intermediate Syndrome (IS) Patients.

Several studies suggest that HTLV-1 infection may be associated with a wider spectrum of neurological and clinical manifestations that do not meet diagnostic criteria for HAM. These conditions may later progress to HAM or constitute an intermediate clinical form: intermediate syndrome (IS), a mid-point between asymptomatic HTLV-1 carriers and those with full myelopathy. Thus, we determined the incidence of HAM cases in the HTLV-1-asymptomatic and IS patients, and the clinical/laboratory associated markers. A total of 204 HTLV-1-positive patients were included in this study, divided into two groups: Group 1, including 145 asymptomatic HTLV-1 subjects (ASY), and Group 2, including 59 patients with inflammatory clinical symptoms in more than three systems and a high proviral load (PVL). During a 60-month follow-up time, with the age ranging from 47 to 79 years, ten patients of the fifty-nine initially diagnosed as IS developed HAM (iHAM), and two patients of the initial 145 ASY developed HAM directly. Women were more prevalent in all groups. For the iHAM patients, the age ranged from 20 to 72 years, with a mean of 53 (±15 SD). Older age was associated with the development of HAM, higher PVL and IS; however, there was no any specific symptom or clinical sign, that was associated with risk for iHAM. In conclusion, IS cases could be an early phase of development of HAM. These findings show the presence of higher incidence probabilities in our cohort than previously reported.

Numerical Analysis of High Frequency Transverse Instabilities in a Can-Type Combustor

Abstract Dry low emissions (DLE) systems are well-known to be susceptible to thermoacoustic instabilities. In particular, transverse, spinning modes of high frequency may appear, and lead to severe damage in a matter of seconds. The thermoacoustic response of an engine is usually specific to the combustor geometry, operating conditions and difficult to reproduce at the lab-scale. In this work, details of high frequency dynamics (HFD) observed during the early development phase of a new DLE system are provided, where a multipeaked spectrum was noticed during testing. Beginning with an analysis of the measured pressure spectra from three different concepts, an analytical model of the clockwise and anticlockwise transverse waves was fitted to the experimental data using a nonlinear curve fitting approach to produce a simple yet useful understanding of the phenomena. A flamelet-based large eddy simulation (LES) of the entire combustion system was used to complement this analysis and confirm the mode shapes using dynamic mode decomposition (DMD). Both approaches independently identified a spinning second-order mode as the dominant one in the high frequency regime. The LES indicates the coupling of a distortion of swirl profile with a precessing vortex core as a possible cause for the onset of instability. With regard to modeling sensitivities, it is shown that subgrid scale combustion modeling has a strong impact on predicted amplitudes. Ultimately, a thickened-flame model with a modified efficiency function provided consistent results.

Enhancing English Proficiency for Thai Music Professionals: A CLT Instructional Package

The study aims to achieve three primary objectives: 1) To identify essential components for developing an instructional package aimed at enhancing English proficiency among individuals working in the Thai music industry; 2) To design an instructional package specifically tailored to improve the English proficiency of personnel in the Thai music industry; and 3) To implement the developed instructional package and assess its effectiveness in advancing English proficiency among music industry personnel. Employing the principles in developing an ESP course, the study comprises three phases: need analysis, instructional package development, and implementation. The need analysis phase involved surveying 150 individuals employed in the Thai music industry using a structured questionnaire. The instructional package development phase enlisted the expertise of five experts to evaluate the instructional model. Finally, phase three involved administering a pre-posttest study with 30 music professionals. The results highlight the successful creation of an English instructional package based on communicative language teaching (CLT) principles, leading to significant enhancements in participants' English proficiency. The study's significance lies in its identification of English language development needs within the music profession and its provision of a practical methodology for designing specialized English for Specific Purposes (ESP) courses tailored to the unique requirements of music professionals.