Various measures to ensure the safety of civil aviation flights in Ukraine from the time of its inception to the present are considered in a historical aspect at certain stages of activity, mainly organizational, scientific and technical and personal factors regarding the minimization of risks in civil aviation. The article confirms that at all stages of the more than 100-year history of civil aviation of Ukraine, various measures were constantly taken to ensure flight safety and minimize risks in aviation, especially since the second half of the 20th century. Innovative achievements of designers, scientists, engineers and technicians, training of highly qualified aviation specialists at the national and international level have become the achievement of global aviation. The integration of domestic aviation into the European and world community contributed to the strengthening of aviation safety in Ukraine.