Development Process Research Articles

Passive well monitoring systems and carbon, capture and storage (CCS) application

With an increasing number of ageing subsea wells and a tightening of global regulations for well management, assuring well integrity is a key feature of risk management for oil and gas operators. Baker Hughes, in collaboration with Sentinel Subsea, has successfully deployed patented passive well monitoring systems able to detect a range of subsea emissions and alert well owners. This early detection and warning technology harnesses the natural forces and processes of chemistry and physics but does not use any electrical power for the monitoring and detection of fluids. Static mechanical structures and the natural buoyancy of escaping fluids of interest are used to gather fluids in the subsea environment where they are detected chemically using specially developed Triggers. By using fluid-specific Triggers, systems respond only to the fluid(s) of interest, not to other fluids typically encountered around subsea assets. When the target fluid has been detected passively, a coded signal beacon (previously dormant) is mechanically released to the ocean surface using self-buoyancy where an alarm is transmitted via satellite and the responsible party alerted. Systems are currently supporting multiple major and independent operators mitigate the risks associated with subsea wells globally. Based on these experiences, this paper discusses the development process of a passive well integrity monitoring system with application for carbon, capture and storage (CCS) sites.

Early Kilogram Scale Delivery of MK-7845 as a Potential COVID-19 Therapy: Rapid Process Development of Key Intermediates

Early Kilogram Scale Delivery of MK-7845 as a Potential COVID-19 Therapy: Rapid Process Development of Key Intermediates

The Importance of Religious Provision in the Development of Elementary School Age Children at SDIT Solok

Development is a process of increasing maturity, thinking and psychological functions in humans. Where these changes are qualitative in nature which refers to changes in typical characteristics towards more advanced ones which will lead to the achievement of new abilities and characteristics. One of the important aspects to help the development process towards a better direction is the cultivation of religious values. Where religion will have a positive impact on the next stage of development. By providing religious education to elementary school-aged children, it is hoped that children will be able to prepare themselves according to existing religious values. The purpose of this article is to find out how important religious training is for elementary school-aged children in carrying out the next stages of development.

A maintainable and iterative development approach of critical systems with FoCaLiZe

The life-cycle development of critical systems follows mainly a V-cycle process overlapped with proofs and/or verification techniques. At the first development stage, a critical system must be, precisely, and as completely as possible described. Thus, it is recommended to use a graphical modeling language standard such as the Unified Modeling Language (UML) and the Object Constraint Language (OCL), to which both customers and developers could contribute. Then, the graphical design with its formal specification (requirements) is mapped into a complete formal development environment, using an MDE (Model-driven engineering) approach. The formal environment has to assess the development until the generation of a secure code. In this context, we propose a life-cycle development approach that combines UML/OCL and the FoCaLiZe formal environment for the secure development of critical systems. The proposed approach ensures essential development constraints such as strict boundaries and traceability between development phases. It also ensures a secure maintenance phase using partial transformation techniques from UML/OCL to FoCaLiZe. The latter enhances the transformation from UML/OCL into FoCaLiZe to support incremental development and assist developers in correcting modeling errors. The proposed approach is mostly dedicated to secure and maintainable lifecycle development processes of critical systems. The formal environment assesses the development process until the generation of a secure code. To illustrate the proposed approach, we present the stages of development of a constrained system controlling military objects. The development of this system uses the iterative, incremental, and maintainability stages as described by the development approach, until the generation of secure code.

An Anticipatory Approach to Ethico-Legal Implications of Future Neurotechnology

This paper provides a justificatory rationale for recommending the inclusion of imagined future use cases in neurotechnology development processes, specifically for legal and policy ends. Including detailed imaginative engagement with future applications of neurotechnology can serve to connect ethical, legal, and policy issues potentially arising from the translation of brain stimulation research to the public consumer domain. Futurist scholars have for some time recommended approaches that merge creative arts with scientific development in order to theorise possible futures toward which current trends in technology development might be steered. Taking a creative, imaginative approach like this in the neurotechnology context can help move development processes beyond considerations of device functioning, safety, and compliance with existing regulation, and into an active engagement with potential future dynamics brought about by the emergence of the neurotechnology itself. Imagined scenarios can engage with potential consumer uses of devices that might come to challenge legal or policy contexts. An anticipatory, creative approach can imagine what such uses might consist in, and what they might imply. Justifying this approach also prompts a co-responsibility perspective for policymaking in technology contexts. Overall, this furnishes a mode of neurotechnology’s emergence that can avoid crises of confidence in terms of ethico-legal issues, and promote policy responses balanced between knowledge, values, protected innovation potential, and regulatory safeguards.

Transparency for AI systems: a value-based approach

With the widespread use of artificial intelligence, it becomes crucial to provide information about these systems and how they are used. Governments aim to disclose their use of algorithms to establish legitimacy and the EU AI Act mandates forms of transparency for all high-risk and limited-risk systems. Yet, what should the standards for transparency be? What information is needed to show to a wide public that a certain system can be used legitimately and responsibly? I argue that process-based approaches fail to satisfy, as knowledge about the development process is insufficient to predict the properties of the resulting system. Current outcome-based approaches [Mitchell et al., 2019; Loi et al., 2021] are also criticized for a lack of attention to the broader socio-technical system and failure to account for empirical results that show that people care about more than just the outcomes of a process [as reported by Meyerson et al. (Procedural justice and relational theory: Empirical, philosophical, and legal perspectives, Taylor & Francis, 2021)]. Instead, I propose value-based transparency, on which the information we need to provide is what values have been considered in the design and how successful these have been realized in the final system. This can handle the objections to other frameworks, matches with current best practices on the design of responsible AI and provides the public with information on the crucial aspects of a system’s design.

Plant-Based Meat Analogues in the Human Diet: What Are the Hazards?

Research regarding meat analogues is mostly based on formulation and process development. Information concerning their safety, shelf life, and long-term nutritional and health effects is limited. This article reviews the existing literature and analyzes potential hazards introduced or modified throughout the processing chain of plant-based meat analogues via extrusion processing, encompassing nutritional, microbiological, chemical, and allergen aspects. It was found that the nutritional value of plant-based raw materials and proteins extracted thereof increases along the processing chain. However, the nutritional value of plant-based meat analogues is lower than that of e.g., animal-based products. Consequently, higher quantities of these products might be needed to achieve a nutritional profile similar to e.g., meat. This could lead to an increased ingestion of undigestible proteins and dietary fiber. Although dietary fibers are known to have many positive health benefits, they present a hazard since their consumption at high concentrations might lead to gastrointestinal reactions. Even though there is plenty of ongoing research on this topic, it is still not clear how the sole absorption of metabolites derived from plant-based products compared with animal-based products ultimately affects human health. Allergens were identified as a hazard since plant-based proteins can induce an allergic reaction, are known to have cross-reactivities with other allergens and cannot be eliminated during the processing of meat analogues. Microbiological hazards, especially the occurrence of spore- and non-spore-forming bacteria, do not represent a particular case if requirements and regulations are met. Lastly, it was concluded that there are still many unknown variables and open questions regarding potential hazards possibly present in meat analogues, including processing-related compounds such as n-nitrosamines, acrylamide, and heterocyclic aromatic amino acids.

Evaluation of the digital teacher professional development TARGET-tool for optimizing the motivational climate in secondary school physical education

AbstractGiven the complexity of teaching, continuing teacher professional development (CPD) is essential for maintaining and enhancing teaching effectiveness, and bridging the gap between ever-evolving theory and practice. Technological advancements have opened new opportunities for digital tools to support CPD. However, the successful integration of such digital tools into practice poses challenges. It requires adherence to CPD prerequisites and acknowledgment of the complexity of the professional development process. This study explored the applicability of the developed digital PE teacher professional development TARGET-tool in a secondary school PE context. We examined the perceived usability of this tool and gained insights into the process of teachers’ professional development as a result of using the tool. Ten PE teachers from different schools implemented the TARGET-tool within their PE context for a period of 4 to 6 weeks. Individual semi-structured interviews and the System Usability Scale provided insights into the perceived usability and the process of teacher professional development. The TARGET-tool demonstrated its potential as an effective tool for supporting teachers’ professional development. Future tool improvements were identified to further optimize the perceived usability, such as simplifying complex features, providing additional support and resources, and improving (data) presentations. Using the Interconnected Model of Professional Growth as a theoretical basis, it was demonstrated how the use of the TARGET-tool engages teachers as active and reflective participants in their professional development and induces changes within the external domain, the domain of practice, the domain of consequences, and the personal domain.

Spatial response of urban land use intensity to ecological networks: a case study of Xi'an Metropolitan Region, China.

In the face of the persistent degradation of ecological environments and fragmentation of ecological networks brought about by rapid urbanization, this study focuses on examining the interaction between urban land use intensity and ecological networks in the Xi'an Metropolitan Region (XAMR), China, and their impact on ecological equilibrium and sustainable development. By comprehensively evaluating the changes in land use intensity in XAMR from 2010 to 2020, the aim is to underscore the pivotal role of ecological networks in maintaining urban ecological balance and promoting sustainable development. The findings indicate a transition in land use intensity in the XAMR from low to high concentration, reflecting an intensification in land resource utilization during urbanization. However, the establishment and management of ecological networks can significantly enhance urban ecological security and biodiversity. Notably, this research identified crucial ecological corridors and source areas, augmenting the connectivity of urban green infrastructure and providing vital support for urban biodiversity. Additionally, a significant finding of this study is the spatial spillover effects generated by socioeconomic factors such as the proportion of tertiary and secondary industries and per capita GDP through the ecological network, which have profound impacts on land use intensity in the surrounding areas. These insights offer a novel understanding of the complex interactions within urban ecosystems, emphasizing the importance of incorporating ecological network construction in urban planning. Overall, through a comprehensive analysis of the relationship between the ecological network and land use intensity in the XAMR, this study proposes new directions for urban ecosystem management and land use planning, highlighting the significance of scientific ecological network planning and management in achieving long-term sustainable development in urbanization processes.

Effect of SiC particle content on the mechanical behavior and deformation mechanism of SiCp/Al composite under high-frequency dynamic loading

SiCp/Al composites exhibit excellent structural properties but suffer from inherent brittleness, which has brought rigorous challenges on the materials processing. Ultrasonic-vibration-assisted approach offers a promising solution to improve the processability. However, the underlying mechanisms of mechanical response and defect suppression under ultrasonic action have been rarely studied for SiCp/Al composites, hindering the development of high-efficiency processing. This work aims to investigate the mechanical behavior and microstructural evolution in this class of composites with varying SiC volume fractions up to 45% under high-frequency dynamic load induced by ultrasonic vibration. The results showed that the deformation stress of SiCp/Al composites under ultrasonic compression was significantly reduced to only about 1/10 of that under conventional quasi-static loading. Moreover, as the SiC fractions increasing, this ultrasonic softening effect of SiCp/Al became more pronounced. The plastic limit of SiCp/Al with 45% SiC fraction nearly doubled under ultrasonic compression without any macroscopic cracks. The subsequent nanoindentation tests revealed a transition in work-hardening behavior of SiCp/Al with different SiC fractions under ultrasonic loading. Microstructure characterization was conducted to analyze the grain refinement, recrystallization, and deformation textures within the deformed areas, revealing the deformation mechanism of SiCp/Al under different loading mode. TEM observations confirmed the distribution of dislocations in Al matrix and dense stacking faults in SiC particles after ultrasonic compression, indicating that the plastic behaviors were enhanced in both Al matrix and SiC phase under the high-frequency cyclic stress. This research revealed the distinct deformation mechanisms of SiCp/Al composites under high-frequency dynamic loading, exhibiting extremely low deformation stress accompanied with significantly enhanced plasticity. The results provide theoretical insights for the high-efficiency processing and rapid property regulation of particle-reinforced-composites based on ultrasonic-vibration-assisted technologies.

Development of competencies in the Medical Informatics Initiative (MII)-educational offers for acompetent and secure handling of medical data

In order to achieve the goals of the Medical Informatics Initiative (MII), staff with skills in the field of medical informatics and data science are required. Each consortium has established training activities. Further, cross-consortium activities have emerged. This article describes the concepts, implemented programs, and experiences in the consortia. Fifty-onenew professorships have been established and 10new study programs have been created: 1bachelor's degree and 6consecutive and 3part-time master's degree programs. Further, learning and training opportunities can be used by all MII partners. Certification and recognition opportunities have been created.The educational offers are aimed at target groups with abackground in computer science, medicine, nursing, bioinformatics, biology, natural science, and data science. Additional qualifications for physicians in computer science and computer scientists in medicine seem to be particularly important. They can lead to higher quality in software development and better support for treatment processes by application systems.Digital learning methods were important in all consortia. They offer flexibility for cross-location and interprofessional training. This enables learning at an individual pace and an exchange between professional groups.The success of the MII depends largely on society's acceptance of the multiple use of medical data in both healthcare and research. The information required for this is provided by the MII's public relations work. There is also an enormous need in society for medical and digital literacy.

Formation of a Digital Economy Model in the Kyrgyz Republic

The article discusses the issues of the digital economy model of the Kyrgyz Republic, based on the economic and legal framework of information relations aimed at the development of digital processes. National legislation must have legal mechanisms capable of regulating information relations in the field of digital transformation of the economy. The construction of a modern digital infrastructure should contribute to the development of the country’s digital economy and provide communication with global information data, which will contribute to digital transformation at the level of modern developed infrastructure. The experience of creating and directing the digital transformation of the economy of the Kyrgyz Republic was studied, based on the development and adoption of national programs and strategies that should be aimed at developing an index for measuring the digital economy, including displaying indicators and tools for assessing the digital development of the Kyrgyz Republic. It has been determined that the digital economy should be built on a developed information infrastructure with a mandatory process of modernization of all sectors of the economy. Proposals were made to further improve the direction of development of the digital economy in the near future.

Internationalization of Chinese Manufacturing Firms: A Perspective from the Uppsala Model

Enhancing firm performance in the turbulent international situation has become an important issue in firm evolution. There has been a large amount of research interest in the rapid development of emerging international firms, but the relevant empirical studies are still limited. The purpose of this study is to investigate three factors that impact firm performance, utilizing the Uppsala model as a main theoretical foundation. Based on empirical analysis of 332 medium and large Chinese manufacturing international firms, this study finds that the degree of internationalization, knowledge development, and commitment processes have positively impact firm performance. This finding contributes to the international business literature's understanding of firm development in emerging markets and enhances the generalizability of the Uppsala model.

The Assessment Model of Robotic Process Automation (RPA) Project Using Benefit Study and Balanced Scorecard (BSC) Approach

Assessing Robotic Process Automation (RPA) projects is challenging, especially for small and medium-sized enterprises (SMEs) with limited resources. The most common approach, cost-benefit analysis, measures the financial success of a project, but it does not capture all RPA benefits, which can lead to erroneous decisions about starting, continuing, delaying, or stopping an RPA project. This research presents a novel RPA project assessment model that combines a benefits approach with the balanced scorecard (BSC) framework. The model identifies RPA benefits from the scientific literature and classifies them into four BSC indicators: financial, business process improvement, customer satisfaction, and learning and development. SMEs can easily use the model by comparing expected and actual benefits to make quick and holistic decisions. The model's simplicity, ease of use, and ability to reveal both monetary and non-monetary RPA benefits make it a valuable tool for SMEs.

Safety and biological outcomes following a phase 1 trial of GD2-specific CAR-T cells in patients with GD2-positive metastatic melanoma and other solid cancers

BackgroundChimeric antigen receptor (CAR) T cell therapies specific for the CD19 and B-cell maturation antigen have become an approved standard of care worldwide for relapsed and refractory B-cell malignancies. If...

Alcohol policy development in Sierra Leone: An assessment of the role of civil society

Objective: To assess the value addition of civil society collaboration with Government in the development of Sierra Leone’s National Alcohol Policy (NAP). Policy Development Process: We reviewed the entire process of lobby, advocacy, and support for the development of the NAP from 2015 when the Siera Leone Alcohol Policy Alliance (SLAPA) was formed to the launch of the NAP in 2023. It also assesses the level of collaboration between FoRUT, SLAPA and Ministry of Health of Health and Sanitation (MoHS). The MoHS coordinated the policy formulation process with substantive technical support from civil society. Results: The quality of the NAP was rated high as it reflected appropriate policy areas and interventions from the Global Strategy to Reduce the Harmful Use of Alcohol, the WHO SAFER initiative, and the Global Action Plan for Alcohol Control (202-2030). The NAP is a solid reference material for the development of a new alcohol bill. MoHS recognized FoRUT and SLAPA as the national champions for alcohol control in the country. FoRUT, directly and through SLAPA influenced the process of developing the NAP and its quality through advocacy, collaboration and technical and financial support. Conclusions: The development of the NAP in Sierra Leone truly reflects civil society-government collaboration, built on mutual trust and a common health and development agenda. Connecting national level lobby and advocacy with regional global advocacy actions to prioritize, influence, support, and monitor the alcohol control agenda is a critical catalyst for civil society to advancing the development of NAPs.

Conceptualisation of the Regulatory Framework of Green Infrastructure for Urban Development: Identifying Barriers and Drivers

Urban green infrastructure plays a crucial role in sustainable city development by offering a multitude of benefits, including improved environmental quality, increased social well-being, and enhanced economic prosperity. Evaluation and monitoring of regulatory implementation stand as essential components in the advancement of urban green infrastructure (GI) as they indicate the efficacy of regulatory acts and enable the assessment of their implementation success and adaptability to identified needs. This study identifies barriers and drivers based on the views of 352 professionals surveyed between 2018 and 2023 in Serbia. The primary data collection method employed questionnaire surveys. This study identified a range of barriers within existing legal frameworks, foremost of which include the lack of coordination and coherence between relevant ministries and governmental agencies, insufficient financial and human resources, the lack of transparency in the regulation development process, the need for strengthening technical capacities, and the absence of an adequate urban GI strategy. This research serves as a foundation for conceptualising GI regulatory elements that enhance urban GI development. Addressing these barriers necessitates efforts to improve coordination and collaboration among stakeholders, increase public participation, and enhance transparency in the regulatory process.

A Human–Machine Interaction Mechanism: Additive Manufacturing for Industry 5.0—Design and Management

Industry 5.0 is an emerging value-driven manufacturing model in which human–machine interface-oriented intelligent manufacturing is one of the core concepts. Based on the theoretical human–cyber–physical system (HCPS), a reference framework for human–machine collaborative additive manufacturing for Industry 5.0 is proposed. This framework establishes a three-level product–economy–ecology model and explains the basic concept of human–machine collaborative additive manufacturing by considering the intrinsic characteristics and functional evolution of additive manufacturing technology. Key enabling technologies for product development process design are discussed, including the Internet of Things (IoT), artificial intelligence (AI), digital twin (DT) technology, extended reality, and intelligent materials. Additionally, the typical applications of human–machine collaborative additive manufacturing in the product, economic, and ecological layers are discussed, including personalized product design, interactive manufacturing, human–machine interaction (HMI) technology for the process chain, collaborative design, distributed manufacturing, and energy conservation and emission reductions. By developing the theory of the HCPS, for the first time its core concepts, key technologies, and typical scenarios are systematically elaborated to promote the transformation of additive manufacturing towards the Industry 5.0 paradigm of human–machine collaboration and to better meet the personalized needs of users.

The Importance of the Product Development Process for Companies: A Bibliometric Analysis of the Stage-gate Model

The article aims to present a bibliometric study that sought to identify the profile of scientific articles in the Scopus database on the term Stage-gate, in the period from 2013 to September 2023, analysing how the evolution of the dissemination of international scientific studies for the area of product development. The research methodology is quantitative through bibliometrics that evaluates scientific metrics. The author who published the most was Robert Cooper with 12 documents, the journal that most addresses the term Stage-gate is Research Technology Management with nine documents and the keyword amiss cited is Stage-gate with 9% of the citations. The country that contributes the most and contributes to the Stage-gate method is the United States with 78 documents. In conclusion, the results presented highlight the relevance of this model, the contribution of different authors, the diversity of academic sources, and the global dispersion of this concept.

Automating Fault Test Cases Generation and Execution for Automotive Safety Validation via NLP and HIL Simulation

The complexity and the criticality of automotive electronic implanted systems are steadily advancing and that is especially the case for automotive software development. ISO 26262 describes requirements for the development process to confirm the safety of such complex systems. Among these requirements, fault injection is a reliable technique to assess the effectiveness of safety mechanisms and verify the correct implementation of the safety requirements. However, the method of injecting the fault in the system under test in many cases is still manual and depends on an expert, requiring a high level of knowledge of the system. In complex systems, it consumes time, is difficult to execute, and takes effort, because the testers limit the fault injection experiments and inject the minimum number of possible test cases. Fault injection enables testers to identify and address potential issues with a system under test before they become actual problems. In the automotive industry, failures can have serious hazards. In these systems, it is essential to ensure that the system can operate safely even in the presence of faults. We propose an approach using natural language processing (NLP) technologies to automatically derive the fault test cases from the functional safety requirements (FSRs) and execute them automatically by hardware-in-the-loop (HIL) in real time according to the black-box concept and the ISO 26262 standard. The approach demonstrates effectiveness in automatically identifying fault injection locations and conditions, simplifying the testing process, and providing a scalable solution for various safety-critical systems.