Development Process Research Articles

Создание нового порта: фактор влияния на развитие транспортной логистики региона

The process of formation, construction and development of a new international port on a section of the river bank received from another country, which has direct access to the sea, is considered. The analysis of the advantageous location and favorable conditions for the creation of the port, including the conditions for entry into the port of sea and river vessels, the availability and accessibility of road, rail and air transport, is carried out. The created structure of the port is illustrated, as well as brief characteristics, capabilities and features of various port terminals for cargo transshipment and passenger transportation are considered. The organizational and technological experience in creating a logistics hub in the region was studied, taking into account the needs of producers, recipients and the characteristics of transport carriers, including the features of asset management. The analysis of indicators of the volume of transshipment of various cargoes was carried out, the main directions of the port's development in the near future were determined. In the process of studying the experience of creating port infrastructure, the created conditions for business development and investment attraction, the peculiarities of the tax and customs regime, as well as the distinctive features of the port's free economic zone from other similar territories are considered. Calculations of the availability of human resources in the port area and their attractiveness for transport companies are given. The process of development of the merchant fleet of the Republic of Moldova is analyzed, and the role of port infrastructure and transport logistics in the development of maritime activities of the state and the region as a whole is shown. A comparative analysis of the development of similar ports in the region was carried out according to the main indicators. Conclusions are drawn about the impact of the intensity of development of ports and transport logistics in the region on strengthening the state’s maritime potential, its infrastructure and trade.

Child Missing with Surveillance Analysis with Multi Phase Extraction Face Monitoring

Abstract: Visual Surveillance has been placed in everywhere for any incidents identification. With the wide developments missing child identification with the computer vision system is the main focus. The implementation carried out with face based detection with rapid advance digital connectivity. Face recognition plays as a major developmental process where the concern person can be identified with face based identification system. Machine learning with artificial intelligence plays a vital role in facial detection and recognition. The paper proposes Haar Cascade on feature extraction from facial points and Hybrid Recurrent Neural System(HRNN) with Long Short Term Memory(LSTM) algorithm, on multi face recognition over public crowded area. Missing child images will be pre- trained in a database where the face matching templates will be provided. On matching the database labeled points with the feature point an E-mail or SMS based alert system can be generated on notification to the authority with cam points. Thus the development carried will give best accuracy solution on finding out from multiple face regions. Mainly identification of the missing child over the road side areas will be done with computer vision frame targeting system.

Preperation of Sambhar Premix

Abstract: A sambhar premix is a convenient blend of dry spices and lentils essential for preparing the popular South Indian dish, sambhar. Comprising roasted and ground ingredients like lentils (toor dal, masoor dal), spices (coriander, cumin, fenugreek, mustard seeds), dried red chilies, and aromatics (turmeric, asafetida, curry leaves); this premix offers a quick solution to recreate the flavorsome and aromatic sambhar. When stored in an airtight container, this premix maintains its freshness, making it a time-saving and versatile addition to various culinary creations. masala development process would highlight the key steps and considerations in creating this traditional South Indian spice blend. It would cover aspects suchas ingredient selection, proportioning, grinding techniques, and the preservation methods employed. Additionally, the abstract might touch upon the cultural significance of masala and its role in enhancing the flavor profile of the iconic dish. This abstract delves into the historical evolution of masala, exploring its traditional ingredients and tracing the development of a premix. The document outlines the meticulous method of preparation for the premix, emphasizing key steps such as ingredient selection, proportioning, and grinding techniques. Additionally, it includes a comprehensive cost analysis of the production process. Proximate testing is employed to evaluate the nutritional composition of the masala, shedding light on itsdietary implications. This abstract aims to provide a holistic overview of the masala development process, combining historical context, preparation methodology, cost considerations, and nutritional insights. This detailed abstract explores the rich history, intricate ingredients, and methodical preparation of masala powder, with a focus on developing a premix. The historical analysis delves into the origins and evolution of the spice blend, highlighting the regional variations and cultural significance associated with its use in South Indian cuisine. The document provides a comprehensive overview of the ingredients, emphasizing the selection of authentic spices crucial to achieving the distinctive flavor profile. The method of preparation for the premix is detailed, encompassing precise measurements, grinding techniques, and the blending process to ensure consistency and optimal flavor infusion. A meticulous cost analysis is presented, covering raw materials, processing expenses,and packaging costs, offering insights into the economic feasibility of producing masala on a larger scale. Furthermore, proximate testing is employed to assess the nutritional composition, detailingthe macronutrient and micronutrient content, contributing to a comprehensive understanding of the spice blend's dietary implications. This abstract aims to serve as a comprehensive reference, encapsulating the historical, culinary, economic, and nutritional dimensions of masala powder and its premix variant.

Technical-technology aspect and financial analysis of sweet potato (Ipomoea batatas L) flour processing agroindustry in Lampung province

Lampung Province is one of the Sumatra archipelago's fifth sweet potato-producing provinces. To provide added value and encourage the growth of agro-industry in Lampung Province, the development of sweet potato flour processing is needed. This study aims to determine the business feasibility of sweet potato flour in Lampung Province from raw materials, technical technology, and financial aspects. The research involved agencies and related institutions in Lampung Province and Lampung Tengah Regency. The research method used was a survey and interview method. The data obtained were analyzed in stages using the Exponential Comparison Method (ECM) and business feasibility analysis. The finding showed that the SP flour agro-industry is feasible to be established with a capacity of 4 tons of fresh SP as raw material in Way Pengubuan, Lampung Tengah District, Lampung Province. The project needs an initial investment capital of 3.36 billion and an annual operational capital of 14.44 billion. The project is projected to yield an NPV value of IDR. 1,320,768,285 over a 10-year business projection period, with an IRR of 21%, Net B/C of 1.11, and a PBP of 4 years and 17 days.

Enhancing registration systems: Implementing database systems in digital boarding schools

Islamic boarding schools, known as pondok pesantren are specialized schools for Islamic education in Indonesia. With the community's increasing interest in religious education, some pesantren have begun to offer online learning opportunities. Pondok Pesantren Bayt Tamyiz is a Islamic boarding school that has started developing online pesantren education under the name Tamyiz Digittren. This program aims to enhance understanding and translation of the Qur'an using the Tamyiz method. The pondok pesantren requires significant changes in its administrative systems, including the registration process. Information system development is often challenging for the pesantren staffs and software developers. One of the fundamental difficulties lies in the user requirement process. Typically, pesantren need help to provide the information system they need. Such difficulties hinder the development process as developers must conduct numerous experiments. This research aims to design and implement a suitable database for the new student registration system with minimal information and limited time development. The research follows a database development method divided into three stages: Requirement Collection and Analysis, Conceptual Database Design, and Logical Database Design. Database development utilizes MySQL as the Database Management System (DBMS) and PHP as the programming language. This research results in a database design capable of storing and managing student data, payments, and other registration information. We expect the results of this database development to be effective in supporting the registration system and in the future development of information systems at Pondok Pesantren Bayt Tamyiz.

Risks and Countermeasures of Internet Consumer Financial Asset Securitization: A Case Study of Jingdong Baitiao

Asset securitization is one of the most important innovations in the financial field in recent decades. The introduction of this financial instrument enables commercial banks to have both functions as "fund lenders" and "fund sellers". JD Baitiao is the product of asset securitization and is the first Internet credit consumption product in Chinese industry. Due to the huge demand in the credit market, it has been popular among users since its establishment in 2014. We will give a basic introduction to of JD and JD financial asset securitization: the development process and an introduction to the fundamentals of the whole company, including the background of the development of JD Baitiao in financial aspect, as well as the benefits of its appearance in stimulating consumption by users on JDs platform. We further provide an analysis of the JD Baitiao, including its background, transaction process, asset pool composition, and credit enhancement arrangement. issuance, pricing, to trading, also with its quota application, repayment forms, as well as its risk control system for users. Next, through data and chart analysis, we analyze the various aspects of the securitization risks. Last, based on our analysis, we recommend several ways to improve issuance efficiency and risk management capabilities.

Mapping the foundations and evolution of career aspiration research: a bibliometric analysis

PurposeThis bibliometric literature review aims to uncover the (1) intellectual foundations and (2) topical evolution in the field of career aspiration research.Design/methodology/approachWe employed the systematic literature review methodology following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. According to the predetermined criteria, 286 articles were included from the Web of Science database. Then, we employed performance analysis, science mapping and natural language processing to address our research objectives.FindingsCo-citation analysis uncovered four foundational themes: (1) gender and leadership aspiration, (2) Social Cognitive Career Theory, (3) process of career development and (4) adolescents’ career aspiration. Moreover, co-word analysis showed that scholarly foci have shifted from adolescents’ career development to diverse streams. This shift was indicated by the exploration of additional research samples, such as university students, and topics related to specific aspirations (e.g. entrepreneurial and managerial aspirations) and gender issues (e.g. women leadership and gender stereotypes).Research limitations/implicationsAlthough this review has limitations related to data selection, it presents implications for practice, theory and future research on career aspirations.Originality/valueThe study illuminated the past and development of a research domain, thus advancing the understanding of career aspirations and inspiring future research.

Three-stage pyrolysis-catalytic dry reforming of waste polyolefins over MFI and Ni-MFI catalysts for BTEX and syngas production

This work presents an experimental proof-of-concept study for a three-stage pyrolysis-catalytic dry reforming process for recovering valuable chemicals from waste plastics. It is demonstrated that depending upon the catalysts, process parameters and reactor configuration, plastic waste and carbon dioxide can be converted into a diverse array of valuable chemicals which can be used as secondary feedstocks in the chemical or petrochemical industry, thus decreasing dependency on fossil resources and contributing to waste reduction. For this work, waste polypropylene was thermally pyrolyzed and the emerging vapors were passed over HZSM-5 catalyst to obtain BTEX-rich pyrolysis oil and pyrolysis gases containing mainly C1 to C4 hydrocarbons. The gaseous products were separated, mixed with CO2 and passed over Ni-silicalite-1 catalyst to obtain syngas, thus upgrading the pyrolysis gases and contributing to CO2 reduction. This study may provide new insights towards the development of processes for the chemical recycling of waste plastics and CO2.

Development and psychometric evaluation of the adjuvant endocrine therapy beliefs scale for breast cancer survivors.

Adjuvant endocrine therapy has a vital role in reducing breast cancer mortality. The beliefs in adjuvant endocrine therapy is a very important factor in the medication adherence of breast cancer survivors. Therefore, it is necessary to develop a standardized scale for assessment of adjuvant endocrine therapy. The purpose of this study was to identify the attributes of adjuvant endocrine therapy beliefs, and to evaluate adjuvant endocrine therapy beliefs scale psychometric properties. A hybrid model was applied to identify the concept of adjuvant endocrine therapy beliefs and measurement question were developed by the scale development process. Statistical analysis using validity analysis and Rasch analysis based on item response theory were performed. A total of 228 breast cancer survivors in South Korea participated in the study. The finally developed adjuvant endocrine therapy beliefs scale consisted of 22 items. The items extracted by 4 factors explained 59.72% of the total variance. The model fit showed an acceptable level. The adjuvant endocrine therapy beliefs scale was excellent in convergent and discriminant validity with reliability. This scale is expected to be practical and useful in identifying adjuvant endocrine therapy beliefs and developing intervention strategies to promote adjuvant endocrine therapy adherence. In addition, continuous education and support should be accompanied so that breast cancer survivors can maintain positive beliefs in adjuvant endocrine therapy adherence.

Ethnic representation within virtual reality: a co-design study in a forensic youth care setting

BackgroundVirtual reality (VR) is one of the most cutting-edge digital technologies currently used to extend and adapt mental health interventions. When designing therapeutic VR-applications, bias related to representational and behavioral features can be introduced. Specific bias, that could result from ethnic stereotyping, should be averted. However, structured debates and clear guidelines on how to deal with such bias are lacking.ObjectiveIn the current paper we describe our iterative, co-design process to develop an augmented version of a 360-degree VR-video that is used in the Street Temptations intervention. In this intervention, aimed at adolescents with disruptive behavior problems, the VR-video provides adolescents with an emotionally engaging situation and forms the basis of Street Temptations’ perspective-taking exercises. By presenting a detailed example of our VR developmental process, specifically focusing on ethnic representation in this virtual environment and related ethical aspects, we aim to positively contribute to the creation of ethically sound therapeutic VR-applications.MethodWe adopted an experience-based co-design approach. The process started by assembling professionals’ experiences with the original VR-video. Following, we conducted four co-design groups with adolescents, young adults, and professionals within the forensic youth care system, as experiential experts, to collaboratively develop an enhanced VR-scenario for the Street Temptations intervention. In total, ten adolescents, four young adults and four professionals participated. The co-design groups were alternated with sessions with a screenwriter, to reflect on the results of the co-design groups. In this way, we enabled continuous feedback on and design of the ameliorated scenario and let development and data collection reinforce each other.ResultsThe most important adjustments that were brought forward included explicit incorporation of diversity, establishing a clear storyline for the scenario, keeping the content close to reality, casting actors in a way to avoid obvious stigmatization, and using only names for the characters that are commonly used across different cultural and ethnic backgrounds.DiscussionBy presenting our developmental process, we give a detailed example of how to reflectively develop ethically sound therapeutic VR-content within a forensic youth care setting. We demonstrated that including stakeholders can help in preventing socially irresponsible and conceivably hurtful stereotypes. By describing the process in detail, we hope to contribute to the responsible use of technology within mental health care.

Covid-19, State Effectiveness, and Core Values of Political Morality

Abstract There are three main failures that occurred during Covid-19 which relate to critical aspects of what Jeremy Waldron has referred to as the constellation of political values or ideals constituting the core of our political morality. These include questions of democracy, human rights, and the rule of law. To analyze how these values were affected by Covid-19, this article begins with an overview of what occurred during the Covid-19 crisis. First, I focus on the deliberation and decision-making processes applied during the crisis. Second, I review key aspects of state effectiveness that the experience exposed. Third, I consider the ways government responses affected human rights protections. I then examine these themes through leading theoretical accounts about the critical components of political morality including rule of law, democracy, and human rights. Drawing on those theoretical perspectives, I seek to identify the broad causal story about the developmental process through which rule of law, democracy, and human rights emerge. A critical component of that story is the role of state effectiveness. In the final section, I confront these theoretical and empirical views with key takeaways from governments’ responses to Covid-19 from the standpoint of Waldron’s constellation of values of democracy, human rights, and rule of law. In conclusion I consider the implications of this understanding for the theory and practice of law and development.

Process development and validation of nextgeneration 3D calibration standards forapplication in optical microscopy

Abstract A scalable wafer-based fabrication process for a new generation of 3D standards enabling the 3D calibration of optical microscopes is presented and validated. The 3D standards are based on step pyramids with several layers in the µm range for height calibration and a system of cylindrical knops distributed across the layers as marks for lateral calibration. This enables calibration for the three coordinate axes and the orthogonality error between them in a single measurement step. The requirements necessary for such a calibration, as optical non-transparency, reproducible flatness of the pyramid step heights and the lowest possible deviations of the lateral marks coordinates, are met by optimising the manufacturing process: The deviation of the height steps distributed over the wafer is ± 3.6 nm and is primarily caused by the layer deposition processes. The lateral manufacturing accuracy was determined using calibrated SEM and show a mean deviation of 20 or 60 nm, depending on the lateral size of the structures. The EBL process and the level of inaccuracy of the SEM standard have an influence on the lateral scaling accuracy. Based on the tactilely generated height values and the coordinates of the mark determined by a calibrated SEM, an example calibration of a CLSM was successfully performed and showed good conformity to conventional calibration techniques.

Long-term administration of royal jelly regulates age-related disorders and improves gut function in naturally aging mice.

A natural aging mouse model can exhibit physiological characteristics that closely resemble those of human aging. Through long-term observation, it reflects the occurrence and development of the aging process more accurately. Although numerous beneficial effects of royal jelly (RJ) have been extensively demonstrated in multiple experimental models, the effects of RJ on naturally aging mice have not yet been investigated. In this study, middle-aged male C57BL/6J mice were given RJ for 9 consecutive months to investigate its impact on the intestinal barrier function, gut microbiota, short-chain fatty acids (SCFAs) content and possible mechanisms. The results confirmed that RJ modulated serum lipids by reducing the levels of total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C). Additionally, it protected the liver by increasing antioxidant enzyme levels while decreasing inflammatory cytokines TNF-α (by 51.97%), IL-6 (by 29.73%), and IL-1β (by 43.89%). Furthermore, RJ inhibited the expression of cell cycle-dependent kinase inhibitors including p16, p21, and p53. Importantly, RJ ameliorated gut dysfunctions by inhibiting reduction of tight junction proteins and reducing inflammatory cytokines content in the colon. We also observed an alteration in gut microbiota characterized by an elevated ratio of Firmicutes to Bacteroides (F/B) along with increased abundance of beneficial bacteria, i.e., Lachnospiraceae NK4A136 and Akkermansia. Correlation analysis revealed positive associations between most bacterial genera and SCFAs production. Functional profiling of gut microbiota composition indicated that RJ intervention regulated amino acid metabolism, glycan biosynthesis, and cofactor/vitamin metabolism. Overall, our findings provide an effective dietary intervention strategy for modulating age-associated frailty through the modulation of the gut microbiota.

The Prospects for the Development of Territorial Branding in the Context of the Experience Economy

The article explores the phenomenon of branding territories in the context of experience economy in its active development in recent years. The relevance of the study stems from a number of reasons. Firstly, there is a need for scientific and practical models of the best development practices of the regions of the Russian Federation. Secondly, the competent branding policies are required in order to revive and develop small towns, as well as to prevent the outflow of employable population to cities. And finally, there is an importance in understanding the impact of experience economy tools on the branding of territories. The subject of the study is territorial branding as one of the forms of the experience economy realization. The purpose of the study is to reveal the process of development of territorial branding in light of the experience economy. The works of local and foreign scientists, as well as materials from specialized websites, online publications on marketing strategies and tools of the new economy are taken into account. Based on a review of the scientific literature, which presents approaches to understanding the specific features of territorial branding and the importance of impressions for customer loyalty, the practical recommendations are offered for the Russian Federation. Promising strategies for forming brands of territories through the use of experience economy tools have been identified. The practical implications and scientific value of the article is in the formulated proposals for improving territorial branding.

ABCD4 is associated with mammary gland development in mammals.

Mammary gland development is a critical process in mammals, crucial for their reproductive success and offspring nourishment. However, the functional roles of key candidate genes associated with teat number, including ABCD4, VRTN, PROX2, and DLST, in this developmental process remain elusive. To address this gap in knowledge, we conducted an in-depth investigation into the dynamic expression patterns, functional implications, and regulatory networks of these candidate genes during mouse mammary gland development. In this study, the spatial and temporal patterns of key genes were characterized in mammary gland development. Using time-series single-cell data, we uncovered differences in the expression of A bcd4, Vrtn, Prox2, and Dlst in cell population of the mammary gland during embryonic and adult stages, while Vrtn was not detected in any cells. We found that only overexpression and knockdown of Abcd4 could inhibit proliferation and promote apoptosis of HC11 mammary epithelial cells, whereas Prox2 and Dlst had no significant effect on these cells. Using RNA-seq and qPCR, further analysis revealed that Abcd4 can induce widespread changes in the expression levels of genes involved in mammary gland development, such as Igfbp3, Ccl5, Tlr2, and Prlr, which were primarily associated with the MAPK, JAK-STAT, and PI3K-AKT pathways by functional enrichment. These findings revealed ABCD4 as a candidate gene pivotal for regulating mammary gland development and lactation during pregnancy by influencing PRLR expression.

Optimal Adjuvant Chemotherapy and Targeted Therapy for Early Breast Cancer-Cyclin-Dependent Kinase 4 and 6 Inhibitors: ASCO Guideline Rapid Recommendation Update.

ASCO Rapid Recommendation Updates highlight revisions to select ASCO guideline recommendations as a response to the emergence of new and practice-changing data. The rapid updates are supported by an evidence review and follow the guideline development processes outlined in the ASCO Guideline Methodology Manual. The goal of these articles is to disseminate updated recommendations, in a timely manner, to better inform health practitioners and the public on the best available cancer care options. Guidelines and updates are not intended to substitute for independent professional judgment of the treating provider and do not account for individual variation among patients. See appendix for disclaimers and other important information (Appendix 1 and Appendix 2, online only).

Prediction of plasma path and analysis of axial fracturing properties in rock fragmentation by high-voltage pulsed discharge (RHPD)

Rock fragmentation by high-voltage pulsed discharge (RHPD) is widely utilized in resource recovery and energy extraction due to its low energy consumption and high efficiency. However, observing the plasma development process during RHPD presents challenges, and the frequency dependence of dielectric properties further complicates plasma path prediction and the analysis of fracturing properties in the axial direction of the plasma. To address these issues, we analyzed the development properties of plasma within rocks and established a segmented breakdown criterion that considered the propagation velocity of plasma. Additionally, utilizing a transient electromagnetic field model and a particle flow model (PFM), we established a multi-physics field model and proposed a predictive method for the plasma path in a rock–liquid combination environment. This allows for the quantification of the velocity, potential, and length of the plasma. Furthermore, we computed the time response of shock waves and analyzed the loading mechanism of shock waves. Based on the spatial distribution of plasma, the PFM was applied to simulate the fracturing properties of rocks under shock wave loading. Finally, we established a comprehensive experimental platform for RHPD and conducted three-dimensional reconstructions of the fractured area to validate the accuracy of plasma path prediction methods and fracturing properties analysis. This study significantly advances plasma development theory and provides insights for optimizing rock fragmentation efficiency.

Use of Ticketing System in Freelancing Platform to Maintaining Client Trust in Product Development Process

Micro, small, and medium enterprises (MSMEs) are considered to be one of the important components in the economic development of a country, especially Indonesia. However, it has been found that MSMEs are lagging in digitalization, the adoption of information technology, and digital marketing. An information system where MSMEs can have easy access to IT and digital marketing professionals can be a solution to boost and encourage digitalization among local MSMEs. Developing such an information system requires the project to be able to quickly adapt and change based on the user’s needs and current trends. This study proposes an incremental solution to building an accessible information system catered for MSMEs by incorporating the ADDIE model into the development cycle. To understand the feasibility of the system, several group meetings are arranged to demonstrate and try out the system’s capability to the target users. The results indicate that the system is generally able to fit the needs of MSMEs and is quite effective at connecting the MSESs to IT and Digital marketing resources and experts.

The future of cancer therapy: exploring the potential of patient-derived organoids in drug development

Cancer therapy is on the brink of a significant transformation with the inclusion of patient-derived organoids (PDOs) in drug development. These three-dimensional cell cultures, directly derived from a patient’s tumor, accurately replicate the complex structure and genetic makeup of the original cancer. This makes them a promising tool for advancing oncology. In this review, we explore the practical applications of PDOs in clinical drug screening and pharmacognostic assessment, as well as their role in refining therapeutic strategies. We provide insights into the latest advancements in PDO technology and its implications for predicting treatment responses and facilitating novel drug discoveries. Additionally, we address the operational challenges associated with incorporating PDOs into the drug development process, such as scaling up organoid cultures, ensuring consistent results, and addressing the ethical use of patient-derived materials. Aimed at researchers, clinicians, and key stakeholders in oncology, this article aims to succinctly present both the extraordinary potential and the obstacles to integrating PDOs, thereby shedding light on their prospective impact on the future of cancer treatment.

Impact of contextual factors on new product development process: evidence from a large company in Thailand

This research investigates the impacts of contextual factors, including organization-, project-, product-, and market-related factors, on New Product Development (NPD) process and explores how these factors shape the NPD process of the company within a specific context—a large-sized company in Thailand. By interviewing 11 managers from a large-sized company in Thailand, the findings reveal different impact of the contextual factors on the company’s NPD process. Based on these findings, we develop a practical NPD model to overcome company-specific challenges and, consequently, offer valuable insights to enhance the NPD process in similar contexts. Importantly, our findings suggest that innovative companies should strategically integrate the route-to-market for radical innovation into their NPD process because it enhances the customer perception of the innovation’s value before commercialization, leading to the success of NPD. Our empirical evidence fills the gaps in the literature regarding the practical configuration of NPD processes in developing countries as well as large-sized companies, acknowledging the variation in the NPD process that depends on contextual factors where innovation occurs. It also provides detailed insights beyond most existing studies that investigate correlation of factors with the NPD process and offers practical implications for management involved in the NPD process, emphasizing the need for contextual awareness in formulating effective NPD strategies.