Three-dimensional (3D) printing technology is an emerging and flourishing technique which has a tremendous potential to bring a paradigm shift in the pharmaceutical sector. Basically, 3D printing is a fabrication technique in which automatically layer-by-layer materials are being deposited to create various design of choice. The primary objective of this manuscript is to discuss modern methods, techniques, and current trends, polymers of choice and recent applications of 3D printing technology applying in the pharmaceutical sector. Recently, the FDA has approved 3D printed tablet called Spritam, which brings a tremendous boost in the preparation of fabricated drug delivery system and personalized medicine. In this review, special importance was given to highlight the challenges and future perspectives of 3D printed technology in the pharmaceutical sector.