Development Of Innovative System Research Articles

A perspective on computer vision in biosensing.

Computer vision has become a powerful tool in the field of biosensing, aiding in the development of innovative and precise systems for the analysis and interpretation of biological data. This interdisciplinary approach harnesses the capabilities of computer vision algorithms and techniques to extract valuable information from various biosensing applications, including medical diagnostics, environmental monitoring, and food health. Despite years of development, there is still significant room for improvement in this area. In this perspective, we outline how computer vision is applied to raw sensor data in biosensors and its advantages to biosensing applications. We then discuss ongoing research and developments in the field and subsequently explore the challenges and opportunities that computer vision faces in biosensor applications. We also suggest directions for future work, ultimately underscoring the significant impact of computer vision on advancing biosensing technologies and their applications.

Analysis on the dynamics and structure of scientific and innovation-information development indicators of the Russian federal districts

The factor of scientific and innovation-information development of the country has a significant impact on the level of its economic security. The article presents an analysis of science, innovation and information systems development in Russia, as they are one of the most important factors of the economic security of the state. An assessment of the leading and lagging regions in terms of innovation activity of organisations and volume of research and development was made. Also, directions for development were identified which require additional detailed study of science, innovation and information systems development at the level of federal districts with respect to their specific features and implementation of national projects. The obtained data are the basis for further assessment of the Russian economic security level within the framework of the National Security Strategy.

Regional models of import substitution processes in the context of modern economic realities (on the example of the Samara region)

Purpose: is to develop regional import substitution models on the example of the Samara region.Methods: the paper uses a systematic approach, a method of evaluation and scientific abstractions, a method of classification and systematization, methods of information analysis and synthesis, a method of data visualization.Results: the author's toolkit of "innovative superiority of domestic products-an analogue of imported ones" has been developed, in the form of a complex of technological advantages available at the enterprise that are not available to others, forming the basis for rapid growth and development of innovations. The authors' hypothesis on the use by enterprises of the region of certain import substitution models based on the tools for the formation of innovative superiority of domestic products-an analogue of imported products, and tools for ensuring national security and overcoming anti-Russian sanctions on the production of products is put forward and proved. It is recommended to include measures to improve this policy, ensuring the development of the market of domestic products based on innovations. A program is proposed to implement for the development of national and regional innovation systems, the formation of regional and sectoral centers of innovation and technological development, the introduction of technologies of excellence and advanced development to ensure the development of the market of domestic industrial products on an innovative basis and meet domestic demand.Conclusions and Relevance: based on the analysis of the activities of industrial enterprises in the conditions of anti-Russian sanctions, it is concluded that regional policy should promote the production of competitive and innovative products, the introduction of energy and resource-saving technologies at industrial enterprises, and support the weakest enterprises with a high level of imported components. The authors of the proposed regional models of import substitution are presented by the interpretation of the really functioning regional models. In the approach proposed by the authors to the study of regional models of import substitution in industry, models of the scale and dynamics of these processes are substantiated, reflecting the production of products using domestic analogues of production, replacing imported technologies, using indicators of the domestic market, with further access to national and world markets.

Unraveling the Effects of Cationic Peptides on Vesicle Structures: Insights into Peptide-Membrane Interactions.

Antimicrobial resistance is a pressing global health issue, with millions of lives at risk by 2050, necessitating the development of alternatives with broad-spectrum activity against pathogenic microbes. Antimicrobial peptides provide a promising solution by combating microbes, modulating immunity, and reducing resistance development through membrane and intracellular targeting. PuroA, a synthetic peptide derived from the tryptophan-rich domain of puroindoline A, exhibits potent antimicrobial activity against various pathogens, while the rationally designed P1 peptide demonstrates enhanced antimicrobial activity with its specific composition. This paper investigates the concentration-dependent effects of these cationic peptides on distinct types of vesicles representing strong-negative bacterial cell membranes (S-vesicles), weak-negative bacterial cell membranes (W-vesicles), and mammalian cell membranes (M-vesicles). To investigate the interactions between the peptides and vesicles, small-angle neutron scattering experiments were conducted. The cationic peptides, PuroA and P1, interact with S-vesicles through electrostatic interactions, leading to distinct effects. PuroA accumulates on the vesicle surface, increasing Rcore and Rtotal, aligning with the carpet model. P1 disrupts the vesicle structure at higher concentrations, consistent with the detergent model. Neither peptide significantly affects W-vesicles, emphasizing the role of charge. In uncharged M-vesicles, both peptides decrease Rcore and Rtotal and increase tshell, indicating peptide insertion and altered bilayer properties. These findings provide valuable insights into peptide-membrane interactions and their impact on vesicle structures. Furthermore, the implications of these findings extend to the potential development of innovative antimicrobial agents and drug delivery systems that specifically target bacterial and mammalian membranes. This research contributes to the advancement of understanding peptide-membrane interactions and lays the foundation for the design of approaches for targeting membranes in various biomedical applications.

Optimal Controllers for the Operation of Activated Sludge Treatment Systems

Objective: Application of Optimal Control Theory to the activated sludge process in order to regulate the removal of the carbonaceous part of the organic matter. Theoretical benchmark: Dynamic models of activated sludge processes are capable of enabling the development of innovative control systems. The Optimal Control Theory, aimed at optimizing the performance of dynamic systems, allows the establishment of control systems that enhance efficiency in adapting to changes in operating conditions, ensuring satisfactory process performance. Method: The proposed control systems were established from the application of Optimal Control Theory, considering the use of the dynamic model of the activated sludge process presented by International Association on Water Pollution Research and Control. Computer simulations were used to assess the performance of the control systems proposed. Results and conclusion: The proposed control systems were capable of curbing substantially the oscillations in the concentrations of biomass, of particulate matter produced by the degradation of biomass and those of the inert particulate substrate. The reductions in the oscillations of the slowly biodegradable part of the influent were relatively smaller. The controller was quite effective in leading the wastewater treatment system sooner to the new equilibrium conditions after the imposition of the disturbances in raw effluent. Implications of research: Development of control systems for activated sludge processes to regulate the removal of the carbonaceous fraction from organic matter. Originality/value: The establishment of optimal control systems for activated sludge processes can enable greater efficiency and operational capacity, especially in industrial facilities or densely populated urban settlements, where such wastewater treatment systems are most commonly used.

Applications of Ionic Liquids in the Field of Agriculture: A Review

This review delves into the diverse applications of ionic liquids (ILs) in modern agriculture, focusing on their pivotal roles in the extraction of natural products and pesticides, as well as their substantial significance in sustainable pesticide delivery systems. The reported extraction methods include ILs and their modified materials as solvents in dispersive liquid–liquid microextraction, solid-phase dispersion, and solid-phase microextraction. The study categorizes ILs according to their utility as herbicides, microbicides, food repellents, and plant growth regulators. This review investigates the use of ILs as plant immunity inducers to elevate the systemic acquired resistance in crops, thereby augmenting their intrinsic ability to defend against plant pathogens. Furthermore, the review explores the application of ILs in pesticide delivery systems, emphasizing their ability to enhance efficacy while promoting environmental sustainability. The biodegradability and toxicity aspects of ILs are also discussed, shedding light on their potential as eco-friendly alternatives in agricultural practices. In conclusion, this comprehensive overview underscores the multifaceted contributions of ILs in agriculture, from efficient extraction methods to the development of innovative and sustainable pesticide delivery systems. As the agricultural landscape evolves towards environmentally conscious practices, the integration of ILs presents a promising avenue for enhancing productivity while minimizing ecological impact. As the agricultural industry seeks innovative and sustainable solutions, the nuanced exploration of ILs in this review highlights their potential to address multiple challenges in modern farming practices.

Synthetic Biohybrids of Red Blood Cells and Cascaded-Enzymes@ Metal-Organic Frameworks for Hyperuricemia Treatment.

Hyperuricemia, caused by an imbalance between the rates of production and excretion of uric acid (UA), may greatly increase the mortality rates in patients with cardiovascular and cerebrovascular diseases. Herein, for fast-acting and long-lasting hyperuricemia treatment, armored red blood cell (RBC) biohybrids, integrated RBCs with proximal, cascaded-enzymes of urate oxidase (UOX) and catalase (CAT) encapsulated within ZIF-8 framework-based nanoparticles, have been fabricated based on a super-assembly approach. Each component is crucial for hyperuricemia treatment: 1) RBCs significantly increase the circulation time of nanoparticles; 2) ZIF-8 nanoparticles-based superstructure greatly enhances RBCs resistance against external stressors while preserving native RBC properties (such as oxygen carrying capability); 3) the ZIF-8 scaffold protects the encapsulated enzymes from enzymatic degradation; 4) no physical barrier exists for urate diffusion, and thus allow fast degradation of UA in blood and neutralizes the toxic by-product H2 O2 . In vivo results demonstrate that the biohybrids can effectively normalize the UA level of an acute hyperuricemia mouse model within 2 h and possess a longer elimination half-life (49.7 ± 4.9 h). They anticipate that their simple and general method that combines functional nanomaterials with living cell carriers will be a starting point for the development of innovative drug delivery systems.

Formation of new narratives in the field of regional economic research

The article studies evolution of main approaches to the study of regional economy. Over the past half a century, the research paradigm in the area of economic sciences has undergone significant changes: the theories of regional economics have changed, significantly evolving, complementing, and mutually reinforcing each other. The original objectives of regional economic research have changed, responding to modern challenges of the world community development and global crisis phenomena. As a result, as shown in the article, in recent years focus of research has shifted significantly towards analyzing strategic aspects and directions of regional development, as a result of which the relevant concepts have become less economics-centric. An important pattern of modernity has also become a new wave of scientific and technological progress, which determined regional innovation systems development and their subsequent digital transformation that also put a significant imprint on the paradigm of regional economy research.

Investigation of the solubility of anticancer drugs in the supercritical solvent for development of innovative drug delivery systems; artificial intelligence paradigms (MLP-ANN) and thermodynamic correlations

The solubility of four established anticancer drugs, including busulfan, decitabine, temozolomide, and tamoxifen, has already been documented in supercritical CO2 (scCO2) to develop advanced formulations. In the current research, their supercritical solubility was theoretically evaluated by some empirical models, such as PR and SRK (cubic equations of state), UNIQUAC and modified Wilson’s models (expanded liquid models), and an artificial intelligent paradigm. The critical properties of these drugs were calculated using approved group contribution methods. Among the empirical models, the Belghait model provided the best fit to the experimental data, yielding an AARD% value within the range of 5.45–9.37 and an approximate Radj value of 0.990. Comparing SRK and PR models, the SRK model exhibited higher accuracy in correlating solubility data of all the mentioned drugs, achieving mean AARD% and Radj values in the range of 9.32–15.37 and 0.98–0.996, respectively. The UNIQUAC model outperformed the modified Wilson model in accurately correlating the solubility data for all the specified drugs, achieving mean AARD% values of 5.04–6.48 and Radj values in the range of 0.981 to 0.991. Moreover, the artificial neural network model offered the highest accuracy in predicting the solubility of the desired drugs. Notably, approximately 99.7% of its predicted data can fit with the experimental data, indicating its extremely good performance.

Amoxicillin-loaded Nanotechnological Carriers for the Effective Treatment of Helicobacter pylori Infection

Background: The bacterium Helicobacter pylori (H. pylori) is known to cause gastroduodenal disorders associated with the stomach lining that grows in the gastrointestinal tract, and can cause gastritis, peptic ulcer, gastric lymphoma, and stomach cancer. Nearly 50% of people worldwide suffer from H. pylori infection. This infection is more prominent in poor nations and undeveloped countries, and is caused by multiple factors, such as consumption of unhygienic food, crowded living style, etc. In the eradication treatment of gastric H. pylori infection, conventional dosage forms have various adverse effects on patients. Methods: In this study, we have explored current developments in the utilization of nanotechnological carriers for the successful management of H. pylori infection. In order to combat rising amoxicillin resistance, this review has focused on therapeutic strategies that use cyclodextrins, niosomes, liposomes, microspheres, nanoparticles, solid lipid nanoparticles, and nanostructure nanoparticles to improve therapy against H. pylori. Results: The entrapment of amoxicillin in various nanotechnological carriers enhances its effectiveness and reduces adverse effects. These carriers lead to targeted drug release and improve drug penetration to the gastroduodenal disease site that locally controls and adjusts the drug release. Conclusion: For the effective treatment of H. pylori infection, nanotechnological carriers have provided a new avenue for the development of innovative, high-impact, and low-dose systems. The main objective of this review was to outline the present limitations of H. pylori therapy and new potential alternatives, as well as to report how nanotechnological carriers may be used to overcome treatment shortcomings.

Intelligent Phase Contrast Meta-Microscope System.

Phase contrast imaging techniques enable the visualization of disparities in the refractive index among various materials. However, these techniques usually come with a cost: the need for bulky, inflexible, and complicated configurations. Here, we propose and experimentally demonstrate an ultracompact meta-microscope, a novel imaging platform designed to accomplish both optical and digital phase contrast imaging. The optical phase contrast imaging system is composed of a pair of metalenses and an intermediate spiral phase metasurface located at the Fourier plane. The performance of the system in generating edge-enhanced images is validated by imaging a variety of human cells, including lung cell lines BEAS-2B, CLY1, and H1299 and other types. Additionally, we integrate the ResNet deep learning model into the meta-microscope to transform bright-field images into edge-enhanced images with high contrast accuracy. This technology promises to aid in the development of innovative miniature optical systems for biomedical and clinical applications.

ИННОВАЦИОННЫЕ СИСТЕМЫ ПОДДЕРЖКИ ПРИНЯТИЯ УПРАВЛЕНЧЕСКИХ РЕШЕНИЙ: АНАЛИЗ СУЩЕСТВУЮЩИХ СИСТЕМ И ИХ ПРИМЕНЕНИЕ

In this scientific article, the analysis, development and application of innovative management decision support systems was carried out. Various systems were reviewed such as SAP Business Objects, IBM Cognos, Oracle Business Intelligence and ITSM 365. Each system was analyzed against a number of criteria such as data analytics capabilities, usability, performance and price. As a result, the advantages and disadvantages of each system were identified, which helped to determine their effectiveness and suitability for use in enterprises. It was found that the development and implementation of management decision support systems can face difficulties, such as the high cost of development, the need to take into account the specifics of each individual organization and business processes, as well as the complexity of implementing and training staff.

EFFECTIVE TAX SYSTEM AS A DRIVER OF INNOVATION PROCESSES: A COMPARATIVE STUDY OF FINLAND AND UKRAINE

This article explores the theoretical and methodological aspects of a country's tax system in terms of its impact on the development of innovation processes. It identifies the role of tax revenues in the economic and innovative development of a state, serving as a primary source of funding for sectors providing public services. The study emphasizes the role of tax policy in the development of a national innovation system, focusing on elements such as startups, venture business, incubators, accelerators, and technology parks within the current business ecosystem. The tax system is defined as a key element in the functioning of a state and the regulation of its economy, considering the needs of innovative structures to facilitate national development. Ukraine and Finland are chosen for the analysis of the impact of the tax system on innovation processes, representing Eastern and Northern Europe, respectively. The study analyzes proportional taxation in Ukraine, including the option of a simplified system, and progressive taxation in Finland, where tax rates increase with income growth. The research highlights significant differences in tax payment culture between the two countries. Finland exhibits a high level of tax culture, supported by the effective use of budgetary funds to create public goods. In contrast, Ukraine has a relatively low tax culture due to the population's low trust in the government and satisfaction with their social needs. The analysis of both countries' tax systems helps determine the role of tax policy in the innovative development of a state and the support of an innovative environment, including the implementation of startup projects.

Use case modeling in a research setting of developing an innovative pilgrimage support system

AbstractWith so much confusion around use case modeling, software developers may be reluctant to apply it. However, use cases are easy to apply and have great benefits even in research settings with nonprofessional software developers involved. We report on our experience on this within an innovative tourist information system developed in a research setting of an ongoing Horizon 2020 project named Promotion of Rural Museums and Heritage Sites in the Vicinity of European Pilgrimage Routes (rurAllure). The resulting use case model comprises forty use cases supported by class diagrams, use case diagrams, sequence diagrams, as well as by the domain model and dictionary. Three quarters of use cases have been implemented at least to some extent. Writing use cases provoked intense communication, which helped consolidate the system architecture. The use cases helped validate and better understand the GUI form wireframes designed beforehand and get quickly to a consistent implementation of the system that can be experimented with further in different ways. Finally, the forthcoming extensive system and user experience testing will be guided by the use case model. The paper also exposes the domain model and dictionary along with selected use cases and the hierarchy of user and system actors, which may be useful as such or as a stimulus for the development of other innovative tourist information systems.

Implementation of innovations in Ukraine during martial state

This scientific article is devoted to the identification of current problems of legislative regulation of priority areas of innovative activity in Ukraine and development of proposals for their solution. It emphasized the need for rapid development of the state program of objectives for forecasting the scientific, technological and innovative development of Ukraine for 2023-2032, which will contribute to the formation of financial opportunities for the development of the national innovation system. Arguments are given that increasing the level of innovative development of Ukraine in the war and post-war period will contribute to: simplification of review and agreement procedures; aligning the content of legislative acts regulating the determination of priority areas of innovative activity; operational development of the state target program, which would determine the most promising directions for the development of scientific, technological and innovative activities. The obtained results allow us to conclude on the expediency of deploying a single national strategy for the development of innovative activity, which would allow clearly defining its objectives, priorities, resources, mechanisms of implementation and control, etc., as well as the "Strategic plan for overcoming the economic crisis in Ukraine for 2023-2025".

Advancing Subcutaneous Dosing Regimens for Biotherapeutics: Clinical Strategies for Expedited Market Access.

In recent years, subcutaneous administration of biotherapeutics has made significant progress. The self-administration market for rheumatoid arthritis has witnessed the introduction of additional follow-on biologics, while the first subcutaneous dosing options for monoclonal antibodies have become available for multiple sclerosis. Oncology has also seen advancements with the authorization of high-volume subcutaneous formulations, facilitated by the development of high-concentration formulations and innovative delivery systems. Regulatory and Health Technology Assessment bodies increasingly consider preference data in filing dossiers, particularly in evaluating novel drug delivery methods. The adoption of a pharmacokinetic-based clinical bridging approach has become standard for transitioning from intravenous to subcutaneous administration. Non-inferiority studies with pharmacokinetics as the only primary endpoint have started deviating from traditional randomization schemes, favoring the subcutaneous route and comparing with historical intravenous data. While nonclinical and computational models made progress in predicting safety and immunogenicity for subcutaneously dosed antibodies, clinical trial evidence remains essential due to inter-individual variations and the impact of formulation parameters on anti-drug antibody formation. Ongoing technological advancements and the expanding knowledge base on pharmacokinetic-pharmacodynamic correlation across specialty areas are expected to further accelerate clinical development of subcutaneous biologics.

Regional innovation systems in tourism: The role of collaboration and competition

The paper explores the concept of Regional Innovation Systems (RIS) in the context of the tourism industry. It emphasizes the importance of collaboration and competition among companies within regional systems to foster innovation. It also discusses the role of social capital, relational assets, and social relationships in driving innovation within RIS. The Campania Region recognizes the importance of tourism for its development and supports the digital transition, modernization of public administration, communication infrastructure, and production system. In this vein, the paper proposes a theoretical framework that combines dynamic capabilities, relational view, and resource-based theory to explain the mechanisms and dynamics of RIS. The co-creation of innovation and strategic plans within a system of regional assets is highlighted as a key aspect of RIS. The paper concludes by emphasizing the need for collaboration, innovation, and the integration of various stakeholders' interests in the development of sustainable and innovative regional systems.

Marketing of BRICS innovation clusters in the context of geopolitical instability

The modern stage of society development is characterized by an increased attention to the issues of formation and development of national innovation systems (NIS), which would ensure the integration of various elements of the innovation process, thereby contributing to the build-up of the country's competitive advantages in the global market. Independent development of countries in modern economic conditions is not possible due to the complexity and turbulence of the external economic circuit. In the new geopolitical realities, the fact that past globalization paradigms are no longer having an impact on the viability of the NIS of many countries is becoming evident. At the same time, due to the changing geopolitical landscape, the role of international associations, such as BRICS, is being significantly transformed and they are becoming new centers of influence, including in matters of scientific and technological cooperation. One of the priority conditions for the effective functioning of international S&T cooperation networks and the NIS of each individual country is the creation and maintenance of innovation infrastructure. Already functioning innovation clusters with technology parks, business incubators, accelerators, etc. can become such an infrastructure. Cluster structures are the most effective form of development of international scientific and technological cooperation, which allows to fully realize the potential of countries and structures involved in the interaction, as well as to obtain a significant synergistic and multiplicative effect. The issues of marketing support of innovative cluster associations, which contribute to the successful promotion of clusters in the professional community and target markets, are of particular relevance in this issue.

Three-dimensional shape optimization of a submerged body under wave diffraction

This study explores the use of shape optimization to reduce wave forces on a submerged floating body subjected to wave diffraction. To this end, gradient-based shape optimization is adopted, in which dimensionless wave excitation forces are the optimization objective. A shape parameterization method based on the Fourier-series expansion is developed that permits the representation of an arbitrary three-dimensional floating body. The discrete adjoint method is utilized to calculate the gradient of the objective function with respect to the shape parameters. Using three-dimensional shape optimization, taking the initial shape to be a hemisphere, a significant reduction in surge, heave, and pitch wave forces is achieved, with a maximum reduction of 48.40%, 68.43%, and 46.22%, respectively. Furthermore, optimization effectively suppresses wave run-up, with a maximum reduction of 15.62%. A comprehensive analysis of parameters is performed to reveal the effects of wave number, incident angle, and shape parameters on the final optimized shape and wave load characteristics. This study provides a solid guide to the optimization of floating offshore platforms and the development of innovative structural systems.

The problem of ensuring the long-term sustainability of research infrastructures in today’s conditions

Problem setting. The research is devoted to the analysis of the problem of ensuring the long-term sustainability of research infrastructures, taking into account the challenges and threats that exist at the current stage. analysis of resent researches and publications. Today, aspects of the development of innovation systems and research infrastructures of the European Union and Ukraine are a topic for research of many foreign and domestic researchers. At the same time, the question of ensuring the long-term sustainability of research infrastructures in modern conditions remains relevant. Purpose of the research is to analyze the problem of ensuring the long-term sustainability of research infrastructures, taking into account the challenges and threats that exist at the present stage. Аrticle’s main body. The European framework programs made a significant contribution to the development of effective, open and effective use of national research infrastructures, and developed together with the European Strategic Forum of Research Infrastructures a consistent approach to the development of national investment policies in pan-European research infrastructures, which gave rise to the development of many European research infrastructures. Emphasis is placed on the fact that in order to maintain scientific excellence and competitiveness, it is necessary to ensure constant funding of both existing and new research infrastructure. It is concluded that it is necessary to promote synergy between funding instruments for research infrastructures (both European and national), to coordinate investments in research and innovation, improve access and translate research results for the benefit of society and the economy. Sufficient funding including adequate and sustainable funding models, required across the whole RI lifecycle to address the diversity of needs and the funding gaps, is indispensable for successful RI strategy. A joint effort combining European, national or other funding sources is vital for the healthy development of the pan-European RI ecosystem. For research infrastructures to remain relevant throughout the entire RI lifecycle, scientific excellence is the necessary condition, which becomes, together with adequate human resources, crucial when it comes to long-term persistence in the operational phase. Effective governance and sustainable long-term funding (public and private) are other key elements for ensuring long-term sustainability of research infrastructures at every stage in their lifecycle. All the long-term sustainability elements form a unique set, which should be considered and implemented as a general strategic guidance, and not only for ESFRI initiated Research infrastructures. conclusions and prospects for the development. Necessary from the development of the situation, in our opinion, it was expedient to start the preparation and implementation of the investment road map for the reconstruction of the scientific infrastructure of Ukraine. After all, the level of increasing the sustainability of research infrastructure remains an urgent issue for Europe and the world as a whole, in particular in the context of exiting the crisis related to the COVID-19 pandemic, the war in Ukraine, and the economic and political situation.