Development Of Devices Research Articles

Theranostic antibacterial hydrogel based on biopolymers cross-linked and doped with phytic acid from rice bran for wound healing

Theranostic antibacterial wound dressing is highly recommended in practical applications. The conventional methods of integrating diagnostic and therapeutic functions have the disadvantages of complicated preparation, mutual interference, inability to effectively broad spectrum antibacterial property, and easy to induce drug-resistant bacteria. Herein, a pH and light-responsive theranostic antibacterial hydrogel is developed by biopolymers polyvinyl alcohol (PVA) and polyaniline (PANI), and cross-linking with phytic acid (PA), which is widely present in rice bran. The biological polymer-based conductive hydrogel enables timely diagnosis and photothermal sterilization in-situ for wound healing. Because PANI is highly sensitive to pH changes in the bacterial microenvironment, the hydrogel can detect bacterial infections at concentrations as low as 103 CFU/mL. Subsequently, PANI absorbs near-infrared light to achieve on-demand exothermic sterilization (under 808 nm irradiation for 20 min, the killing ratios for Staphylococcus aureus and Escherichia coli reached almost 100 %). In addition, the hydrogel can monitor the intensity of joint movement to avoid wound re-tearing sensitively. In vitro cytotoxicity and hemocompatibility experiments and in vivo full-thickness infected wound model indicate that the hydrogel has good biocompatibility, antibacterial ability, and can accelerate the wound healing effectively. This work will promote the development of wearable electronic devices and precision medicine.

Creation of a soft circular patch antenna for bio-medical applications for 5G at frequency 2.45 GHz

In the medical field, efforts are currently focused on the development of devices implanted in the human body, to build a high-performance infrastructure and a working tool adapted to patients' needs. One such implanted device is the pacemaker, which is playing an increasingly important role in today's medicine. Moreover, in the general context of medical activities, we speak of telemedicine. This involves the transmission of medical information (images, reports, recordings) via antennae implanted or fixed on the human body, to obtain a remote diagnosis, specialist advice, constant patient monitoring, and a therapeutic decision. This paper presents a study and design of a circular flexible patch antenna with half-circle-shaped gaps on its sides and a slot on the opposite part of its feed; it is implemented on a bio-sourced type substrate intended for industrial, scientific, and medical applications. In addition, it is fed by microstrip technology, which features notches for impedance matching. In addition, this antenna offers improved performance compared with the literature.

The Curriculum in NDT Training Have to Include Basics Information Technology to Accomplish Reliability of Automated NDT Result's

Automation in Non-Destructive Testing (NDT) is a reality of modern manufacturing and quality assurance. Information technology applications are simultaneously developed and applied to different fields of NDT methods. The future of doing reliability checks using automated system is inevitable. The results are important to make a variety of decisions regarding the quality of a product and/or service, hence affecting safety and reliability. Depending on artificial intelligence and quantum device development, various NDT training schemes have to adopt a new curriculum to address the issue of the basic knowledge of information technology and automation in NDT. NDT operators are basically dependent on the end results of software, in which the software developer uses a set of algorithms. These are obtained in three categories; 1) Real time database; 2) Synthetic database and 3) Hybrid or combination of them. The developers should know how the NDT systems run and NDT operators in the other hand know the mechanism of the program, so that appropriate action can be taken, in case there is a missed detection, or a detected indication is not very much detrimental to the reliability of the part (Over sizing or wrongly evaluated). For example, a set of algorithms are used to create the focal laws in a phased array ultrasonic test software in space of 1˚ beam steering. Each has a limit of maximum up to 2nd Critical angle. Operators try to copy the same algorithm and set up to 89˚ refraction angle, which will just create creep wave with unreliable results to detect effective size the reflector. Programming knowledge of the operator can effectively eliminate this type of unreliability. In various Schemes of NDT Syllabus which are in common place to employ and train plus certify operators does not have it; actually, the operators do the scope of work which does includes application of Artificial Intelligence (AI) and Software. With the development of Q coupler (Quantum Computing) system, it is obvious to adopt the upcoming technology into the application of NDT industry. Training needs to update the curriculum accordingly. The current topic has intended to focus on the training gap and to address related kind of unreliability.

Radiofrequency and Electrical Muscle Stimulation: A Synergistic Treatment That Achieves Lipolysis and Circumferential Waist Reduction in Non-Invasive Body Contouring

Abstract Background Surgeons and providers in aesthetic medicine seek non-invasive devices that can be utilized for safe, efficient and effective body contouring. Patient demand has propelled the development of novel devices that can simultaneously improve skin laxity, adipolysis along with stimulation of muscle hypertrophy. Objectives To determine the efficacy of body contouring after three treatments using the non-invasive Transform (InMode, Lake Forest, CA) device. Methods A prospective, multi-center study was performed. Outcomes evaluated include: standardized caliper and ultrasound measurements of abdominal skin/soft tissue thickness, waist circumference, histologic evaluation, patient comfort and satisfaction assessments. Results Forty-four patients were successfully enrolled in the study and completed the series of three treatments which involved combined electrical muscle stimulation (EMS) and non-invasive bipolar radiofrequency (RF). Abdominal ultrasound measurements reveal a decrease in soft-tissue thickness (average 3.1mm; p=0.001), there was a significant decrease in caliper measurements of peri-umbilical skin thickness (p<0.003) and the average reduction of abdominal circumference was 1.9cm (p<0.0001) three months after the treatment series. Histology confirmed subcutaneous adipolysis without damaging the dermal layer. Patients reported a high degree of satisfaction with the overall result (p=0.003) and that each of the three treatments were progressively more comfortable (p<0.005). Conclusions This study demonstrates that a series of simultaneous non-invasive RF with EMS treatments to the abdomen decreases subcutaneous soft tissue thickness of the treated area. These comfortable treatments ultimately result in a high degree of patient satisfaction at three months.

Guest Editorial: Implantable bioelectronics

The realm of implantable bioelectronics represents a frontier in medical science, merging technology, biology, and medicine to innovate treatments that enhance, restore, or monitor physiological functions. This field has yielded devices like cochlear implants, cardiac pacemakers, deep brain stimulators, and vagus nerve stimulators, each designed to address a specific health condition, ranging from sensorineural hearing loss to chronic pain, neurological disorders, and heart rhythm irregularities. Such devices underscore the potential of bioelectronics to significantly improve patient outcomes and quality of life. Recent technological breakthroughs in materials science, nanotechnology, and microfabrication have enabled the development of more sophisticated, smaller, and biocompatible bioelectronic devices. However, the field also encounters challenges, particularly in extending the capabilities of devices such as retinal prostheses, which aim to restore vision but currently offer limited visual acuity. Research in implantable bioelectronics is highly timely, driven by an aging global population with a growing prevalence of chronic diseases that could benefit from these technologies. The convergence of societal health needs, advancing technological capabilities, and a supportive ecosystem for innovation marks this era as pivotal for bioelectronic research.

Pediatric Monitoring Technologies and Congenital Heart Disease: A Systematic Review.

Outpatient monitoring of infants with congenital heart disease has been shown to significantly reduce rates of mortality in the single ventricle population. Despite the accelerating development of miniaturized biosensors and electronics, and a growing market demand for at-home monitoring devices, the application of these technologies to infants and children is significantly delayed compared with the development of devices for adults. This article aims to review the current landscape of available monitoring technologies and devices for pediatric patients to describe the gap between technologies and clinical needs with the goal of progressing development of clinically and scientifically validated pediatric monitoring devices.

Superconducting electronic device response linearity calculation method using discrete fourier analysis

A highly effective method of the device linearity calculation on the stage of the device development is worked out and reported. The method allows expressing the linearity in terms of the achievable spurious-free dynamic range (SFDR) of the created devices, in particular superconductive electronic devices, and therefore can be easy correlated with the obtained experimental data. The algorithm scheme and the method accuracy are considered and discussed in detail.

Electrochemical Paper-Based Microfluidics: Harnessing Capillary Flow for Advanced Diagnostics.

Electrochemical paper-based microfluidics has attracted much attention due to the promise of transforming point-of-care diagnostics by facilitating quantitative analysis with low-cost and portable analyzers. Such devices harness capillary flow to transport samples and reagents, enabling bioassays to be executed passively. Despite exciting demonstrations of capillary-driven electrochemical tests, conventional methods for fabricating electrodes on paper impede capillary flow, limit fluidic pathways, and constrain accessible device architectures. This account reviews recent developments in paper-based electroanalytical devices and offers perspective by revisiting key milestones in lateral flow tests and paper-based microfluidics engineering. The study highlights the benefits associated with electrochemical sensing and discusses how the detection modality can be leveraged to unlock novel functionalities. Particular focus is given to electrofluidic platforms that embed electrodes into paper for enhanced biosensing applications. Together, these innovations pave the way for diagnostic technologies that offer portability, quantitative analysis, and seamless integration with digital healthcare, all without compromising the simplicity of commercially available rapid diagnostic tests.

Development of an HPLC device with water/acetonitrile with NaCl mixed solution that induces a phase-separation multiphase flow as the eluent in the separation column.

We developed a novel HPLC device where the phase-separation multiphase flow worked as the eluent in the separation column by using a water/acetonitrile/ethyl acetate triple mixed solution as a dual-phase-separation solution. Dual-phase-separation solutions form a phase-separation multiphase flow in a microscopic space. The new separation mechanism in the HPLC is called phase-separation mode. In this study, we used water and acetonitrile with NaCl mixed solution as a dual-phase-separation solution instead of the triple mixed solution. Octadecylsilyl (ODS)-modified particle- and porous silica particle-packed separation columns were united with the HPLC device for phase-separation mode caused by phase-separation multiphase flow. NA (1-naphthol) and NDS (2,6-naphthalenedisulfonic acid) were analyzed by the device as model sample. Using the water and acetonitrile with NaCl mixed solution at the solvent volume ratio of 5:5, NA and NDS were not separated on either column at 25°C. On the other hand, they were separated with the order NDS and NA on the ODS column and separated with the order NA and NDS on the silica column in phase-separation mode at 0°C. We discuss the separation mechanism of phase-separation mode using the water and acetonitrile with NaCl mixed solution at 0°C.

Development of portable deterioration diagnosis device for oil filled transformers based on near‐infrared spectroscopic information

AbstractA transformer plays a key role in electric power distribution system; therefore, when the transformer fails, several electrical components may get affected. As a result, diagnosing the deterioration of transformers is important for the management of electric power distribution system. The furfural content in the insulating oil of a transformer is widely used as an indicator of deterioration because furfural is generated by the decomposition of insulating paper. However, analyzing the furfural content is time consuming because of the requirement of a professional and the complexity of the diagnosis process. In this study, we propose a novel method for analyzing the amount of furfural in the insulating oil based on near‐infrared spectroscopic data obtained using the developed portable spectrometer, which can be used for the on‐site analysis at transformer installation sites. We selected wavenumbers with high correlation coefficients between the furfural content of oil and the spectroscopic data and estimated the furfural content by partial least squares regression. The results suggest that the furfural content can be analyzed in a few minutes using a small amount of oil through a portable diagnostic device.

DIW-Printed Thermal Management PDMS Composites with 3D Structural Thermal Conductive Network of h-BN Platelets and Al2O3 Nanoparticles

Electronic devices play an increasingly vital role in modern society, and heat accumulation is a major concern during device development, which causes strong market demand for thermal conductivity materials and components. In this paper, a novel thermal conductive material consisting of polydimethylsiloxane (PDMS) and a binary filler system of h-BN platelets and Al2O3 nanoparticles was successfully fabricated using direct ink writing (DIW) 3D printing technology. The addictive manufacturing process not only endows the DIW-printed composites with various geometries but also promotes the construction of a 3D structural thermal conductive network through the shearing force during the printing process. Moreover, the integrity of the thermal conductive network can be optimized by filling the gaps between the BN platelets with Al2O3 particles. Resultingly, the configuration of the binary fillers is arranged by the shearing force during the DIW process, fabricating the thermal conductive network of oriented fillers. The DIW-printed BN/Al2O3/PDMS with 45 wt% thermal conductive binary filler can reach a thermal conductivity of 0.98 W/(m·K), higher than the 0.62 W/(m·K) of the control sample. In this study, a novel strategy for the thermal conductive performance improvement of composites based on DIW technology is successfully verified, paving a new way for thermal management.

Choosing a camera and optimizing system parameters for speckle contrast optical spectroscopy

Speckle contrast optical spectroscopy (SCOS) is an emerging camera-based technique that can measure human cerebral blood flow (CBF) with high signal-to-noise ratio (SNR). At low photon flux levels typically encountered in human CBF measurements, camera noise and nonidealities could significantly impact SCOS measurement SNR and accuracy. Thus, a guide for characterizing, selecting, and optimizing a camera for SCOS measurements is crucial for the development of next-generation optical devices for monitoring human CBF and brain function. Here, we provide such a guide and illustrate it by evaluating three commercially available complementary metal–oxide–semiconductor cameras, considering a variety of factors including linearity, read noise, and quantization distortion. We show that some cameras that are well-suited for general intensity imaging could be challenged in accurately quantifying spatial contrast for SCOS. We then determine the optimal operating parameters for the preferred camera among the three and demonstrate measurement of human CBF with this selected low-cost camera. This work establishes a guideline for characterizing and selecting cameras as well as for determining optimal parameters for SCOS systems.

Tunnel junctions based on interfacial two dimensional ferroelectrics

Van der Waals heterostructures have opened new opportunities to develop atomically thin (opto)electronic devices with a wide range of functionalities. The recent focus on manipulating the interlayer twist angle has led to the observation of out-of-plane room temperature ferroelectricity in twisted rhombohedral bilayers of transition metal dichalcogenides. Here we explore the switching behaviour of sliding ferroelectricity using scanning probe microscopy domain mapping and tunnelling transport measurements. We observe well-pronounced ambipolar switching behaviour in ferroelectric tunnelling junctions with composite ferroelectric/non-polar insulator barriers and support our experimental results with complementary theoretical modelling. Furthermore, we show that the switching behaviour is strongly influenced by the underlying domain structure, allowing the fabrication of diverse ferroelectric tunnelling junction devices with various functionalities. We show that to observe the polarisation reversal, at least one partial dislocation must be present in the device area. This behaviour is drastically different from that of conventional ferroelectric materials, and its understanding is an important milestone for the future development of optoelectronic devices based on sliding ferroelectricity.

All van der Waals Semiconducting PtSe2 Field Effect Transistors with Low Contact Resistance Graphite Electrodes.

Contact resistance is a multifaceted challenge faced by the 2D materials community. Large Schottky barrier heights and gap-state pinning are active obstacles that require an integrated approach to achieve the development of high-performance electronic devices based on 2D materials. In this work, we present semiconducting PtSe2 field effect transistors with all-van-der-Waals electrode and dielectric interfaces. We use graphite contacts, which enable high ION/IOFF ratios up to 109 with currents above 100 μA μm-1 and mobilities of 50 cm2 V-1 s-1 at room temperature and over 400 cm2 V-1 s-1 at 10 K. The devices exhibit high stability with a maximum hysteresis width below 36 mV nm-1. The contact resistance at the graphite-PtSe2 interface is found to be below 700 Ω μm. Our results present PtSe2 as a promising candidate for the realization of high-performance 2D circuits built solely with 2D materials.

Integration and Implementation of Scaled Agile Framework and V-Model in the Healthcare Sector Organization

The development of medical technology devices leads to the introduction and use of agile methods, which enable the delivery of increasingly complex software with the fastest possible innovations. Delivery of the highest quality software must be considered during development, as medical products are important elements in saving human lives. Their development begins with determining a set of product requirements that exactly correspond to it. The development of specified medical products is finally delivered to the customer, who participates in the development. In this article, we present the use and combination of agile methods in software development, which correct and facilitate timely and continuous delivery of products. They also know how to smooth out a quick reaction to the customer’s changing needs and mainly focus on team management and communication. Specific agile methods make it possible to implement development through gradual improvements by integrating customer requirements towards the product. This article identifies three interconnected approaches to integrating agile methods and principles: SCRUM, SAFe, and Kanban combined with the V-model. The methods are gradually analysed based on the literature review, and the article presents a practical application in Siemens Healthcare Slovakia.

Chirality-Dependent Dynamic Evolution for Trions in Monolayer WS2.

Monolayer transition metal dichalcogenides exhibit valley-dependent excitonic characters with a large binding energy, acting as the building block for future optoelectronic functionalities. Herein, combined with pump-probe ultrafast transient transmission spectroscopy and theoretical simulations, we reveal the chirality-dependent trion dynamics in h-BN encapsulated monolayer tungsten disulfide. By resonantly pumping trions in a single valley and monitoring their temporal evolution, we identify the temperature-dependent competition between two relaxation channels driven by chirality-dependent scattering processes. At room temperature, the phonon-assisted upconversion process predominates, converting excited trions to excitons within the same valley on a sub-picosecond (ps) time scale. As temperature decreases, this process becomes less efficient, while alternative channels, notably valley depolarization process for trions, assume importance, leading to an increase of trion density in the unpumped valley within a ps time scale. Our time-resolved valley-contrast results provide a comprehensive insight into trion dynamics in 2D materials, thereby advancing the development of novel valleytronic devices.

Designing semiconductor materials and devices in the post-Moore era by tackling computational challenges with data-driven strategies.

In the post-Moore's law era, the progress of electronics relies on discovering superior semiconductor materials and optimizing device fabrication. Computational methods, augmented by emerging data-driven strategies, offer a promising alternative to the traditional trial-and-error approach. In this Perspective, we highlight data-driven computational frameworks for enhancing semiconductor discovery and device development by elaborating on their advances in exploring the materials design space, predicting semiconductor properties and optimizing device fabrication, with a concluding discussion on the challenges and opportunities in these areas.

Zeolite-Loaded Hydrogels as Wound pH-Modulating Dressings for Diabetic Wound Healing.

Wound pH has emerged as a promising therapeutic target in diabetic foot ulcers (DFU). Here, we aimed to develop a microparticle-loaded hydrogel for pH modulation in wound fluid. In a screen of polymeric and inorganic microparticles, zeolites were identified as pH-modulating microparticles. Zeolites were encapsulated in a calcium cross-linked alginate hydrogel, a biocompatible matrix clinically used as a wound dressing. This hydrogel potently neutralized hydroxide ions in serum-containing simulated wound fluid. These findings encourage a further development of this pH-modulating device as a molecular therapeutic system for DFUs.

Hygro‐Dynamic and Conductive Actuator That Restructures and Heals by Water

AbstractThe prospects of endowing stimuli‐responsive materials with various life‐like behaviors are promoting the development of intelligent robotic and electronic devices. However, it is challenging to incorporate stimuli‐responsive actuating and healing capabilities into one single material system. Herein, the design and assembly of humidity‐responsive thin films composed of poly(3,4‐ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) and sodium carboxymethyl cellulose (NaCMC) forming a conducting polymer composite through a physically cross‐linked and hydrogen‐bonded supramolecular network are described. Owing to its enhanced dynamics of hydrogen bonding at an elevated humidity, the PEDOT:PSS/NaCMC thin film exhibits a rapid humidity‐responsive actuating performance in an environment with humidity gradient, as well as a repairing function of the structural, mechanical, electrical, and actuating properties after being damaged through a humidifying‐drying cycle. Based on a combined analytical approach, a structural model is proposed for the rearrangement of the thin film when being exposed to stepwise humidity levels at multi‐length scales. Due to the structural rearrangement powered by humidity variations, the film exhibits tunable actuating and healing performance, which makes it a promising candidate material for applications in intelligent soft robotics such as artificial muscles.

Time-Resolved Mechanistic Depiction of Photoinduced CO2 Reduction Catalysis on a Urea-Modified Iron Porphyrin.

The development of functional artificial photosynthetic devices relies on the understanding of mechanistic aspects involved in specialized photocatalysts. Modified iron porphyrins have long been explored as efficient catalysts for the light-induced reduction of carbon dioxide (CO2) towards solar fuels. In spite of the advancements in homogeneous catalysis, the development of the next generation of catalysts requires a complete understanding of the fundamental photoinduced processes taking place prior to and after activation of the substrate by the catalyst. In this work, we employ a state-of-the-art nanosecond optical transient absorption spectroscopic setup with a double excitation capability to induce charge accumulation and trigger the reduction of CO2 to carbon monoxide (CO). Our biomimetic system is composed of a urea-modified iron(III) tetraphenylporphyrin (UrFeIII) catalyst, the prototypical [Ru(bpy)3]2+ (bpy = 2,2'-bipyridine) used as a photosensitizer, and sodium ascorbate as an electron donor. Under inert atmosphere, we show that two electrons can be successively accumulated on the catalyst as the fates of the photogenerated UrFeII and UrFeI reduced species are tracked. In the presence of CO2, the catalytic cycle is kick-started providing further evidence on CO2 activation by the UrFe catalyst in its formal FeI oxidation state.