Development Of Continuous Process Research Articles

Religious Freedom and Legal Education

For what was obvious yesterday is not necessarily obvious today, i.e., to the present generation of young citizens. In the past, freedom of religion for all has always been an important element of constitutional guarantees, but one wonders whether religious freedom would be defended by the present younger generation. In particular, would the young of Europe defend it? The answer, unfortunately, is most probably in the negative. But maybe the United States is different - is indeed our Euro-Atlantic world divided on the issue of religion and its role in modern societies? Legal history, in giving the opportunity to take advantage of the experience of past generations and their systems, can prove itself to be quite practical when applied in the field of legal studies, i.e., for legal research or analyses. Legal history teaches that constitutional orders have been formed for centuries and it seems likely that all were established with the intent of enduring forever; nevertheless, we know that in practice they are always in a continuous process of refinement and development and will change during the life of any particular society or state. Inevitably, then, some systems and epochs will be richer than others in their understanding of ways to put in normative order what is needed for a society in those situations that require regulation. Legal history teaches that freedom of religion always comes at a price. The crucial point is who has to pay the price. Freedom cannot defend itself. It needs its own witnesses, martyrs and, above all, guardians and protectors. Recently, that is during the last two terms, the Supreme Court of the United States has sent out a series of instructive and influential signals that protection of religion should be strengthened. The relevant cases are American Legion v. American Humanist Association (2019), Espinoza v. Montana Department of Revenue (2020), Little Sisters for the Poor Saints Peter and Paul Home v. Pennsylvania (2020), Our Lady of Guadalupe v. Morrissey-Berru (2020) and Fulton v. City of Philadelphia (2021).

Resveratrol Nanocrystal Incorporated into Mesoporous Material: Rational Design and Screening through Quality-by-Design Approach.

Bioflavonoids from grape seeds feature powerful antioxidant and immunostimulant activities, but they present problems related to solubility and bioavailability. Nanocrystal (NC) incorporated into a mesoporous carrier is a promising strategy to address these issues. However, the preparation of this formulation involves the selection of factors affecting its critical quality attributes. Hence, this study aimed to develop an NC formulation incorporating resveratrol into a soluble mesoporous carrier based on rational screening design using a systematic and continuous development process, the quality-by-design paradigm. A mesoporous soluble carrier was prepared by spray-drying mannitol and ammonium carbonate. The NC was obtained by introducing the evaporated solvent containing a drug/polymer/surfactant and mesoporous carrier to the medium. A 26−2 fractional factorial design (FFD) approach was carried out in the screening process to understand the main effect factors. The type and concentration of polymer and surfactant, resveratrol loading, and solvent were determined on the NC characteristics. The results indicated that drug loading, particle size, and solubility were mainly affected by RSV loading, PEG concentration, and Kolliphor EL concentration. The polymer contributed dominantly to reducing the particle size and enhancing solubility in this screening design. The presence of surfactants in this system made it possible to prolong the supersaturation process. According to the 26−2 FFD, the factors selected to be further developed using a statistical technique according to the quality-by design-approach, Box Behnken Design, were Kolliphor EL, PEG400, and RSV loading.

From Negative to Descriptive: An Approach to Marxist Ideological Theory

The theory of "ideology" has experienced a process of continuous enrichment and development in the history of Marxist development. Clarifying the evolution of the concept of "ideology" is the basic premise for a correct understanding of the theory of Marxist ideology. The connotation of ideology has gone through a process from negativity to descriptiveness from Marx's "false consciousness" to Lenin's "scientific ideology". On the basis of proposing the theory of "scientific ideology", Lenin further elaborated the theory of ideological leadership. Its core essentials include that the proletarian party's grasp of ideological leadership is its basic principle, the unity of criticality and construction is the essence of its theory, and the theory of ideological indoctrination is its important method and strategy.

СУЧАСНІ ТЕНДЕНЦІЇ ЦИФРОВІЗАЦІЇ РЕГІОНАЛЬНИХ ЕКОНОМІЧНИХ СИСТЕМ

In the modern conditions of socio-economic development, the process of digitization, which af-fects various spheres of activity, is gaining more and more popularity. The experience of successful countries proves that the competitiveness of regional economic systems depends on the ability to gen-erate, implement, and effectively and successfully apply digital technologies in all spheres of activity. Currently, the digitalization of regional economic systems is one of the main components of the strate-gic development of the regions of our country.The article is devoted to the study of modern trends in digitalization of regional economicsys-tems. The main goals are defined, the manifestations and advantages of digitalization of regional eco-nomic systems are clarified. Risks and problems associated with the formation, functioning and devel-opment of digitalization of regions have been identified. The factors of institutional and digital changes are outlined and the trends of digitalization of regional economic systems are analyzed. It has been proven that the implementation of digitization processes will provide an opportunity to solve numerous social problems, which in turn will lead to increased economic, innovative and so-cial development of regional economic systems. It was determined that the leading advantage of digi-talization of regional economic systems is the automation of managementprocesses, which will signif-icantly increase the level of efficiency of regional development management.The authors are convinced that digital platforms and portals facilitate operations, speed up the process of data and information exchange, and facilitate the establishment of relationships and inter-action. For business entities of regional economic systems, digitalization manifests itself in improving the quality of their products, goods and services and reducing their cost, as well as new opportunitiesfor increasing added value and other structural transformations.According to the authors, digitalization of regional economic systems is a continuous process of development of various spheres of activity and generation of innovative technologies. It has been proven that in order to achieve successful implementation of digitalization processes, coordinated work of business structures, citizens, regional and state authorities is necessary.

IMPROVING THE FUNCTION OF ACCOUNTING AND ANALYTICAL SUPPORT OF LEASE RELATIONS IN TECHNICAL SUPPORT FOR AN AGRICULTURAL ENTERPRISE

Introduction. The possibilities of significant progress in the efficiency of an agricultural enterprise in modern conditions of dynamic development of technological progress are determined by ensuring technical conditions for the introduction of innovative solutions in production technology. The development of lease relations is a more affordable means of supporting the technical support of an agricultural enterprise, but requires careful consideration of processes in order to concentrate competitive advantages within its own economic activities. Methods. The research was conducted on the basis of the use of monographic, abstract and logical, and historical methods. The methodological basis for the study of the material was the dialectical method of cognition of social and economic phenomena. Results. Based on the results of the study of the functional load of accounting in the framework of the development of lease relations, the need to integrate the balance accounting functions into the accounting and analytical support of agricultural enterprises in substantiating the prospects of lease relations is established. In this particular case, we emphasize the need to monitor the maximum scale of involvement of leased property in the production process of agricultural enterprises in order to limit the financial risks associated with violations of the financial stability of agricultural enterprises. To perform this function, there is a need to develop analytical support tools for management decisions on managing the property of an agricultural enterprise. Discussion. In the course of scientific research, it was determined that the specifics of the organization of means of mechanization of production processes of agricultural enterprises can become a significant factor in identifying the object of lease relations. The complimentary nature of agricultural implements with a strict connection to system productivity significantly affects the efficiency of the technical and technological system of agricultural enterprises. Accounting information forms a rule-making function in the planning of the technical park and will determine the strategy for the development of lease relations. Thus, the continuous process of economic development and its current state require further research aimed at improving the function of accounting and analytical support of lease relations in the formation of technical support for agricultural enterprises. Keywords: lease relations, technical support, accounting and analytical support, efficiency, financial stability.

АКМЕОЛОГІЧНИЙ АСПЕКТ ПРОФЕСІЙНОЇ ДІЯЛЬНОСТІ МАЙСТРІВ ВИРОБНИЧОГО НАВЧАННЯ

The article reveals the essence of the acmeological approach in the field of education, which is chosen to create conditions that encourage the individual to progressive self-development, self-organization and, accordingly, professional self-improvement in achieving the optimal level of professional development. The internal conditions for achieving professional acme of masters of industrial training are determined: positive motivation to achieve the expected results with a high level of demands and self-realization; focus on the ascending trajectory of the professional path; productive activity in performing professional functions; the desire to preserve and increase their achievements; the ability to mobilize potential opportunities (motivational, intellectual, operational, emotional and volitional) and recover from physical and psychological stress. The external conditions for the emergence of acme masters of industrial training are determined: assistance in mastering the means necessary for the development of pedagogical thinking, creativity, individuality of the personality and his spiritual potential; ensuring the implementation of personally and socially significant prospects in professional activities; stimulating the process of self-improvement; strengthening the integration role of acme-psychological support as a holistic and continuous process of study, analysis, formation, development, self-development and correction of the specialist's personality; development and realization of the corresponding maintenance, models, algorithms of acmeological technologies, adequate means of methodical maintenance, diagnostics and assessment of the professional developmentdynamics. The tools of accumulation of professional activityresults in the context of acme are characterized. In particular, the acmeogram, which indicates the types of professional activities and personality qualities that lead not only to the masters of industrial training socially necessary results, but also provide progressive development and professional development, promotion to high levels of professionalism; portfolio as a description in any form of educational and professional achievements of industrial trainingmasters, which includes information on the main stages of activity, professional development, including the achieved results, information on participation in projects, publications, methodological developments, etc. Key words: acmeology, master of industrial training, vocational education institution.

თანამედროვე ტექნოლოგიების გავლენა საბრძოლო მოქმედებებსა და სამხედრო გადაწყვეტილების მიღებაზე

The history of the society development and its scientific and technological progress is constantly correlated with the history of wars. The desire to raise a person’s standard of living, the rapid pace of life and the aspiration to its high quality have always depended on inventions, technological innovations and the continuous process of development. Military science and the military industry are no exception. The importance of using modern technologies and precision intellectual weapons in a 21st century war is discussed. The issue of reconnaissance drones and the kinetic-strike capability of drones in combat is highlighted, as well as their support by space-based systems. This opened a new era in the art of modern warfare and pointed to the transformation of modern warfare. The article discusses features that have actually emerged in combat in airspace and cyberspace. All the challenges and problems that accompany military decision-making process are shown in the synthesis of these actions. The role and significance of reconnaissance and fighter drones in modern large-scale or local combat operations, especially for a small country like Georgia, are also discussed.

Arapça Sözcük Türetme Yollarına Genel Bir Bakış

In this study, the word formation methods used in Arabic were examined. The aim of the study is to eliminate the deficiency in this field by considering the word derivation ways in Arabic holistically. Another aim of the study is to provide the recognition of new methods in addition to the known methods by addressing some methods that are at the least not used. Within the scope of the study, firstly the words and their types were introduced and then the ways and examples of word formation were examined. Accordingly, the ways of word derivation seen in Arabic will be examined under the headings of reactionary, istiqâq, tarîb, naht, stereotyping (siyağa), ba'su'l-kelimât, reflection (esmâ al-aswat), analogy (tamsil) and borrowing (iqtirâz). were studied and examples of the words derived in these ways were given. As a result of the research, it has been seen that there is a great need to derive new words because the language undergoes a continuous development and change process. Especially today, in addition to the rapid development of science and technology, the interaction between societies and languages through the possibilities of communication and transportation has made it inevitable to derive new words and terms.

‘Technology is Everywhere, we have the Opportunity to Learn it in the Valley’: The Appropriation of a Socio-Technical Enabling Infrastructure in the Moroccan High Atlas

This paper describes the appropriation processes involved in establishing a socio-technical enabling infrastructure in a valley in the High Atlas of Morocco. We focus on the challenges of co-establishing such an intervention in a rural/mountainous region that is already undergoing a process of continuous development and profound transformation. We reflect upon the changes and unforeseen appropriation by our local partners and inhabitants in the valley of a computer club primarily used as an informal learning centre for school children. We followed an ethnographic approach and combined research perspectives from both socio-informatics and anthropology. This paper sheds light on what a successful cooperation and intervention in this kind of challenging environment can look like. It does this by taking seriously competing expectations, fragile infrastructural foundations and the socio-cultural context. Despite the challenges, the intervention managed to lead to the establishment of a socio-technical enabling infrastructure that plays a particularly valuable role in local educational endeavours and that is now moving towards supporting other members of the community. The paper thus provides insights regarding what has to be considered to create a mutually beneficial cooperation with all relevant stakeholders as well as a sustainable intervention.

Development of continuous process for the preparation of tetraethyl orthosilicate through the reaction of metallurgical silicon with ethanol in the presence of base salt catalyst

In this study, tetraethyl orthosilicate (TEOS) was synthesized by the continuous reaction of metallurgical silicon (MSi) with ethanol. The results obtained herein suggest that among all the alkali metal base catalysts, diethylene glycol monoethyl ether sodium (DEGEE-Na) is the best catalyst; this is because it does not require any extra diethylene glycol monoethyl ether (DEGEE-H) as excess DEGEE-H results in its decomposition products. It is present in a solid phase at room temperature; however, it changes into a liquid phase under the reaction conditions. In contrast, DEGEE-Li was not suitable for this reaction, whereas DEGEE-K required extra DEGEE-H as a solvent because of the solidification of the reaction mixture in the reaction with MSi. When the continuous reaction was carried out by feeding ethanol into a mixture of MSi and DEGEE–Na salt catalyst (1:1 wt.% ratio) at 175 °C, TEOS was obtained with a yield of 70.6%. In addition to TEOS, small amounts of byproducts, such as (2-ethoxyethoxy)triethoxysilane and hexaethoxydisiloxane were obtained and unreacted ethanol was recovered and recycled. For the preparation of TEOS, activation of MSi is an important step in the reaction with ethanol. We believe that this continuous process for preparing TEOS is more economically competitive and eco-friendly method.

Effect of Health Education on Patients with Cervical Human Papilloma Virus Infection

Cervical HPV is an important factor leading to the occurrence of cervical cancer. Its occurrence and development is a gradual pathological change process, including high-risk HPV persistent infection, CIN, early invasive cancer and invasive cancer from quantitative to qualitative changes Continuous development process. At present, there is no good treatment for patients who have been infected with HPV. In order to enable HPV to achieve better prevention effects and postoperative rehabilitation effects, we have analyzed the application effects of health education in patients with cervical HPV infection to understand the importance of health education. Through a survey of patients who have undergone HPV treatment in hospitals in this city, the rehabilitation of patients who have adopted the same treatment method is compared. Experimental results prove that patients who have undergone the same treatment, but nave different levels of understanding of health education, have a great difference in their rehabilitation. Patients who understand health education are less than those who do not understand health education, and they receive treatment in patients. Later, patients who understand health education recover more than 40% faster than those who do not. This shows that health education plays an important role in the prevention and treatment of HPV, which can effectively prevent the occurrence of HPV, improve the postoperative rehabilitation effect of patients, and reduce postoperative risks.

Perancangan Design Mesin Pelontar Pakan Ikan Berbasis Mikrokontroler Arduino Mega 2560

Fish feeder machine is a machine designed to perform a feeding process that works automatically according to a predetermined feeding schedule, this machine can help improve efficiency both in terms of feed quantity and time in the feeding process. The purpose of designing and calculating machine elements in this Fish Feeder is to calculate parts of machine elements, determine the concept of machine design, draw machine drawing detail, and determine bill of material. The manufacture of this machine uses approach method of James H Earle and concept selection using the method of Stuart Pugh, drawing software using Solidworks 2015 and working drawing using ISO Standard. The design of the throwing machine that has been made is the result of a literature approach and field surveys (direct surveys at the Fisheries Service and at the Fish Seed Center where fish feed throwing machines are needed). This machine needs a continuous process of development and testing

Modeling the change trajectory of sleep duration and its associated factors: based on an 11-year longitudinal survey in China

BackgroundSleep duration is a vital public health topic, yet most existing studies have been limited to cross-sectional surveys or inconsistent classifications of sleep duration categories, and few characterized its continuous development process. The current study aimed to depict its change trajectory in the general population and identify associated factors from a dynamic perspective.MethodsA total of 3788 subjects (45.4% male, mean age 46.72 ± 14.89 years) from the China Health and Nutrition Survey were recruited, and their daily sleep duration for five consecutive measurements from 2004 to 2015 was recorded. We adopted latent growth modelling to establish systematic relations between sleep duration and time. Participants’ sociodemographic characteristics, lifestyle, and health factors were taken as covariates.ResultsThe change in sleep duration could be depicted by a linear decreasing trajectory with the mean yearly decrease at 2.5 min/day. The trajectory did not differ by residence, BMI category, chronic disease situation, smoking status, or drinking status. Moreover, there were sex and age differences in the trajectory, and females and those under 30 were prone to larger decrease rates.ConclusionThe quantified yearly change in sleep duration provided insights for the prediction and early warning of insufficient sleep. Public health interventions focusing on slowing down the decrease rates among females and young individuals are warranted.

Modeling-Assisted Design of Thermostable Benzaldehyde Lyases from Rhodococcus erythropolis for Continuous Production of α-Hydroxy Ketones.

Enantiopure α‐hydroxy ketones are important building blocks of active pharmaceutical ingredients (APIs), which can be produced by thiamine‐diphosphate‐dependent lyases, such as benzaldehyde lyase. Here we report the discovery of a novel thermostable benzaldehyde lyase from Rhodococcus erythropolis R138 (ReBAL). While the overall sequence identity to the only experimentally confirmed benzaldehyde lyase from Pseudomonas fluorescens Biovar I (PfBAL) was only 65 %, comparison of a structural model of ReBAL with the crystal structure of PfBAL revealed only four divergent amino acids in the substrate binding cavity. Based on rational design, we generated two ReBAL variants, which were characterized along with the wild‐type enzyme in terms of their substrate spectrum, thermostability and biocatalytic performance in the presence of different co‐solvents. We found that the new enzyme variants have a significantly higher thermostability (up to 22 °C increase in T50) and a different co‐solvent‐dependent activity. Using the most stable variant immobilized in packed‐bed reactors via the SpyCatcher/SpyTag system, (R)‐benzoin was synthesized from benzaldehyde over a period of seven days with a stable space‐time‐yield of 9.3 mmol ⋅ L‐1 ⋅ d−1. Our work expands the important class of benzaldehyde lyases and therefore contributes to the development of continuous biocatalytic processes for the production of α‐hydroxy ketones and APIs.

Action research and collaborative reflective practice in English language teaching

ABSTRACT The purpose of this investigation was to explore how reflective practice (RP) could be implemented and systematized in diverse ELT Mexican contexts in order to foster continuous professional development. Hence, this collaborative action research was conducted over aperiod of 22 months with different English Language Teaching (ELT) practitioners; 24 Mexican teacher educators and two in-serviceEnglish language teachers from Longford, Ireland and Texas, USA who were living and working in Mexico. The data was collected by means of classroom observations, feedback sessions, individual interviews, and professional dialogues–informal meetings, self-reporting,and text messaging. Overall, the findings of this investigation showed that teachers, who had the openness to challenge inconsistencies, gaps and at times fears in their teaching stances, beliefs and therefore practices, also had the willingness to carry out reflective actions that were guided by critical inquiry, collaboration with the researcher and modelled practices by other colleagues; enabling teacher effective engagement in reflective procedures as well as in personal continuous professional development processes.

Benzylic Photobromination for the Synthesis of Belzutifan: Elucidation of Reaction Mechanisms Using In Situ LED-NMR.

A detailed mechanistic understanding of a benzylic photobromination en route to belzutifan (MK-6482, a small molecule for the treatment of renal cell carcinoma associated with von Hippel-Lindau syndrome) has been achieved using in situ LED-NMR spectroscopy in conjunction with kinetic analysis. Two distinct mechanisms of overbromination, namely, the ionic and radical pathways, have been revealed by this study. The behavior of the major reaction species, including reactants, intermediates, products, and side products, has been elucidated. Comprehensive understanding of both pathways informed and enabled mitigation of a major process risk: a sudden product decomposition. Detailed knowledge of the processes occurring during the reaction and their potential liabilities enabled the development of a robust photochemical continuous flow process implemented for commercial manufacturing.

Development of continuous process for surimi seafood by microwave heating

Development of continuous process for surimi seafood by microwave heating

The Political Development of Contemporary China from the Perspective of Historical Political Science

The political development of contemporary China defies existing political theories. The framework of “political science” based on the ‘rational man hypothesis’ has proven to be fallible in terms of correctly envisioning China’s future. Appertaining to the Chinese political history, historical political science offers not only epistemology and methodology of the subject, but also an ontological element, for observation. With respect to historical political science, contemporary Chinese politics is considered to be the natural genetic extension of the Chinese civilization as well as a continuous and unified development process spanning over a period of 70 years ever since the People’s Republic of China was founded. Historical political science, deemed to be a tailored research approach for the development of contemporary Chinese politics, essentially adds further value and significance to this discipline.

The clinical practice experience in psychiatric clinic of nursing students and career intention in China: A qualitative study.

Nursing students face a lot of complicated situations and problems when they participate in psychiatric clinical practice for the first time. However, the nursing students' internship experience and career intention in psychiatry have not been well described in China. This study aims to explore the experience and career intention of Chinese nursing undergraduates during their first psychiatric internship. This is a qualitative design using phenomenological approach. Data were collected through a case-study, semi-structured, two face-to-face in-depth interviews (N=13) with third-year nursing students from a university in China on their first clinical internship in a psychiatric department. We followed the consolidated criteria for reporting qualitative research (COREQ) checklist. Four themes were identified: negative stereotype perceptions about mental illness, professional maturation, personal development, attitude towards psychiatric patients and career choice. The experience of nursing students in psychiatric clinical practice was constantly changing. This study indicated that nursing students went through a continuous development process of psychiatric care professional maturation and personal development. However, psychiatric nursing was not an ideal career choice of nursing students. This study provides guidance for educators to optimize the internship experience and take comprehensive measures to improve the professional attractiveness and professional identity of psychiatric nursing.

LOOKING THROUGH TEACHERS’ EYES – INVESTIGATING TEACHER AGENCY

ABSTRACT Societal, structural, value-based or economic changes and changes related to technological developments necessitate a continuous development process in the field of education. In responding to the changes, teacher agency becomes a key factor. This study explores when the context of reform provides the basis for the growth of agency and when it disables the potential for teacher agency. The analysis is based on empirical data gathered as part of a large-scale mixed-methods study of the professionalism of Estonian teachers. This study identified the strong presence of professional knowledge and skills among teachers related mainly to classroom work and we argue that this is a result of focusing on short-term professional aims. But a prerequisite for the growth of teacher agency is support so that teachers can develop their professional vocabulary and theoretical knowledge base.