The present study proposes an analytical investigation of the natural resources and social framework of the Hodh el Chargui region (Mauritania), aiming to offer a useful instrument for planning and management to the local authorities. The situation of the region was evaluated by means of a participatory survey carried out among the local inhabitants. The obtained results include a collection of data about population, territorial organization, access to basic education and health services, infrastructure, main economic activities, and natural resources (in terms of water, both surface and groundwater, duration and intensity of rainfalls, soil types, and vegetal resources). The survey outcomes were completed with an integrated approach based on Earth Observation (EO) data supports, such as digital elevation models (DEMs) and Landsat8 imagery. The interdependence among the different data was evaluated and discussed, with regard to the influence of the availability of natural resources on the development of agricultural activities and on the general social welfare. The results are organized in the form of digital maps and a user-friendly webmap platform to facilitate access for all the technical and nontechnical actors involved in the project.