Population In Developed Countries Research Articles

Factors associated with adherence to pharmacological treatment by hypertensive patients

Today, arterial hypertension represents one of the most prevalent diseases in Brazil and in the world, being considered as one of the most important public health problems. It is a chronic-degenerative disease, responsible for causing morbidity in the population in developed and underdeveloped countries. The treatment adopted for the control of SAH is based on non-pharmacological and pharmacological measures. Among the non-pharmacological treatments is the adoption of physical exercise practices. Pharmacological treatment consists of taking available antihypertensive drugs. Objective: to evaluate the factors associated with adherence to pharmacological treatment by hypertensive patients in the city of Montes Claros - MG. Materials and Methods: the present work is a descriptive study, with quantitative field analyzes with cross section. The population of this research was composed of 200 hypertensive patients from the Basic Health Units of the city of both genders, selected at random by lot. Results: the prevalence of adherence to pharmacological treatment was 70% in its entirety and of these 73% are able to farm through SUS. Conclusion: Public health directly influences patients' adherence to pharmaceuticals.

Evaluation of antibody immunochromatography testing for diagnosis of current Helicobacter pylori infection

BackgroundHelicobacter pylori infection represents a major gastrointestinal complaint associated with gastritis, gastric ulcer and stomach tumors. It is present in 90 % of developing countries population. H. pylori diagnosis in these countries, where resources are limited, is accomplished with simple non-invasive tests such as stool antigen and serum antibody tests. The aim of this study was to evaluate the serum antibody test in the diagnosis of current H. pylori infection. Subject and methodsA total of 117 patients were included in this prospective diagnosis accuracy testing study, who clinically presented with dyspepsia, heartburn, abdominal pain, diarrhea, or halitosis. A stool sample was collected from each patient and tested for H. pylori antigen using immunochromatographic method.Blood sample was also collected, half of which was EDTA-sampled and analyzed for complete blood count, while the remaining half was left to clot, the separated serum was tested for antibodies against H. pylori with immunochromatographic cassette. ResultsAbout 35 % of sixty six patients who were positive for stool antigen test gave a negative for serum antibodies test. Meanwhile, the non-consistent results within 51 negative stool antigen test patients was exhibited by 47 % of them. The discrepancies were not affected by age or disease duration. The calculated sensitivity, specificity, positive predictive value and negative predictive values were 50 %, 65 %, 65 % and 50 % respectively. ConclusionThe serum antibody test is not reliable in the diagnosis of current H. pylori infection. In developing countries, with limited facilities and primary care units, stool antigen test diagnosis is useful for diagnosis.

An Overview About the Role of Adaptive Immunity in Keeping SARS-CoV-2 Reinfections at Bay.

Coronavirus disease 2019 (COVID-19) is a worldwide emergency that has affected millions of populations in developed and underdeveloped countries. To our surprise, many people have been tested positive twice. Few cases of true reinfections involved genetic alterations in the virus. Appearance of multiple positive tests may be due to human errors or remnant genetic material, but genetic modification in virus represents very serious issue of controlling this pandemic. It is the need of the day that all the gaps and deficiencies, represented by variable response of adaptive immune system toward this infection, be filled and rectified. We have discussed reinfections with variable outcomes along with the possible reasons for variable response. Phenomena such as T cell memory, absence of cross-reactive immunity, T cell exhaustion, drawbacks pertaining to neutralizing antibodies, and immune enhancement are crucial areas by which adaptive immune response can weaken considerably. Earlier and stronger herd immunity is also at the mercy of strong adaptive immune system to avoid future pandemics by the same microorganism. Likewise, consequences of this phenomenon should also be considered during vaccine development as resources worth billions are being used and staked. Many countries have entered the second/third waves of COVID-19. Therefore, we need to come up with ways toward uniform strengthening of adaptive immune response to fight off this pandemic. Also, to develop and maintain constant resistance to severe acute respiratory syndrome coronavirus (SARS-CoV-2), the mentioned weakened links in the chain of adaptive immunity may be explored to keep viral invasion and physiological damage to minimum.

Polyplex-Loaded Hydrogels for Local Gene Delivery to Human Dermal Fibroblasts.

Impaired cutaneous healing leading to chronic wounds affects between 2 and 6% of the total population in most developed countries and it places a substantial burden on healthcare budgets. Current treatments involving antibiotic dressings and mechanical debridement are often not effective, causing severe pain, emotional distress, and social isolation in patients for years or even decades, ultimately resulting in limb amputation. Alternatively, gene therapy (such as mRNA therapies) has emerged as a viable option to promote wound healing through modulation of gene expression. However, protecting the genetic cargo from degradation and efficient transfection into primary cells remain significant challenges in the push to clinical translation. Another limiting aspect of current therapies is the lack of sustained release of drugs to match the therapeutic window. Herein, we have developed an injectable, biodegradable and cytocompatible hydrogel-based wound dressing that delivers poly(β-amino ester)s (pBAEs) nanoparticles in a sustained manner over a range of therapeutic windows. We also demonstrate that pBAE nanoparticles, successfully used in previous in vivo studies, protect the mRNA load and efficiently transfect human dermal fibroblasts upon sustained release from the hydrogel wound dressing. This prototype wound dressing technology can enable the development of novel gene therapies for the treatment of chronic wounds.

Risk factors for prediction of delirium at hospital admittance

AbstractAging population in many developed countries, moves the issue of healthy aging at the forefront of the political, scientific and technological concerns. Delirium is a multifactorial disorder that is highly prevalent in hospitalized elderly people that causes complications in the patient care and increases mortality at the hospital and soon after discharge. Early diagnostics would allow improved treatment and prevention for a syndrome that requires very personalized treatment. This paper deals with machine learning based prediction of delirium at hospital admittance as a computer aided diagnostic tool, as well as with the identification of risk factors by means of the variable importance computed by the classifier model building approaches. We achieve almost 0.80 classification accuracy, which is encourages further exploration of improved classifier models. Exploration of variable importance shows that frailty, dementia and some pharmacological factors are relevant risk factors for delirium at hospital admittance.

Voluntary Private Investments Role in Pension System in Latvia

Pension systems have become one of the main priorities for the national governments. Developed countries population is getting older by putting the pressure on the state budgets and work age people tax load. The current pension system in Latvia performs according to regulation of state compulsory unfunded pension scheme since 1996 and regulation of the state funded or accumulated pension scheme since 2001. The third pension system pillar is private voluntary pension schemes realized in form of people contributions into pension funds and life insurance policies. Aim of the research – deeper analyses of voluntary private investments as the pension system part and its development challenges in Latvia. Research methods: scientific publications and previous conducted research analysis; analysis of time series on private pension fund developments in Latvia and comparisons with the situation in other OECD countries. The authors were looking for answer on the question – can voluntary private investments cover the gap between pre-retirement and after-retirement income of population in Latvia and what are the pre-conditions for it.

Technology Entrepreneurship in Developing Countries: Role of Telepresence Robots in Healthcare

Developing countries represent about three-quarters of the world's population and have become the main driver for the global population and economic growth. Technology entrepreneurship plays an important role in sustainable development of vulnerable social groups and element. These efforts can channel technological benefits to underdeveloped regions. We discuss technology entrepreneurship in developing countries, with a focus on mobile health (mHealth) and telepresence robots. Specifically, we discuss how mHealth can help aged and disadvantaged developing country populations cope with normal life difficulties and challenges-but also in the extreme case and threat of a pandemic. Using past practices and lessons in telepresence robots, we propose FLEXTRA, a flexible robot mechanism to support instant video calls, smart medicine dispensation, and remote control. We also illustrate the applications of FLEXTRA in healthcare, e.g., fighting against COVID-19.

Fasting and fasting-mimicking diets for chemotherapy augmentation.

The increasingly older population in most developed countries will likely experience aging-related chronic diseases such as diabetes, metabolic syndrome, heart and lung diseases, osteoporosis, arthritis, dementia, and/or cancer. Genetic and environmental factors, but also lifestyle choices including physical activity and dietary habits, play essential roles in disease onset and progression. Sixty-five percent of Americans diagnosed with cancer now survive more than 5 years, making the need for informed lifestyle choices particularly important to successfully complete their treatment, increase the recovery from the cytotoxic therapy options, and improve cancer-free survival. This review will discuss the findings on the use of prolonged fasting, as well as fasting-mimicking diets to augment cancer treatment. Preclinical studies in rodents strongly support the implementation of these dietary interventions and a small number of clinical trials begin to provide encouraging results for cancer patients and cancer survivors.

Risk factors of under nutrition among indigenous children under five years in developing countries: A scoping review

Undernutrition is a leading cause of child mortality, especially among indigenous peoples worldwide. Understanding associated predictors is essential for mitigation strategies. This review was undertaken to identify existing literature on the determinants of undernutrition among under-five indigenous children in developing countries, and to reveal existing knowledge gaps. Using relevant terms, we searched for relevant literature from PubMed, Medline, Scopus, and Google scholar databases, WHO and UNICEF websites, and reference lists of included studies from 2009 to 2019. Of the 10 records that met the eligibility criteria, 4, 3, 2, and 1, were conducted in Brazil, India, Guatemala and Malaysia, respectively. Seven were cross-sectional, studies, 2 were population-based studies and 1 a mixed-method studies. All studies included under-five children, ranging in sample size from 74 to 6075. Regarding anthropometric indicators, study 1 focused on anaemia, 2 on wasting, 3 on underweight, and 8 focused on stunting. Factors associated with undernutrition were maternal educational status, maternal stunting, health care seeking behaviour, child age, child sex, child morbidity status, socio-economic status, inadequate water quality, hygiene and sanitation conditions. These results are relevant in informing undernutrition-reduction policies and interventions among indigenous populations in developing countries. The study revealed a paucity of research, particularly, in Africa where no study was identified. Key words: Under nutrition, risk factors, under-five children, indigenous, developing countries.

Expert round-table Constipation: diagnosis, treatment, risks

According to epidemiological data, nearly a quarter of the adult population in developed countries suffers from constipation. Due to a significant decrease in quality of life, it represents a serious medical and social problem. Constipation occurs more frequently in the elderly, but both children and adults face this problem. This disease is often caused by the features of modern life: hypodynamia, diet violations, a fiber- and water-depleted diet, frequent stress, etc. Unfortunately, despite the high prevalence of the disease, patients do not seek immediate medical advice. We will discuss this urgent problem and look for new efficient solutions of it with the leading experts: Gastroenterologist Yuri A. Kucheryavy, Cand. of Sci. (Med.), Associate Professor of Department of Propedeutics of Internal Diseases and Gastroenterology, A.I.Yevdokimov Moscow State University of Medicine and Dentistry, Chief Gastroenterologist of Central Healthcare Directorate – Branch of Joint Stock Company “Russian Railways”; Endoscopist Ekaterina V. Ivanova, Dr. of Sci. (Med.), Chief Researcher, Research Laboratory of Surgical Gastroenterology and Endoscopy, Head of Endoscopy Department of Petrovskie Vorota Medical Center, and Coloproctologist Daniil R. Markaryan, Cand. of Sci. (Med.), Senior Researcher, M.V. Lomonosov Moscow State University Clinic.

Psychological distress among carers and the moderating effects of social support

BackgroundCarers provide both practical and emotional support and often play an important role in coordination of care for recipients. The demands of caring may lead to increased levels of stress for the carer, which can affect mental health and quality of life. This study examined the relationship between being a carer and psychological distress (assessed using the Kessler Psychological Distress Scale [K10]), and explored the moderating effect of social support in that relationship using a large sample.MethodsThe study used data from the 45 and Up study, a large cohort study of individuals aged 45 years and over in New South Wales, Australia, and applied multiple regression methods and moderation analysis. The sample for the current study comprised 267,041 participants drawn from the baseline dataset, with valid data on the primary outcome (carer status).ResultsThe mean age of participants was 62.73 (±11.18) years, and 4.23% and 7.13% were identified as full-time and part-time carers, respectively. Compared to non-carers, full-time carers had K10 scores that were on average, higher by 1.87, while part-time carers’ K10 scores were on average higher by 1.60 points. A perception of social support reduced the strength of the relationship between carer status and psychological distress by 40% for full-time carers and 60% for part-time carers.ConclusionsThe findings have important implications, for both prevention and treatment of psychological problems among carers. In terms of prevention, they suggest that public health campaigns focused on increasing awareness regarding the psychological burden faced by carers would be useful. In terms of intervention, potential treatments that focus on improving social support networks may be helpful. The results are particularly important in the current context of an ageing population in Australian and other developed countries, where caregiving is likely to play an increasing role in the care and support services.

Sigmoid Activation Function in Selecting the Best Model of Artificial Neural Networks

The aim of the research is to make predictions from the best architectural model of backpropagation neural networks. In determining the outcome in the form of a prediction model, the activation function in the artificial neural network is useful to transform an input into a certain output. In this study the activation function used is sigmoid. The study uses the case of population density in Indonesia considering that for developing countries population growth has many negative impacts such as increased poverty, unemployment and crime rates. This study uses data from Badan Pusat Statistic Indonesia for population categories in 2003-2015. The process of determining the architectural model is carried out 2 stages including: the training stage and the testing stage. The two architectural models used (5-2-1 and 5-10-1), the selection of architectural models is done by looking at several assessment parameters such as epoch, accuracy, MSE training and MSE testing. The process of training and testing of data is done by using the help of the Matlab application. The results of the study obtained that the architectural model 5-2-1 is the best model for predicting with an accuracy of 65%, MSE Training 0,0009997254, MSE Testing 0.0014897214 and Epoch 28548.

P767 Prevalence and incidence rates of inflammatory bowel disease among First Nations: Population-based evidence from Saskatchewan, Canada

Abstract Background Worldwide, the epidemiology of inflammatory bowel disease (IBD) has been widely studied in the general population; however, there is limited-to-no evidence about IBD among Indigenous peoples, specifically among First Nations (FNs). Saskatchewan (SK) is a province in western Canada with a population of 1.1 million, 11% of whom are FNs. We aimed to estimate the prevalence, incidence, and trends of IBD among FNs in SK since 1999. Methods As part of a patient-oriented research project, we conducted a retrospective population-based study between 1999 and 2016 fiscal years using administrative data for the province of SK. A previously validated algorithm that required multiple health care contacts was applied to identify IBD cases (Crohn’s disease [CD] and ulcerative colitis [UC]). The ‘self-declared FN status’ variable in the Person Health Registration System was used to determine FNs meeting the IBD case definition and the population at risk. Generalised linear models (GLMs) with generalised estimated equations and a negative binomial distribution were used to estimate the annual prevalence of IBD, CD, and UC. Incidence rates and their corresponding 95% confidence intervals (95%CI) were estimated using GLMs with a negative binomial distribution. The GLMs were used to test trends overtime. Results The annual prevalence of IBD among FNs in SK increased from 64 (95%CI 62–66) per 100,000 people in 1999 to 142 (95%CI 140–144) per 100,000 population in 2016. Also, the prevalence of CD and UC increased during the study period, with 53/100,000 (95%CI 52–55) for CD and 87/100,000 (95%CI 86–89) for UC in 2016. The average increase in the prevalence of IBD was 4.2% (95%CI 3.2–5.2) per year, with similar trends observed in CD (4.1% [95%CI 3.3–4.9]) and UC (3.4% [95%CI 2.3–4.6]). The incidence rates of IBD among FNs were 11 (95%CI 5–25) per 100,000 people in 1999 and 3 (95%CI 1–11) per 100,000 population in 2016. No statistically significant changes were observed in the incidence rates over time (p = 0.09). Conclusion This study is the first epidemiological work providing detailed evidence of IBD among FNs. We identified that FNs have increasing trends in the prevalence of IBD, which has also been described in the Canadian general population. In contrast to the general population of Canada and other developed countries that have shown decreasing trends, the incidence rates of IBD among FNs appear to be stable over time. Also, among FNs, UC appears to be more prevalent than CD; this pattern has been observed in the general populations of developing countries. These results illuminate the need to advocate for better health care and wellness for FNs living with IBD.

Urban space and physical activity are a risk factor for cardiovascular diseases

Lack of physical activity (PA) is considered as one of the risk factors for a number of chronic non-communicable diseases. The sedentary lifestyle of a significant part of developed countries population, along with the insufficient effectiveness of traditional tools to stimulate the PA of the population, determine the interest of healthcare in optimizing urban space for increasing PA. In Russia, the number of studies in this area is extremely small, which determines the purpose of this review: presentation of the foreign results of the implementation of practical concepts and programs for optimizing urban space, as well as prospective studies that demonstrate the most evidence-based causal relationships of PA changes. Focus in prevention of diseases in Russia over the past decade, determines the scientific interest in risk factors, the features of its formation, and possible ways of implementation. In this regard, the results of such topics will be in demand by Russian health care, which will require the conduct of own Russian studies, taking into account foreign experience.

Modelling hospital readmissions under frailty conditions for healthy aging

AbstractIn the current context of an aging population in many developed countries, the issue of healthy aging is at the forefront of the political, scientific, and technological concerns. The frailty accompanying the late years of elderly people (>70 years old) deserves special consideration due to its great economical and personal costs and the workload imposed on the health care system. Hospital readmissions under a short time after hospital discharge are one of the sources of concern, and much effort is being devoted to their prediction for better care of the elder and optimized resource management. In this paper, we consider the prediction of readmissions for patients that are evaluated positively in the frailty scales. The computational experiments are carried out over a gender‐balanced cohort of 645 patients recruited at the University Hospital of Alava. We report machine‐learning prediction results of the readmission before the standard readmission limit of 30 days. We apply an upsampling technique to correct for class imbalance. Results are positive, encouraging further research and the creation of larger cohorts in international efforts.

Gastrointestinal bleeding and the prevention of thromboembolism

About 2 percent of developed countries population use vitamin K antagonists (VKA), such as warfarin. These anticoagulation drugs are commonly prescribed for the purpose of thromboembolism prevention, in cases of atrial fibrillation, mechanical heart valves, deep vein thrombosis, pulmonary embolism and etc. The frequency of VKA prescription is massively increasing in the whole world. The main reason for it is the ageing of the population. As the usage of anticoagulants is increasing, doctors more often get to encounter patients with gastrointestinal bleeding taking anticoagulating drugs. The treatment of these patients is difficult because there are several important factors that have to be considered while choosing the tactic of treatment, such as the intensity of bleeding, coagulation, thrombotic risk and endoscopic findings. Even if practical guidelines partially indicate the main principles of actions for similar cases, the treatment of bleeding patients taking anticoagulants remains seriously challenging. This article contains clinical case report and the discussion of the treatment that has been chosen in this case, based on practical guidelines provided by American Society for Gastrointestinal Endoscopy (ASGE), European Society of Gastrointestinal Endoscopy (ESGE) and European Society of Cardiology (ESC). This topic is also addressed in guidelines from the American College of Gastroenterology, the American College of Chest Physicians, the American College of Cardiology, which give similar recommendations.

Assessing Electronic Health Literacy in the State of Kuwait: Survey of Internet Users From an Arab State.

BackgroundThe internet and social media have become an important source for health information. In 2017, the State of Kuwait ranked first in mobile subscription penetration in the Arab world; nearly 90% of its population uses the internet. Electronic health (eHealth) literacy is important in populations that have easy and affordable access to internet resources to more effectively manage health conditions as well as improve general population health.ObjectiveThe aim of this study was to assess eHealth literacy levels across internet users in Kuwait and identify demographic characteristics that influence eHealth literacy. Furthermore, the study aimed to identify the reasons and type of information that people seek online. Finally, this study examined the utilization of various social media channels for accessing online health information. The social media platforms considered were as follows: WhatsApp, Twitter, Instagram, YouTube, Facebook, and Snapchat.MethodsA cross-sectional anonymous Web-based survey was used to collect data about eHealth literacy and related information. The eHealth literacy scale (eHEALS), originally developed by Norman and Skinner, is measured using 8 Likert-type scales. A linear regression model estimates the effect of demographic variables such as age, gender, and education on eHealth literacy while controlling for participants’ perceived usefulness and importance of the internet. Participants were also surveyed about their frequency in using social media platforms for seeking health information.ResultsKuwait’s composite eHEALS, based on a sample of 386 participants, was 28.63, which is very similar to eHEALS observed among adult populations in other developed countries. Females in Kuwait demonstrated a higher average eHEALS compared with males. Among the social media platforms, the survey results indicated that YouTube is the most frequently used to seek health information, with Facebook being the least frequently used.ConclusionsInternet users in Kuwait appear confident in their ability to search for health-related information online compared with other populations, as indicated by aggregate eHEALS scores. Considering this finding, government and health care organizations should shift more efforts from traditional media toward online health information, focusing on the social media outlets that people in Kuwait find more useful for seeking health information.

Interventions to Increase Blood Donation among Ethnic/Racial Minorities: A Systematic Review.

Ethnic/racial minorities are under-represented in blood donor populations in most developed countries. This is of particular concern where minorities differ from a country's majority population in terms of blood or tissue typing, especially where type matching is required for effective management of rare disorders such as sickle-cell disease that require multiple transfusions. This systematic review assessed the effectiveness of interventions to increase blood donation among ethnic/racial minority populations in developed countries. We searched MEDLINE, EMBASE, CINAHL, and ProQuest on 20 March 2017 with no date restrictions and supplemented this with searches on Google Scholar, blood collection agency websites, reference lists of included studies, and a forward search of citations of included studies. We included intervention studies designed to increase recruitment and/or retention of adult, ethnic/racial minority blood donors in developed countries. The review identified eight studies reported in nine publications. Six were conducted in the USA with African Americans. Four studies reported on multifaceted, community-based interventions; three reported on one-off information and educational video interventions, presented face-to-face, or delivered via post or e-mail. The level of evidence for efficacy was low, and the majority of studies were assessed as having some risk of bias related to one or more methodological issues. All eight studies reported positive outcomes in blood donation and/or intention to donate. Seven trials found that the intervention increased presentation for donation, and three found an increase in the percentage of new donors from the ethnic minority targeted. The review findings demonstrate that it is possible to design and implement effective interventions to motivate individuals from ethnic/racial minority groups to donate blood. One-off interventions may be as effective as multifaceted, community-based interventions. There was insufficient evidence to recommend particular interventions, and future research should empirically assess alternative interventions using robust study designs.

Food choice and food consumption frequency of Cape Verde inhabitants

The knowledge of the food pattern of a population is crucial for establishing nutritional and epidemiological profiles, as well as for controlling the market of foodstuffs and to help in the management of stock of staple foods. This study aims to evaluate food consumption and its association with the underlying motives for consumers' food choices, through the application of a Food Frequency Questionnaire (FFQ) followed by a Food Choice Questionnaire (FCQ). Face to face interviews were conducted with 503 participants, recruited at their homes, workplaces, health centers and other central locations in Cape Verde, only including subjects aged ≥18 years, without a self-reported history of chronic diseases. Food frequency analysis, as well as exploratory factorial analysis (EFA) were used to determine dietary patterns and nonparametric statistical tests for comparisons and associations of variables. The EFA yielded 4 patterns termed as: “Traditional”, “Western”, “Balanced” and “Energetic”. Using an FCQ structure of 9 factors, three different groups were obtained from hierarchical clustering. (Cabral, de Almeida, & Cunha, 2017). The results show that Cape Verdean inhabitants follow global diet trends (towards the so-called “westernization”), however, in a more moderate rate if compared to other developing country populations. Consuming “junk food” is infrequent in Cape Verde, which appears to be due to limited availability and accessibility of this type of food. The rural coastal population remains more attached to traditional foods, consuming local products and traditional dishes, whereas in the urban population, one may notice the “westernization” of consumption. The application of an FFQ in combination with the FCQ provided in-depth information on eating attitudes and behaviors.

Synergistic Effect of the Extracts of Vernonia amygdalina and Solenostemon monostachyus on Gram-negative Bacteria.

Herbal medicines are getting more importance in the treatment of infections ailments because most of the synthetic drugs have side effects. A large proportion of the developing countries populations depend on herbal remedy for their physical and psychological health needs depend. Hence, the anti-bacterial activity of the mixture of the extracts of Solenostemon monostachyus and Vernonia amygdalina, common medicinal plants use in Africa, Asia and Europe on some Gram-negative bacteria was investigated. The plants that were cultivated in a well-drained soil and the bacteria, Salmonella typhii, Escherichi coli and Enterobacter aerogenes freshly isolated from clinical samples were used for this study. The plant leaves were grounded separately into a powder and analyzed quantitatively for phytochemical composition and extracted using acetone. Similarly, equal volume of the two plants was homogenized. The sensitivity of the bacteria isolates was performed using disk diffusion method and the antimicrobial activity was determined by measuring the diameter zones of inhibition and for the sensitive measurement (inhibitory zones >20) and resistant measurement (inhibitory zones <17). Analysis of the plants revealed their phytochemical composition. The plant's extracts had high diameter zones of inhibition at the higher concentrations and the concoction treatment was more sensitive. In V. amygdalina, the zone of inhibition varied significantly between S. typhi and E. aerogenes (p<0.05, F = 7.2) and between E. coli and E. aerogenes (p<0.05, F = 6.7), while in S. monostachyus, it varid significantly between S. typhi and E. coli (p<0.05, F = 9.2) and between E. coli and E. aerogenes (p<0.05, F = 5.8). These plants were readily available at no cost therefore, they could be exploited to provide novel compounds that may be used as starting materials for the production of drug that can obliterate resistance bacteria.