The use of dirty (fossil fuel-based) energy in the process of economic growth challenges humanity through different health issues. This research examines the health risks in the form of mortality rates and the occurrence of respiratory illnesses due to energy usage, greenhouse gas discharges, and economic venture in twenty developing countries of Asian. For this objective, the study investigated a panel dataset of twenty-three years (1995–2018) to measure the short and long-term consequences of environmental contamination on health issues. Results of this study generated through the Autoregressive-Distributed lag (ARDL) technique of econometric. Experimental outcomes of the study confirm that dirty energy, carbon emission, and the process of natural resource exhaustion have a significant and positive impact on health risks on the people of the developing region of Asia. On the other hand, the per capita income growth and clean energy usage contributing positively to human health improvement. The high mortality is positively associated with carbon emission in the case of short-run analysis. These results suggest a comprehensive governance policy set to protect people from the negative impact of dirty energy usage and carbon emission discharge.