Development Of Innovative Strategies Research Articles

Radiation-Induced Macrovessel/Microvessel Disease.

Radiation therapy (RT) is a cornerstone in cancer treatment (used in 50% of cases), yet challenges persist because damage to normal tissue through direct impact of radiation or bystander effects is inevitable. Injury of macrovessels by RT manifests as obstructive disease, which is akin to atherosclerotic disease. Historically observed in coronary arteries of patients treated for breast cancer and lymphoma, it also affects patients receiving contemporary therapy for lung and chest cancers. Moreover, radiation at various sites can lead to peripheral vascular disease. An aspect of radiation-induced injury that has received little attention is microvascular injury, which typically results from damage to the endothelium and is considered the primary driver of RT-induced toxicity in the skin, kidney, and brain. This review delves into the clinical manifestations of RT-induced vascular disease, signaling pathways, cellular targets affected by radiation injury, and preclinical models of RT-induced vascular injury. The goal is to inspire the development of innovative strategies to prevent RT-related cardiovascular disease.

Trend, challenges, and determinants of technology integration in geometry problems-solving: A sequential explanatory analysis

This study explores trends, challenges, and success factors in integrating technology to enhance students' conceptual understanding and problem-solving skills in geometry. Using a sequential explanatory design, a quantitative analysis based on text mining and bibliometric methods was conducted on 197 articles from the ERIC database, followed by thematic analysis. The results indicate an annual publication growth of 32.26%, with key success factors including teacher competence, students' mathematical literacy, pedagogy-technology integration, and evaluation of instructional effectiveness. The COVID-19 pandemic accelerated the transformation of technology from an auxiliary tool to a core element of active learning. However, limited access and technological adaptation to complex problems remain significant obstacles. This study recommends teacher training, exploration of technology in teaching, and the development of innovative strategies and accessible technological tools. The implications of this study provide strategic guidance for policymakers, educators, and developers to optimize the use of technology in geometry education more innovatively and inclusively.

Protacs in cancer therapy: mechanisms, design, clinical trials, and future directions.

Cancer develops as a result of changes in both genetic and epigenetic mechanisms, which lead to the activation of oncogenes and the suppression of tumor suppressor genes. Despite advancements in cancer treatments, the primary approach still involves a combination of chemotherapy, radiotherapy, and surgery, typically providing a median survival of approximately five years for patients. Unfortunately, these therapeutic interventions often bring about substantial side effects and toxicities, significantly impacting the overall quality of life for individuals undergoing treatment. Therefore, urgent need of research required which comes up with effective treatment of cancer. This review explores the transformative role of Proteolysis-Targeting Chimeras (PROTACs) in cancer therapy. PROTACs, an innovative drug development strategy, utilize the cell's protein degradation machinery to selectively eliminate disease-causing proteins. The review covers the historical background, mechanism of action, design, and structure of PROTACs, emphasizing their precision in targeting oncogenic proteins. The discussion extends to the challenges, nanotechnology applications, and ongoing clinical trials, showcasing promising results and clinical progress. The review concludes with insights into patents, future directions, and the potential impact of PROTACs in addressing dysregulated protein expression across various diseases. Overall, it provides a concise yet comprehensive overview for researchers, clinicians, and industry professionals involved in developing targeted therapies.

How to Build a Rural Community to Develop High-Quality Rural Tourism: A Case Study of Innovative Development Strategies for Idle Rural Homesteads in China

In China, rural tourism development constitutes a significant strategy for integrating and utilizing rural resources to achieve rural prosperity. However, reconciling the interests of villagers, government entities, and market actors is difficult in practice, leading to potential pitfalls such as the erosion of rural characteristics, villagers’ rights, and sustainability. The establishment of rural communities in China’s current rural areas can effectively resolve conflicts of interest among diverse stakeholders and address bottlenecks in rural tourism development. However, there is still a lack of theoretical and practical exploration of the maintenance and value realization of rural communities. This study explores the impact of innovative strategies employed during rural tourism development on community growth through a case study of the village of Baifeng in the Anhui province. The results indicate that fostering a sense of community among stakeholders and supporting marginalized groups are the most significant values in the development of rural communities. In practice, effective collaboration and communication among stakeholders, mutual acceptance and conflict resolution, and the development of community emotions/consciousness can help rural communities achieve high-quality construction. This study offers valuable insights into the theoretical advancement of rural communities and represents an excellent case study for the research on rural revitalization and common prosperity.

Формування інноваційної стратегії розвитку як напрям підвищення прибутковості підприємства

The article examines forming an innovative strategy for developing an enterprise as an important tool for increasing its profitability. It has been proven that implementing innovative strategies is a key component of the successful development of the enterprise in modern conditions of rapid changes in the external environment and fierce competition. Innovations make it possible to discover new opportunities for creating unique products and optimizing processes, contributing to the company’s competitiveness growth. It was determined that the development strategy should focus on modern challenges and meet the requirements of customers and the market, which, in turn, allows the enterprise to adapt to changes and ensures a stable increase in its competitiveness. The importance of a comprehensive approach to developing an innovative strategy, which includes goals, mission, analysis of internal and external factors, forecasting of market trends, and assessment of resources and capabilities of the enterprise, is substantiated. The step-by-step process of developing an innovative strategy is presented, which involves determining priorities, choosing development directions, and developing tactical and operational measures. It is shown that the innovative strategy directly affects the enterprise’s profitability, providing the possibility of its sustainable development in dynamic market conditions. In addition, it is stated that the innovative development strategy should consider global trends, such as digital transformation, environmental sustainability, and changes in consumer preferences because these factors directly affect the enterprise’s profitability. Enterprises that implement the latest technologies focus on trends, such as digital transformation, environmental sustainability, and changes in consumer preferences, because these factors directly affect the enterprise’s profitability. Enterprises that implement the latest technologies and focus on social responsibility can optimize operational processes, reduce costs, and increase productivity, which is positively reflected in financial indicators. In addition, innovative approaches help strengthen the company’s positive image, contributing to customer loyalty and expanding sales markets. The article emphasizes that a strategic focus on innovation allows the enterprise to adapt to market conditions and proactively shape them, creating new standards of quality and services. This approach helps to increase market share and consolidate leadership positions, which ultimately ensures stable profit growth in the long term. Keywords: innovation, strategy, innovation strategy, development strategy, profit, enterprise.

THE MANAGEMENT MECHANISM OF INNOVATIVE COMMUNITIES DEVELOPMENT IN THE CONDITIONS OF POST-WAR RECONSTRUCTION OF THE TERRITORY

The formation and effective management of innovative communities within the territories of Ukraine is a necessary condition for their post-war recovery.. The analysis of the activities of the leaders of innovative development shows that they are involved in the innovation process with almost all structures that act in a coordinated manner. Thus, the formation of the foundations of the organizational and economic management mechanism for the development of innovative communities in the current operating conditions is relevant. The purpose of the article is the formation of a complete set of tasks for managing the development of innovative communities in the direction of sustainable post-war recovery. Approaches to the separation of the function in terms of management of innovative activity and the formation of the corresponding mechanism are considered. According to the results of the analysis of the existing developments in the field of separation of functions for the implementation of various organizational and economic mechanisms, as well as based on the essence and content of the management of innovative development, the main functions of the organizational and economic mechanism of managing the development of innovative communities are highlighted. They are presented in blocks: functions of analysis of external conditions; functions of analyzing the internal environment of the community; the functions of producing (receiving) and using knowledge for the formation of competitive advantages of innovative communities to ensure their development; functions of managing the selection and implementation of directions and strategies of innovative development. In order to form a more reasonable list of principles within the framework of the mechanism, existing approaches to distinguishing management principles inherent in innovative development are considered. Therefore, the principles of the higher echelon include those that are basic for the implementation of innovative sustainable development. Medium-level principles include those inherent to any innovative and active entity that wants long-term development. The principles of the lower level include basic principles. It was determined that the mechanism's management object is the development strategies of innovative communities, and these strategies are the subject of management. The main subsystems of the mechanism include the subsystem of providing information and knowledge, analyzing the state of the components of the innovative development potential, and managing innovative development strategies. In general, the organizational and economic mechanism of managing the development of innovative communities is considered as a system of interconnected and mutually coordinated economic and organizational methods, levers, forms and management tools for the development and implementation of strategies for the innovative development of communities, which are oriented towards a "technological breakthrough" and bringing to the market "subversive » innovative products, formation of sustainable competitive advantages on this basis and ensuring high competitiveness of the community on national and foreign markets.

Analysis of the Impact of Import and Export Trade on the Innovation Ability of Chinese Industrial Enterprises

In recent years, the process of economic globalization and industrial globalization has been accelerating. In order to consolidate their competitiveness in the international market, countries have deployed and implemented innovative development strategies. At present, although China has become a major industrial and manufacturing country in the world, and the only country in the world with all industrial categories, compared with the advanced level in the world, it still needs to strengthen independent innovation, improve the scientific and technological content and informatization level, improve the level of industrial structure, and promote high-quality economic development. With China's accession to the World Trade Organization, it continues to "go out and introduce", pushing Chinese manufacturing to the world, and also continuously bringing high-quality foreign resources and advanced technology into China. At present, a large number of scholars have also studied the innovation capabilities of enterprises and high-tech industries, but the selection criteria are not the same. This article is based on the innovation capability evaluation system proposed by the Ministry of Science and Technology of China, combined with the entropy weight method, and weights 10 secondary indicators selected from the evaluation system to calculate the comprehensive score of high-tech industry innovation capability for each province from 2010 to 2019. Select import and export trade as the core explanatory variable to study the impact of import and export trade on China's high-tech industry innovation capacity, and propose policy recommendations for this.

МЕХАНІЗМ ФОРМУВАННЯ СТРАТЕГІЇ ІННОВАЦІЙНОГО РОЗВИТКУ БУДІВЕЛЬНИХ ПІДПРИЄМСТВ

The article identifies that as of today, Ukraine's construction industry is operating under challenging conditions during the period of the full-scale invasion of Ukraine by the Russian Federation. It was found that in 2022, the construction sector lost its position in the structure of the country's GDP by 1.6%, compared to 2020-2021, where it accounted for 2.8%. It is determined that the share of the construction industry in the GDP throughout the examined period did not exceed 3%, which is significantly lower than the corresponding period in European countries. Additionally, the article examines the mechanism for forming a strategy of innovative development for construction enterprises, which enhances their competitiveness and adaptability to market changes. The key aspects of developing an innovation strategy for construction enterprises are described: improving production efficiency; enhancing the quality and durability of structures; adapting to market conditions; ensuring competitiveness; promoting sustainable development; improving working conditions and safety on-site; attracting investment and business growth. Key steps at the main stages of developing an innovation strategy are proposed, including an analysis of the external and internal environment, the determination of strategic goals, the development of innovative solutions, investment in resources and personnel, as well as strategy monitoring and adaptation. The importance of applying various methods and tools to optimize, increase productivity, and improve enterprise adaptability was emphasized. The proposed approach allows construction companies to enhance production efficiency and achieve sustainable development in the face of modern challenges and technological changes. Keywords: innovations, innovative development, competitiveness, construction enterprise, 3D printing, modular construction.

Innovative biopolymers composite based thin film for wound healing applications

Efficient wound and burn healing is crucial for minimising complications, preventing infections, and enhancing overall well-being, necessitating the development of innovative strategies. This study aimed to formulate a novel thin film combining chitosan, carboxymethyl cellulose, tannic acid, and beeswax for improved wound healing applications. Several formulations, incorporating chitosan, carboxymethyl cellulose, tannic acid, and beeswax in various percentages, were utilized to deposit thin films via the solvent evaporation technique, Mechanical properties, morphology, antioxidant activity, antibacterial efficacy, and wound healing potential were evaluated. The optimized thin film (M4), composed of 2% chitosan, 2% carboxymethyl cellulose, and 1% tannic acid, along with 0.2% glycerol and 0.2% tween80, exhibited a thickness of 39.0 ± 1.14 μm and a tensile strength of 0.275 ± 0.003 MPa. It demonstrated a swelling degree of 283.0 ± 2.0% and a drug release capacity of 89.4% within 24 h. The film also showed a low contact angle of 40.5° and a water vapour transmission rate of 1912.25 ± 13.10 g m−2 0.24 h−1. FT-IR spectroscopy indicated that chitosan and carboxymethyl cellulose were cross-linked through amide linkages, with tannic acid occupying the interstitial spaces and hydrogen bonding stabilizing the structure. Microscopy of M4 revealed a uniform morphology. The film exhibited strong antioxidant activity of (95.17 ± 0.02%) and antibacterial efficiency (80.8%) against S. aureus. In a rabbit model, the film significantly enhanced burn and excision wound recovery, with 90.0 ± 3.3% healing for burns and 88.85 ± 1.7% for infected wounds by day 7. Complete skin regeneration was observed within 10–12 days. The M4 thin film demonstrated exceptional mechanical properties and bioactivity, offering protection against pathogens and promoting efficient wound healing. These findings suggest its potential for further investigation in treating various infections and its role in developing novel therapeutic interventions.

Prokaryote- and Eukaryote-Based Expression Systems: Advances in Post-Pandemic Viral Antigen Production for Vaccines.

This review addresses the ongoing global challenge posed by emerging and evolving viral diseases, underscoring the need for innovative vaccine development strategies. It focuses on the modern approaches to creating vaccines based on recombinant proteins produced in different expression systems, including bacteria, yeast, plants, insects, and mammals. This review analyses the advantages, limitations, and applications of these expression systems for producing vaccine antigens, as well as strategies for designing safer, more effective, and potentially 'universal' antigens. The review discusses the development of vaccines for a range of viral diseases, excluding SARS-CoV-2, which has already been extensively studied. The authors present these findings with the aim of contributing to ongoing research and advancing the development of antiviral vaccines.

Challenges and opportunities in implementing telemedical solutions for COPD management in the Polish healthcare sector: a presenting own experience.

Aim: The aim of this article is to present and discuss the conclusions of a fi nalized pilot project implementing telemedical solutions for COPD management within the senior population in Wrocław and the Lower Silesian Voivodeship during 2022-2023. It also aimed to contribute to the development of innovative strategies to improve care for individuals with COPD through the use of telemedical technologies. Materials and methods: An interdisciplinary and comprehensive pilot project in pulmonology was applied, dividing it into health, organizational, and tech-nological areas. The steps and data collection strategy were presented, enabling the implementation of telemedical solutions among COPD patients in Poland. Results: The implementation of telemedical solutions in COPD represented an innovative approach to improving care. Among the main goals of the project were to reduce patient waiting times, enhance disease progress monitoring, and provide access to specialized healthcare through the use of modern telemedical technologies. Various telemedical solutions were implemented, including remote monitoring of health parameters, online consultations with pulmonology specialists, and patient education on self-monitoring of symptoms. The fi nal summary of the materials collected within the described methodology allowed for a holistic view of the implementation of telemedicine in pulmonary healthcare in Poland, using the discussed pilot project as an example. Conclusions: The analysis of the pilot project implementing telemedical solutions in the fi eld of pulmonology in the Polish healthcare sector has shown that telemedicine can improve care for COPD patients. The project's outcomes indicate the potential for reducing patient waiting times and better monitoring of disease progression. However, these aspects require improvement and ref i nement, particularly in terms of systemic solutions.

Mitochondrial dysfunction and NLRP3 inflammasome: key players in kidney stone formation.

The mitochondrion serves as a critical intracellular organelle, engaging in essential roles in the regulation of energy production, oxidative stress management, calcium homeostasis, and apoptosis. One such disease that has been particularly associated with these functions is kidney stone disease (KSD), specifically calcium oxalate (CaOx). It is underpinned by oxidative stress and tissue inflammation. Recent studies have shed light on the vital involvement of mitochondrial dysfunction, the nucleotide-binding domain and leucine-rich repeat containing protein 3 (NLRP3) inflammasome, endoplasmic reticulum stress and subsequent cell death in CaOx crystal retention and aggregation. These processes are pivotal in the pathogenesis of kidney stone formation. This review focuses on the pivotal roles of mitochondria in renal cell functions and provides an overview of the intricate interconnectedness between mitochondrial dysfunction and NLRP3 inflammasome activation in the context of KSD. It is essential to recognise the utmost significance of gaining a comprehensive understanding of the mechanisms that safeguard mitochondrial function and regulate the NLRP3 inflammasome. Such knowledge carries significant scientific implications and opens up promising avenues for the development of innovative strategies to prevent the formation of kidney stones.

A Review on Plant-microbe Interactions and its Defence Mechanism

Plant-microbe interactions are fundamental to plant health, growth, and defense, influencing agricultural productivity and ecosystem dynamics. These interactions range from symbiotic relationships, such as those with mycorrhizal fungi and nitrogen-fixing bacteria, to pathogenic encounters that trigger complex plant immune responses. Beneficial microbes, including rhizobacteria, mycorrhizae, and endophytes, play a crucial role in enhancing plant defenses through mechanisms like induced systemic resistance (ISR) and production of antimicrobial compounds. Advances in our understanding of these interactions have enabled the development of innovative strategies for crop protection, such as the use of biocontrol agents and microbial inoculants. Additionally, plant breeding and genetic engineering have been employed to introduce resistance genes and modify plant immune responses, resulting in disease-resistant varieties. However, harnessing plant-microbe interactions for sustainable agriculture faces challenges due to the complexity of these interactions in natural environments and the influence of abiotic factors. Limitations in research methodologies, such as difficulties in isolating and studying unculturable microbes, further complicate the translation of findings into practical applications. To overcome these barriers, future research should focus on integrating multi-omics approaches, employing synthetic microbial communities (SynComs), and leveraging CRISPR/Cas technologies for precise manipulation of plant and microbial genes. Microbiome engineering holds promise for promoting beneficial microbial communities, improving plant resilience, and reducing chemical inputs in agriculture. Addressing these challenges will be critical for realizing the full potential of plant-microbe interactions, ultimately contributing to sustainable crop production, improved food security, and ecosystem health. This review highlights current advances, applications, and future directions in the study of plant-microbe interactions, emphasizing their significance for modern agriculture.

Influenza A as a True Zoonotic Pathogen: Transmission through Reservoir Hosts

Influenza A virus (IAV) represents a considerable global health threat due to its rapid mutation rates and broad host range, facilitating cross-species transmission and enabling the virus to evade immune defenses. This review explores the molecular mechanisms underlying IAV's pathogenicity, focusing on its zoonotic potential through reservoir hosts, such as wild birds and swine. The virus's ability to undergo antigenic shift and drift allows it to continually adapt to new hosts and environments, posing challenges for control and treatment. Current antiviral therapies are limited by the emergence of resistant strains, underscoring the necessity for innovative vaccine development and treatment strategies. By examining IAV's molecular evolution, immune evasion tactics, and transmission dynamics, this review highlights the critical need for enhanced surveillance, improved therapeutic options, and international cooperation to mitigate future outbreaks. A deeper understanding of these processes is essential to inform public health efforts and combat the persistent threat of IAV.

CONCEPT AND CHARACTERISTICS OF CUSTOMS AUTHORITIES’ COMPETENCE IN THE CONTEXT OF INNOVATIVE PROCESSES IN UKRAINIAN CUSTOMS AFFAIRS

This article analyzes the concept and characteristics of customs authorities’ competencies in Ukraine within the context of ongoing innovations in customs practices. As Ukraine pursues its Euro-integration goals — aimed at modernizing economic infrastructure, overcoming technological lag, attracting foreign investments, and enhancing international competitiveness — customs authorities play a pivotal role in ensuring the effective functioning of foreign economic activities. The focus of the article is on the necessity to modernize the competencies of customs authorities in line with global standards and to implement advanced innovative technologies, as outlined in Ukraine’s Innovation Development Strategy up to 2030. It examines the impact and significance of innovations such as the ‘Single Window’ system, ‘Smart Customs’ initiatives, pre-arrival cargo information technologies radio-frequency identification (RFID), and blockchain for enhancing customs control, management, and interactions with external partners. A central issue discussed in the article is the development of new competencies required for the effective implementation of these innovations by customs authorities. Specifically, it addresses the need to cultivate digital, intellectual, partnership, and security skills. The article also explores the effects of economic and political instability, particularly the wartime conditions in Ukraine, on the implementation of innovations in customs operations. Key challenges are identified, such as difficulties in exporting high-tech goods, granting incentives for importing innovative equipment, and applying non-tariff regulatory measures, including certification, quotas, and licensing. Recommendations are provided for improving the organizational structures of customs authorities and updating the legal and regulatory framework to adapt to modern requirements and standards. The article advocates for the development of a new, intelligent customs system that can swiftly and effectively respond to changes by employing cutting-edge digital technologies and security methods. Emphasis is placed on the importance of enhancing the qualifications of customs professionals, which is essential for the successful implementation of innovations in customs control.

Modern trends in development of innovative activities of enterprises

In the article, the main essence of the economic strategy of the enterprises operating in the conditions of the innovative economy is explained and the main influencing principles are listed. The necessity of careful study and scientific-theoretical research of existing innovations for the successful management of innovation activities of the enterprise was brought to attention. Also, the main factors affecting the innovative activity of enterprises were analyzed, the creation of long-term guidelines as ways of increasing innovative potential, the transparency of the financial sector, the aspects of promoting new inventions in the field of fundamental and applied sciences were shown, the main development directions for strengthening the mutual relations between the state, business and science and the modern development trends of innovation activities characterizing the selection of their implementation methods were investigated. The necessity of creating a methodology for evaluating external and internal risk factors, which serves the successful implementation of innovative activity and accurate determination of existing working conditions, as well as the need to use new innovations to solve existing problems in the innovative economy, was especially noted. The scientific results obtained on the basis of theoretical analyzes once again confirm the importance of creating an innovative development strategy of each enterprise as the main factor in obtaining competitive advantages in domestic and foreign economic markets, high profitability of capital and the processes of increasing the market value of the enterprise.

Customs competencies in ukraine: embracing innovation for enhanced efficiency

This article provides a comprehensive analysis of the concept and features of the competencies of Ukrainian customs authorities considering ongoing innovations in the customs sector. As Ukraine follows its Euro-integration path, aimed at modernizing its economic infrastructure, addressing technological gaps, attracting foreign investments, and enhancing its international competitiveness, the role of customs authorities becomes vital in facilitating effective foreign economic activities. The article underscores the critical need to update the competencies of customs authorities to meet global standards and incorporate advanced innovative technologies, as envisioned in Ukraine’s Innovation Development Strategy up to 2030. It explores the impact and relevance of innovations such as the ‘Smart Customs’ initiatives, ‘Single Window’ system, pre-arrival cargo information systems, radio-frequency identification, and blockchain technology in improving customs control, management, and interactions with external partners. A major focus of the article is on the new competencies required by customs authorities to successfully implement these innovations. It highlights the importance of developing digital, intellectual, partnership, and security skills. Furthermore, the article examines the effects of economic and political instability, particularly the ongoing conflict in Ukraine, on the innovation processes within customs operations. It identifies significant challenges such as the difficulties in exporting high-tech goods, offering incentives for the import of innovative equipment, and the application of non-tariff regulatory measures, including certification, quotas, and licensing. The article provides detailed recommendations for enhancing the organizational structures of customs authorities and calls for updating the legal and regulatory framework to align with current demands and standards. It advocates for the creation of a modern, intelligent customs system that can rapidly and effectively adapt to changes using state-of-the-art digital technologies and security methods. Emphasis is placed on the necessity of enhancing the qualifications of customs professionals, which is deemed essential for the successful integration of innovations in customs control.

Development and activation of the innovative potential of the Russian economy: regional features, structural priorities, levels of implementation

Relevance. The idea of developing and implementing innovative solutions in various spheres of society implies the existence of ways to find such solutions, their active use and improvement. For this reason, the essence of innovative thinking on the scale of both a single enterprise and the state as a whole requires appropriate provision.The purpose of the research is a comprehensive analysis of the chronological cross-section of the level of innovative development of the subjects of the Russian Federation in the context of multiple global economic and political crises and the internal activation of strategic innovative trends in the formats of lawmaking and modernization.Objectives. To achieve this goal, within the framework of this study, the current legislative situation regarding the state's innovation policy and its projected consequences were considered; the factors of growth in the level of innovative development of the regions of the Russian Federation in the context of statistical dominants were studied; the complex results of regional innovation activity and the all-Russian state of the innovative sphere of development, production, export and import of goods and services were analyzed.Methodology. The methodological basis of this study is the method of chronological extrapolation analysis of trends with constant adjustment in conditions of the selective nature of the analytical data bank; in addition, a theoretical generalization of the indexed result and a priori trend forecasting within the observation period are used.Results. The general principles of the innovation segment development are the same for the whole state, but their applicability in different regions depends on the degree of their convergence with border territorial entities — the basis of the innovation development strategy is the assessment of regional potential in the sum of all indicators. Nevertheless, there is always the possibility of finding a thematic statistical trend.Conclusions. It is fundamentally important for the innovative development of the state to take into account the specifics of each individual region. With all the variety of means and methods of innovative development at all levels of management, priority is given to only a few. In this case, rating systems are an auxiliary element of management structures.

The Impact of Innovation, Circular Economy and Sustainable Development Strategies Aimed at Low-carbon Economy on Brazilian Business Performance

The Impact of Innovation, Circular Economy and Sustainable Development Strategies Aimed at Low-carbon Economy on Brazilian Business Performance

Mesoporous cerium oxide nanoenzyme for Efficacious impeding tumor and metastasis via Conferring resistance to anoikis

Tumor cells can survive when detached from the extracellular matrix or lose cell-to-cell connections, leading to a phenomenon known as anoikis resistance (AR). AR is closely associated with the metastasis and proliferation of tumor cells, enabling them to disseminate, migrate, and invade after detachment. Here, we have investigated a novel composite nanoenzyme comprising mesoporous silica/nano-cerium oxide (MSN-Ce@SP/PEG). This nanoenzyme exhibited satisfactory catalase (CAT) activity, efficiently converting high levels of H2O2 within tumor cells into O2, effectively alleviating tumor hypoxia. Furthermore, MSN-Ce@SP/PEG nanoenzyme demonstrated high peroxidase (POD) activity, elevating reactive oxygen species (ROS) levels and attenuating AR in hepatocellular carcinoma (HCC) cells. The MSN-Ce@SP/PEG nanoenzyme exhibited satisfactory dual bioactivity in CAT and POD and was significantly enhanced under favorable photothermal conditions. Through the synergistic effects of these capabilities, the nanoenzyme disrupted the epithelial-mesenchymal transition (EMT) process in detached HCC cells, ultimately inhibiting the recurrence and metastasis potential of anoikis-resistant HCC cells. This study represents the first report of a novel nanoenzyme based on mesoporous silica/nano-cerium oxide for treating AR in HCC cells, thereby suppressing HCC recurrence and metastasis. The findings of this work offer a pioneering perspective for the development of innovative strategies to prevent the recurrence and metastasis of HCC.