Detection Of Serum Markers Research Articles

Application of CRISPR/Cas13a-based biosensors in serum marker detection.

The detection of serum markers is important for the early diagnosis and monitoring of diseases, but conventional detection methods have the problem of low specificity or sensitivity. CRISPR/Cas13a-based biosensors have the characteristics of simple detection methods and high sensitivity, which have a certain potential to solve the problems of conventional detection. This paper focuses on the research progress of CRISPR/Cas13a-based biosensors in serum marker detection, introduces the principles and applications of fluorescence, electrochemistry, colorimetric, and other biosensors based on CRISPR/Cas13a in the detection of serum markers, compares and analyzes the differences between the above CRISPR/Cas13a-based biosensors, and looks forward to the future development direction of CRISPR/Cas13a-based biosensors.

Application progress of serum laboratory tests in the diagnosis and treatment of lupus nephritis

There are a variety of serological changes in the blood circulation of patients with lupus nephritis, including complement, autoantibodies, immunoglobulin and cytokines and so on.These substances not only involved in the development of the disease leads to renal pathological damage, but also can be used as a biomarker to reflect changes in disease.In this paper, the detection of serum markers in lupus nephritis diagnosis, determine the pathological classification, disease activity, evaluation of therapeutic effect and prognosis were reviewed, in order to provide scientific basis for the early diagnosis and treatment of lupus nephritis by monitoring the changes of serum indicators. Key words: Lupus nephritis; Systemic lupus erythematosus; Complement; Autoantibody; Immunoglobulin; Cytokine