Epileptic Seizure Detection Research Articles

Medical Devices for the Management of Patients with Epilepsy

The increasing number of medical devices developed and marketed towards management of patients with epilepsy reflects the growing interest in translating technological advances and knowledge about epilepsy into better healthcare for this population. The objective of this narrative literature review is to analyze the available options of medical devices for detecting, treating, and recording epileptic seizures, and their potential clinical application. The included articles were selected from the PubMed database using the query “(Epilepsy[MeSH Terms]) AND (SUDEP)) AND (Medical Device)) AND (English[Language])”. The detection of epileptic seizures is essential for early intervention and to optimize the therapy for each patient. In outpatient settings, this detection is further challenging due to their unpredictability. Traditionally electroencephalography is the direct detection method used in a hospital environment. Indirect methods, such as electrocardiogram, photoplethysmography, oximeter, electrodermal activity, accelerometer, and electromyography, have shown potential for detecting seizures in the outpatient setting. Several medical devices have been developed based on the mentioned methods, with the aim of providing patients with solutions they can use in their daily lives. Behind-the-ear EEG, wristbands, armbands and bed sensors are some of the designs available. Equipped with different features, these devices can answer the need for early seizure detection and improve patients’ and caregivers’ quality of life. There are also devices available for the treatment of epileptic seizures. Through neuromodulation techniques such as vagus nerve stimulation, deep brain stimulation, and responsive neurostimulation, these devices are presented as solutions for patients with refractory epilepsy not eligible for ressective surgery. Patients with epilepsy have several apps available online for proper recording of seizures. These apps help doctors optimize therapy based on clinical evolution. The wide range of devices available creates the opportunity to personalize the approach to patient’s specific needs. Understanding each device’s characteristics can help clinicians improve management of patients with epilepsy.

Seizure stage detection of epileptic seizure using convolutional neural networks

According to the World Health Organization (WHO), seventy million individuals worldwide suffer from epilepsy, a neurological disorder. While electroencephalography (EEG) is crucial for diagnosing epilepsy and monitoring the brain activity of epilepsy patients, it requires a specialist to examine all EEG recordings to find epileptic behavior. This procedure needs an experienced doctor, and a precise epilepsy diagnosis is crucial for appropriate treatment. To identify epileptic seizures, this study employed a convolutional neural network (CNN) based on raw scalp EEG signals to discriminate between preictal, ictal, postictal, and interictal segments. The possibility of these characteristics is explored by examining how well time-domain signals work in the detection of epileptic signals using intracranial Freiburg Hospital (FH), scalp Children's Hospital Boston-Massachusetts Institute of Technology (CHB-MIT) databases, and Temple University Hospital (TUH) EEG. To test the viability of this approach, two types of experiments were carried out. Firstly, binary class classification (preictal, ictal, postictal each versus interictal) and four-class classification (interictal versus preictal versus ictal versus postictal). The average accuracy for stage detection using CHB-MIT database was 84.4%, while the Freiburg database's time-domain signals had an accuracy of 79.7% and the highest accuracy of 94.02% for classification in the TUH EEG database when comparing interictal stage to preictal stage.

Automatic Detection of Epileptic Seizures from EEG Signals Using Artificial Intelligence Methods

Epilepsy is a neurological disorder in which involuntary contractions, sensory abnormalities, and changes occur as a result of abrupt and uncontrolled discharges in the neurons in the brain, which disrupt the systems regulated by the brain. In epilepsy, abnormal electrical impulses from cells in various brain areas are noticed. The accurate interpretation of these electrical impulses is critical in the illness diagnosis. This study aims to use different machine-learning algorithms to diagnose epileptic seizures. The frequency components of EEG data were extracted using parametric approaches. This feature extraction approach was fed into machine learning classification algorithms, including Artificial Neural Network (ANN), Gradient Boosting, and Random Forest. The ANN classifier was shown to have the most significant test performance in this investigation, with roughly 97% accuracy and a 91% F1 score in recognizing epileptic episodes. The Gradient Boosting classifier, on the other hand, performed similarly to the ANN, with 96% accuracy and a 93% F1 score.

Evaluation of the Relation between Ictal EEG Features and XAI Explanations.

Epilepsy is a neurological disease with one of the highest rates of incidence worldwide. Although EEG is a crucial tool for its diagnosis, the manual detection of epileptic seizures is time consuming. Automated methods are needed to streamline this process; although there are already several works that have achieved this, the process by which it is executed remains a black box that prevents understanding of the ways in which machine learning algorithms make their decisions. A state-of-the-art deep learning model for seizure detection and three EEG databases were chosen for this study. The developed models were trained and evaluated under different conditions (i.e., three distinct levels of overlap among the chosen EEG data windows). The classifiers with the best performance were selected, then Shapley Additive Explanations (SHAPs) and Local Interpretable Model-Agnostic Explanations (LIMEs) were employed to estimate the importance value of each EEG channel and the Spearman's rank correlation coefficient was computed between the EEG features of epileptic signals and the importance values. The results show that the database and training conditions may affect a classifier's performance. The most significant accuracy rates were 0.84, 0.73, and 0.64 for the CHB-MIT, Siena, and TUSZ EEG datasets, respectively. In addition, most EEG features displayed negligible or low correlation with the importance values. Finally, it was concluded that a correlation between the EEG features and the importance values (generated by SHAP and LIME) may have been absent even for the high-performance models.

Novel deep learning framework for detection of epileptic seizures using EEG signals.

Epilepsy is a chronic neurological disorder characterized by abnormal electrical activity in the brain, often leading to recurrent seizures. With 50 million people worldwide affected by epilepsy, there is a pressing need for efficient and accurate methods to detect and diagnose seizures. Electroencephalogram (EEG) signals have emerged as a valuable tool in detecting epilepsy and other neurological disorders. Traditionally, the process of analyzing EEG signals for seizure detection has relied on manual inspection by experts, which is time-consuming, labor-intensive, and susceptible to human error. To address these limitations, researchers have turned to machine learning and deep learning techniques to automate the seizure detection process. In this work, we propose a novel method for epileptic seizure detection, leveraging the power of 1-D Convolutional layers in combination with Bidirectional Long Short-Term Memory (LSTM) and Gated Recurrent Unit (GRU) and Average pooling Layer as a single unit. This unit is repeatedly used in the proposed model to extract the features. The features are then passed to the Dense layers to predict the class of the EEG waveform. The performance of the proposed model is verified on the Bonn dataset. To assess the robustness and generalizability of our proposed architecture, we employ five-fold cross-validation. By dividing the dataset into five subsets and iteratively training and testing the model on different combinations of these subsets, we obtain robust performance measures, including accuracy, sensitivity, and specificity. Our proposed model achieves an accuracy of 99-100% for binary classifications into seizure and normal waveforms, 97.2%-99.2% accuracy for classifications into normal-interictal-seizure waveforms, 96.2%-98.4% accuracy for four class classification and accuracy of 95.81%-98% for five class classification. Our proposed models have achieved significant improvements in the performance metrics for the binary classifications and multiclass classifications. We demonstrate the effectiveness of the proposed architecture in accurately detecting epileptic seizures from EEG signals by using EEG signals of varying lengths. The results indicate its potential as a reliable and efficient tool for automated seizure detection, paving the way for improved diagnosis and management of epilepsy.

Automated analysis and detection of epileptic seizures in video recordings using artificial intelligence.

Automated seizure detection promises to aid in the prevention of SUDEP and improve the quality of care by assisting in epilepsy diagnosis and treatment adjustment. In this phase 2 exploratory study, the performance of a contactless, marker-free, video-based motor seizure detection system is assessed, considering video recordings of patients (age 0-80 years), in terms of sensitivity, specificity, and Receiver Operating Characteristic (ROC) curves, with respect to video-electroencephalographic monitoring (VEM) as the medical gold standard. Detection performances of five categories of motor epileptic seizures (tonic-clonic, hyperkinetic, tonic, unclassified motor, automatisms) and psychogenic non-epileptic seizures (PNES) with a motor behavioral component lasting for >10 s were assessed independently at different detection thresholds (rather than as a categorical classification problem). A total of 230 patients were recruited in the study, of which 334 in-scope (>10 s) motor seizures (out of 1,114 total seizures) were identified by VEM reported from 81 patients. We analyzed both daytime and nocturnal recordings. The control threshold was evaluated at a range of values to compare the sensitivity (n = 81 subjects with seizures) and false detection rate (FDR) (n = all 230 subjects). At optimal thresholds, the performance of seizure groups in terms of sensitivity (CI) and FDR/h (CI): tonic-clonic- 95.2% (82.4, 100%); 0.09 (0.077, 0.103), hyperkinetic- 92.9% (68.5, 98.7%); 0.64 (0.59, 0.69), tonic- 78.3% (64.4, 87.7%); 5.87 (5.51, 6.23), automatism- 86.7% (73.5, 97.7%); 3.34 (3.12, 3.58), unclassified motor seizures- 78% (65.4, 90.4%); 4.81 (4.50, 5.14), and PNES- 97.7% (97.7, 100%); 1.73 (1.61, 1.86). A generic threshold recommended for all motor seizures under study asserted 88% sensitivity and 6.48 FDR/h. These results indicate an achievable performance for major motor seizure detection that is clinically applicable for use as a seizure screening solution in diagnostic workflows.

Detection of epileptic seizure using EEG signals analysis based on deep learning techniques

The brain neurons' electrical activities represented by Electroencephalogram (EEG) signals are the most common data for diagnosing Epilepsy seizure, which is considered a chronic nervous disorder that cannot be controlled medically using surgical operation or medications with more than 40 % of Epilepsy seizure case. With the progress and development of artificial intelligence and deep learning techniques, it becomes possible to detect these seizures over the observation of the non-stationary-dynamic EEG signals, which contain important information about the mental state of patients. This paper provides a concerted deep machine learning model consisting of two simultaneous techniques detecting the activity of epileptic seizures using EEG signals. The time-frequency image of EEG waves and EEG raw waves are used as input components for the convolution neural network (CNN) and recurrent neural network (RNN) with long- and short-term memory (LSTM). Two processing signal methods have been used, Short-Time Fourier Transform (STFT) and Continuous Wavelet Transformation (CWT), have been used for generating spectrogram and scalogram images with sizes of 77 × 75 and 32 × 32, respectively. The experimental results showed a detection accuracy of 99.57 %, 99.57 % using CWT Scalograms, and 99.26 %, 97.12 % using STFT spectrograms as CNN input for the Bonn University dataset and the CHB-MIT dataset, respectively. Thus, the proposed models provide the ability to detect epileptic seizures with high success compared to previous studies.

ConceFT-based epileptic seizure detection via transfer learning

ConceFT-based epileptic seizure detection via transfer learning

An efficient epileptic seizure detection by classifying focal and non-focal EEG signals using optimized deep dual adaptive CNN-HMM classifier

An efficient epileptic seizure detection by classifying focal and non-focal EEG signals using optimized deep dual adaptive CNN-HMM classifier

A Deep Convolutional Spiking Neural Network for embedded applications

Deep neural networks (DNNs) have received a great deal of interest in solving everyday tasks in recent years. However, their computational and energy costs limit their use on mobile and edge devices. The neuromorphic computing approach called spiking neural networks (SNNs) represents a potential solution for bridging the gap between performance and computational expense. Despite the potential benefits of energy efficiency, the current SNNs are being used with datasets such as MNIST, Fashion-MNIST, and CIFAR10, limiting their applications compared to DNNs. Therefore, the applicability of SNNs to real-world applications, such as scene classification and forecasting epileptic seizures, must be demonstrated yet. This paper develops a deep convolutional spiking neural network (DCSNN) for embedded applications. We explore a convolutional architecture, Visual Geometry Group (VGG16), to implement deeper SNNs. To train a spiking model, we convert the pre-trained VGG16 into corresponding spiking equivalents with nearly comparable performance to the original one. The trained weights of VGG16 were then transferred to the equivalent SNN architecture while performing a proper weight–threshold balancing. The model is evaluated in two case studies: land use and land cover classification, and epileptic seizure detection. Experimental results show a classification accuracy of 94.88%, and seizure detection specificity of 99.45% and a sensitivity of 95.06%. It is confirmed that conversion-based training SNNs are promising, and the benefits of DNNs, such as solving complex and real-world problems, become available to SNNs.

Retraction: “Implementation of deep neural networks for classifying electroencephalogram signal using fractional S‐transform for epileptic seizure detection”

Retraction: Ashokkumar SR, Anupallavi S, Premkumar M, Jeevanantham V. Implementation of deep neural networks for classifying electroencephalogram signal using fractional S‐transform for epileptic seizure detection. Int J Imaging Syst Technol. 2021;31:895–908. https://doi.org/10.1002/ima.22565The above article, published online on 02 March 2021 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor‐in‐Chief Dr. Mohamed Seghier, and Wiley Periodicals, LLC. The retraction has been agreed due to major overlap between this article and the following article: Liu G, Zhou W, Geng M. Automatic Seizure Detection Based on S‐Transform and Deep Convolutional Neural Network. Int. J. Neural Syst. 2020;30:1950024. https://doi.org/10.1142/S0129065719500242. Following a complaint from a third party, an investigation by the editorial office and Wiley concluded that Figures 5 and 10 were duplicated from the previously‐published article and that the degree of overlap between the articles' topics, preprocessing methods, and proposed AI tools constitutes plagiarism. The authors responded to an inquiry by the publisher, but did not provide original data. The authors were notified about the retraction but did not respond.

A comparative study of CNN-capsule-net, CNN-transformer encoder, and Traditional machine learning algorithms to classify epileptic seizure

IntroductionEpilepsy is a disease characterized by an excessive discharge in neurons generally provoked without any external stimulus, known as convulsions. About 2 million people are diagnosed each year in the world. This process is carried out by a neurological doctor using an electroencephalogram (EEG), which is lengthy.MethodTo optimize these processes and make them more efficient, we have resorted to innovative artificial intelligence methods essential in classifying EEG signals. For this, comparing traditional models, such as machine learning or deep learning, with cutting-edge models, in this case, using Capsule-Net architectures and Transformer Encoder, has a crucial role in finding the most accurate model and helping the doctor to have a faster diagnosis.ResultIn this paper, a comparison was made between different models for binary and multiclass classification of the epileptic seizure detection database, achieving a binary accuracy of 99.92% with the Capsule-Net model and a multiclass accuracy with the Transformer Encoder model of 87.30%.ConclusionArtificial intelligence is essential in diagnosing pathology. The comparison between models is helpful as it helps to discard those that are not efficient. State-of-the-art models overshadow conventional models, but data processing also plays an essential role in evaluating the higher accuracy of the models.

MCU-Enabled Epileptic Seizure Detection System With Compressed Learning

MCU-Enabled Epileptic Seizure Detection System With Compressed Learning

Analysis of EEG signals for the detection of epileptic seizures using feature extraction

The electroencephalogram, which tracks electrical signals in the central nervous system, has been extensively used to diagnose epilepsy, which represents a particular sort of brain abnormality. However, developing seizure classification techniques with significantly better precision and reduced complexity remains challenging. The Epileptic Seizure Recognition dataset, which is publicly accessible in the Kaagle and in the machine learning repository, was used to identify seizures. To identify the seizure, we compared six classification methods to determine which one had the highest success rate. The dataset is subsequently divided, trained, and tested in order to categorize it further using six machine learning algorithms: Stochastic Gradient Descent, Logistic Regression, Naïve Bayes, K-Nearest Neighbors Algorithm, Extra Tree Classifier and Decision Tree. When contrasted with alternative techniques, Extra Trees Classifier possesses the highest accuracy results. The algorithm attained a 96 percent success rate.

Detection of seizures with ictal tachycardia, using heart rate variability and patient adaptive logistic regression machine learning methods: A hospital-based validation study.

Automated seizure detection of focal epileptic seizures is needed for objective seizure quantification to optimize the treatment of patients with epilepsy. Heart rate variability (HRV)-based seizure detection using patient-adaptive threshold with logistic regression machine learning (LRML) methods has presented promising performance in a study with a Danish patient cohort. The objective of this study was to assess the generalizability of the novel LRML seizure detection algorithm by validating it in a dataset recorded from long-term video-EEG monitoring (LTM) in a Brazilian patient cohort. Ictal and inter-ictal ECG-data epochs recorded during LTM were analyzed retrospectively. Thirty-four patients had 107 seizures (79 focal, 28 generalized tonic-clonic [GTC] including focal-to-bilateral-tonic-clonic seizures) eligible for analysis, with a total of 185.5 h recording. Because HRV-based seizure detection is only suitable in patients with marked ictal autonomic change, patients with >50 beats/min change in heart rate during seizures were selected as responders. The patient-adaptive LRML seizure detection algorithm was applied to all elected ECG data, and results were computed separately for responders and non-responders. The patient-adaptive LRML seizure detection algorithm yielded a sensitivity of 84.8% (95% CI: 75.6-93.9) with a false alarm rate of .25/24 h in the responder group (22 patients, 59 seizures). Twenty-five of the 26 GTC seizures were detected (96.2%), and 25 of the 33 focal seizures without bilateral convulsions were detected (75.8%). The study confirms in a new, independent external dataset the good performance of seizure detection from a previous study and suggests that the method is generalizable. This method seems useful for detecting both generalized and focal epileptic seizures. The algorithm can be embedded in a wearable seizure detection system to alert patients and caregivers of seizures and generate objective seizure counts helping to optimize the treatment of the patients.

Automatic Seizure Detection Using Multi-Input Deep Feature Learning Networks for EEG Signals

Epilepsy, a neurological disease associated with seizures, affects the normal behavior of human beings. The unpredictability of epileptic seizures has caused great obstacles to the treatment of the disease. The automatic seizure detection method based on electroencephalogram (EEG) can assist experts in predicting seizures to improve treatment efficiency. Epileptic seizure detection cannot be achieved accurately using the single-view characteristics of the signals. Moreover, manual feature extraction is a time-consuming task. To design a high-performance seizure identification method, automatic learning of multi-view features becomes an indispensable part for seizure detection. Therefore, the paper proposes a multi-input deep feature learning networks (MDFLN) model, which comprehensively considers the features from the time domain and the time–frequency (TF) domain for EEG signals. The MDFLN model automatically extracts the feature information of the signals through deep learning networks. Then, the bidirectional long short-term memory (BLSTM) network is used to distinguish seizure and nonseizure events. Furthermore, the effectiveness of the proposed network structure is verified in two public datasets. The experimental results demonstrate that the classification accuracy of the proposed method based on multi-view features is at least 2.2% higher than the single-view features. The MDFLN achieves better performance on CHB-MIT and Bonn datasets with accuracy of 98.09% and 98.4%, respectively. The fine-tuned model with the validation set also improves the classification performance. Compare with the state-of-the-art seizure detection methods, the multi-input deep learning network has superior competence with high sensitivity on the CHB-MIT dataset. The proposed automatic seizure detection method can reduce time consumption and effectively assist experts in the clinical diagnosis and treatment.

A Novel Framework for Epileptic Seizure Detection Using Electroencephalogram Signals Based on the Bat Feature Selection Algorithm

The precise electroencephalogram (EEG) signal classification with the highest possible accuracy is a key goal in the brain-computer interface (BCI). Considering the complexity and nonstationary nature of the EEG signals, there is an urgent need for effective feature extraction and data mining techniques. Here, we introduce a novel pipeline based on Bat and genetic algorithms for feature construction and dimension reduction of EEG signals. After wavelet extraction and segmentation, the Bat algorithm identifies the most relevant features. We use these features and a genetic algorithm combined with a neural network method to automatically classify the segments of the epilepsy EEG signals. We also use available classification methods based on k-Nearest Neighbors or naïve Bayes for comparison purposes. The code distinguishes individual signals within various combinations of data obtained from healthy volunteers with open or closed eyes and patients suffering from epilepsy disorders during seizure-free periods or seizure activities. Compared to the previously introduced methods, our proposed framework demonstrates a superior balance of high accuracy and short runtime. The minimum achieved accuracies for balanced and unbalanced classes are 100% and 75.9%, respectively. This approach has the potential for direct applications in clinics, enabling accurate and rapid analysis of the epilepsy EEG signals obtained from patients.

A Multi Representation Deep Learning Approach for Epileptic Seizure Detection

Epileptic seizures, unpredictable in nature and potentially dangerous during activities like driving, pose significant risks to individual and public safety. Traditional diagnostic methods, which involve labour-intensive manual feature extraction from Electroencephalography (EEG) data, are being supplanted by automated deep learning frameworks. This paper introduces an automated epileptic seizure detection framework utilizing deep learning to bypass manual feature extraction. Our framework incorporates detailed pre-processing techniques: normalization via L2 normalization, filtering with an 80 Hz and 0,5 Hz Butterworth low-pass and high-pass filter, and a 50 Hz IIR Notch filter, channel selection based on standard deviation calculations and Mutual Information algorithm, and frequency domain transformation using FFT or STFT with Hann windows and 50% hop. We evaluated on two datasets: the first comprising 4 canines and 8 patients with 2.299 ictal, 23.445 interictal, and 32.915 test data, 400-5000Hz sampling rate across 16-72 channels; the second dataset, intended for testing, 733 icatal, 4.314 interictal, and 1908 test data, each 10 minutes long, recorded at 400Hz across 16 channels. Three deep learning architectures were assessed: CNN, LSTM, and a hybrid CNN-LSTM model-stems from their demonstrated efficacy in handling the complex nature of EEG data. Each model offers unique strengths, with the CNN excelling in spatial feature extraction, LSTM in temporal dynamics, and the hybrid model combining these advantages. The CNN model, comprising 31 layers, yielded highest accuracy, achieving 91% on the first dataset (precision 92%, recall 91%, F1-score 91%) and 82% on the second dataset using a 30-second threshold. This threshold was chosen for its clinical relevance. The research advances epileptic seizure detection using deep learning, indicating a promising direction for future medical technology. Future work will focus on expanding dataset diversity and refining methodologies to build upon these foundational results.

Detection of epileptic seizure in EEG signals using machine learning and deep learning techniques

Around 50 million individuals worldwide suffer from epilepsy, a chronic, non-communicable brain disorder. Several screening methods, including electroencephalography, have been proposed to identify epileptic episodes. EEG data, which are frequently utilised to enhance epilepsy analysis, offer essential information on the electrical processes of the brain. Prior to the emergence of deep learning (DL), feature extraction was accomplished by standard machine learning techniques. As a result, they were only as good as the people who made the features by hand. But with DL, both feature extraction and classification are fully automated. These methods have significantly advanced several fields of medicine, including the diagnosis of epilepsy. In this paper, the works focused on automated epileptic seizure detection using ML and DL techniques are presented as well as their comparative analysis is done. The UCI-Epileptic Seizure Recognition dataset is used for training and validation. Some of the conventional ML and DL algorithms are used with a proposed model which uses long short-term memory (LSTM) to find the best approach. Post that comparative analysis is performed on these algorithms to find the best approach for epileptic seizure detection. As a result, the proposed model LSTM gives a validation accuracy of 97% giving the most appropriate and precise result as compared to other mentioned algorithms used in this study.

Epileptic Seizure Detection with an End-to-End Temporal Convolutional Network and Bidirectional Long Short-Term Memory Model.

Automatic seizure detection plays a key role in assisting clinicians for rapid diagnosis and treatment of epilepsy. In view of the parallelism of temporal convolutional network (TCN) and the capability of bidirectional long short-term memory (BiLSTM) in mining the long-range dependency of multi-channel time-series, we propose an automatic seizure detection method with a novel end-to-end TCN-BiLSTM model in this work. First, raw EEG is filtered with a 0.5-45 Hz band-pass filter, and the filtered data are input into the proposed TCN-BiLSTM network for feature extraction and classification. Post-processing process including moving average filtering, thresholding and collar technique is then employed to further improve the detection performance. The method was evaluated on two EEG database. On the CHB-MIT scalp EEG database, our method achieved a segment-based sensitivity of 94.31%, specificity of 97.13%, and accuracy of 97.09%. Meanwhile, an event-based sensitivity of 96.48% and an average false detection rate (FDR) of 0.38/h were obtained. On the SH-SDU database we collected, the segment-based sensitivity of 94.99%, specificity of 93.25%, and accuracy of 93.27% were achieved. In addition, an event-based sensitivity of 99.35% and a false detection rate of 0.54/h were yielded. The total detection time consumed for 1[Formula: see text]h EEG data was 5.65[Formula: see text]s. These results demonstrate the superiority and promising potential of the proposed method in real-time monitoring of epileptic seizures.