Comprehensive and bolstered analysis of data available in domestic and global quantitative data bases provides the following reasonable and implementable measures that have the potential to mitigate Antibiotic Resistance Pandemic (ARP). The establishment of a centralized national and global data base and infrastructure that will: i. Monitor the amount of antibiotics manufactured per year, ii. Require periodic reporting (Quarterly/semi‐annual/annual) of the volume of antibiotics utilized on a regional, national and global scale, iii. Evaluate the volume of prescription antibiotics recovered by the “National Drug Take Back Program” sponsored cooperatively by the United States Drug Enforcement Agency, Department of Justice, and the Food and Drug Administration (DEA, DOJ, and FDA), iv. Survey and audit the process of disposal of unused prescription antibiotics by the DEA, DOJ, and FDA to ensure that employed destructive practices are conventional and appropriate. Particular oversight and monitoring must be given to incineration and solid waste facilities, v. Detection and evaluative analysis of metabolic breakdown, intermediate, and mother formulation of antibiotics in ground water, portable water systems, raw sewage and waste water, water captured from bio‐remediation processes, rivers, standing storage water reservoirs, storm runoff, and bio‐solids, vi. Collect and maintain epidemiological data on morbidity and mortality rates attributed to AR pathogenic induced infectious diseases on regional, national, and global scales, vii. Collection of data concerned with the effectiveness of antibiotics timeout (ATO) from private practice physicians, institutional reports from mental health facilities and hospitals, both private and public, nursing homes, hospice care, and infant and adult day care facilities, viii. Arrange and contribute to periodic updates concerned with ARP threats discovered or supposed by the United States Department of Health and Human Services Centers for Disease Control and Prevention (CDCP), ix. Research, collection, and reporting of data attentive to the hoarding of antibiotics and partitioning data to regional, national, and global levels, x. Data surveillance of the efficacy of antibiotics, and xi. Elimination of ineffective antibiotics(antibiotics with an increased morbidity and mortality rate) from the pharmacopeia and clinical practice. Taken together, effective universal adoption and implementation of aforesaid measures in health care facilities, and regulatory agencies across the globe, would potentially mitigate the ARP.Support or Funding InformationProfessional development funds to Subburaj Kannan