Availability of regionalized design rainfall is crucial for flood modeling, particularly over the regions with sparse raingauge networks. This study proposes a new comprehensive framework for generating regionalized design rainfall time series for data-poor catchments involving non-linear and non-parametric optimization approaches. A large set of parametric and non-parametric families of distribution were considered for multivariate rainfall frequency analysis using at-site station data, while a unique design temporal pattern over the region was derived by quantifying the flood causing potential of design hyetographs. The regionalized design rainfall time series was used as one of the inputs to a two-dimensional (2D) flood model. The accuracy and performance of the derived regionalized design rainfall for flood inundation modeling were evaluated by comparing with those derived from different spatial interpolation methods. There was a high consensus of the former with those of widely used kriging and spline interpolation methods. A severely flood-prone and data-poor (no raingauge available within study area) large coastal catchment lying along the coast of the Bay of Bengal, India, was chosen for a demonstration of the proposed framework. The study showed that the framework can be used for extreme events arising due to floods, even under changing climatic scenarios. It further invokes the necessity for incorporating the proposed framework into various commercially and freely available flood models along with other existing interpolation techniques to support improved flood management.