The objective of the work is the design and simulation of a flexible manufacturing structure with two robots, integrated in a welding application, using the Roboguide software. FANUC ROBOGUIDE is a robot simulator that simulates both the movement of the robots and the commands from the designed application, significantly reducing the time needed to create new motion configurations.The possibility to import the CAD models of the components, of the fixing devices and of the final effectors of the robots integrated into the designed application, allows the creation and evaluation of various structures. Automatic program generation simplifies manual programming operations. ROBOGUIDE allows pre-programming of robots before they are installed in a cell, as well as visualization and confirmation of robot trajectories before downloading the programs to the real robot.