This research introduces an innovative resilient design framework, addressing gaps in building performance optimization by considering a holistic life cycle perspective and factoring in climate projection uncertainties from the 2020s to 2090s. The study concludes that in the case study, future climate scenarios in different Shared Socio-Economic Paths significantly impact building life cycle performance, with wall U-value, windows U-value, and wall density identified as major factors affecting building performance under future climate uncertainty. The ensemble learning model achieves high fidelity in predicting life cycle carbon emissions (LCCE), life cycle cost (LCC), and indoor discomfort hours (IDH) through input feature screening and hyperparameter optimization. Comparing optimization algorithms, Two-Archive Evolutionary Algorithm for Constrained multi-objective optimization (C-TAEA) demonstrates better convergence degree and optimization effect. Among the tested multi-criteria decision making methods, the VIKOR method selects the best building resilient design scheme from the Pareto data set, effectively reducing LCCE, LCC, and IDH, and leading to an overall improvement in building life cycle performance. Applying this framework, the finalized scheme for an office building in cold region optimizes 44.0% of LCCE, 8.2% of LCC, and 4.3% of IDH. This framework develops a new approach to improve building life cycle performance under future climate uncertainty and supports informed decision-making for resilient building design. To promote carbon neutrality in construction, it is urged that future studies incorporate additional sources of uncertainty, such as occupant behavior, into the proposed framework.
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