Experimental Study Design Research Articles

Effect of digital game intervention on cognitive functions in older adults: a multiple baseline single case experimental design study

BackgroundResidents in nursing homes are prone to cognitive decline affecting memory, visuospatial cognition, and executive functions. Cognitive decline can lead to dementia, necessitating prioritized intervention.MethodsThe current study aimed to investigate whether an intervention using a digital game was effective for preserving and improving the cognitive function of residents in nursing homes. An intervention study was conducted using a single-case AB design with multiple baselines. The participants in the study were five older adults aged 65 and over who do not play digital games regularly. The study ran for 15 weeks, including a baseline (phase A) and an intervention phase (phase B). Phase A had five baselines (5 to 9 weeks) with random participant assignment. In phase B, participants engaged in a digital game (Space Invaders) individually. Cognitive function was assessed as the outcome, measured using the Brain Assessment (performed on a tablet through the Internet) at 16 measurement points. Four of five participants (two female and two male) were included in the analysis, using visual inspection and Bayesian statistics with multi-level modeling.ResultsVisual inspection of the graphs revealed cognitive function score improvements after the intervention for most layers in terms of memory of numbers, memory of words, mental rotation test (visuospatial ability), and total scores in the Brain Assessment. These effects were also significant in the analysis by multi-level modeling.ConclusionsThe results suggest that the use of digital games may be effective for preserving and improving cognitive function among residents of nursing home.Trial registrationThis study was registered in the University Hospital Medical Information Network Clinical Trials Registry (UMIN000048677; public title: Effect of a Digital Game Intervention for Cognitive Functions in Older People; registration date: August 30, 2022).

Coaching entrepreneurs towards growth: an experimental design study of coaching effectiveness for business leaders’ psychological capabilities

ABSTRACT Coaching has a well-established history over the past two decades as a development tool and it can help entrepreneurs deal with the psychological challenges of building a venture. But there is a lack of understanding how coaching can support entrepreneurs on their journey. This study uses a coaching psychology framework to investigate the effectiveness of evidence-based (EB) coaching for entrepreneurs. The aim of this study was to understand how coaches can support cognition change, wellbeing, and accelerated performance improvement of entrepreneurs. The study used a within participant design, and data were collected using a pre and post coaching survey. The study involved n = 19 participants who were early-stage entrepreneurs. Pre and post surveys were assessed using paired sample t-tests. For cognitions, the results indicate higher levels in solution-focused thinking, hope sub-scales agency thinking and goal-orientation. No changes were found for sub-scales pathways thinking and self-efficacy. For Wellbeing, the findings show psychological wellbeing increased with sub-scales autonomy, self-acceptance, personal growth and purpose in life while relationship with others and environment mastery did not change. Negative emotions reduced while positive emotions did not change. For performance, the results show that participants progressed significantly towards attaining their coaching goals.

A Pilot Study of the Effectiveness of Cognitive Resilience Training on Anxiety, Depression, and Suicidal Ideation Among Students of a Selected University in Mexico

ABSTRACT Mental distress burdens student populations; meanwhile, intervention-based studies are insufficient. This pilot study examined the effectiveness of cognitive resilience training (CRT) in enhancing students’ mental health. This experimental design study recruited 29 participants (mean age = 21.70; SD = 2.55) from the Autonomous University of Ciudad Juarez (UACJ) in northern Mexico. A questionnaire pack containing the General Anxiety Disorder-2, Patient Health Questionnaire-2, Plutchik Suicide Risk Scale, and Brief Resilience Scale was utilized. At the pretest, there was no significant difference between the experimental group (EG) and the control group (CG). At the posttest, the CG scored higher on anxiety, depression, and suicidal ideation compared to its EG counterparts. However, the EG’s participants exhibited higher resilience, leading to a reduction in mental distress compared to their control group counterparts. The study concluded that CRT is an effective intervention for enhancing students’ mental health. Therefore, it is recommended for use in university clinical settings.

Preventive and restorative alternatives to caries by irradiation: a scoping review.

This study is to conduct a comprehensive scoping review to map scientific evidence and clarify concepts regarding the commonly recommended preventive and restorative dental treatments for patients diagnosed with head and neck cancer (HNC) and subjected to radiotherapy. This systematic scoping review was performed under the PRISMA-ScR guidelines. The study's experimental design was registered in the Open Science Framework. In vitro studies that evaluated preventive and restorative dental treatment over 50Gy radiation doses were included. The search was conducted in November 2023 in five electronic databases (PubMed, Scopus, Web of Science, Cochrane Library, and Embase) without language or date restriction. A search strategy was applied based on keywords, MeSh terms, or synonyms. A descriptive analysis was conducted. A total of 49 studies, out of 3679 original articles identified, were included and reviewed. Of the included studies, three evaluated saliva stimulants and 35 evaluated fluoride-based preventive materials: gel (n = 18) toothpaste (n = 11) mouth rinse (n = 8) and varnish (n = 5) while 14 evaluated restorative materials: resin composite (n = 12) glass ionomer cement (n = 6) and amalgam (n = 1) Of those studies, 36 were clinical trials and 13 were in vitro studies. Fluoride gel was the most frequently recommended preventive material for preventing radiation caries with supportive clinical evidence. Resin composite and glass ionomer were the most frequently used restorative materials, respectively. However, there is not yet clinical evidence to support the use of resin composite in irradiated teeth.

Effectiveness of NOTES versus traditional techniques on surgical outcomes in adults with diverticulitis: a systematic review protocol.

This review will evaluate the effectiveness of natural orifice transluminal endoscopic surgery (NOTES)/hybrid NOTES versus traditional surgical techniques in the management of diverticular disease. Diverticular disease can have a significant impact on a patient's quality of life, especially the changes affecting bowel function. Recurrent/severe symptoms may require surgery. Resections are invasive and can have significant operative complications. There has been a shift from an open resection to a more minimally invasive technique such as laparoscopy. Furthermore, the use of natural orifice transluminal endoscopic resection, using a transanal/transvaginal approach, has begun to be used in colorectal resections. Eligible studies will include patients who underwent surgical resection for diverticular disease or diverticulitis. The review will consider studies that evaluate NOTES in the management of diverticular disease or diverticulitis. This will include hybrid procedures involving both NOTES and natural orifice specimen extraction (NOSE), with the aid of laparoscopy/endoscopy/robotic equipment. Studies on participants under 18 years of age and presenting with non-diverticular pathologies will be excluded. This review will follow the JBI methodology for systematic reviews of effectiveness and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 statement. Databases to be searched will include PubMed, MEDLINE (Ovid), CINAHL (EBSCOhost), Cochrane Library, Web of Science, Scopus, ProQuest, ClinicalTrials.gov, and ANZCTR, with no language limitations. The reference lists of included studies will be screened for additional studies. This review will preferentially consider experimental and quasi-experimental study designs. Two reviewers will conduct critical appraisal and data extraction. Studies will, where possible, be pooled in statistical meta-analyses. PROSPERO CRD42023420771.

Implementing serious games through a pedagogical lens in engineering education: an experimental study

ABSTRACT Serious games are instructional tools that harmonise different pedagogical approaches and pursue specific behavioural and learning outcomes. Characterised by flexibility and complexity, serious games can draw from a vast number of elements and game mechanics. We argue that such adaptability requires specific pedagogical competencies from designers to avoid using game elements counterproductively for user learning. The literature shows lack of studies based on this perspective: if the influence of single instructional techniques has been studied, the impact of pedagogical expertise is missing, and this represents the knowledge gap this study intends to bridge. This paper reports on an experimental study of a serious game that is part of a course in Industrial Systems Engineering. Through collaborative efforts between an engineering professor and a pedagogical expert rooted in neuroeducation and syntheses of meta-analyses tied to learning achievement, the serious game was redesigned. This pre-test-post-test control and experimental group design study investigates how designers’ pedagogical competencies can impact learning outcomes, motivation, and decision-making processes. The pedagogically revised serious game outperforms the original one in motivation and, in specific subgroups, in learning performance, highlighting the importance of combining pedagogical and engineering insights.

Kejadian Mortalitas Wanita dengan Kanker Payudara Berdasarkan Indeks Massa Tubuh (BMI): Tinjauan Naratif

Breast cancer is the most common cancer found in women of all types of cancer in the world. The relationship between body mass index and the death rate from breast cancer in women has drawn attention recently. This study sought to ascertain the relevance of the variation in death rates between women with breast cancer who had a normal body mass index (BMI) and those who had a BMI of ≥25. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) references were used to guide the systematic review process in this investigation. The Newcastle-Ottawa Scale for cohort design studies and the Robins-I test for single-arm experimental design studies were used to assess the quality of the articles. The data source consisted of 142 Pubmed publications published between 2016 and 2023. The analysis's findings revealed differences between the five publications that discussed the connection between obesity and breast cancer. The development of breast cancer is linked to an increase in leptin and estrogen, which is consistent with an increase in fat. It is concluded that individuals with a body mass index (BMI) of ≥ 25 had a poorer chance of surviving breast cancer than patients with a normal BMI.

Palladium Complexes Derived from Waste as Catalysts for C-H Functionalisation and C-N Bond Formation

Three-way catalysts (TWCs) are widely used in vehicles to convert the exhaust emissions from internal combustion engines into less toxic pollutants. After around 8–10 years of use, the declining catalytic activity of TWCs causes them to need replacing, leading to the generation of substantial amounts of spent TWC material containing precious metals, including palladium. It has previously been reported that [NnBu4]2[Pd2I6] is obtained in high yield and purity from model TWC material using a simple, inexpensive and mild reaction based on tetrabutylammonium iodide in the presence of iodine. In this contribution, it is shown that, through a simple ligand exchange reaction, this dimeric recovery complex can be converted into PdI2(dppf) (dppf = 1,1′-bis(diphenylphosphino)ferrocene), which is a direct analogue of a commonly used catalyst, PdCl2(dppf). [NnBu4]2[Pd2I6] displayed high catalytic activity in the oxidative functionalisation of benzo[h]quinoline to 10-alkoxybenzo[h]quinoline and 8-methylquinoline to 8-(methoxymethyl)quinoline in the presence of an oxidant, PhI(OAc)2. Near-quantitative conversions to the desired product were obtained using a catalyst recovered from waste under milder conditions (50 °C, 1–2 mol% Pd loading) and shorter reaction times (2 h) than those typically used in the literature. The [NnBu4]2[Pd2I6] catalyst could also be recovered and re-used multiple times after the reaction, providing additional sustainability benefits. Both [NnBu4]2[Pd2I6] and PdI2(dppf) were also found to be active in Buchwald–Hartwig amination reactions, and their performance was optimised through a Design of Experiments (DoE) study. The optimised conditions for this waste-derived palladium catalyst (1–2 mol% Pd loading, 3–6 mol% of dppf) in a bioderived solvent, cyclopentyl methyl ether (CPME), offer a more sustainable approach to C-N bond formation than comparable amination protocols.

Application of graphene oxide/titanium dioxide nanoparticle on the rheological, filtration and shale swelling characteristics in water-based mud system: experimental and full factorial design study

Application of graphene oxide/titanium dioxide nanoparticle on the rheological, filtration and shale swelling characteristics in water-based mud system: experimental and full factorial design study

Enhancing Athletes' Foot Stability: A Comparative Analysis of Gluteus Maximus and Gluteus Medius Muscle Strengthening Effects on Navicular Drop, Balance, and Foot Posture Index in Over-Pronated Foot

This study aimed to determine the effectiveness of gluteus maximus versus gluteus medius muscle strengthening exercises on the navicular drop (ND), balance, and foot posture index (FPI 6) among athletes with over-pronated feet. A pre-post experimental study design with a total of 54 athletes with bilateral over-pronated feet were randomly assigned into group A (n=18), group B (n=18), and group C (n=18). Medial longitudinal arch height (MLA) was assessed with the Navicular Drop Test, the static and dynamic balance was determined with the stork stance test (SST) and modified Star Excursion Balance Test, and Foot Posture was assessed with Foot Posture Index 6. Multivariate Repeated measures ANOVA was used to analyze the effects of gluteus maximus versus gluteus medius muscle strengthening and short foot exercises. At four weeks, the gluteus medius along with short foot exercises (group B) showed significantly less ND and FPI 6 while showing more excellent SST and modified SEBT than the gluteus maximus muscle strengthening along with short foot exercises (group A) and control group (group C). These results suggest that adding gluteus medius muscle strengthening exercises to short foot exercises (SFE) was more effective in supporting the medial longitudinal arch and improving balance than performing SFE alone.

My AI students: Evaluating the proficiency of three AI chatbots in <i>completeness</i> and <i>accuracy</i>

A new era of artificial intelligence (AI) has begun, which can radically alter how humans interact with and profit from technology. The confluence of chat interfaces with large language models lets humans write a natural language inquiry and receive a natural language response from a machine. This experimental design study tests the capabilities of three popular AI chatbot services referred to as my AI students: Microsoft Bing, Google Bard, and OpenAI ChatGPT on <i>completeness</i> and <i>accuracy</i>. A Likert scale was used to rate c<i>ompleteness </i>and <i>accuracy,</i> respectively, a three-point and five-point. Descriptive statistics and non-parametric tests were used to compare marks and scale ratings. The results show that AI chatbots were awarded a score of 80.0% overall. However, they struggled with answering questions from the higher Bloom’s taxonomic levels. The median <i>completeness</i> was 3.00 with a mean of 2.75 and the median <i>accuracy</i> was 5.00 with a mean of 4.48 across all Bloom’s taxonomy questions (n=128). Overall, the<i> completeness</i> of the solution was rated mostly incomplete due to limited response (76.2%), while <i>accuracy</i> was rated mostly correct (83.3%). In some cases, generative text was found to be verbose and disembodied, lacking perspective and coherency. Microsoft Bing ranked first among the three AI text generative tools in providing correct answers (92.0%). The Kruskal-Wallis test revealed a significant difference in <i>completeness </i>(asymp. sig.=0.037, p<0.05) and <i>accuracy</i> (asymp. sig.=0.006, p<0.05) among the three AI chatbots. A series of Mann and Whitney tests were carried out showing no significance between AI chatbots for <i>completeness</i> (all p-values>0.015 and 0<r<0.2), while a significant difference was found for <i>accuracy</i> between Google Bard and Microsoft Bing (asymp. sig.=0.002, p<0.05, r=0.3 medium effect). The findings suggest that while AI chatbots can generate comprehensive and correct responses, they may have limits when dealing with more complicated cognitive tasks.

Design Optimization and Tradeoff Analysis of an Actuated Continuum Probe for Pulmonary Nodule Localization and Resection.

Pulmonary nodules are abnormal tissue masses in the lungs, typically less than 3.0 cm in diameter, commonly detected during imaging of the chest and lungs. While most pulmonary nodules are not cancerous, surgical resection may be required if growth is detected between scans. This resection is typically performed without the benefit of intraoperative imaging, making it difficult for surgeons to confidently provide appropriate margins. To enhance the efficacy of wedge resection, researchers have developed a modified ultrasound imaging approach that utilizes both multiple scattering (MS) and single scattering (SS) to enhance the accuracy of margin delineation. Clinical deployment of this novel ultrasound technology requires a highly maneuverable ultrasound probe, ideally one that could be deployed and actuated with minimal invasiveness. This study details the design optimization and tradeoff analysis of an actuated continuum probe for pulmonary nodule localization and resection. This device, deployed through intercostal ports, would enable the intraoperative imaging and precise mapping of nodules for improved margin delineation and patient outcomes. To achieve this objective, multiple objective genetic algorithms (MOGAs) and a design of experiments (DOE) study are used to explore the design space and quantify key dimensional relationships and their effects on probe actuation.

COVID-19 Imposed Closure of Rural Co-Housing and Loneliness in Older Adults Living Alone: Longitudinal Evidence From South Korea.

This study aimed to examine the impact of COVID-19 on loneliness among rural older women in senior cohousing in Korea. Using a natural experimental study design, we investigated how the pandemic-induced closure of cohousing affected the former residents' loneliness. The sample comprised 84 cohousing residents and 51 individuals in conventional homes. The dependent variable is loneliness, and the independent variables include housing transition, social contact, and support from neighbors and friends. Our findings from fixed effect regression models showed former cohousing residents were less likely to experience loneliness when they had more contact with their friends and neighbors, while negative relationships exacerbated feelings of loneliness. Sharing meals and participating in activities with friends and neighbors in cohousing helped the residents develop effective coping strategies. Senior cohousing in rural areas has the potential to strengthen social ties and protect the most vulnerable subgroup of older adults from social isolation and loneliness.

A Randomized Controlled Trial to Assess the Effectiveness of Warm Foot Soak Therapy on Reduction of Blood Pressure among Hypertensive Patients

Introduction : Hypertension is known as the “silent killer” because of its uncertain symptom. Therefore, early detection efforts are needed such as regular blood pressure check and effective management. Both Pharmacological and Non-pharmacological management strategies for hypertension. This study aimed to determine the effectiveness of one of the non-pharmacological management : “warm water foot soak therapy” in reduction of blood pressure among hypertensive patients. Method : Experimental study design - Randomized Controlled Trial was conducted among 60 hypertensive patients using convenient sampling technique. Participants were randomly and equally allocated into Experimental and Control group with the help of computer generated randomization list. Sequentially Numbered Opaque Sealed Envelope (SNOSE) were used for allocation concealment. Experimental group received “Warm foot soak therapy” of both feet for 10-15 cm above ankle in warm water of temperature 37-40 degree Celsius for 15 minutes, once a day for 3 consecutive days. Before and after intervention blood pressure assessment were taken in both groups. Data were analyzed using SPSS ver. 27 Result : Homogenity of socio-demographic, clinical and pre-intervention blood pressure among both groups were statistically established using chi-square test (p> 0.05). Paired t test concluded that, warm foot soak therapy were having statistically significant effect on blood pressure ( p < 0.05) and there was a significant reduction in blood pressure among hypertensive patients (p=0.01). The study also discovered that there is no significant association between selected sociodemographic & clinical variables with pre-interventional change in blood pressure except for the dietary pattern (Veg) in both groups & presence of comorbidity (DM) in experimental group among hypertensive patients at level of significance 0.05. Conclusion : The study demonstrated that warm foot soak therapy have an effect on reduction of blood pressure among hypertensive patients.

Innovative Green Alginate-Cellulose Composite for Light Lanthanides: Experimental Design and Comprehensive Studies on Kinetics, Equilibrium, Thermodynamics, and Reusability.

Nowadays, there is a great interest in efficient adsorbent development due to the recent demand for lanthanides, which are widely used in high-tech technology. Alginates, owing to their natural occurrence, gel formation capability, and safety, could be promising feasible adsorbents for lanthanide removal. This study proposes the alginate-cellulose composite as an ecological, sustainable adsorbent for light lanthanide sorption. The structure, morphology, qualitative and quantitative compositions, average diameter, and pHpzc of the composite were discussed in great detail. Using the batch approach, sorption trials were performed to evaluate the metal sorption performance. The maximum lanthanide accumulation was attained at pH 5.0 and a dosage of 0.05 g. The uptake kinetics are successfully explained by the Ho and McKay model, whereas the equilibrium data is best represented by the Langmuir equation. The presence of Cl-, NO3 -, SO4 2-, Ni(II), and Co(II) did not have any impact on the adsorption capacity. In turn, the presence of Fe(III) ions led to a 15 % reduction in the adsorption. The lanthanide ions were eluted from the adsorbent following the treatment with 0.1 M HNO3. The adsorbent retained over 95 % of its initial adsorption capacity after 6 series of sorption/desorption studies.

Fine-grained effect sizes.

To make transparent individuals' responses to intervention over time in the systematic review of single-case experimental designs, we developed a method of estimating and graphing fine-grained effect sizes. Fine-grained effect sizes are both case- and time-specific and thus provide more nuanced information than effect size estimates that average effects across time, across cases, or both. We demonstrate the method for estimating fine-grained effect sizes under three different baseline stability assumptions: outcome stability, level stability, and trend stability. We then use the method to graph individual effect trajectories from three single-case experimental design studies that examined the impact of self-management interventions on students identified with autism. We conclude by discussing limitations associated with estimating and graphing fine-grained effect sizes and directions for further development. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Knowledge on Use of Diaper and Its Impact on Child Health among Mothers of Infants

The present study aims to assess the knowledge on use of diaper and its impact on child health among mothers of infants. The objectives of the study was to assess the knowledge on use of diaper and its impact on child health among mothers of infants and to find out the association between the knowledge onuse of diaper and its impact of child health among the mothers of infants and selected socio personal variables. Non experimental descriptive study design was used in the study. The data was collected by using a semi structured questionnaire. The collected data was analysed using descriptive and inferential statistics. The result shows that out of 50 samples majority of the children are of age range 0-2 months, 52% were male children and was first born (54%). Majority of the sample are at age group 26-30 years ( 36%) , 58% samples are educated upto graduate level, 42% of samples were housewives and 48% have family income above 30,000, 94% of children were using disposable diapers ,42% of children using diapers for 3-4 hours and 80% children had no exposure to diaper rash.Among the samples, 56% of mother had moderate knowledge, 34% of mothers had poor knowledge and, 10% of mothers had good knowledge. There is significant association between the age of mother and occupation of mother and there is no association between age of child, sex of child, birth order of child, education of mother, income of family, type of diaper used, duration of diaper used, previous exposure to diaper rash.

Formalization of annual performance feedback and employees’ job satisfaction in the SME context

ABSTRACT Human resource management (HRM) practices in small and medium-sized enterprises (SMEs) to increase employees’ job satisfaction are on the rise. Given that SMEs often adopt highly formalized HRM practices of large companies, for example, in the case of annual performance appraisals, we investigate the relationship between the degree of formalization of annual performance feedback and employees’ job satisfaction in the SME context. Using an experimental survey study design (N = 166) in a German SME, we find that employees receiving annual performance feedback with a high degree of formalization report lower job satisfaction directly after the annual performance feedback than those who are still to receive their feedback. In contrast, in the case of annual performance feedback with a low degree of formalization, employees report higher job satisfaction right after the annual performance feedback than employees before the feedback. Moreover, we find that employees’ feedback orientation is an important moderator in this relationship.

The Influence of Alpha Frequency on Temporal Binding across the Senses: Response to the Special Focus.

The papers collected in this Special Focus, prompted by S. Buergers and U. Noppeney [The role of alpha oscillations in temporal binding within and across the senses. Nature Human Behaviour, 6, 732-742, 2022], have raised several interesting ideas, arguments, and empirical results relating to the alpha temporal resolution hypothesis. Here we briefly respond to these, and in the process emphasize four challenges for future research: defining the scope and limitation of the hypothesis; developing experimental paradigms and study designs that rigorously test its tenets; decomposing the scalp-level signal and isolating underlying neural circuits; and bringing uniformity to the current diversity of analysis and statistical methods. Addressing these challenges will facilitate the progression from merely correlating alpha frequency with various perceptual phenomena to establishing whether and (if so) how alpha frequency influences sensory integration and segregation.

INTERVENTIONS TO REDUCE MENOPAUSE SIGNS AND SYMPTOMS IN MENOPAUSE WOMEN A NARRATIVE REVIEW

Introduction: Women who experience menopause will experience a decrease in the hormones estrogen and progesterone that occurs before menopause caused by ovarian atrophy, so it needs to be overcome with pharmacological and non-pharmacological therapy. One type of non-pharmacological therapy is complementary therapy. Objective: This study aims to identify interventions that can be taken to reduce menopausal signs and symptoms. Methods: CINAHL, PubMed, and Sage Journal databases were used for searching articles with sample inclusion criteria of menopausal women, Randomized Controlled Trials or quasi experimental study design, published in 2017-2022, in English, and full text. The exclusion criteria used were the focus of articles discussing interventions to reduce menopausal signs and symptoms with pharmacological therapy, protocol study articles, and pre-proof articles. Results: The search results for 14 matching articles were found. Interventions that can be done to reduce menopausal signs and symptoms are grouped into 4 approaches, namely psychological approaches (self hypnosis and mindfulness stress reduction programs), physical approaches (foot soaking and physical activity), nutritional approaches (herbal medicine, administration of magnesium, fluid nutrition, administration of isoflavones), and combined approaches (electroacupuncture, combined diet guidance and anti-resistance exercises). Conclusions: From the 14 articles obtained, it can be concluded that there are 4 categories of therapeutic approaches that can be taken to reduce menopausal symptoms.It is recommended that further research focus on interventions that are effective in reducing menopausal symptoms.