Introduction: Palm prints formed once does not change throughout life and is not influenced by environment. Palmar Dermatoglyphics can indicate the development of potentially malignant and malignant lesions and help in identifying persons at high risk of developing Oral submucous fibrosis (OSMF) and Oral squamous cell carcinoma (OSSC). Materials and Methods: Dermatoglyphic patterns were collected from randomly selected 120 patients using 3M™ CSD200i. Single-digit Optical Scanner (3M™, Canada, 2015) with automatic capture mechanism was applied to capture finger prints of all the 10 fingers of patients, who were divided in control and test group with respective subgroups of leukoplakia and OSMF. Mean total ridge count and ATD angle were measured in all patients and comparison was done between control group and patients with OSMF and leukoplakia. Results: The collected data was subjected to analysis using Chi-square test for comparison between the groups. The mean ATD angle in patints with osmf is 43.38, leukoplakia is 43.53, patients without lesion but with habit is 44.78, and patients without habit is 45.65.