Owing to the unique properties of 2D graphene derivatives (2D GDs), their composites with other materials possess superior characteristics over other existing materials in the universe. Accordingly, 2D GDs-based composites have emerged as leading materials for substantial advancements of various technological industries such as energy, electronics, sensors, catalysis, environmental remediation, biomedical and structural sectors. Recently, numerous research innovations, have been developed for reliable production of 2D GDs-based composites with high quality, plentiful availability and competitive costs. The overall performance of 2D GDs-based composites is controlled by three main issues. First, the synthesis strategy of GD sheets, which determines the characteristic properties, quantity and cost of the 2D GD product. Second, the surface functionalization of GD sheets, which enhances the compatibility and chemical affinity between GD sheets and other materials within the composites. Finally, the processing method of the composite that strongly affects its microstructure, properties, productivity and cost. This makes such three processes, matters of great concern when designing 2D GDs-based composites for specific application. In this article, the structure, properties, synthesis and surface functionalization of 2D GDs are reviewed. Then, the review article discusses the research developments of 2D GDs-based composites with inorganic materials and polymers, in terms of preparation, properties and applications. Particular focus is placed on Green and/or clean production technologies. The recent research interest in the 2D GDs/multicomponent hybrid composites, with their distinctive multifunctional properties, is highlighted. Also, the new implemented applications of 2D GDs-based composites from 2021, are pointed out, as well as the currently running practical projects, which are proposing innovative futural applications prospects.