Reduction In Depth Research Articles

The Dipole Mode of Summer Wet‐Bulb Temperature Over Eastern China and the Possible Mechanisms

AbstractOne prominent mode of the variability in the summer wet‐bulb temperature (WBT) over eastern China exhibits a distinct north‒south dipole pattern. This pattern demonstrates a positive center in northern China (NC), while a negative center is observed in southern China (SC). Our results indicate that the dipole mode of WBT could be partially ascribed to the impact of spring snow anomalies in eastern Europe–western Siberia (EEWS). The reduction in the snow depth, coupled with dry soil conditions, enhances the surface heat flux and consequently leads to an increase in the near‐surface air temperature. The signal of soil moisture could persist from spring to summer, stimulating the generation of zonal Rossby waves. Consequently, the significant wave flux anomalies propagate from EEWS downstream and influence the atmospheric circulation over eastern China. These patterns play a role in the increase in the surface air temperature and moisture accumulation over NC, ultimately leading to the establishment of the dipole mode of WBT over eastern China in summer. Further analysis indicates that the atypical low sea surface temperature in the tropical Ocean, induced by the El Niño‐Southern Oscillation, establishes a climatic context favorable for the persistence of an anomalous cyclone in the Northwest Pacific (NWP) throughout the summer season. The strengthened convection over the NWP and SC induces a dipole pattern of atmospheric circulation by stimulating a meridional wave train. This pattern creates favorable temperature and moisture conditions, contributing to the development of the dipole mode of the summer WBT across eastern China.

Assessing lateral torsional buckling of stepped steel I beams using finite element method

The use of steel beams with variable sections along their length is getting more attention in recent years. These variable sections can vary gradually along the beam or change abruptly as a drop or a step. The current study investigates the lateral torsional buckling (LTB) of stepped steel beams with flanged I section subjected to uniformly distributed pressure on the top flange. The studied parameters are the step height, the step length, and the boundary conditions of the beam. The finite element method is used to carry out a linear buckling analysis of the beams’ models. The results show significant degradation in beams LTB strength due to the jump of the beam's section. Reducing the simply supported beam depth by 25 % reduces LTB strength by about 40–50 %, while reducing the fixed beam depth by 25 % reduces LTB strength by about 30–40 %. Further reduction in depth showed no significant additional reduction in simply supported beams strength, while the fixed beams showed another 30–40 % reduction in strength with another 25 % reduction in beam total depth. The step made the compressive stress transfer between the two flange parts through the web.

Multi-scale study on penetration performance of steel fiber reinforced ultra-high performance concrete

This paper not only studies the influence of fiber content on the mechanical properties of steel fiber ultra-high performance concrete (SFRUHPC), but also conducts high-speed impact tests and simulations on high-volume fiber targets with varying thicknesses to evaluate the damage characteristics of the SFRUHPC targets, such as residual velocity and penetration depth of the projectile. The results indicate that compared with ordinary concrete and low fiber content targets, the flexural strength and compressive strength of the target incorporated with 7% steel fiber reach the maximum values of 87.9 MPa and 362.9 MPa, respectively, which are significantly improved. On the other hand, the 7% steel fiber reinforced target demonstrates excellent anti-penetration performance which is evidenced by a 51.9% lower residual velocity compared to ordinary concrete targets in thin target tests, as well as a 37.4% reduction in penetration depth in thick target tests. Additionally, the rebound phenomenon of the projectile is observed during the tests. Furthermore, the three-dimensional mesoscopic numerical model established exhibits a good correlation with the experimental results. Finally, the model adopted in this paper can better predict the residual velocity and depth of penetration of the projectile.

Genetic analysis of impaired healing responses after periodontal therapy in type 2 diabetes: Clinical and invivo studies.

This study aims to investigate the mechanisms underlying the impaired healing response by diabetes after periodontal therapy. Outcomes of periodontal therapy in patients with diabetes are impaired compared with those in patients without diabetes. However, the mechanisms underlying impaired healing response to periodontal therapy have not been sufficiently investigated. Zucker diabetic fatty (ZDF) and lean (ZL) rats underwent experimental periodontitis by ligating the mandibular molars for one week. The gingiva at the ligated sites was harvested one day after ligature removal, and gene expression was comprehensively analyzed using RNA-Seq. In patients with and without type 2 diabetes (T2D), the corresponding gene expression was quantified in the gingiva of the shallow sulcus and residual periodontal pocket after non-surgical periodontal therapy. Ligation-induced bone resorption and its recovery after ligature removal were significantly impaired in the ZDF group than in the ZL group. The RNA-Seq analysis revealed 252 differentially expressed genes. Pathway analysis demonstrated the enrichment of downregulated genes involved in the peroxisome proliferator-activated receptor (PPAR) signaling pathway. PPARα and PPARγ were decreased in mRNA level and immunohistochemistry in the ZDF group than in the ZL group. In clinical, probing depth reduction was significantly less in the T2D group than control. Significantly downregulated expression of PPARα and PPARγ were detected in the residual periodontal pocket of the T2D group compared with those of the control group, but not in the shallow sulcus between the groups. Downregulated PPAR subtypes expression may involve the impaired healing of periodontal tissues by diabetes.

Synergistic effect of in-situ synthetic GE@Cu particles as additives for enhancement in lubrication performances

Graphene-encased copper particles (GE@Cu) with fluctuating particle sizes ranging from 3 to 15 nm, 80-210 nm, 270-530 nm, and 1.2–3.5 μm are prepared by metal-organic chemical vapor deposition using cupric tartrate and cupric acetylacetonate as precursors.The reaction temperature has been found a significant effect on the decomposition of the organocopper compounds, the coalescence of Cu/C clusters, and the morphology evolution of GE@Cu particles. Thus, the size of copper particles and thickness of the graphene cladding layer (few-layer and multi-layer) can be strictly controlled by modulating the pyrolysis temperatures of the organocopper compounds. The optimized GE@Cu particles with 0.5 wt% mass ratio in lubricants exhibit the reduction of wear track depths and coefficient of friction comparing with the pure lubricants. The corresponding wear rate for the 0.5 wt% few-layer graphene@Cu (FLGE@Cu) and 0.5 wt% multi-layer graphene@Cu (MLGE@Cu) decreases by 60.3 % and 62.5 %, respectively. Additionally, Raman spectroscopy illustrates the formation of a self-lubricating graphene layer on the wearing surface during the friction with GE@Cu as the lubricant additives. The hybridized structure of this nanoadditive introduces synergistic lubrication effects, involving sliding friction (graphene) and rolling friction (copper particles) at the friction contact surface, leading to enhanced lubrication performance. The comprehensive encapsulation of copper particles by GE established the suitability of this lubricant additive for enduring prolonged and intricate environments. In conclusion, GE@Cu lubricant additives hold great promise across the fields of mechanical equipment, bearings, and engines.

Assessing silvopasture management as a strategy to reduce fuel loads and mitigate wildfire risk

Managing private forests for wildfire resilience is challenging due to conflicting social, economic, and ecological decisions that may result in an increase of surface fuel loads leading to greater fire risk. Due to fire suppression and a changing climate, land managers in fire-prone regions face an increasing threat of high severity fires. Thus, land managers need fuel treatment options that match their forest types and management objectives. One potential option for producers that graze livestock is silvopasture management, where livestock, forages, and overstory vegetation are carefully managed for co-benefits on the same unit of land. This study compared forest composition and structure, fuel types, and vegetative biomass between silvopasture and non-grazed managed forests in Washington, U.S. We show that silvopasture management results in reductions in grass biomass, litter, and duff depth when compared to non-grazed managed forest. These findings point to the integrated nature of silvopasture, where management of overstory composition and structure, understory vegetation, and grazing can reduce fuel loads and potential wildfire risk.

Performance analysis of columnar convex-concave compound microtexture thrust bearing

PurposeThis study aims to enhance the lubrication performance of thrust bearings. The influence of columnar convex–concave compound microtexture on bearing performance is investigatedDesign/methodology/approachBased on the compound microtexture model of thrust bearings, considering surface roughness and turbulent effect, the variation of lubrication characteristics with the change in the compound microtexture parameters is studied.FindingsThe results indicate that, compared with circular microtexture, the maximum pressure of compound microtexture of thrust bearings increases by 7.42%. Optimal bearing performance is achieved when the internal microtexture depth is 0.02 mm. Turbulent flow states and surface roughness lead to a reduction in the optimal depth. The maximum pressure and load-carrying capacity of the bearing decrease as the initial angle increases, whereas the friction coefficient increases with the increase in the initial angle. The lubrication performance is best for bearings with a circumferential parallel arrangement of microtexture.Originality/valueThe novel composite microtexture with columnar convex-concave is proposed, and the computational model of thrust bearings is set. The influence of surface roughness and turbulent flow on the bearing performance should be considered for better conforming with engineering practice. The effect of microtexture depth, arrangement method and distribution position on the lubrication performance of the compound microtexture thrust bearing is investigated, which is of great significance for improving tribology, thrust bearings and surface microtexture theory.

Ecological degradation of a fragile semi-arid wetland and the implications in its microbial community: The case study of Las Tablas de Daimiel National Park (Spain)

Las Tablas de Daimiel National Park (TDNP, Iberian Peninsula) is a semi-arid wetland of international significance for waterfowl and serves as a migratory route for various bird species. However, TDNP presents strong anthropization and fluctuating water levels, making it a highly fragile ecosystem. Water physico-chemical parameters and microbial diversity of the three domains (Bacteria-Archaea- Eukarya) were analysed in Zone A and Zone B of the wetland (a total of eight stations) during spring and summer, aiming to determine how seasonal changes influence the water quality, trophic status and ultimately, the microbial community composition. Additionally, Photosynthetically Active Radiation (PAR) was used to determine the trophic status instead of transparency using Secchi disk, setting the threshold to 20–40 μmol/sm2 for benthic vegetation growth. In spring, both zones of the wetland were considered eutrophic, and physico-chemical parameters as well as microbial diversity were similar to other wetlands, with most abundant bacteria affiliated to Actinobacteriota, Cyanobacteria, Bacteroidota, Gammaproteobacteria and Verrumicrobiota. Methane-related taxa like Methanosarcinales and photosynthetic Chlorophyta were respectively the most representative archaeal and eukaryotic groups. In summer, phytoplankton bloom led by an unclassified Cyanobacteria and mainly alga Hydrodictyon was observed in Zone A, resulting in an increase of turbidity, pH, phosphorus, nitrogen, chlorophyll-a and phycocyanin indicating the change to hypertrophic state. Microbial community composition was geographical and seasonal shaped within the wetland as response to changes in trophic status. Archaeal diversity decreases and methane-related species increase due to sediment disturbance driven by fish activity, wind, and substantial water depth reduction. Zone B in summer suffers less seasonal changes, maintaining the eutrophic state and still detecting macrophyte growth in some stations.This study provides a new understanding of the interdomain microbial adaptation following the ecological evolution of the wetland, which is crucial to knowing these systems that are ecological niches with high environmental value.

Clinical benefits of autologous platelet concentrate in periodontal intrabony defects: A network meta-analysis of randomized controlled trials.

This study aimed to compare clinical benefits of autologous platelet concentrate with other periodontal regenerative approaches in intrabony defects. An electronic and hand search of studies up to December 2022 was conducted. Randomized controlled trials with at least 6 months of follow-up were identified to compare autologous platelet concentrates with enamel matrix derivative, bone graft, guided tissue regeneration, and open-flap debridement. All approaches involved papilla preservation flap surgery. The outcomes included probing depth reduction, clinical attachment level gain, linear bone fill, and safety. A network meta-analysis and meta-regression were performed. Fifty-seven studies were included in five network meta-analyses. Autologous platelets concentrate and its adjunct treatments achieved significantly greater clinical and radiographic parameters than did open-flap debridement, and had comparable or better performance than other regenerative treatments. Platelet-rich fibrin showed superiority over platelet-rich plasma in probing depth reduction at 6-month follow-up. Minimal pain and improved wound healing were observed in the treatments with autologous platelet concentrate. Meta-regression showed that deeper baseline intrabony defects resulted in larger probing depth reductions, while smoking impaired the effectiveness of regenerative surgeries. Minimal invasive flap designs led to less effect of regenerative materials. Autologous platelet concentrate is a promising biomaterial in periodontal regeneration due to its convenience, safety, and biocompatibility characteristics.

Molybdenum Disulfide‐based Lossy Mode Resonance Sensors: Uncovering Wider Dynamic Range and High Sensitivity Through Computational Approaches

AbstractUntil now, Surface Plasmon Resonance (SPR) biosensors still rely on gold as their transducer element, and this makes cheap analytical devices difficult to achieve. On the other hand, lossy mode resonance (LMR) sensors offer transducers with more alternative materials due to their flexibility, which can be excited in p‐ and s‐polarized light. In this research it is carried out a numerical investigation using the transfer matrix method on LMR sensor composed of molybdenum disulfide (MoS2) as lossy layer and Cytop as matching layer. The reflectance curves for different thicknesses of MoS2 and Cytop are numerically investigated. The results obtained show that the chip consisting of 250 nm Cytop and 4 layers of MoS2 has a penetration depth 3 times higher than conventional SPR chips. If sensors with two types of polarization are compared, sensors with s‐polarized light have shown higher sensitivity reaching 72.13°/RIU with a wider dynamic range starting from a refractive index of 1.331 to 1.401. In this refractive index range, this sensor has displayed good signal stability where the reduction in resonance dip depth is only ≈6%. These computational results make the proposed structure very promising to be applied in the quantification of biological materials.

Synergistic effects of melamine functionalized graphene oxide and imidazolium ionic liquid on the tribological performance and thermal stability of polyalphaolefin based hybrid nanolubricants

Tribological and thermophysical characteristics of a new hybrid nanolubricant that incorporates melamine functionalized graphene oxide (mGO) and imidazolium cation based ionic liquid (IL) in a polyalphaolefin (PAO-6) base oil have been investigated. Different formulations of nanolubricants with 0.05 wt%, 0.1 wt% nanosheets and 1 wt% ionic liquid were studied to examine the synergistic effects of surface functionalization and ionic liquid addition on the antifriction and antiwear properties of the PAO-6 base oil. Thermal stability studies involved Thermogravimetric analysis to analyze the oxidation onset and decomposition temperature of different formulatons at varying weight concentrations of nanoadditives. Anti-friction performance was quantified by the coefficient of friction (COF) reduction compared to neat lubricant. The highest reduction in COF was observed for 0.05 wt% mGO + 1 wt% IL with an outstanding 73.33% reduction followed by 0.05 wt% mGO and 0.05 wt% GO with 73% and 67% reduction respectively. Post-wear analysis of the wear scars was performed using 3D optical profiler, SEM micrographs, EDX elemental composition and Raman spectra. The highest reduction in wear depth was observed in the case of PAO-6 + 0.05% mGO with a value of 46.3% followed by a 39.9% reduction in the case of PAO-6 + 0.05% GO. The morphologies of samples containing both ionic liquid and nanosheets exhibited a much smoother surface with the absence of deep grooves and pits which was attributed to the formation of a strongly bonded tribofilm owing to the chemical interactions between ionic liquid capped nanosheets and metal substrate. Strong interfacial interactions also induced a significant increase in the thermal stability of the nanofluids. The maximum shift observed in the oxidation onset temperature compared to neat PAO-6 was 68◦C while the decomposition temperature increased by 61◦C. Due to their excellent friction, wear, and thermal properties, these hybrid nanofluids could be applied in various highly demanding industrial sectors such as automotive, machining operations, aerospace, thermal power plants and micro/nano-electromechanical systems.

Assessing hydrothermal changes in the upper Yellow River Basin amidst permafrost degradation

Since the 20th century, the temperature on the Qinghai–Tibetan Plateau (QTP) has increased at a rate of 2–3 times that of global warming. Consequently, the soil temperature and active layer thickness have also increased, which have directly caused severe degradation of the frozen ground on the QTP. Using a hydrological model driven by climate and vegetation forcing, the spatial and temporal changes in the hydrothermal characteristics of the Upper Yellow River Basin (UYRB) from 1960 to 2019 were modeled and the mechanism of the changes was analyzed. During the past six decades, the soil temperature in the UYRB exhibited an increasing trend. The degradation of permafrost in the UYRB was accompanied by thickening of the active layer, a reduction of the maximum depth of the seasonal frost penetration, and continuous extension of the basin thawing time. This degradation was also associated with the increase in the soil moisture content and decrease in the soil ice content, resulting in degradation of the permafrost area by one-tenth of the total area in the UYRB. The reduction of the permafrost area and the thickening of the active layer can profoundly impact hydrological processes and ecosystems. These findings play a critical role in designing efficient strategies to manage and protect frozen ground and serve as a valuable reference for understanding the consequences of frozen ground degradation globally.

Investigation of optimal machining Monel 400 superalloy considering carbon emissions using FEM, regression and ANN methods

In this study, the optimal machining parameters for the machining of Monel 400 superalloy considering carbon emission were investigated. Monel 400 stands out among nickel alloys with its resistance to high corrosive environments. First, the Johnson-Cook material model for Monel 400 was developed for FEM simulations. Then, FEM simulations were performed using seven different machining parameters, including cutting and geometric, and validated with experimental results in the literature. The obtained FEM results were trained and predicted by regression and Artificial Neural Network (ANN) analysis. With this study, the Johnson-Cook material model of Monel 400 superalloy and the optimal machining parameters considering carbon emission with different cutting and geometric machining parameters are provided to the literature. As a result, it was determined that the most effective machining parameters in terms of cutting force were 139.04% increase in depth of cut, 74.23% increase in feed and 9.57% decrease in side rake angle. In terms of carbon emission, the most effective machining parameters were found to be −338.9g reduction in depth of cut, −294.3g reduction in feed rate and −171.9g reduction in cutting speed. In terms of training and prediction of FEM results, it was observed that the regression model was 89.19% for cutting force data and 95.39% for carbon emission, while the ANN model was 98.081% for cutting force data and 99.978% for carbon emission. Optimal machining parameters were determined by ANN method. The optimal machining parameters (cutting speed, feed, cutting depth, side rake angle, back rake angle, lead angle and nose radius) of Monel 400 superalloy with the lowest cutting force and carbon emission were determined as 100 m/min, 0.15mm/rev, 0.375 mm, 0°, 5°, 0°, 0°, 0°, 0.4 mm and 100 m/min, 0.2mm/rev, 0.25 mm, −5°, 5°, 0°, 0.8 mm, respectively.

Efficacy and Safety of Skin Radiance Collagen on Skin and Hair Matrix: A Placebo-Controlled Clinical Trial in Healthy Human Subjects.

Collagen supplements are rising in the market as collagen has been demonstrated to be an important protein in the human aging process. Also, it is safe and easily absorbed in the body. Hence the aim of this study was to examine the effectiveness and safety of a collagen and antioxidant-rich treatment compared to a placebo in relation to various skin and hair indicators in healthy adult human subjects. Forty healthy adult non-pregnant/non-lactating women (aged 38-50 years) provided their informed consent in writing before their participation. Skin Radiance Collagen (SRC) treatment and a placebo were assessed for efficacy before application on Day 1, and post-application on Days 28 and 56, to measure changes in skin elasticity, hydration, brightness, pigmentation; texture, wrinkles, dryness, smoothness, fine lines, changes in the crow's feet region; as well as hair strength and hair fall. It was observed after 56 days that therapy with SRC, compared to placebo, produced a substantial effect on reduction of wrinkle depth and fine lines by 48.11% and 39%, respectively, with p-value <0.01 in the test group. There was a 15.69% improvement in skin hydration observed and 28% reduction in hair fall with p-value <0.01. SRC, a combination of collagen with hyaluronic acid (HA), biotin, and vitamins C and E, showed a significant improvement in skin and hair health, including improvements in skin elasticity, skin hydration, reduction in crow's feet area wrinkles and fine lines, hair fall, and decrease in roughness, leading to improved skin texture. Vitamin C in the formulation also acts as a collagen builder for the body and helps in preventing oxidative stress in the body. The test treatment SRC was found to be efficacious and safe in healthy human adult subjects.

Investigating the impact of added Profhilo mesogel to subcision versus subcision monotherapy in treating acne scars; a single-blinded, split-face randomized trial.

Acne scar is an inflammatory condition, which commonly occurs in patients with acne vulgaris, especially in adults. Mesogels have been reported effective in improving atrophic acne scars. We investigated the efficacy of adding Profhilo (a hyaluronic acid-based filler) to subcision as a new treatment method. Twelve patients aged 18-45 years with atrophic acne scars on both sides of the face participated in this single-blinded, split-face, randomized controlled trial. Each side of the face was randomly assigned to one of the treatment methods, including subcision alone and subcision + Profhilo. Patients in the Profhilo arm received mesogel (1 cc) in addition to the subcision procedure. Both methods were carried out two times at 1-month intervals. Assessments were done based on the sonographic depth of scars, and two blinded observers examined photographs at baseline and 3 months after the final session and the results were reported based on an exclusively made formula as the total score. The Global Improvement Scale and Visual Analogue Scale (VAS) (for patient satisfaction) were also used. The VAS score of patient satisfaction was statistically significant in the Profhilo arm, with a mean improvement of 528.08 and 219.06 in the subcision arm (p = 0.02). No significant difference was seen in total acne scar reduction comparing the two methods (29.74 in the Profhilo arm and 22.27 in the subcision arm, p = 0.56). Sonographic depth reduction was also non-significant, with a mean of 29.21 in the Profhilo arm and 28.53 in the subcision arm (p = 0.4). The mean global improvement was reported as four in both arms, and no statistical significance was observed (p = 0.89). The best response to treatment belonged to the rolling subtype in both methods (p = 0.029 for the Profhilo arm and p = 0.001 for the subcision arm). Despite no significant difference between the methods, Profhilo is more effective due to a higher satisfaction rate and better physiologic effects.

Efficacy of systemic use of antibiotics as an adjunct to nonsurgical treatment of peri-implantitis: a meta-analysis of randomized controlled trials.

The role of antibiotics as an adjunct to nonsurgical peri-implantitis treatment approaches has not reached a consensus. This meta-analysis aimed to review the adjunctive effect of systemic use of metronidazole and amoxicillin in patients with peri-implantitis. PubMed, Embase, and the Cochrane Library were searched for randomized controlled trials published from inception to January 2023. A total of five clinical trials with a total of 211 patients were included in the analyses. No significant difference was found in the reduction of probing pocket depth at 3 and 6 months of follow-up (3 months: weighted mean difference [WMD] = -0.336, 95% CI -0.966 to 0.233, P = .231; 6 months: WMD = -0.533, 95% CI -1.654 to 0.587, P = .351). A statistically significant difference was found at 12 months of follow-up (WMD = -1.327, 95% CI -1.803 to -0.852, P < .001) between the treatment and control groups. The combined results indicated that the differences in reduction of bleeding on probing, Plaque Index score, and bone level at 6 months of follow-up were significant (P < .05). The study demonstrated that the adjunctive use of systemic metronidazole and amoxicillin did not significantly improve probing pocket depth compared to nonsurgical treatment alone, and should not be routinely recommended. However, the significant reductions in bleeding on probing, Plaque Index, and bone level at 6 months may indicate a potential effect of treating peri-implantitis with adjunctive systemic metronidazole and amoxicillin.

The impact of different states of type 2 diabetes when stratified by baseline HbA1c on the periodontal outcomes of non-surgical periodontal treatment: A systematic review and network meta-analysis.

Type 2 diabetes mellitus (T2DM) has been considered by many studies to have a bidirectional relationship with periodontitis. This systematic review and network meta-analysis aimed to investigate the impact of different states of T2DM when stratified by baseline HbA1c on the clinical outcomes of non-surgical periodontal treatment (NSPT). This study followed the Preferred Reporting Items for Meta-Analyses (PRISMA) guidelines and involved an electronic literature search (from inception to the 2nd of January 2023). The study included at least two groups of patients: chronic periodontitis only (No-DM) or periodontitis and well-controlled/poorly controlled type 2 diabetes mellitus (WC/PC-T2DM). Clinical outcomes included probing depth (PD) reduction, bleeding on probing reduction, and clinical attachment level (CAL) gain. Direct and indirect comparisons between groups were assessed by network meta-analysis, thus allowing us to establish a treatment ranking. Ten prospective cohort studies (11 data sets) were included for qualitative analysis and network meta-analysis. The data included in this study had high consistency; in addition, a funnel plot and Egger's test showed that the articles had low publication bias. Network meta-analysis showed that the effect of NSPT in the No-DM group was significantly better than the WC-T2DM group [weighted mean difference (WMD) = 0.09, 95% confidence interval (CI) (0.01, 0.18)] and the PC-T2DM group [WMD = 0.09, 95% CI (0.01, 0.18)] in terms of CAL gain and better than the PC-T2DM group [WMD = 0.15, 95% CI (0.02, 0.28)] in terms of PD reduction. According to the surface under the cumulative ranking value, the No-DM group had the highest probability of achieving the best outcome following NSPT. Collectively, our analyses show that T2DM exerts significant effects on the outcomes of NSPT.

Influence of Photosensitizer on Photodynamic Therapy for Peri-Implantitis: A Systematic Review.

The treatment of peri-implantitis is challenging in the clinical practice of implant dentistry. With limited therapeutic options and drug resistance, there is a need for alternative methods, such as photodynamic therapy (PDT), which is a minimally invasive procedure used to treat peri-implantitis. This study evaluated whether the type of photosensitizer used influences the results of inflammatory control, reduction in peri-implant pocket depth, bleeding during probing, and reduction in bone loss in the dental implant region. We registered the study in the PROSPERO (International Prospective Register of Systematic Review) database. We searched three main databases and gray literature in English without date restrictions. In vivo randomized clinical studies involving individuals with peri-implantitis, smokers, patients with diabetes, and healthy controls were included. PDT was used as the primary intervention. Comparators considered mechanical debridement with a reduction in pocket depth as the primary outcome and clinical attachment level, bleeding on probing, gingival index, plaque index, and microbiological analysis as secondary outcomes. After reviewing the eligibility criteria, we included seven articles out of 266. A great variety of photosensitizers were observed, and it was concluded that the selection of the most appropriate type of photosensitizer must consider the patient's characteristics and peri-implantitis conditions. The effectiveness of PDT, its effects on the oral microbiome, and the clinical patterns of peri-implantitis may vary depending on the photosensitizer chosen, which is a crucial factor in personalizing peri-implantitis treatment.

Evaluation of the Efficacy of Stem Cells Therapy in the Periodontal Regeneration: A Meta-Analysis and Mendelian Randomization Study.

Stem cell therapy for periodontal defects has shown good promise in preclinical studies. The purpose of this study was to evaluate the impact of stem cell support on the regeneration of both soft and hard tissues in periodontal treatment. PubMed, Cochrane Library, Embase, and Web of Science were searched and patients with periodontal defects who received stem cell therapy were included in this study. The quality of the included articles was assessed using Cochrane's tool for evaluating bias, and heterogeneity was analyzed using the I2 method. An Mendelian randomizationinvestigation was conducted using abstract data from the IEU public databases obtained through GWAS. Nine articles were included for the meta-analysis. Stem cell therapy effectively rebuilds periodontal tissues in patients with periodontal defects, as evidenced by a reduction in probing depth, clinical attachment level andbone defect depth . And delta-like homolog 1 is a protective factor against periodontal defects alternative indicator of tooth loosening. The findings of this research endorse the utilization of stem cell treatment for repairing periodontal defects in individuals suffering from periodontitis. It is recommended that additional extensive clinical investigations be carried out to validate the efficacy of stem cell therapy and encourage its widespread adoption.

Performance evaluation of geosynthetic reinforced marginal material as base layer over weak subgrade

ABSTRACT The availability of quality materials for construction has been an issue in some regions. This scarcity obliged using marginal materials reinforced with geosynthetic materials as one of the quests for sustainability in the pavement industry. In this study, an attempt was made to stabilize the marginal materials by incorporating geosynthetics. The different geosynthetics used in the study are geogrid, geocell, double geogrid, and geocell + geogrid. A series of unreinforced (UR) and geosynthetic reinforced (GR) pavement prototypes were constructed in the laboratory with landslide debris as base material underlain by black cotton soil subgrade. Large-scale cyclic plate load (CPL) tests were performed on test prototypes constructed in the laboratory under cyclic loading following the trapezoidal loading pattern with 0.77 Hz frequency. The efficacy of geosynthetic reinforcement was quantified concerning permanent deformation (PD), resilient deformation (RD), Rut depth reduction (RDR), Traffic improvement ratio (TIR), and reduction in vertical stresses transmitted to the subgrade and reduction in base layer thickness. The test results indicate that the GR significantly reduced the rut depth and improved the traffic capacity. In addition, over all types of GRs, the combination of geogrid and geocell outperformed in terms of permanent deformation and rut depth reduction.