Deposition Area Research Articles

Effects of Patch Properties of Submerged Vegetation on Sediment Scouring and Deposition

Vegetation plays a key role in trapping sediments and further controlling pollutants. However, few studies were conducted to clarify the erosion and deposition laws of sediments and the influence factors caused by vegetation patch properties, which is not conducive to the revelation of riverbank protection and erosion prevention. Therefore, this study investigated the change in scouring and deposition characteristics around submerged vegetation patches of nine kinds of typical configurations and their influencing factors. Vegetation patches were assembled from three vegetation densities (G/d = 0.83, 1.3, and 1.77, representing dense, medium, and sparse, respectively), and three vegetation patch thicknesses (dn = 170, 400, and 630, representing narrow, usual, and wide, respectively), to measure vegetation patch property influences. Flow velocity, scouring, and deposition characteristics under nine patches were determined by a hydraulic flume experiment, three-dimensional acoustic Doppler velocimetry (ADV), and three-dimensional laser scanner, and then ten geometry and morphology indices were measured and calculated based on the results of laser scanning. Results showed that both vegetation patch density and thickness were positively related to the turbulence kinetic energy (TKE) above the vegetation canopy, and only vegetation patch density was negatively related to the flow velocity above the vegetation canopy. The relation between the product of density and vegetation patch thickness and erosion area in planform (EA) showed a power function (R2 = 0.644). Both density and vegetation patch thickness determined the scouring degree, but deposition location and amount did not rely on each one simply. On average, medium density showed the smallest maximum erosion length (MEL), EA, deposition area in planform (DA), and average deposition length (ADL) and a minimum of the above parameters also occurred at narrow vegetation patch thickness. The shape factor of the erosion volume (SFEV), the shape factor of the deposition volume (SFDV), ADL, and MEL of medium density and narrow thickness vegetation patch (G/d = 1.3, dn = 170) were significantly smaller than that of other types of patches. DA and equivalent prismatic erosion depth on the erosion area (EPED) were significantly linearly related (R2 = 0.766). Consequently, most sediment was deposited close to the vegetation patch edge. It is suggested that vegetation patch thickness and density should be given to control sediment transport. In particular, natural vegetation growth changes vegetation patch density and then alters vegetation patch thickness. Management and repair need to be first considered. The results of this study shed light on riparian zone recovery and vegetation filter strip mechanism.

Technogenic gold deposits of the Trans-Baikal Territory

Relevance. The need to expand the mineral resource base of the Trans-Baikal Territory. Aim. To study the geochemical composition of technozems of tailings dumps of gold deposits of the Trans-Baikal Territory, their correspondence, in terms of gold content, to technogenic deposits, to calculate the exceeding the maximum permissible concentrations of toxic elements in technozems of tailings dumps. Objects. Technozems of tailings dumps of gold deposits of the Trans-Baikal Territory. Methods. Silicate, X-ray fluorescence ISP-AES methods in analytical laboratories of the Geological Institute of the SB RAS (Ulan-Ude) and JSC "SGS Vostok Limited" (Chita). Results. It was found that in terms of gold content (Au>0.4 g/t), the technozems of the tailings of the gold deposits of the Trans-Baikal Territory, in general, correspond to technogenic gold deposits. The largest volumes and contents of gold (1.2 g/t) are characterized by technozems of the Baleysky tailings dam deposits with insignificant gold contents are technozems of Darasunsky (0.36 g/t) and Kariysky (0.35 g/t) deposits. It is determined that the chemical composition of the technozems of the tailings depends on the composition of the host rocks developed in the areas of deposits. They correspond to the rocks of both basic and medium compositions. The distinctive features of the content of impurity elements in the technozems of tailings are due to the different compositions of the initial ores of gold deposits. These differences are reflected in the values of exceeding the maximum permissible concentrations relative to soils. Among the toxic elements, arsenic is characterized by maximum exceedances of the maximum permissible concentrations. In the technozems of the Lyubavinsky deposit, the excess of the maximum permissible concentrations of arsenic relative to the soil is 933 times, and the Baley deposit is 397 times.

Elemental Composition of the Leaves of the Hanging Birch (<i>Betula pendula</i> Roth) in the Area of the Transbaikalia Gold Deposit

The influence of gold mining on the concentration of chemical elements in Betula pendula Roth leaves was studied. The intensity of absorption by the plant of a number of chemical elements, the possibility of using birch as a medicinal and forage plant, as well as for monitoring habitat changes were investigated. The study was conducted in plant communities located at production facilities and natural habitats in the area of the Baley gold deposit: tailings dumps of gold recovery factories (ZIF-1 and ZIF-2), a drainage landfill, a dump of the SredneGolgotai gold deposit, a tailings dump after processing monocytes, as well as in natural plant communities located in the vicinity of Baley at 13 trial sites in 2008, 2008 and 2021. The concentrations of elements in the leaves were arranged in descending order in the following sequence: Ca Mg P Mn Fe Zn Na Ba B Cr Ni As Cu Mo Sb Pb Co Li V Cd Bi Se Be. With respect to the clark of terrestrial plants, the concentrations of the elements were in the following order: Cr As Sb Li Ni Ba Fe Mo Bi Co Zn Mg Clark Mn P Ca Cu B Pb Se Cd V Be Na. The absorption of As at production facilities exceeded the norm established for medicinal plant raw materials. The use of branch feed in a number of areas is not allowed due to the high level of Zn, Fe, Sb, Ni, Cr, Co, As, Cd. A relatively high coefficient of biological absorption by birch leaves Zn, Mn, P, Ca, Mg was obtained.

Triple-enhanced Raman scattering sensor based on superhydrophobic/-philic microsphere platform and heating evaporation assisted for high-sensitivity detection

The ability to detect molecules in small volumes of highly diluted solutions is crucial for applications such as food quality and safety, environmental monitoring, biomedical diagnostics, and so on. The primary concern lies in the sensitivity and efficiency of detection technology. In this work, an ultra-sensitive surface-enhanced Raman scattering (SERS) detection strategy is presented, which is based on superhydrophobic/-philic microsphere SERS (SSM-SERS) platform and heating evaporation assisted for high-sensitivity detection. Relying on the heating-assisted evaporation, the evaporation efficiency of the droplet is increased by 378.5 times, and the deposition area after evaporation is reduced by 10.4 times, leading to the extremely high detection efficiency and further enrichment of the target molecules. When the microspheres array approaches the superhydrophobic/-philic (SH/SHL) substrate, the optical-plasmonic hybrid structure is formed, enhancing light-matter interactions and resulting in an improvement of the Raman signal. The optimized SERS sensor is capable of detecting Rhodamine 6 G (R6G) at the femtomolar level (10−16 M), with a sample volume of only 5 μL and an enhancement factor of 3.29 × 109. Considering the misuse of fish drugs, malachite green (MG) and methylene blue (MB) were chosen to validate the performance of SERS sensor. These findings highlight the consistent high sensitivity of the SERS sensor, offering valuable insights for applications in food safety and related fields.

Integrated monitoring of the area of Zhilandy deposits

Integrated monitoring of the area of Zhilandy deposits

Diastolic dysfunction in Alzheimer’s disease model mice is associated with Aβ-amyloid aggregate formation and mitochondrial dysfunction

Alzheimer's Disease (AD) is a progressive neurodegenerative disease caused by the deposition of Aβ aggregates or neurofibrillary tangles. AD patients are primarily diagnosed with the concurrent development of several cardiovascular dysfunctions. While few studies have indicated the presence of intramyocardial Aβ aggregates, none of the studies have performed detailed analyses for pathomechanism of cardiac dysfunction in AD patients. This manuscript used aged APPSWE/PS1 Tg and littermate age-matched wildtype (Wt) mice to characterize cardiac dysfunction and analyze associated pathophysiology. Detailed assessment of cardiac functional parameters demonstrated the development of diastolic dysfunction in APPSWE/PS1 Tg hearts compared to Wt hearts. Muscle function evaluation showed functional impairment (decreased exercise tolerance and muscle strength) in APPSWE/PS1 Tg mice. Biochemical and histochemical analysis revealed Aβ aggregate accumulation in APPSWE/PS1 Tg mice myocardium. APPSWE/PS1 Tg mice hearts also demonstrated histopathological remodeling (increased collagen deposition and myocyte cross-sectional area). Additionally, APPSWE/PS1 Tg hearts showed altered mitochondrial dynamics, reduced antioxidant protein levels, and impaired mitochondrial proteostasis compared to Wt mice. APPSWE/PS1 Tg hearts also developed mitochondrial dysfunction with decreased OXPHOS and PDH protein complex expressions, altered ETC complex dynamics, decreased complex activities, and reduced mitochondrial respiration. Our results indicated that Aβ aggregates in APPSWE/PS1 Tg hearts are associated with defects in mitochondrial respiration and complex activities, which may collectively lead to cardiac diastolic dysfunction and myocardial pathological remodeling.

Evolution of wetlands in the northern part of the Po Delta: The experience of unmanaged realignments

AbstractIt is increasingly recognised that nature‐based solutions in coastal ecosystems provide significant services compared to hard engineering measures. Several restoration projects are now being conducted worldwide to protect coastlines against flood risk and improve the ecosystems' quality. In the case of river deltas, managed realignment through levee breaching is becoming a recognised strategy for coastal wetland restoration. This study focusses on the formation of new wetlands in the Po River Delta after several natural dyke failures that occurred during the last century, when a large part of the land was abandoned and became wetlands. An historical review was performed to quantify the variation of the marsh extent in time developed after natural levee breaching in the easternmost lagoons of the delta and to understand the processes that determined their evolution. The analyses were based on orthophotos from the 1950s to the present‐day integrated with tidal records, water and sediment discharge records, and GPS survey for vegetation distribution. The review indicated that, between the 1950s and 1980s, anthropisation and natural processes caused a strong decline in marsh extent, thus leading to the recent shape of the lagoons. Several breaches and inlets were developed because of a combination of human intervention and erosive processes, and new tidal systems were born. Three main depositional areas connecting the main river branches were identified in three separated lagoons of the delta. These lagoons presented a ‘crevasse splay’ type of deposition which allowed the development of new tidal flats and, in certain cases, of large freshwater marsh systems within less than 8 years after the breach. The newly formed wetland systems (>100 ha) demonstrate the ability of the Po River Delta to build new wetlands, also during periods of human‐induced sediment starvation and high rates of subsidence, suggesting that further levee breaching should be exploited to favour marsh recovery.

Isotopically light Mo in sediments of methane seepage controlled by the benthic Fe–Mn redox shuttle process

Methane seepage has been extensively observed in various continental margin settings. It has profound effects on the marine redox environment and the molybdenum (Mo) cycles in marine sediments. Therefore, there has been much recent attention on the redox-sensitive behavior of Mo in methane seepage environments. However, the characteristics of the Mo isotope composition in the cold-seep system remain poorly understood. In this study, we performed geochemical analyses, including Mo content and isotope composition, on sediment samples (core QDN-MS6) from the “Haima” cold-seep deposit area in the South China Sea. The analysis reveals a significant concentration of authigenic pyrite in the mid-section of QDN-MS6 core (373–403 cm). Moreover, the δ34S value in this interval is notably elevated with high total sulfur/total organic carbon ratio. Additionally, the sediments in the mid-section exhibits substantial enrichment in Mo (enrichment factors of Mo ranging from 5.29 to 39.32). This implies that the sediments in the mid-section are influenced by sulfate-driven anaerobic oxidation of methane. Most notably, the sediments in the mid-section displayed distinct low δ98Mo values (with an average of −0.7‰). After careful consideration, we ruled out the influence of organic matter, an oxic environment, a weakly sulfidic environment, and incomplete removal of thiopolybdate as contributing factors. Based on δ56Fe-Fe/Al ratios, (Mo–U) enrichment factors, and As enrichment factors, we propose that the “benthic Fe-Mn redox shuttle process” is the primary cause of the observed light δ98Mo signatures in sediments. This newly identified mechanism sheds light on Mo isotope cycling in methane seepage environments and enhances our understanding of the Mo isotope cycling process.

The role of ruminant urine and faeces in the recycling of nutrients by forages

This study addresses the effect of using animal excreta on the nutritional content of forages, focusing on macro- and micro-element concentrations (nitrogen; N, phosphorus; P, sulphur; S, copper; Cu, zinc; Zn, manganese; Mn, selenium; Se) from animal feed to excreta, soil, and plants. Data were collected from pot and field trials using separate applications of sheep or cattle urine and faeces. Key findings indicate that soil organic carbon (SOC) and the type of excreta significantly influences nutrient uptake by forages, with varied responses among the seven elements defined above. Although urine contributes fewer micronutrients compared to faeces (as applied at a natural volume/mass basis, respectively), it notably improves forage yield and micronutrient accumulation, thus potentially delivering positive consequences at the farm level regarding economic performance and soil fertility when swards upon clayey soil types receive said urine in temperate agro-climatic regions (i.e., South West England in the current context). In contrast, faeces application in isolation hinders Se and Mn uptake, once again potentially delivering unintended consequences such as micronutrient deficiencies in areas of high faeces deposition. As it is unlikely that (b)ovine grazing fields will receive either urine or faeces in isolation, we also explored combined applications of both excreta types which demonstrates synergistic effects on N, Cu, and Zn uptake, with either synergistic or dilution effects being observed for P and S, depending largely on SOC levels. Additionally, interactions between excreta types can result in dilution or antagonistic effects on Mn and Se uptake. Notably, high SOC combined with faeces reduces Mn and Se in forages, raising concerns for grazed ruminant systems under certain biotic situations, e.g., due to insufficient soil Se levels typically observed in UK pastures for livestock growth. These findings underscore the importance of considering SOC and excreta nutritional composition when designing forage management to optimize nutrient uptake. It should be noted that these findings have potential ramifications for broader studies of sustainable agriculture through system-scale analyses, as the granularity of results reported herein elucidate gaps in knowledge which could affect, both positively and negatively, the interpretation of model-based environmental impact assessments of cattle and sheep production (e.g., in the case of increased yields [beneficial] or the requirement of additional synthetic supplementation [detrimental]).

Experimental and numerical investigations of secondary granular flow

AbstractAmong the geological disasters in the form of granular flow, the secondary slide mass is often neglected, potentially leading to unexpected losses. Results indicate that under conditions of a certain sliding total mass, the secondary granular flow in the deposition area is significantly influenced by pre‐formed deposits when tested in a flow flume. When the initial sliding mass is small and the mass ratio of two slides is less than 12.5%, the secondary sliding mass expands the runout distance, thereby increasing potential harm. To elucidate the interaction between the secondary sliding mass and the previously formed deposition, DEM (the discrete element method) was employed based on experimental tests.. The numerical results show that the previous deposition effectively blocks the secondary granular flow. When the initial sliding mass is small, the front edge of the second slide may overtop the previous deposition, extending the runout distance by impact, extrusion, and pushing. The DEM proves to be a reliable and effective tool for studying the secondary granular flow, revealing complex phenomena and processes that complement experimental research. This study provides valuable references for a more in‐depth understanding of multi‐phase continuous disaster processes.

An alternative approach for the sediment control of in-channel stony debris flows with an application to the case study of Ru Secco Creek (Venetian Dolomites, Northeast Italy)

Controlling sediment to reduce debris-flow hazard is generally approached using retention basins that can be closed or have an outlet structure, generally an open check dam. They are usually placed in mild slope zones that allow minimal works for the excavation and the foundation of the outlet structure if present. Recently, it has been shown that the detention of sediments can also be achieved in the high-sloping reaches of debris-flow channels using deposition areas, basins that are open on the downstream side. In this work, we propose an approach for controlling the sediment volume transported by debris flows consisting of a cascade of deposition areas and retention basins. We also include a framework for planning, sizing, and checking the works. Two scenarios are considered, corresponding to the maximum values of the debris-flow peak discharge and volume, respectively. Moreover, the presence or absence of boulders is also considered. For this purpose, a method that evaluates the clogging of a single open check dam as a function of the coarse fraction of the sediment volume is simply extended to the case of multiple dams and implemented in a routing model. The proposed approach is applied along Ru Secco Creek in northeast Italy to defend a resort area and a village hit by a high-magnitude debris flow in 2015. After a careful survey and study, a solution with a combination of deposition areas and retention basins is planned and sized. The validity and performance of the proposed solution are analyzed using debris-flow modeling for two scenarios, considering both the absence and presence of boulders. Most of the sediment volume transported by debris flows is trapped, and a small solid discharge flows downstream of the works.

Diagnostics of phase composition of lithium niobate films on sapphire by principal component analysis using Raman spectra

Thin films of lithium niobate were deposited by RF diode sputtering of a LiNbO3 single-crystal target on a heated sapphire substrate (R-cut, 650 °C). Radial distributions of the phase composition of the films along the substrate were obtained by principal component analysis (PCA) using Raman spectra. It was found that at small target-substrate distances (12 mm is the distance between the target and the substrate, 76 mm is the diameters of the target and the substrate holder, 30 mm is the size of the film deposition area in axial geometry), the effects of resputtering of the deposited film do not lead to a considerable decrease in the lithium content: no phases other than LiNbO3 are formed in the extended central part of the film, the edge of the film contains no more than 2 % of the undesirable LiNb3O8 phase, and the difference in the measured values of deviation of LiNbO3 phase composition from stoichiometry in the film compared to the target is 0.7 mol% Li2O. These results indicate that the technology for depositing of lithium niobate films can be improved since there is no need to produce a target additionally enriched with Li2O.

Hydrogeochemical characteristics and enrichment regularities of groundwater uranium in the Erlian basin, China

Groundwater is a key medium for the migration and enrichment of elements into ore bodies in sandstone-type uranium deposits, with anomalies of uranium elements and their associated components in water serving as indicators for exploring such deposits. The Erlian Basin, located in central-northern Inner Mongolia, is a crucial production area for sandstone-type uranium deposits in China. The groundwater flow system in the basin plays a significant role in the formation of uranium deposits. To study the hydrogeochemical characteristics and enrichment regularities of groundwater uranium in the Erlian Basin, 269 groundwater samples were collected. Hydrogeochemical analysis methods, such as Piper diagrams, Gibbs diagrams, and contour maps, were employed to determine the distribution characteristics and occurrence forms of groundwater uranium in the study area. The primary water chemistry types in the study area were HCO3–Ca•Na, HCO3–Na, HCO3•SO4–Na, and SO4•HCO3–Na•Ca. The distribution range of uranium content in groundwater in the study area was 0.1–453 μg/L (average of 53.08 μg/L). A comprehensive analysis, based on the direction of groundwater flow and changes in the redox environment, suggested that the higher uranium values in groundwater were distributed in the runoff and discharge areas, with uranium anomaly points existing in areas with alternating oxidation and reduction zones. These uranium anomaly points were in good agreement with the known large uranium deposits of Nuheting, Qiharigetu, Daoersu, and others, thereby predicting six other uranium hydrochemical anomaly points as prospective areas for uranium mineralization. The pH value distribution range in the study area's groundwater was 6.8–9.1, and the redox potential (Eh) value range was -126–52 mV, indicating that uranium exists in groundwater in the form of UO2(CO3)34− and UO2(CO3)22−. An increase in bicarbonate (HCO3−) is conducive to uranium dissolution. The enrichment and occurrence forms of uranium in groundwater are influenced by the concentrations of Fe and (Ca2++Mg2+), with uranium precipitation and enrichment occurring as the groundwater evolves and changes in the redox environment. The uranium content in deep wells is higher than in nearby shallow wells, indicating that deep water circulation is beneficial for mineralization. The pH, Eh, HCO3−, Fe, and other hydrogeochemical indicators are indicative of uranium enrichment; thus, they can be considered as reference bases when exploring for potential uranium resources.

A NEW MID-MIOCENE WOOD FROM OCNA DEJ SALT MINE

Ocna Dej is an iconic locality for salt mining in Transylvania, being located in the north - north-western area of the Middle Miocene sedimentary basin of Transylvania. In this salt the fossils are rare and refer strictly to plant remains (fragments of wood, pine cones, etc.). A sample of charred wood collected from the area of Ocna Dej salt deposit of Middle Badenian age (Wielician) was submitted to a microscopic study for a taxonomic assignation. It was identified as Cupressinoxylon sp. aff. Thujoxylon sp. as a remain of the synchronous vegetation. This wood type is found for the first time in Ocna Dej salt and could contributes to the paleo-environmental reconstruction of this area. Obviously, wildfires occurred at that time around the marine sedimentary basin of Transylvania.

The April 11, 2023 Catastrophic Explosive Eruption of Sheveluch Volcano (Kamchatka)

The paper presents the data on the April 11, 2023 Sheveluch Volcano eruption. We conducted post-eruption impact assessment. The directed blast resulted in the collapse of the lava dome which had been forming for more than 42 years. The data obtained just before the eruption evidence that the total volume of the lava dome comprised about 0.53 km3. The volcanic explosion resulted in the formation of the field of pyroclastic deposits ~70 km2 in size and 0.49 km3 in volume. The directed blast was accompanied by the 25–30 km long pyroclastic flows and the ashfall more than 200 km away from the volcano. The weight of the ash deposits samples was ranging from 1.2 to 43.9 kg/m2, depending on the distance from the volcano. The area of ash deposits (ash samples of more than 50 g/m2 in weight) covered the area of 17000 m2 and comprised the volume of 0.09 km3. Taking into account the total volume of erupted products (0.6 km3), the April 11, 2023 Sheveluch Volcano eruption can be referred to the largest catastrophic eruption of this century.

Minor Effects of Canopy and Understory Nitrogen Addition on Soil Organic Carbon Turnover Time in Moso Bamboo Forests

Increased atmospheric nitrogen (N) deposition has greatly influenced soil organic carbon (SOC) dynamics. Currently, the response of SOC to atmospheric N deposition is generally detected through understory N addition, while canopy processes have been largely ignored. In the present study, canopy N addition (CN) and understory N addition (UN, 50 and 100 kg N ha−1 year−1) were performed in a Moso bamboo forest to compare whether CN and UN addition have consistent effects on SOC and SOC turnover times (τsoil: defined as the ratio of SOC stock and soil heterotrophic respiration) with a local NHx:NOy ratio of 2.08:1. The experimental results showed that after five years, the SOC content of canopy water addition without N addition (CN0) was 82.9 g C kg−1, while it was 79.3, 70.7, 79.5 and 74.5 g C kg−1 for CN50, CN100, UN50 and UN100, respectively, and no significant difference was found for the SOC content between CN and UN. Five-year N addition did not significantly change τsoil, which was 34.5 ± 7.4 (mean ± standard error) for CN0, and it was 24.9 ± 4.8, 22.4 ± 4.9, 30.5 ± 4.0 and 22.1 ± 6.5 years for CN0, CN50, CN100, UN50 and UN100, respectively. Partial least squares structural equation modeling explained 93% of the variance in τsoil, and the results showed that soil enzyme activity was the most important positive factor controlling τsoil. These findings contradicted the previous assumption that UN may overestimate the impacts of N deposition on SOC. Our findings were mainly related to the high N deposition background in the study area, the special forest type of Moso bamboo and the short duration of the experiment. Therefore, our study had significant implications for modeling SOC dynamics to N deposition for high N deposition areas.

Mechanism of astragaloside Ⅳ modulation of Nrf2/HO-1/GPX4 pathway to inhibit ferroptosis and ameliorate atherosclerosis in ApoE~(-/-) mice

The intervention effect of astragaloside Ⅳ(AS-Ⅳ) on atherosclerosis in apolipoprotein E gene knockout(ApoE)~(-/-) mice was observed based on the nuclear factor erythroid-2-related factor 2(Nrf2)/heme oxygenase-1(HO-1)/glutathione peroxidase 4(GPX4) signaling pathway to explore the potential mechanism of AS-Ⅳ in improving ferroptosis in atherosclerotic mice. This study established an atherosclerosis mouse model by feeding them a high-fat diet. After modeling for 8 weeks, ApoE~(-/-) mice were randomly divided into the model group, AS-Ⅳ group, AS-Ⅳ+Nrf2 inhibitor(ML385) group, and ferrostatin-1(Fer-1) group. Additionally, a blank control group was also established. Corresponding drugs were administered via intraperitoneal injection, with the control group receiving an equivalent amount of normal saline injection as the model group. After the experiment, serum biochemical levels were measured using an automatic blood lipid analyzer, hematoxylin-eosin(HE) staining was used to observe morphological changes in aortic sinus tissues, colorimetric methods were used to detect levels of ferrous ion(Fe~(2+)), malondialdehyde(MDA), glutathione(GSH), and superoxide dismutase(SOD) in mouse serum, immunofluorescence was used to observe the expressions of ferritin heavy chain 1(FTH1) and ferritin light chain(FTL) proteins in the aortic sinus of mice, Western blot was used to detect the protein levels of Nrf2, HO-1, and GPX4 in mouse aortic tissues, and transmission electron microscopy was used to observe ultrastructural changes in aortic tissues. RESULTS:: showed that compared to the control group, the model group of mice had significantly increased calcification and plaque deposition areas in the aortic sinus, increased mitochondrial membrane density, decreased or disappeared mitochondrial cristae, elevated levels of total cholesterol(TC), triglycerides(TG), low-density lipoprotein cholesterol(LDL-C), Fe~(2+), and MDA, decreased levels of high-density lipoprotein cholesterol(HDL-C), SOD, and GSH, and significant inhibition of Nrf2, HO-1, GPX4 proteins, as well as iron storage proteins FTH1 and FTL expressions in the aorta. Compared to the model group, AS-Ⅳ treatment resulted in decreased serum TC, TG, LDL-C, Fe~(2+), and MDA levels, increased HDL-C, SOD, and GSH levels, increased expressions of Nrf2, HO-1, and GPX4 proteins, and iron storage proteins FTH1 and FTL, and significant improvement in aortic tissue morphology. Compared to the AS-Ⅳ group, the Nrf2 inhibitor ML385 could reverse the therapeutic effect of AS-Ⅳ on atherosclerosis mice. These findings suggest that AS-Ⅳ can inhibit ferroptosis and improve atherosclerosis in ApoE~(-/-) mice, and its mechanism of action may be related to the regulation of the Nrf2/HO-1/GPX4 signaling pathway.

Effect of compatibility of Corni Fructus before and after wine-processing with Astragali Radix on plasma metabolomics in diabetic nephropathy rats based on UHPLC-Q-TOF-MS/MS

Based on the processing and compatibility, this study explored the effects of components in Corni Fructus(CF) and Astragali Radix(AR) on plasma metabolomics in diabetic nephropathy rats. SD rats were randomly divided into four groups and diabetic nephropathy rat model was induced by high-fat diet combined with 30 mg·kg~(-1) streptozotocin(STZ). Histopathological observations of kidney tissue sections of rats in each group were conducted using HE, PAS, and Masson staining. Ultra-high performance liquid chromatography-quadrupole time-of-flight tandem mass spectrometry(UHPLC-Q-TOF-MS/MS) metabolomics method was employed to investigate the effects of CF before and after wine-processing combined with AR-related components on plasma metabolites in diabetic nephropathy rats. After drug treatment, kidney tissue damage and interstitial collagen fiber deposition area in diabetic nephropathy rats were improved to varying degrees(P<0.001). The detection results of plasma metabolomics showed that 71 biomarkers related to the pathogenesis of diabetic nephropathy were identified in diseased rats, mainly involving linoleic acid metabolism, caffeine metabolism, glycerophospholipid metabolism, phenylalanine, tyrosine and tryptophan biosynthesis, arachidonic acid metabolism, phenylalanine metabolism, retinol metabolism, and ether lipid metabolism. After drug intervention, 26 of them were significantly downregulated, with better efficacy observed in precision processed herb-pair group(P-CG_5). This study elucidated from the perspective of plasma metabolomics that P-CG_5 could improve metabolic disorders in diabetic nephropathy through pathways such as phenylalanine, tyrosine and tryptophan biosynthesis, phenylalanine metabolism, and caffeine metabolism, providing theoretical support and experimental basis for the clinical application of CF and AR compatibility in traditional Chinese medicine.

SPECIFICS OF DESIGNING AN INFRARED PYROMETER-REFLECTOMETER FOR SEMICONDUCTOR HETEROSTRUCTURE FABRICATION

There are general technical requirements for all types of reactors for chemical vapour deposition technology using AIII- BV metalorganic compounds. Among them, it is worth highlighting the large temperature gradients that cause the origin of convection loops, which in turn, taking into account the high speed of the gas flow, lead to turbulence in the reactor instead of the expected laminar flow. It is also important to take into account the change in parameters of the wafer surface during the growth process and the need for signal separation between the useful signal from the wafer surface and the background signal from the wafer carrier, which rotates at fixed speed for uniform deposition of compounds. To obtain high-quality heterostructures with reproducible parameters, it is important to have a system of precise temperature control on the wafer surface directly in the deposition area, since the deposition process for many complex semiconductor devices (for example, laser diodes, LEDs, photodiodes, transistors on heterojunctions) is very sensitive to temperature changes. The method of optical pyrometry is a non-contact method that allows to precisely determine the temperature of the wafer surface and meets the technical requirements of CVD epitaxy growth reactors. This article is devoted to the analysis of the features of the development of optoelectronic systems for precise temperature measurement during epitaxial growth in order to determine the criteria for the selection or development of components of the optoelectronic system of the pyrometer-reflectometer. The main physical processes, electro-optical characteristics of Si photodiode, AlGaAs/GaAs LED and parameters of bandpass interference filters were investigated. Based on the analysis of the obtained research and measurement results, scientific recommendations have been developed. The recommendations aimed at the selection and optimization of the parameters of the components of the pyrometer-reflectometer (photodetectors, light emitting diodes, optical filters) in order to improve the accuracy and temperature stability of measurements in the pyrometer’s operation conditions, which take into account the compensation of emissivity change from the surface of the wafer.

Facies and depositional sequences of Melendiz Confluence Holocene sediments, Central Anatolia, Turkey

The aim of this article is to investigate the Çiftlik Plain and the Central Anatolia Cappadocia Volcanic Province, the unexplored Quaternary fills, and their climate records. This studies has gained importance as it completes a deficiency in the region.A confluence is where a tributary joins a larger river which depicts an important area of deposition which is an essential geomorphological node that controls the downstream routing of flow and (P2), located between latitudes N38°11' and longitudes E34°27', at an altitude of 1532m above sea level in the Çiftlik Basin. In this Confluence in Çiftlik (M-1 to M-10) (A-J), consisting of paleosols and terrestrial sediments (P2), in which a profile from a collection of 41 specimens was initially examined. This article evaluates therefore the depositional sequences of sediments brought in by the Melendiz stream that flourished during the Early Quaternary. The Quaternary fills are made up of terrestrial sediments and paleosols and consisted of fined, medium and coarse grains ranging from peat, silt. clay, sands, pebbles of various different sizes. Some of these grains came from the immediate surroundings seen from their coarse and angular shapes while the fined grains must have travelled for a long distance having been worked and reworked by wind and running water. To determine the quality and quantity of the collected samples, the samples were prepared for measurement by passing the necessary processes according to the type of sedimentological, mineralogical, soil types and XRD. By analyzing the data obtained from these measurements, the mineral types, distributions, chemical components, and trace elements contained in partially lithified or unconsolidated sediments of the region were determined. The relationship of these data with paleoclimate has been revealed and compared with the Central Anatolian climate records. The Pliocene lake regressed toward the west on account of the progressions in the structural system and geomorphological cycles during the late Pliocene (~ 3 Ma ago) and the underlying Melendiz Waterway created on the lake base. During the Quaternary the Melendiz Stream created heavily influenced by both the neotectonic system and the environment. The sediments are very poorly sorted in some levels of unconsolidated or partially lithified sediments and paleosol, and poorly sorted in some levels. On the other hand, quartz, feldspar, amphibole, and rock fragments such as metamorphic, volcanic and igneous are commonly observed in paleosol, silty and sandy levels. In XRD measurements, paleosol, silty and sandy levels contain common feldspar, quartz, amphibole, Opal CT and Opal A minerals. The amounts of smectite, chlorite, illite as clay minerals at these levels vary at various levels of the profiles. The results of these calculations help us to explain the sediment-paleosol formation processes. They are of the Quaternary and primarily Holocene.