While the Hamiltonians used in standard quantum mechanics are Hermitian, it is also possible to extend the theory to non-Hermitian Hamiltonians. Particularly interesting are non-Hermitian Hamiltonians satisfying parity–time (PT) symmetry, or more generally pseudo-Hermiticity, since such non-Hermitian Hamiltonians can still exhibit real eigenvalues. In this article, we present a quantum simulation of the time-dependent non-Hermitian non-PT-symmetric Hamiltonian used in a pseudo-Hermitian extension of the Landau–Zener–Stückelberg–Majorana (LZSM) model. The simulation is implemented on a superconducting processor by using Naimark dilation to transform a non-Hermitian Hamiltonian for one qubit into a Hermitian Hamiltonian for a qubit and an ancilla; postselection on the ancilla state ensures that the qubit undergoes nonunitary time evolution corresponding to the original non-Hermitian Hamiltonian. We observe properties such as the dependence of transition probabilities on time and the replacement of conservation of total probability by other dynamical invariants in agreement with predictions based on a theoretical treatment of the pseudo-Hermitian LZSM system. Published by the American Physical Society 2024