Teaching might not be the most popular profession in the world, but it is undoubtedly the most populated. With the change in the Department of Education in the Philippines, school leaders and teachers are challenged to maintain work performance under stressful conditions. The aim of this study is to investigate the implication of leader-member exchange relationship, school culture, job satisfaction on teachers’ work performance. This study utilized descriptive correlational design and stratified random sampling on the selection of the 157 senior high school teachers from two private universities in Cagayan de Oro City, Academic Year 2023-2024. Data revealed that teachers and principals have a very strong leader-member exchange relationship and shows no significant difference on their relationship. Teachers’ meets their expectations in their overall school culture, has an overall moderate job satisfaction, and exhibits strength on their overall work performance. The study also reveals no significant difference of the teachers’ overall work performance in terms of profile. However, contribution on LMX, teachers’ collaboration on school culture, and job responsibilities and community attachments/linkages have contributed teachers’ work performance. Thus, the theory of Maslow confirms teachers’ needs based on the study’s results. Therefore, this study recommends teachers to possibly show sense of openness to their principal, foster collaboration with colleagues, enroll in graduates studies, engage in community services and teachers serving 5 years above to possibly improve their personal attributes and engagement in community activities. Principals, on the other hand, to provide equal opportunities and minimize the work of the teachers. School administrators to possibly meet the needs of the teaching staff in improving job satisfaction and future research to consider other variables as part of the study’s limitations.